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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AlphaK1
Full Name:
Alpha-protein kinase 3
Alias:
Alpha-kinase 3; ALPK3; KIAA1330; MAK; Midori; Muscle alpha-kinase; Muscle alpha-protein kinase; Myocyte induction differentiation originator
Type:
Protein kinase, atypical; EC 2.7.11.-;
ATYPICAL
group; Alpha family
Mass (Da):
201284
Number AA:
1907
UniProt ID:
Q96L96
International Prot ID:
IPI00064935
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007507
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S41
W
L
P
G
L
P
R
S
S
P
S
W
P
A
V
Site 2
S42
L
P
G
L
P
R
S
S
P
S
W
P
A
V
D
Site 3
S44
G
L
P
R
S
S
P
S
W
P
A
V
D
L
A
Site 4
T66
R
G
P
L
I
C
H
T
G
H
E
Q
A
G
R
Site 5
S79
G
R
E
P
G
P
G
S
S
T
K
G
P
V
L
Site 6
S80
R
E
P
G
P
G
S
S
T
K
G
P
V
L
H
Site 7
T81
E
P
G
P
G
S
S
T
K
G
P
V
L
H
D
Site 8
T91
P
V
L
H
D
Q
D
T
R
C
A
F
L
P
R
Site 9
T105
R
P
P
G
P
L
Q
T
R
R
Y
C
R
H
Q
Site 10
Y108
G
P
L
Q
T
R
R
Y
C
R
H
Q
G
R
Q
Site 11
S117
R
H
Q
G
R
Q
G
S
G
L
G
A
G
P
G
Site 12
T127
G
A
G
P
G
A
G
T
W
A
P
A
P
P
G
Site 13
S136
A
P
A
P
P
G
V
S
K
P
R
C
P
G
R
Site 14
T155
E
G
Q
Q
Q
V
T
T
A
R
P
P
A
I
N
Site 15
S192
R
T
G
E
A
A
A
S
A
G
P
A
V
G
E
Site 16
S205
G
E
G
G
A
M
G
S
R
R
A
P
T
R
G
Site 17
T210
M
G
S
R
R
A
P
T
R
G
W
G
A
G
G
Site 18
S219
G
W
G
A
G
G
R
S
G
A
G
G
D
G
E
Site 19
S235
D
G
P
V
W
I
P
S
P
A
S
R
S
Y
L
Site 20
S240
I
P
S
P
A
S
R
S
Y
L
L
S
V
R
P
Site 21
Y241
P
S
P
A
S
R
S
Y
L
L
S
V
R
P
E
Site 22
S244
A
S
R
S
Y
L
L
S
V
R
P
E
T
S
L
Site 23
T249
L
L
S
V
R
P
E
T
S
L
S
S
N
R
L
Site 24
S250
L
S
V
R
P
E
T
S
L
S
S
N
R
L
S
Site 25
S252
V
R
P
E
T
S
L
S
S
N
R
L
S
H
P
Site 26
S253
R
P
E
T
S
L
S
S
N
R
L
S
H
P
S
Site 27
S257
S
L
S
S
N
R
L
S
H
P
S
S
G
R
S
Site 28
S260
S
N
R
L
S
H
P
S
S
G
R
S
T
F
C
Site 29
S261
N
R
L
S
H
P
S
S
G
R
S
T
F
C
S
Site 30
S264
S
H
P
S
S
G
R
S
T
F
C
S
I
I
A
Site 31
T265
H
P
S
S
G
R
S
T
F
C
S
I
I
A
Q
Site 32
T283
E
T
Q
P
L
F
E
T
T
L
K
S
R
S
V
Site 33
S287
L
F
E
T
T
L
K
S
R
S
V
S
E
D
S
Site 34
S289
E
T
T
L
K
S
R
S
V
S
E
D
S
D
V
Site 35
S291
T
L
K
S
R
S
V
S
E
D
S
D
V
R
F
Site 36
S294
S
R
S
V
S
E
D
S
D
V
R
F
T
C
I
Site 37
T299
E
D
S
D
V
R
F
T
C
I
V
T
G
Y
P
Site 38
T311
G
Y
P
E
P
E
V
T
W
Y
K
D
D
T
E
Site 39
Y313
P
E
P
E
V
T
W
Y
K
D
D
T
E
L
D
Site 40
Y322
D
D
T
E
L
D
R
Y
C
G
L
P
K
Y
E
Site 41
Y328
R
Y
C
G
L
P
K
Y
E
I
T
H
Q
G
N
Site 42
T338
T
H
Q
G
N
R
H
T
L
Q
L
Y
R
C
R
Site 43
Y342
N
R
H
T
L
Q
L
Y
R
C
R
E
E
D
A
Site 44
Y352
R
E
E
D
A
A
I
Y
Q
A
S
A
Q
N
S
Site 45
S359
Y
Q
A
S
A
Q
N
S
K
G
I
V
S
C
S
Site 46
S401
K
L
R
E
I
E
Q
S
W
K
H
E
K
A
V
Site 47
T414
A
V
P
G
E
V
D
T
L
R
K
L
S
P
D
Site 48
S419
V
D
T
L
R
K
L
S
P
D
R
F
Q
R
K
Site 49
S430
F
Q
R
K
R
R
L
S
G
A
Q
A
P
G
P
Site 50
S438
G
A
Q
A
P
G
P
S
V
P
T
R
E
P
E
Site 51
T441
A
P
G
P
S
V
P
T
R
E
P
E
G
G
T
Site 52
T477
S
F
A
S
G
E
V
T
T
N
G
E
A
A
P
Site 53
S540
E
L
E
K
A
A
Q
S
R
R
S
S
E
N
C
Site 54
S543
K
A
A
Q
S
R
R
S
S
E
N
C
I
P
S
Site 55
S544
A
A
Q
S
R
R
S
S
E
N
C
I
P
S
S
Site 56
S550
S
S
E
N
C
I
P
S
S
D
E
P
D
S
C
Site 57
S551
S
E
N
C
I
P
S
S
D
E
P
D
S
C
G
Site 58
S556
P
S
S
D
E
P
D
S
C
G
T
Q
G
P
V
Site 59
T570
V
G
V
E
Q
V
Q
T
Q
P
R
G
R
A
A
Site 60
S582
R
A
A
R
G
P
G
S
S
G
T
D
S
T
R
Site 61
S583
A
A
R
G
P
G
S
S
G
T
D
S
T
R
K
Site 62
S587
P
G
S
S
G
T
D
S
T
R
K
P
A
S
A
Site 63
T588
G
S
S
G
T
D
S
T
R
K
P
A
S
A
V
Site 64
S593
D
S
T
R
K
P
A
S
A
V
G
T
P
D
K
Site 65
T597
K
P
A
S
A
V
G
T
P
D
K
A
Q
K
A
Site 66
Y614
P
G
P
G
Q
E
V
Y
F
S
L
K
D
M
Y
Site 67
S616
P
G
Q
E
V
Y
F
S
L
K
D
M
Y
L
E
Site 68
Y621
Y
F
S
L
K
D
M
Y
L
E
N
T
Q
A
V
Site 69
T625
K
D
M
Y
L
E
N
T
Q
A
V
R
P
L
G
Site 70
T638
L
G
E
E
G
P
Q
T
L
S
V
R
A
P
G
Site 71
S640
E
E
G
P
Q
T
L
S
V
R
A
P
G
E
S
Site 72
S647
S
V
R
A
P
G
E
S
P
K
G
K
A
P
L
Site 73
S658
K
A
P
L
R
A
R
S
E
G
V
P
G
A
P
Site 74
T669
P
G
A
P
G
Q
P
T
H
S
L
T
P
Q
P
Site 75
S671
A
P
G
Q
P
T
H
S
L
T
P
Q
P
T
R
Site 76
T673
G
Q
P
T
H
S
L
T
P
Q
P
T
R
P
F
Site 77
T695
P
K
P
K
G
E
A
T
T
D
S
K
P
I
S
Site 78
S698
K
G
E
A
T
T
D
S
K
P
I
S
S
L
S
Site 79
S702
T
T
D
S
K
P
I
S
S
L
S
Q
A
P
E
Site 80
S703
T
D
S
K
P
I
S
S
L
S
Q
A
P
E
C
Site 81
S705
S
K
P
I
S
S
L
S
Q
A
P
E
C
G
A
Site 82
S714
A
P
E
C
G
A
Q
S
L
G
K
A
P
P
Q
Site 83
S723
G
K
A
P
P
Q
A
S
V
Q
V
P
T
P
P
Site 84
T728
Q
A
S
V
Q
V
P
T
P
P
A
R
R
R
H
Site 85
T737
P
A
R
R
R
H
G
T
R
D
S
T
L
Q
G
Site 86
S740
R
R
H
G
T
R
D
S
T
L
Q
G
Q
A
G
Site 87
T741
R
H
G
T
R
D
S
T
L
Q
G
Q
A
G
H
Site 88
T750
Q
G
Q
A
G
H
R
T
P
G
E
V
L
E
C
Site 89
T760
E
V
L
E
C
Q
T
T
T
A
P
T
M
S
A
Site 90
T764
C
Q
T
T
T
A
P
T
M
S
A
S
S
S
S
Site 91
S766
T
T
T
A
P
T
M
S
A
S
S
S
S
D
V
Site 92
S768
T
A
P
T
M
S
A
S
S
S
S
D
V
A
S
Site 93
S770
P
T
M
S
A
S
S
S
S
D
V
A
S
I
G
Site 94
S775
S
S
S
S
D
V
A
S
I
G
V
S
T
S
G
Site 95
T794
I
E
P
M
D
M
E
T
Q
E
D
G
R
T
S
Site 96
T800
E
T
Q
E
D
G
R
T
S
A
N
Q
R
T
G
Site 97
S801
T
Q
E
D
G
R
T
S
A
N
Q
R
T
G
S
Site 98
S808
S
A
N
Q
R
T
G
S
K
K
N
V
Q
A
D
Site 99
T829
G
R
T
R
G
D
G
T
Q
T
A
Q
R
T
R
Site 100
T841
R
T
R
A
D
R
K
T
Q
V
D
A
G
T
Q
Site 101
T847
K
T
Q
V
D
A
G
T
Q
E
S
K
R
P
Q
Site 102
S850
V
D
A
G
T
Q
E
S
K
R
P
Q
S
D
R
Site 103
S855
Q
E
S
K
R
P
Q
S
D
R
S
A
Q
K
G
Site 104
T871
M
T
Q
G
R
A
E
T
Q
L
E
T
T
Q
A
Site 105
S914
Q
G
E
K
G
T
Q
S
E
G
S
A
P
T
A
Site 106
S917
K
G
T
Q
S
E
G
S
A
P
T
A
M
E
G
Site 107
S933
S
E
Q
E
V
A
T
S
L
G
P
P
S
R
T
Site 108
S938
A
T
S
L
G
P
P
S
R
T
P
K
L
P
P
Site 109
T940
S
L
G
P
P
S
R
T
P
K
L
P
P
T
A
Site 110
T946
R
T
P
K
L
P
P
T
A
G
P
R
A
P
L
Site 111
T961
N
I
E
C
F
V
Q
T
P
E
G
S
C
F
P
Site 112
S965
F
V
Q
T
P
E
G
S
C
F
P
K
K
P
G
Site 113
S977
K
P
G
C
L
P
R
S
E
E
A
V
V
T
A
Site 114
T983
R
S
E
E
A
V
V
T
A
S
R
N
H
E
Q
Site 115
T991
A
S
R
N
H
E
Q
T
V
L
G
P
L
S
G
Site 116
S1011
A
Q
P
P
H
E
G
S
V
E
Q
V
G
G
E
Site 117
S1025
E
R
C
R
G
P
Q
S
S
G
P
V
E
A
K
Site 118
S1026
R
C
R
G
P
Q
S
S
G
P
V
E
A
K
Q
Site 119
S1036
V
E
A
K
Q
E
D
S
P
F
Q
C
P
K
E
Site 120
S1071
Q
E
V
P
T
M
P
S
L
P
G
T
G
L
T
Site 121
T1075
T
M
P
S
L
P
G
T
G
L
T
A
S
P
K
Site 122
T1078
S
L
P
G
T
G
L
T
A
S
P
K
A
G
P
Site 123
S1080
P
G
T
G
L
T
A
S
P
K
A
G
P
C
S
Site 124
S1087
S
P
K
A
G
P
C
S
T
P
T
S
Q
H
G
Site 125
T1088
P
K
A
G
P
C
S
T
P
T
S
Q
H
G
S
Site 126
S1091
G
P
C
S
T
P
T
S
Q
H
G
S
T
A
T
Site 127
S1095
T
P
T
S
Q
H
G
S
T
A
T
F
L
P
S
Site 128
T1098
S
Q
H
G
S
T
A
T
F
L
P
S
E
D
Q
Site 129
S1102
S
T
A
T
F
L
P
S
E
D
Q
V
L
M
S
Site 130
S1109
S
E
D
Q
V
L
M
S
S
A
P
T
L
H
L
Site 131
S1110
E
D
Q
V
L
M
S
S
A
P
T
L
H
L
G
Site 132
T1120
T
L
H
L
G
L
G
T
P
T
Q
S
H
P
P
Site 133
S1124
G
L
G
T
P
T
Q
S
H
P
P
E
T
M
A
Site 134
T1129
T
Q
S
H
P
P
E
T
M
A
T
S
S
E
G
Site 135
T1132
H
P
P
E
T
M
A
T
S
S
E
G
A
C
A
Site 136
S1134
P
E
T
M
A
T
S
S
E
G
A
C
A
Q
V
Site 137
T1148
V
P
D
V
E
G
R
T
P
G
P
R
S
C
D
Site 138
S1153
G
R
T
P
G
P
R
S
C
D
P
G
L
I
D
Site 139
T1177
L
K
L
S
S
T
E
T
S
G
A
G
G
E
S
Site 140
S1178
K
L
S
S
T
E
T
S
G
A
G
G
E
S
Q
Site 141
S1184
T
S
G
A
G
G
E
S
Q
V
G
A
A
T
G
Site 142
S1209
T
V
E
V
A
G
L
S
P
R
T
S
R
R
I
Site 143
T1212
V
A
G
L
S
P
R
T
S
R
R
I
L
E
R
Site 144
S1213
A
G
L
S
P
R
T
S
R
R
I
L
E
R
V
Site 145
S1235
S
A
Q
T
L
L
L
S
P
C
T
S
R
R
L
Site 146
T1243
P
C
T
S
R
R
L
T
G
L
L
D
R
E
V
Site 147
S1263
A
L
A
A
A
R
G
S
W
G
P
G
P
S
S
Site 148
S1287
E
E
D
P
G
L
A
S
E
G
A
S
E
G
E
Site 149
S1291
G
L
A
S
E
G
A
S
E
G
E
G
E
V
S
Site 150
S1298
S
E
G
E
G
E
V
S
L
E
G
P
G
L
L
Site 151
S1308
G
P
G
L
L
G
A
S
Q
E
S
S
M
A
G
Site 152
S1312
L
G
A
S
Q
E
S
S
M
A
G
R
L
G
E
Site 153
S1334
G
Q
G
P
S
A
E
S
I
A
Q
E
P
S
Q
Site 154
S1340
E
S
I
A
Q
E
P
S
Q
E
E
K
F
P
G
Site 155
T1384
A
G
D
G
E
A
T
T
P
E
E
R
E
S
P
Site 156
S1390
T
T
P
E
E
R
E
S
P
T
V
S
P
R
G
Site 157
T1392
P
E
E
R
E
S
P
T
V
S
P
R
G
P
R
Site 158
S1394
E
R
E
S
P
T
V
S
P
R
G
P
R
K
S
Site 159
S1401
S
P
R
G
P
R
K
S
L
V
P
G
S
P
G
Site 160
S1406
R
K
S
L
V
P
G
S
P
G
T
P
G
R
E
Site 161
T1409
L
V
P
G
S
P
G
T
P
G
R
E
R
R
S
Site 162
S1416
T
P
G
R
E
R
R
S
P
T
Q
G
R
K
A
Site 163
T1418
G
R
E
R
R
S
P
T
Q
G
R
K
A
S
M
Site 164
S1424
P
T
Q
G
R
K
A
S
M
L
E
V
P
R
A
Site 165
S1443
A
A
G
D
L
G
P
S
P
K
A
G
G
L
D
Site 166
T1451
P
K
A
G
G
L
D
T
E
V
A
L
D
E
G
Site 167
S1491
V
E
Q
F
P
D
A
S
G
S
L
K
L
W
C
Site 168
S1493
Q
F
P
D
A
S
G
S
L
K
L
W
C
Q
F
Site 169
S1524
P
V
G
E
V
G
R
S
A
G
D
E
G
P
A
Site 170
Y1546
S
P
V
D
C
G
V
Y
R
C
T
I
H
N
E
Site 171
S1558
H
N
E
H
G
S
A
S
T
D
F
C
L
S
P
Site 172
S1569
C
L
S
P
E
V
L
S
G
F
I
S
R
E
E
Site 173
S1573
E
V
L
S
G
F
I
S
R
E
E
G
E
V
G
Site 174
S1597
F
A
K
G
L
A
D
S
G
C
W
G
D
K
L
Site 175
S1610
K
L
F
G
R
L
V
S
E
E
L
R
G
G
G
Site 176
Y1618
E
E
L
R
G
G
G
Y
G
C
G
L
R
K
A
Site 177
S1626
G
C
G
L
R
K
A
S
Q
A
K
V
I
Y
G
Site 178
Y1632
A
S
Q
A
K
V
I
Y
G
L
E
P
I
F
E
Site 179
S1661
F
G
P
S
S
E
T
S
L
V
G
R
N
Y
D
Site 180
Y1667
T
S
L
V
G
R
N
Y
D
V
T
I
Q
G
C
Site 181
Y1683
I
Q
N
M
S
R
E
Y
C
K
I
F
A
A
E
Site 182
S1731
D
L
G
K
P
L
E
S
Y
C
S
R
E
W
G
Site 183
Y1732
L
G
K
P
L
E
S
Y
C
S
R
E
W
G
C
Site 184
S1734
K
P
L
E
S
Y
C
S
R
E
W
G
C
A
E
Site 185
T1744
W
G
C
A
E
A
P
T
A
S
G
S
S
E
A
Site 186
T1773
T
N
G
S
F
L
V
T
D
L
A
G
V
D
W
Site 187
Y1794
I
A
T
K
L
R
G
Y
Q
G
L
K
E
S
C
Site 188
S1800
G
Y
Q
G
L
K
E
S
C
F
P
A
L
L
D
Site 189
S1811
A
L
L
D
R
F
A
S
S
H
Q
C
N
A
Y
Site 190
S1812
L
L
D
R
F
A
S
S
H
Q
C
N
A
Y
C
Site 191
Y1818
S
S
H
Q
C
N
A
Y
C
E
L
L
G
L
T
Site 192
S1842
P
Q
A
K
A
K
G
S
K
S
P
S
A
G
R
Site 193
S1844
A
K
A
K
G
S
K
S
P
S
A
G
R
K
G
Site 194
S1846
A
K
G
S
K
S
P
S
A
G
R
K
G
S
Q
Site 195
S1852
P
S
A
G
R
K
G
S
Q
L
S
P
Q
P
Q
Site 196
S1855
G
R
K
G
S
Q
L
S
P
Q
P
Q
K
K
G
Site 197
S1865
P
Q
K
K
G
L
P
S
P
Q
G
T
R
K
S
Site 198
T1869
G
L
P
S
P
Q
G
T
R
K
S
A
P
S
S
Site 199
S1872
S
P
Q
G
T
R
K
S
A
P
S
S
K
A
T
Site 200
S1875
G
T
R
K
S
A
P
S
S
K
A
T
P
Q
A
Site 201
S1876
T
R
K
S
A
P
S
S
K
A
T
P
Q
A
S
Site 202
T1879
S
A
P
S
S
K
A
T
P
Q
A
S
E
P
V
Site 203
S1883
S
K
A
T
P
Q
A
S
E
P
V
T
T
Q
L
Site 204
T1887
P
Q
A
S
E
P
V
T
T
Q
L
L
G
Q
P
Site 205
T1888
Q
A
S
E
P
V
T
T
Q
L
L
G
Q
P
P
Site 206
T1896
Q
L
L
G
Q
P
P
T
Q
E
E
G
S
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation