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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP1R13B
Full Name:
Apoptosis-stimulating of p53 protein 1
Alias:
ASPP1; KIAA0771; P53BP2-like; P85; Protein phosphatase 1 regulatory subunit 13B; Protein phosphatase 1, regulatory (inhibitor) subunit 13B
Type:
Protein phosphatase, regulatory subunit; Tumor suppressor; Apoptosis
Mass (Da):
119585
Number AA:
1090
UniProt ID:
Q96KQ4
International Prot ID:
IPI00306903
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0006917
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
S
N
N
E
Q
I
L
T
E
V
P
I
T
P
E
Site 2
T23
I
L
T
E
V
P
I
T
P
E
T
T
C
R
D
Site 3
T26
E
V
P
I
T
P
E
T
T
C
R
D
V
V
E
Site 4
S85
F
F
L
R
H
E
D
S
P
T
E
N
S
E
Q
Site 5
T87
L
R
H
E
D
S
P
T
E
N
S
E
Q
G
G
Site 6
S90
E
D
S
P
T
E
N
S
E
Q
G
G
R
Q
T
Site 7
T97
S
E
Q
G
G
R
Q
T
Q
E
Q
R
T
Q
R
Site 8
T102
R
Q
T
Q
E
Q
R
T
Q
R
N
V
I
N
V
Site 9
T115
N
V
P
G
D
K
R
T
E
Y
G
V
G
N
P
Site 10
Y117
P
G
D
K
R
T
E
Y
G
V
G
N
P
R
V
Site 11
T127
G
N
P
R
V
E
L
T
L
S
E
L
Q
D
M
Site 12
S129
P
R
V
E
L
T
L
S
E
L
Q
D
M
A
A
Site 13
S169
Q
E
R
R
Q
Q
Q
S
I
S
E
N
E
K
L
Site 14
S171
R
R
Q
Q
Q
S
I
S
E
N
E
K
L
Q
K
Site 15
Y202
A
M
R
G
Q
V
D
Y
S
K
I
M
N
G
N
Site 16
S218
S
A
E
I
E
R
F
S
A
M
F
Q
E
K
K
Site 17
T230
E
K
K
Q
E
V
Q
T
A
I
L
R
V
D
Q
Site 18
S239
I
L
R
V
D
Q
L
S
Q
Q
L
E
D
L
K
Site 19
S255
G
K
L
N
G
F
Q
S
Y
N
G
K
L
T
G
Site 20
Y272
A
V
E
L
K
R
L
Y
Q
E
L
Q
I
R
N
Site 21
S311
A
M
M
D
K
R
I
S
E
L
R
E
R
L
Y
Site 22
Y318
S
E
L
R
E
R
L
Y
G
K
K
I
Q
L
N
Site 23
T330
Q
L
N
R
V
N
G
T
S
S
P
Q
S
P
L
Site 24
S331
L
N
R
V
N
G
T
S
S
P
Q
S
P
L
S
Site 25
S332
N
R
V
N
G
T
S
S
P
Q
S
P
L
S
T
Site 26
S335
N
G
T
S
S
P
Q
S
P
L
S
T
S
G
R
Site 27
S338
S
S
P
Q
S
P
L
S
T
S
G
R
V
A
A
Site 28
T339
S
P
Q
S
P
L
S
T
S
G
R
V
A
A
V
Site 29
S340
P
Q
S
P
L
S
T
S
G
R
V
A
A
V
G
Site 30
Y349
R
V
A
A
V
G
P
Y
I
Q
V
P
S
A
G
Site 31
S369
G
D
P
I
K
P
Q
S
L
S
I
A
S
N
A
Site 32
S371
P
I
K
P
Q
S
L
S
I
A
S
N
A
A
H
Site 33
S383
A
A
H
G
R
S
K
S
A
N
D
G
N
W
P
Site 34
T391
A
N
D
G
N
W
P
T
L
K
Q
N
S
S
S
Site 35
S397
P
T
L
K
Q
N
S
S
S
S
V
K
P
V
Q
Site 36
S399
L
K
Q
N
S
S
S
S
V
K
P
V
Q
V
A
Site 37
S414
G
A
D
W
K
D
P
S
V
E
G
S
V
K
Q
Site 38
S418
K
D
P
S
V
E
G
S
V
K
Q
G
T
V
S
Site 39
T423
E
G
S
V
K
Q
G
T
V
S
S
Q
P
V
P
Site 40
S425
S
V
K
Q
G
T
V
S
S
Q
P
V
P
F
S
Site 41
S426
V
K
Q
G
T
V
S
S
Q
P
V
P
F
S
A
Site 42
S432
S
S
Q
P
V
P
F
S
A
L
G
P
T
E
K
Site 43
S461
V
G
K
Q
L
P
P
S
Y
G
T
Y
P
S
P
Site 44
Y462
G
K
Q
L
P
P
S
Y
G
T
Y
P
S
P
T
Site 45
Y465
L
P
P
S
Y
G
T
Y
P
S
P
T
P
L
G
Site 46
S467
P
S
Y
G
T
Y
P
S
P
T
P
L
G
P
G
Site 47
T469
Y
G
T
Y
P
S
P
T
P
L
G
P
G
S
T
Site 48
S475
P
T
P
L
G
P
G
S
T
S
S
L
E
R
R
Site 49
S478
L
G
P
G
S
T
S
S
L
E
R
R
K
E
G
Site 50
S486
L
E
R
R
K
E
G
S
L
P
R
P
S
A
G
Site 51
S491
E
G
S
L
P
R
P
S
A
G
L
P
S
R
Q
Site 52
T501
L
P
S
R
Q
R
P
T
L
L
P
A
T
G
S
Site 53
S508
T
L
L
P
A
T
G
S
T
P
Q
P
G
S
S
Site 54
T509
L
L
P
A
T
G
S
T
P
Q
P
G
S
S
Q
Site 55
S514
G
S
T
P
Q
P
G
S
S
Q
Q
I
Q
Q
R
Site 56
S515
S
T
P
Q
P
G
S
S
Q
Q
I
Q
Q
R
I
Site 57
S523
Q
Q
I
Q
Q
R
I
S
V
P
P
S
P
T
Y
Site 58
S527
Q
R
I
S
V
P
P
S
P
T
Y
P
P
A
G
Site 59
T529
I
S
V
P
P
S
P
T
Y
P
P
A
G
P
P
Site 60
Y530
S
V
P
P
S
P
T
Y
P
P
A
G
P
P
A
Site 61
S543
P
A
F
P
A
G
D
S
K
P
E
L
P
L
T
Site 62
S562
P
F
L
A
D
K
G
S
R
P
Q
S
P
R
K
Site 63
S566
D
K
G
S
R
P
Q
S
P
R
K
G
P
Q
T
Site 64
T573
S
P
R
K
G
P
Q
T
V
N
S
S
S
I
Y
Site 65
S576
K
G
P
Q
T
V
N
S
S
S
I
Y
S
M
Y
Site 66
S577
G
P
Q
T
V
N
S
S
S
I
Y
S
M
Y
L
Site 67
S578
P
Q
T
V
N
S
S
S
I
Y
S
M
Y
L
Q
Site 68
S581
V
N
S
S
S
I
Y
S
M
Y
L
Q
Q
A
T
Site 69
Y583
S
S
S
I
Y
S
M
Y
L
Q
Q
A
T
P
P
Site 70
T588
S
M
Y
L
Q
Q
A
T
P
P
K
N
Y
Q
P
Site 71
S604
A
H
S
A
L
N
K
S
V
K
A
V
Y
G
K
Site 72
Y609
N
K
S
V
K
A
V
Y
G
K
P
V
L
P
S
Site 73
S616
Y
G
K
P
V
L
P
S
G
S
T
S
P
S
P
Site 74
S618
K
P
V
L
P
S
G
S
T
S
P
S
P
L
P
Site 75
S620
V
L
P
S
G
S
T
S
P
S
P
L
P
F
L
Site 76
S622
P
S
G
S
T
S
P
S
P
L
P
F
L
H
G
Site 77
S630
P
L
P
F
L
H
G
S
L
S
T
G
T
P
Q
Site 78
S632
P
F
L
H
G
S
L
S
T
G
T
P
Q
P
Q
Site 79
T635
H
G
S
L
S
T
G
T
P
Q
P
Q
P
P
S
Site 80
S642
T
P
Q
P
Q
P
P
S
E
S
T
E
K
E
P
Site 81
S644
Q
P
Q
P
P
S
E
S
T
E
K
E
P
E
Q
Site 82
S661
P
A
A
P
A
D
G
S
T
V
E
S
L
P
R
Site 83
T662
A
A
P
A
D
G
S
T
V
E
S
L
P
R
P
Site 84
S665
A
D
G
S
T
V
E
S
L
P
R
P
L
S
P
Site 85
S671
E
S
L
P
R
P
L
S
P
T
K
L
T
P
I
Site 86
T673
L
P
R
P
L
S
P
T
K
L
T
P
I
V
H
Site 87
S681
K
L
T
P
I
V
H
S
P
L
R
Y
Q
S
D
Site 88
Y685
I
V
H
S
P
L
R
Y
Q
S
D
A
D
L
E
Site 89
S687
H
S
P
L
R
Y
Q
S
D
A
D
L
E
A
L
Site 90
S709
P
R
P
L
K
K
R
S
S
I
T
E
P
E
G
Site 91
S710
R
P
L
K
K
R
S
S
I
T
E
P
E
G
P
Site 92
T712
L
K
K
R
S
S
I
T
E
P
E
G
P
G
G
Site 93
Y727
P
N
I
Q
K
L
L
Y
Q
R
F
N
T
L
A
Site 94
T732
L
L
Y
Q
R
F
N
T
L
A
G
G
M
E
G
Site 95
T740
L
A
G
G
M
E
G
T
P
F
Y
Q
P
S
P
Site 96
Y743
G
M
E
G
T
P
F
Y
Q
P
S
P
S
Q
D
Site 97
S746
G
T
P
F
Y
Q
P
S
P
S
Q
D
F
M
G
Site 98
S748
P
F
Y
Q
P
S
P
S
Q
D
F
M
G
T
L
Site 99
T754
P
S
Q
D
F
M
G
T
L
A
D
V
D
N
G
Site 100
S788
L
P
A
E
P
A
P
S
S
D
A
N
D
N
E
Site 101
S789
P
A
E
P
A
P
S
S
D
A
N
D
N
E
L
Site 102
S798
A
N
D
N
E
L
P
S
P
E
P
E
E
L
I
Site 103
S835
P
T
T
E
Q
I
P
S
P
V
A
E
A
P
S
Site 104
S842
S
P
V
A
E
A
P
S
P
G
E
E
Q
V
P
Site 105
S857
P
A
P
L
P
P
A
S
H
P
P
A
T
S
T
Site 106
S863
A
S
H
P
P
A
T
S
T
N
K
R
T
N
L
Site 107
T864
S
H
P
P
A
T
S
T
N
K
R
T
N
L
K
Site 108
S875
T
N
L
K
K
P
N
S
E
R
T
G
H
G
L
Site 109
Y909
D
L
V
Q
R
I
I
Y
E
V
E
D
P
S
K
Site 110
T923
K
P
N
D
E
G
I
T
P
L
H
N
A
V
C
Site 111
S952
V
N
V
N
A
A
D
S
D
G
W
T
P
L
H
Site 112
T956
A
A
D
S
D
G
W
T
P
L
H
C
A
A
S
Site 113
T990
S
T
I
S
D
I
E
T
A
A
D
K
C
E
E
Site 114
Y1010
I
Q
C
S
Q
F
L
Y
G
V
Q
E
K
L
G
Site 115
Y1030
V
A
Y
A
L
W
D
Y
E
A
Q
N
S
D
E
Site 116
S1035
W
D
Y
E
A
Q
N
S
D
E
L
S
F
H
E
Site 117
S1039
A
Q
N
S
D
E
L
S
F
H
E
G
D
A
L
Site 118
T1047
F
H
E
G
D
A
L
T
I
L
R
R
K
D
E
Site 119
Y1070
R
L
G
D
R
E
G
Y
V
P
K
N
L
L
G
Site 120
Y1079
P
K
N
L
L
G
L
Y
P
R
I
K
P
R
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation