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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNH8
Full Name:
Potassium voltage-gated channel subfamily H member 8
Alias:
ELK1;Ether-a-go-go-like potassium channel 3;Voltage-gated potassium channel subunit Kv12.1
Type:
Mass (Da):
123804
Number AA:
1107
UniProt ID:
Q96L42
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
P
Q
N
T
F
L
D
T
I
A
T
R
F
D
G
Site 2
S86
L
M
L
Q
I
E
K
S
L
E
E
K
T
E
F
Site 3
Y100
F
K
G
E
I
M
F
Y
K
K
N
G
S
P
F
Site 4
T134
L
A
S
F
K
D
I
T
D
T
K
V
K
I
T
Site 5
T136
S
F
K
D
I
T
D
T
K
V
K
I
T
P
E
Site 6
T141
T
D
T
K
V
K
I
T
P
E
D
K
K
E
D
Site 7
T158
K
G
R
S
R
A
G
T
H
F
D
S
A
R
R
Site 8
S162
R
A
G
T
H
F
D
S
A
R
R
R
S
R
A
Site 9
S167
F
D
S
A
R
R
R
S
R
A
V
L
Y
H
I
Site 10
Y172
R
R
S
R
A
V
L
Y
H
I
S
G
H
L
Q
Site 11
Y202
D
K
P
A
F
P
E
Y
K
V
S
D
A
K
K
Site 12
S205
A
F
P
E
Y
K
V
S
D
A
K
K
S
K
F
Site 13
S210
K
V
S
D
A
K
K
S
K
F
I
L
L
H
F
Site 14
S252
F
I
G
N
D
D
L
S
T
T
R
S
T
T
V
Site 15
T253
I
G
N
D
D
L
S
T
T
R
S
T
T
V
S
Site 16
S256
D
D
L
S
T
T
R
S
T
T
V
S
D
I
A
Site 17
T257
D
L
S
T
T
R
S
T
T
V
S
D
I
A
V
Site 18
T258
L
S
T
T
R
S
T
T
V
S
D
I
A
V
E
Site 19
T278
D
I
I
L
N
F
R
T
T
Y
V
S
K
S
G
Site 20
T279
I
I
L
N
F
R
T
T
Y
V
S
K
S
G
Q
Site 21
Y280
I
L
N
F
R
T
T
Y
V
S
K
S
G
Q
V
Site 22
S282
N
F
R
T
T
Y
V
S
K
S
G
Q
V
I
F
Site 23
S284
R
T
T
Y
V
S
K
S
G
Q
V
I
F
E
A
Site 24
Y348
L
L
Q
K
L
D
R
Y
S
Q
H
S
T
I
V
Site 25
S349
L
Q
K
L
D
R
Y
S
Q
H
S
T
I
V
L
Site 26
S386
K
M
E
R
E
D
N
S
L
L
K
W
E
V
G
Site 27
S404
E
L
G
K
R
L
E
S
P
Y
Y
G
N
N
T
Site 28
Y406
G
K
R
L
E
S
P
Y
Y
G
N
N
T
L
G
Site 29
Y407
K
R
L
E
S
P
Y
Y
G
N
N
T
L
G
G
Site 30
T411
S
P
Y
Y
G
N
N
T
L
G
G
P
S
I
R
Site 31
Y477
T
A
I
I
Q
R
M
Y
S
R
W
S
L
Y
H
Site 32
Y483
M
Y
S
R
W
S
L
Y
H
T
R
T
K
D
L
Site 33
T485
S
R
W
S
L
Y
H
T
R
T
K
D
L
K
D
Site 34
Y510
L
K
Q
R
M
L
E
Y
F
Q
T
T
W
S
V
Site 35
S536
D
F
P
D
E
L
R
S
D
I
T
M
H
L
N
Site 36
T539
D
E
L
R
S
D
I
T
M
H
L
N
K
E
I
Site 37
S550
N
K
E
I
L
Q
L
S
L
F
E
C
A
S
R
Site 38
S562
A
S
R
G
C
L
R
S
L
S
L
H
I
K
T
Site 39
S564
R
G
C
L
R
S
L
S
L
H
I
K
T
S
F
Site 40
Y577
S
F
C
A
P
G
E
Y
L
L
R
Q
G
D
A
Site 41
Y657
V
L
D
L
Y
P
E
Y
A
H
K
F
V
E
D
Site 42
T670
E
D
I
Q
H
D
L
T
Y
N
L
R
E
G
H
Site 43
Y671
D
I
Q
H
D
L
T
Y
N
L
R
E
G
H
E
Site 44
S679
N
L
R
E
G
H
E
S
D
V
I
S
R
L
S
Site 45
S683
G
H
E
S
D
V
I
S
R
L
S
N
K
S
M
Site 46
S686
S
D
V
I
S
R
L
S
N
K
S
M
V
S
Q
Site 47
S689
I
S
R
L
S
N
K
S
M
V
S
Q
S
E
P
Site 48
S692
L
S
N
K
S
M
V
S
Q
S
E
P
K
G
N
Site 49
S694
N
K
S
M
V
S
Q
S
E
P
K
G
N
G
N
Site 50
S708
N
I
N
K
R
L
P
S
I
V
E
D
E
E
E
Site 51
S726
G
E
E
E
E
A
V
S
L
S
P
I
C
T
R
Site 52
S728
E
E
E
A
V
S
L
S
P
I
C
T
R
G
S
Site 53
T732
V
S
L
S
P
I
C
T
R
G
S
S
S
R
N
Site 54
S735
S
P
I
C
T
R
G
S
S
S
R
N
K
K
V
Site 55
S736
P
I
C
T
R
G
S
S
S
R
N
K
K
V
G
Site 56
S737
I
C
T
R
G
S
S
S
R
N
K
K
V
G
S
Site 57
S744
S
R
N
K
K
V
G
S
N
K
A
Y
L
G
L
Site 58
Y748
K
V
G
S
N
K
A
Y
L
G
L
S
L
K
Q
Site 59
S752
N
K
A
Y
L
G
L
S
L
K
Q
L
A
S
G
Site 60
S765
S
G
T
V
P
F
H
S
P
I
R
V
S
R
S
Site 61
S770
F
H
S
P
I
R
V
S
R
S
N
S
P
K
T
Site 62
S772
S
P
I
R
V
S
R
S
N
S
P
K
T
K
Q
Site 63
S774
I
R
V
S
R
S
N
S
P
K
T
K
Q
E
I
Site 64
T777
S
R
S
N
S
P
K
T
K
Q
E
I
D
P
P
Site 65
S799
K
N
L
K
L
Q
L
S
T
L
N
N
A
G
P
Site 66
S810
N
A
G
P
P
D
L
S
P
R
I
V
D
G
I
Site 67
S822
D
G
I
E
D
G
N
S
S
E
E
S
Q
T
F
Site 68
S823
G
I
E
D
G
N
S
S
E
E
S
Q
T
F
D
Site 69
S826
D
G
N
S
S
E
E
S
Q
T
F
D
F
G
S
Site 70
T828
N
S
S
E
E
S
Q
T
F
D
F
G
S
E
R
Site 71
S833
S
Q
T
F
D
F
G
S
E
R
I
R
S
E
P
Site 72
S838
F
G
S
E
R
I
R
S
E
P
R
I
S
P
P
Site 73
S843
I
R
S
E
P
R
I
S
P
P
L
G
D
P
E
Site 74
T876
K
L
N
S
E
V
T
T
L
T
Q
E
V
S
Q
Site 75
T878
N
S
E
V
T
T
L
T
Q
E
V
S
Q
L
G
Site 76
S882
T
T
L
T
Q
E
V
S
Q
L
G
K
D
M
R
Site 77
S900
Q
L
L
E
N
V
L
S
P
Q
Q
P
S
R
F
Site 78
S905
V
L
S
P
Q
Q
P
S
R
F
C
S
L
H
S
Site 79
S909
Q
Q
P
S
R
F
C
S
L
H
S
T
S
V
C
Site 80
S912
S
R
F
C
S
L
H
S
T
S
V
C
P
S
R
Site 81
T913
R
F
C
S
L
H
S
T
S
V
C
P
S
R
E
Site 82
S914
F
C
S
L
H
S
T
S
V
C
P
S
R
E
S
Site 83
S918
H
S
T
S
V
C
P
S
R
E
S
L
Q
T
R
Site 84
S921
S
V
C
P
S
R
E
S
L
Q
T
R
T
S
W
Site 85
T924
P
S
R
E
S
L
Q
T
R
T
S
W
S
A
H
Site 86
S927
E
S
L
Q
T
R
T
S
W
S
A
H
Q
P
C
Site 87
T955
Q
L
C
S
S
N
I
T
S
D
I
W
S
V
D
Site 88
S956
L
C
S
S
N
I
T
S
D
I
W
S
V
D
P
Site 89
S960
N
I
T
S
D
I
W
S
V
D
P
S
S
V
G
Site 90
S964
D
I
W
S
V
D
P
S
S
V
G
S
S
P
Q
Site 91
S965
I
W
S
V
D
P
S
S
V
G
S
S
P
Q
R
Site 92
S968
V
D
P
S
S
V
G
S
S
P
Q
R
T
G
A
Site 93
S969
D
P
S
S
V
G
S
S
P
Q
R
T
G
A
H
Site 94
T973
V
G
S
S
P
Q
R
T
G
A
H
E
Q
N
P
Site 95
Y986
N
P
A
D
S
E
L
Y
H
S
P
S
L
D
Y
Site 96
S988
A
D
S
E
L
Y
H
S
P
S
L
D
Y
S
P
Site 97
S990
S
E
L
Y
H
S
P
S
L
D
Y
S
P
S
H
Site 98
Y993
Y
H
S
P
S
L
D
Y
S
P
S
H
Y
Q
V
Site 99
S994
H
S
P
S
L
D
Y
S
P
S
H
Y
Q
V
V
Site 100
S996
P
S
L
D
Y
S
P
S
H
Y
Q
V
V
Q
E
Site 101
Y998
L
D
Y
S
P
S
H
Y
Q
V
V
Q
E
G
H
Site 102
S1013
L
Q
F
L
R
C
I
S
P
H
S
D
S
T
L
Site 103
S1016
L
R
C
I
S
P
H
S
D
S
T
L
T
P
L
Site 104
S1018
C
I
S
P
H
S
D
S
T
L
T
P
L
Q
S
Site 105
T1019
I
S
P
H
S
D
S
T
L
T
P
L
Q
S
I
Site 106
T1021
P
H
S
D
S
T
L
T
P
L
Q
S
I
S
A
Site 107
S1031
Q
S
I
S
A
T
L
S
S
S
V
C
S
S
S
Site 108
S1032
S
I
S
A
T
L
S
S
S
V
C
S
S
S
E
Site 109
S1036
T
L
S
S
S
V
C
S
S
S
E
T
S
L
H
Site 110
S1037
L
S
S
S
V
C
S
S
S
E
T
S
L
H
L
Site 111
S1038
S
S
S
V
C
S
S
S
E
T
S
L
H
L
V
Site 112
S1048
S
L
H
L
V
L
P
S
R
S
E
E
G
S
F
Site 113
S1050
H
L
V
L
P
S
R
S
E
E
G
S
F
S
Q
Site 114
S1054
P
S
R
S
E
E
G
S
F
S
Q
G
T
V
S
Site 115
S1056
R
S
E
E
G
S
F
S
Q
G
T
V
S
S
F
Site 116
T1059
E
G
S
F
S
Q
G
T
V
S
S
F
S
L
E
Site 117
S1061
S
F
S
Q
G
T
V
S
S
F
S
L
E
N
L
Site 118
S1062
F
S
Q
G
T
V
S
S
F
S
L
E
N
L
P
Site 119
S1064
Q
G
T
V
S
S
F
S
L
E
N
L
P
G
S
Site 120
S1071
S
L
E
N
L
P
G
S
W
N
Q
E
G
M
A
Site 121
S1079
W
N
Q
E
G
M
A
S
A
S
T
K
P
L
E
Site 122
S1081
Q
E
G
M
A
S
A
S
T
K
P
L
E
N
L
Site 123
S1095
L
P
L
E
V
V
T
S
T
A
E
V
K
D
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation