KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EHMT2
Full Name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
Alias:
EC 2.1.1.43; G9a; H3-K9-HMTase 3; Histone H3-K9 methyltransferase 3; HLA-B associated transcript 8; NG36
Type:
Methyltransferase, Amino Acid Metabolism group, Lysine degradation family
Mass (Da):
132370
Number AA:
1210
UniProt ID:
Q96KQ7
International Prot ID:
IPI00096972
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0018024
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0000239
GO:0006325
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
E
K
E
T
R
G
A
T
E
R
V
H
G
S
L
Site 2
S40
A
T
E
R
V
H
G
S
L
G
D
T
P
R
S
Site 3
T44
V
H
G
S
L
G
D
T
P
R
S
E
E
T
L
Site 4
S47
S
L
G
D
T
P
R
S
E
E
T
L
P
K
A
Site 5
T55
E
E
T
L
P
K
A
T
P
D
S
L
E
P
A
Site 6
S58
L
P
K
A
T
P
D
S
L
E
P
A
G
P
S
Site 7
S65
S
L
E
P
A
G
P
S
S
P
A
S
V
T
V
Site 8
S66
L
E
P
A
G
P
S
S
P
A
S
V
T
V
T
Site 9
S69
A
G
P
S
S
P
A
S
V
T
V
T
V
G
D
Site 10
T71
P
S
S
P
A
S
V
T
V
T
V
G
D
E
G
Site 11
T73
S
P
A
S
V
T
V
T
V
G
D
E
G
A
D
Site 12
T81
V
G
D
E
G
A
D
T
P
V
G
A
T
P
L
Site 13
T86
A
D
T
P
V
G
A
T
P
L
I
G
D
E
S
Site 14
S93
T
P
L
I
G
D
E
S
E
N
L
E
G
D
G
Site 15
T113
R
I
L
L
G
H
A
T
K
S
F
P
S
S
P
Site 16
S115
L
L
G
H
A
T
K
S
F
P
S
S
P
S
K
Site 17
S118
H
A
T
K
S
F
P
S
S
P
S
K
G
G
S
Site 18
S119
A
T
K
S
F
P
S
S
P
S
K
G
G
S
C
Site 19
S121
K
S
F
P
S
S
P
S
K
G
G
S
C
P
S
Site 20
S125
S
S
P
S
K
G
G
S
C
P
S
R
A
K
M
Site 21
S128
S
K
G
G
S
C
P
S
R
A
K
M
S
M
T
Site 22
S133
C
P
S
R
A
K
M
S
M
T
G
A
G
K
S
Site 23
T135
S
R
A
K
M
S
M
T
G
A
G
K
S
P
P
Site 24
S140
S
M
T
G
A
G
K
S
P
P
S
V
Q
S
L
Site 25
S143
G
A
G
K
S
P
P
S
V
Q
S
L
A
M
R
Site 26
S146
K
S
P
P
S
V
Q
S
L
A
M
R
L
L
S
Site 27
S165
Q
G
A
A
A
A
G
S
E
P
P
P
A
T
T
Site 28
T171
G
S
E
P
P
P
A
T
T
S
P
E
G
Q
P
Site 29
T172
S
E
P
P
P
A
T
T
S
P
E
G
Q
P
K
Site 30
S173
E
P
P
P
A
T
T
S
P
E
G
Q
P
K
V
Site 31
T186
K
V
H
R
A
R
K
T
M
S
K
P
G
N
G
Site 32
S188
H
R
A
R
K
T
M
S
K
P
G
N
G
Q
P
Site 33
S211
E
I
Q
H
F
R
M
S
D
D
V
H
S
L
G
Site 34
S216
R
M
S
D
D
V
H
S
L
G
K
V
T
S
D
Site 35
S222
H
S
L
G
K
V
T
S
D
L
A
K
R
R
K
Site 36
S232
A
K
R
R
K
L
N
S
G
G
G
L
S
E
E
Site 37
S237
L
N
S
G
G
G
L
S
E
E
L
G
S
A
R
Site 38
S242
G
L
S
E
E
L
G
S
A
R
R
S
G
E
V
Site 39
S246
E
L
G
S
A
R
R
S
G
E
V
T
L
T
K
Site 40
T250
A
R
R
S
G
E
V
T
L
T
K
G
D
P
G
Site 41
T252
R
S
G
E
V
T
L
T
K
G
D
P
G
S
L
Site 42
S258
L
T
K
G
D
P
G
S
L
E
E
W
E
T
V
Site 43
T264
G
S
L
E
E
W
E
T
V
V
G
D
D
F
S
Site 44
S271
T
V
V
G
D
D
F
S
L
Y
Y
D
S
Y
S
Site 45
Y273
V
G
D
D
F
S
L
Y
Y
D
S
Y
S
V
D
Site 46
Y274
G
D
D
F
S
L
Y
Y
D
S
Y
S
V
D
E
Site 47
S276
D
F
S
L
Y
Y
D
S
Y
S
V
D
E
R
V
Site 48
Y277
F
S
L
Y
Y
D
S
Y
S
V
D
E
R
V
D
Site 49
S278
S
L
Y
Y
D
S
Y
S
V
D
E
R
V
D
S
Site 50
S285
S
V
D
E
R
V
D
S
D
S
K
S
E
V
E
Site 51
S287
D
E
R
V
D
S
D
S
K
S
E
V
E
A
L
Site 52
S289
R
V
D
S
D
S
K
S
E
V
E
A
L
T
E
Site 53
S299
E
A
L
T
E
Q
L
S
E
E
E
E
E
E
E
Site 54
S327
E
E
E
E
D
E
E
S
G
N
Q
S
D
R
S
Site 55
S331
D
E
E
S
G
N
Q
S
D
R
S
G
S
S
G
Site 56
S334
S
G
N
Q
S
D
R
S
G
S
S
G
R
R
K
Site 57
S336
N
Q
S
D
R
S
G
S
S
G
R
R
K
A
K
Site 58
S337
Q
S
D
R
S
G
S
S
G
R
R
K
A
K
K
Site 59
S350
K
K
K
W
R
K
D
S
P
W
V
K
P
S
R
Site 60
S356
D
S
P
W
V
K
P
S
R
K
R
R
K
R
E
Site 61
S378
R
G
V
N
G
V
G
S
S
G
P
S
E
Y
M
Site 62
S379
G
V
N
G
V
G
S
S
G
P
S
E
Y
M
E
Site 63
S382
G
V
G
S
S
G
P
S
E
Y
M
E
V
P
L
Site 64
Y384
G
S
S
G
P
S
E
Y
M
E
V
P
L
G
S
Site 65
S391
Y
M
E
V
P
L
G
S
L
E
L
P
S
E
G
Site 66
S396
L
G
S
L
E
L
P
S
E
G
T
L
S
P
N
Site 67
T399
L
E
L
P
S
E
G
T
L
S
P
N
H
A
G
Site 68
S401
L
P
S
E
G
T
L
S
P
N
H
A
G
V
S
Site 69
S408
S
P
N
H
A
G
V
S
N
D
T
S
S
L
E
Site 70
S412
A
G
V
S
N
D
T
S
S
L
E
T
E
R
G
Site 71
S413
G
V
S
N
D
T
S
S
L
E
T
E
R
G
F
Site 72
T416
N
D
T
S
S
L
E
T
E
R
G
F
E
E
L
Site 73
S439
A
P
K
I
D
R
I
S
E
R
A
G
H
K
C
Site 74
T449
A
G
H
K
C
M
A
T
E
S
V
D
G
E
L
Site 75
S451
H
K
C
M
A
T
E
S
V
D
G
E
L
S
G
Site 76
T468
A
A
I
L
K
R
E
T
M
R
P
S
S
R
V
Site 77
S472
K
R
E
T
M
R
P
S
S
R
V
A
L
M
V
Site 78
S473
R
E
T
M
R
P
S
S
R
V
A
L
M
V
L
Site 79
S541
P
H
C
G
E
D
A
S
E
A
Q
E
V
T
I
Site 80
T555
I
P
R
G
D
G
V
T
P
P
A
G
T
A
A
Site 81
T560
G
V
T
P
P
A
G
T
A
A
P
A
P
P
P
Site 82
S569
A
P
A
P
P
P
L
S
Q
D
V
P
G
R
A
Site 83
T578
D
V
P
G
R
A
D
T
S
Q
P
S
A
R
M
Site 84
S579
V
P
G
R
A
D
T
S
Q
P
S
A
R
M
R
Site 85
S582
R
A
D
T
S
Q
P
S
A
R
M
R
G
H
G
Site 86
T602
P
C
D
P
L
A
D
T
I
D
S
S
G
P
S
Site 87
S609
T
I
D
S
S
G
P
S
L
T
L
P
N
G
G
Site 88
T611
D
S
S
G
P
S
L
T
L
P
N
G
G
C
L
Site 89
S641
K
A
L
V
I
Q
E
S
E
R
R
K
K
L
R
Site 90
Y655
R
F
H
P
R
Q
L
Y
L
S
V
K
Q
G
E
Site 91
S657
H
P
R
Q
L
Y
L
S
V
K
Q
G
E
L
Q
Site 92
S680
N
L
D
P
N
F
Q
S
D
Q
Q
S
K
R
T
Site 93
S684
N
F
Q
S
D
Q
Q
S
K
R
T
P
L
H
A
Site 94
T687
S
D
Q
Q
S
K
R
T
P
L
H
A
A
A
Q
Site 95
T720
A
V
D
K
Q
Q
R
T
P
L
M
E
A
V
V
Site 96
Y736
N
H
L
E
V
A
R
Y
M
V
Q
R
G
G
C
Site 97
Y745
V
Q
R
G
G
C
V
Y
S
K
E
E
D
G
S
Site 98
S746
Q
R
G
G
C
V
Y
S
K
E
E
D
G
S
T
Site 99
S752
Y
S
K
E
E
D
G
S
T
C
L
H
H
A
A
Site 100
T753
S
K
E
E
D
G
S
T
C
L
H
H
A
A
K
Site 101
S783
V
D
V
N
A
Q
D
S
G
G
W
T
P
I
I
Site 102
T787
A
Q
D
S
G
G
W
T
P
I
I
W
A
A
E
Site 103
T812
L
T
R
G
A
D
V
T
L
T
D
N
E
E
N
Site 104
T814
R
G
A
D
V
T
L
T
D
N
E
E
N
I
C
Site 105
Y849
C
D
L
H
A
V
N
Y
H
G
D
T
P
L
H
Site 106
T853
A
V
N
Y
H
G
D
T
P
L
H
I
A
A
R
Site 107
T891
G
D
T
A
W
D
L
T
P
E
R
S
D
V
W
Site 108
Y930
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
Site 109
Y950
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
Site 110
Y952
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
Site 111
Y996
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Site 112
Y1043
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
Site 113
S1084
A
D
V
R
E
D
D
S
Y
L
F
D
L
D
N
Site 114
Y1085
D
V
R
E
D
D
S
Y
L
F
D
L
D
N
K
Site 115
Y1097
D
N
K
D
G
E
V
Y
C
I
D
A
R
Y
Y
Site 116
Y1103
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
Site 117
Y1104
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
Site 118
S1140
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
Site 119
T1146
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Site 120
Y1154
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
Site 121
T1167
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
Site 122
T1210
G
S
L
P
P
V
N
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation