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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LMLN
Full Name:
Leishmanolysin-like peptidase
Alias:
Gp63; leishmanolysin-like; metallopeptidase M8 family; Msp
Type:
Protease; EC 3.4.24.-
Mass (Da):
73540
Number AA:
UniProt ID:
Q96KR4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
E
W
G
G
G
V
G
Y
S
G
S
G
P
G
R
Site 2
S20
W
G
G
G
V
G
Y
S
G
S
G
P
G
R
S
Site 3
S22
G
G
V
G
Y
S
G
S
G
P
G
R
S
R
W
Site 4
S27
S
G
S
G
P
G
R
S
R
W
R
W
S
G
S
Site 5
S32
G
R
S
R
W
R
W
S
G
S
V
W
V
R
S
Site 6
S34
S
R
W
R
W
S
G
S
V
W
V
R
S
V
L
Site 7
T54
L
R
A
S
A
T
S
T
P
V
S
L
G
S
S
Site 8
S57
S
A
T
S
T
P
V
S
L
G
S
S
P
P
C
Site 9
S60
S
T
P
V
S
L
G
S
S
P
P
C
R
H
H
Site 10
S61
T
P
V
S
L
G
S
S
P
P
C
R
H
H
V
Site 11
S70
P
C
R
H
H
V
P
S
D
T
E
V
I
N
K
Site 12
T72
R
H
H
V
P
S
D
T
E
V
I
N
K
V
H
Site 13
T98
D
E
H
L
R
I
K
T
V
Y
D
K
S
V
E
Site 14
Y100
H
L
R
I
K
T
V
Y
D
K
S
V
E
E
L
Site 15
S103
I
K
T
V
Y
D
K
S
V
E
E
L
L
P
E
Site 16
T130
A
I
S
Y
L
E
K
T
F
Q
V
R
R
P
A
Site 17
T139
Q
V
R
R
P
A
G
T
I
L
L
S
R
Q
C
Site 18
S143
P
A
G
T
I
L
L
S
R
Q
C
A
T
N
Q
Site 19
Y151
R
Q
C
A
T
N
Q
Y
L
R
K
E
N
D
P
Site 20
Y161
K
E
N
D
P
H
R
Y
C
T
G
E
C
A
A
Site 21
T163
N
D
P
H
R
Y
C
T
G
E
C
A
A
H
T
Site 22
T170
T
G
E
C
A
A
H
T
K
C
G
P
V
I
V
Site 23
S207
V
P
D
Q
E
G
I
S
D
A
D
F
V
L
Y
Site 24
T220
L
Y
V
G
A
L
A
T
E
R
C
S
H
E
N
Site 25
S224
A
L
A
T
E
R
C
S
H
E
N
I
I
S
Y
Site 26
Y234
N
I
I
S
Y
A
A
Y
C
Q
Q
E
A
N
M
Site 27
Y248
M
D
R
P
I
A
G
Y
A
N
L
C
P
N
M
Site 28
S257
N
L
C
P
N
M
I
S
T
Q
P
Q
E
F
V
Site 29
S268
Q
E
F
V
G
M
L
S
T
V
K
H
E
V
I
Site 30
T269
E
F
V
G
M
L
S
T
V
K
H
E
V
I
H
Site 31
Y288
S
A
G
L
F
A
F
Y
H
D
K
D
G
N
P
Site 32
T297
D
K
D
G
N
P
L
T
S
R
F
A
D
G
L
Site 33
Y309
D
G
L
P
P
F
N
Y
S
L
G
L
Y
Q
W
Site 34
S310
G
L
P
P
F
N
Y
S
L
G
L
Y
Q
W
S
Site 35
Y314
F
N
Y
S
L
G
L
Y
Q
W
S
D
K
V
V
Site 36
T394
E
A
M
T
G
S
H
T
Q
N
R
V
L
S
R
Site 37
T410
T
L
A
L
M
E
D
T
G
R
Q
M
L
S
P
Site 38
S416
D
T
G
R
Q
M
L
S
P
Y
C
D
T
L
R
Site 39
Y418
G
R
Q
M
L
S
P
Y
C
D
T
L
R
S
N
Site 40
T421
M
L
S
P
Y
C
D
T
L
R
S
N
P
L
Q
Site 41
S424
P
Y
C
D
T
L
R
S
N
P
L
Q
L
T
C
Site 42
T430
R
S
N
P
L
Q
L
T
C
R
Q
D
Q
R
A
Site 43
Y456
P
L
P
Q
E
Y
Q
Y
F
D
E
L
S
G
I
Site 44
S461
Y
Q
Y
F
D
E
L
S
G
I
P
A
E
D
L
Site 45
Y470
I
P
A
E
D
L
P
Y
Y
G
G
S
V
E
I
Site 46
Y471
P
A
E
D
L
P
Y
Y
G
G
S
V
E
I
A
Site 47
Y480
G
S
V
E
I
A
D
Y
C
P
F
S
Q
E
F
Site 48
S492
Q
E
F
S
W
H
L
S
G
E
Y
Q
R
S
S
Site 49
Y495
S
W
H
L
S
G
E
Y
Q
R
S
S
D
C
R
Site 50
S499
S
G
E
Y
Q
R
S
S
D
C
R
I
L
E
N
Site 51
Y514
Q
P
E
I
F
K
N
Y
G
A
E
K
Y
G
P
Site 52
Y519
K
N
Y
G
A
E
K
Y
G
P
H
S
V
C
L
Site 53
S523
A
E
K
Y
G
P
H
S
V
C
L
I
Q
K
S
Site 54
S542
E
K
C
E
K
K
L
S
Y
P
D
W
G
S
G
Site 55
Y543
K
C
E
K
K
L
S
Y
P
D
W
G
S
G
C
Site 56
Y551
P
D
W
G
S
G
C
Y
Q
V
S
C
S
P
Q
Site 57
S554
G
S
G
C
Y
Q
V
S
C
S
P
Q
G
L
K
Site 58
S568
K
V
W
V
Q
D
T
S
Y
L
C
S
R
A
G
Site 59
Y569
V
W
V
Q
D
T
S
Y
L
C
S
R
A
G
Q
Site 60
S572
Q
D
T
S
Y
L
C
S
R
A
G
Q
V
L
P
Site 61
T609
C
E
L
C
P
P
E
T
D
P
P
A
T
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation