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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHACTR3
Full Name:
Phosphatase and actin regulator 3
Alias:
Scaffold-associated PP1-inhibiting protein
Type:
Mass (Da):
62552
Number AA:
559
UniProt ID:
Q96KR7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
A
S
E
D
G
S
G
C
L
V
S
R
G
Site 2
S13
D
G
S
G
C
L
V
S
R
G
R
S
Q
S
D
Site 3
S17
C
L
V
S
R
G
R
S
Q
S
D
P
S
V
L
Site 4
S19
V
S
R
G
R
S
Q
S
D
P
S
V
L
T
D
Site 5
S22
G
R
S
Q
S
D
P
S
V
L
T
D
S
S
A
Site 6
T25
Q
S
D
P
S
V
L
T
D
S
S
A
T
S
S
Site 7
S27
D
P
S
V
L
T
D
S
S
A
T
S
S
A
D
Site 8
S28
P
S
V
L
T
D
S
S
A
T
S
S
A
D
A
Site 9
S31
L
T
D
S
S
A
T
S
S
A
D
A
G
E
N
Site 10
S32
T
D
S
S
A
T
S
S
A
D
A
G
E
N
P
Site 11
T45
N
P
D
E
M
D
Q
T
P
P
A
R
P
E
Y
Site 12
Y52
T
P
P
A
R
P
E
Y
L
V
S
G
I
R
T
Site 13
S55
A
R
P
E
Y
L
V
S
G
I
R
T
P
P
V
Site 14
T59
Y
L
V
S
G
I
R
T
P
P
V
R
R
N
S
Site 15
S66
T
P
P
V
R
R
N
S
K
L
A
T
L
G
R
Site 16
T70
R
R
N
S
K
L
A
T
L
G
R
I
F
K
P
Site 17
S93
E
K
L
K
Q
T
T
S
A
L
E
K
K
M
A
Site 18
T125
E
Q
D
A
E
S
K
T
C
N
P
D
G
G
P
Site 19
S134
N
P
D
G
G
P
R
S
V
Q
S
E
P
P
T
Site 20
S137
G
G
P
R
S
V
Q
S
E
P
P
T
P
K
S
Site 21
T141
S
V
Q
S
E
P
P
T
P
K
S
E
T
L
T
Site 22
S144
S
E
P
P
T
P
K
S
E
T
L
T
S
E
D
Site 23
T148
T
P
K
S
E
T
L
T
S
E
D
A
Q
P
G
Site 24
S149
P
K
S
E
T
L
T
S
E
D
A
Q
P
G
S
Site 25
S156
S
E
D
A
Q
P
G
S
P
L
A
T
G
T
D
Site 26
T160
Q
P
G
S
P
L
A
T
G
T
D
Q
V
S
L
Site 27
T162
G
S
P
L
A
T
G
T
D
Q
V
S
L
D
K
Site 28
S166
A
T
G
T
D
Q
V
S
L
D
K
P
L
S
S
Site 29
S172
V
S
L
D
K
P
L
S
S
A
A
H
L
D
D
Site 30
S173
S
L
D
K
P
L
S
S
A
A
H
L
D
D
A
Site 31
S196
G
E
E
A
D
A
G
S
L
L
P
T
T
N
E
Site 32
T200
D
A
G
S
L
L
P
T
T
N
E
L
S
Q
A
Site 33
S205
L
P
T
T
N
E
L
S
Q
A
L
A
G
A
D
Site 34
S213
Q
A
L
A
G
A
D
S
L
D
S
P
P
R
P
Site 35
S216
A
G
A
D
S
L
D
S
P
P
R
P
L
E
R
Site 36
S224
P
P
R
P
L
E
R
S
V
G
Q
L
P
S
P
Site 37
S230
R
S
V
G
Q
L
P
S
P
P
L
L
P
T
P
Site 38
T236
P
S
P
P
L
L
P
T
P
P
P
K
A
S
S
Site 39
T245
P
P
K
A
S
S
K
T
T
K
N
V
T
G
Q
Site 40
T246
P
K
A
S
S
K
T
T
K
N
V
T
G
Q
A
Site 41
T254
K
N
V
T
G
Q
A
T
L
F
Q
A
S
S
M
Site 42
S259
Q
A
T
L
F
Q
A
S
S
M
K
S
A
D
P
Site 43
S260
A
T
L
F
Q
A
S
S
M
K
S
A
D
P
S
Site 44
S263
F
Q
A
S
S
M
K
S
A
D
P
S
L
R
G
Site 45
S267
S
M
K
S
A
D
P
S
L
R
G
Q
L
S
T
Site 46
S273
P
S
L
R
G
Q
L
S
T
P
T
G
S
P
H
Site 47
T274
S
L
R
G
Q
L
S
T
P
T
G
S
P
H
L
Site 48
T276
R
G
Q
L
S
T
P
T
G
S
P
H
L
T
T
Site 49
S278
Q
L
S
T
P
T
G
S
P
H
L
T
T
V
H
Site 50
T282
P
T
G
S
P
H
L
T
T
V
H
R
P
L
P
Site 51
T283
T
G
S
P
H
L
T
T
V
H
R
P
L
P
P
Site 52
S291
V
H
R
P
L
P
P
S
R
V
I
E
E
L
H
Site 53
S309
A
T
K
H
R
Q
D
S
F
Q
G
R
E
S
K
Site 54
S315
D
S
F
Q
G
R
E
S
K
G
S
P
K
K
R
Site 55
S318
Q
G
R
E
S
K
G
S
P
K
K
R
L
D
V
Site 56
S328
K
R
L
D
V
R
L
S
R
T
S
S
V
E
R
Site 57
S331
D
V
R
L
S
R
T
S
S
V
E
R
G
K
E
Site 58
S332
V
R
L
S
R
T
S
S
V
E
R
G
K
E
R
Site 59
S344
K
E
R
E
E
A
W
S
F
D
G
A
L
E
N
Site 60
T354
G
A
L
E
N
K
R
T
A
A
K
E
S
E
E
Site 61
Y379
L
K
D
D
L
L
L
Y
Q
D
E
E
A
L
N
Site 62
S388
D
E
E
A
L
N
D
S
I
I
S
G
T
L
P
Site 63
T393
N
D
S
I
I
S
G
T
L
P
R
K
C
K
K
Site 64
S412
V
K
L
R
N
R
P
S
K
Q
E
L
E
D
R
Site 65
T426
R
N
I
F
P
R
R
T
D
E
E
R
Q
E
I
Site 66
S442
Q
Q
I
E
M
K
L
S
K
R
L
S
Q
R
P
Site 67
S446
M
K
L
S
K
R
L
S
Q
R
P
A
V
E
E
Site 68
T480
R
E
I
K
Q
R
L
T
R
K
L
N
Q
R
P
Site 69
T488
R
K
L
N
Q
R
P
T
V
D
E
L
R
D
R
Site 70
S502
R
K
I
L
I
R
F
S
D
Y
V
E
V
A
K
Site 71
Y513
E
V
A
K
A
Q
D
Y
D
R
R
A
D
K
P
Site 72
S525
D
K
P
W
T
R
L
S
A
A
D
K
A
A
I
Site 73
Y539
I
R
K
E
L
N
E
Y
K
S
N
E
M
E
V
Site 74
S541
K
E
L
N
E
Y
K
S
N
E
M
E
V
H
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation