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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPGRIP1
Full Name:
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
Alias:
LCA6; Retinitis pigmentosa GTPase regulator interacting protein 1; RGI1; RPG1; RPGR1; RPGR-interacting protein 1; RPGRIP
Type:
Unknown function
Mass (Da):
146681
Number AA:
1286
UniProt ID:
Q96KN7
International Prot ID:
IPI00179169
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0050896
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
H
L
V
D
P
T
S
G
D
L
P
V
R
D
Site 2
S27
I
P
L
V
L
P
A
S
K
G
K
N
M
K
T
Site 3
T34
S
K
G
K
N
M
K
T
Q
P
P
L
S
R
M
Site 4
S39
M
K
T
Q
P
P
L
S
R
M
N
R
E
E
L
Site 5
S49
N
R
E
E
L
E
D
S
F
F
R
L
R
E
D
Site 6
T76
D
E
I
K
R
L
R
T
T
L
L
R
L
T
A
Site 7
T77
E
I
K
R
L
R
T
T
L
L
R
L
T
A
A
Site 8
T82
R
T
T
L
L
R
L
T
A
A
G
R
D
L
R
Site 9
S98
A
E
E
A
A
P
L
S
E
T
A
R
R
G
Q
Site 10
T100
E
A
A
P
L
S
E
T
A
R
R
G
Q
K
A
Site 11
S135
F
H
C
V
G
P
A
S
P
R
R
A
Q
P
R
Site 12
S170
R
G
P
R
D
R
L
S
Y
T
A
P
P
S
F
Site 13
Y171
G
P
R
D
R
L
S
Y
T
A
P
P
S
F
K
Site 14
T172
P
R
D
R
L
S
Y
T
A
P
P
S
F
K
E
Site 15
S176
L
S
Y
T
A
P
P
S
F
K
E
H
A
T
N
Site 16
S191
E
N
R
G
E
V
A
S
K
P
S
E
L
V
S
Site 17
S194
G
E
V
A
S
K
P
S
E
L
V
S
G
S
N
Site 18
S198
S
K
P
S
E
L
V
S
G
S
N
S
I
I
S
Site 19
S240
Q
V
E
E
P
P
K
S
P
E
K
M
W
P
K
Site 20
S256
E
N
F
E
Q
R
S
S
L
E
C
A
Q
K
A
Site 21
S269
K
A
A
E
L
R
A
S
I
K
E
K
V
E
L
Site 22
S289
L
L
H
E
R
N
A
S
L
V
M
T
K
A
Q
Site 23
T293
R
N
A
S
L
V
M
T
K
A
Q
L
T
E
V
Site 24
T306
E
V
Q
E
A
Y
E
T
L
L
Q
K
N
Q
G
Site 25
S316
Q
K
N
Q
G
I
L
S
A
A
H
E
A
L
L
Site 26
S337
R
A
E
L
K
E
E
S
K
K
A
V
S
L
K
Site 27
S342
E
E
S
K
K
A
V
S
L
K
S
Q
L
E
D
Site 28
S345
K
K
A
V
S
L
K
S
Q
L
E
D
V
S
I
Site 29
S351
K
S
Q
L
E
D
V
S
I
L
Q
M
T
L
K
Site 30
Y378
R
K
L
L
N
D
N
Y
D
K
L
L
E
S
M
Site 31
S384
N
Y
D
K
L
L
E
S
M
L
D
S
S
D
S
Site 32
S388
L
L
E
S
M
L
D
S
S
D
S
S
S
Q
P
Site 33
S389
L
E
S
M
L
D
S
S
D
S
S
S
Q
P
H
Site 34
S391
S
M
L
D
S
S
D
S
S
S
Q
P
H
W
S
Site 35
S392
M
L
D
S
S
D
S
S
S
Q
P
H
W
S
N
Site 36
S393
L
D
S
S
D
S
S
S
Q
P
H
W
S
N
E
Site 37
S398
S
S
S
Q
P
H
W
S
N
E
L
I
A
E
Q
Site 38
S411
E
Q
L
Q
Q
Q
V
S
Q
L
Q
D
Q
L
D
Site 39
T464
E
L
L
Q
N
A
A
T
I
S
Q
P
P
D
R
Site 40
S466
L
Q
N
A
A
T
I
S
Q
P
P
D
R
Q
S
Site 41
S473
S
Q
P
P
D
R
Q
S
E
P
A
T
H
P
A
Site 42
T477
D
R
Q
S
E
P
A
T
H
P
A
V
L
Q
E
Site 43
S502
N
Q
E
E
K
K
L
S
Q
V
L
N
E
L
Q
Site 44
S511
V
L
N
E
L
Q
V
S
H
A
E
T
T
L
E
Site 45
T522
T
T
L
E
L
E
K
T
R
D
M
L
I
L
Q
Site 46
T545
E
E
L
E
A
M
M
T
K
A
D
N
D
N
R
Site 47
T562
K
E
K
L
E
R
L
T
R
L
L
D
L
K
N
Site 48
S581
Q
L
E
G
I
L
R
S
H
D
L
P
T
S
E
Site 49
S587
R
S
H
D
L
P
T
S
E
Q
L
K
D
V
A
Site 50
Y595
E
Q
L
K
D
V
A
Y
G
T
R
P
L
S
L
Site 51
S619
D
E
D
K
V
D
I
S
L
L
H
Q
G
E
N
Site 52
T666
Y
D
F
E
T
H
C
T
P
L
S
V
G
P
Q
Site 53
S669
E
T
H
C
T
P
L
S
V
G
P
Q
P
L
Y
Site 54
Y676
S
V
G
P
Q
P
L
Y
D
F
T
S
Q
Y
V
Site 55
T679
P
Q
P
L
Y
D
F
T
S
Q
Y
V
M
E
T
Site 56
Y682
L
Y
D
F
T
S
Q
Y
V
M
E
T
D
S
L
Site 57
T686
T
S
Q
Y
V
M
E
T
D
S
L
F
L
H
Y
Site 58
S698
L
H
Y
L
Q
E
A
S
A
R
L
D
I
H
Q
Site 59
Y750
E
E
F
G
V
L
E
Y
W
M
R
L
R
F
P
Site 60
Y774
K
R
K
K
A
Q
V
Y
L
S
T
D
V
L
G
Site 61
S776
K
K
A
Q
V
Y
L
S
T
D
V
L
G
G
R
Site 62
S792
A
Q
E
E
E
F
R
S
E
S
W
E
P
Q
N
Site 63
S794
E
E
E
F
R
S
E
S
W
E
P
Q
N
E
L
Site 64
S821
R
W
L
G
T
Q
P
S
P
Y
A
V
Y
R
F
Site 65
Y823
L
G
T
Q
P
S
P
Y
A
V
Y
R
F
F
T
Site 66
Y826
Q
P
S
P
Y
A
V
Y
R
F
F
T
F
S
D
Site 67
T836
F
T
F
S
D
H
D
T
A
I
I
P
A
S
N
Site 68
S842
D
T
A
I
I
P
A
S
N
N
P
Y
F
R
D
Site 69
Y846
I
P
A
S
N
N
P
Y
F
R
D
Q
A
R
F
Site 70
S859
R
F
P
V
L
V
T
S
D
L
D
H
Y
L
R
Site 71
Y864
V
T
S
D
L
D
H
Y
L
R
R
E
A
L
S
Site 72
S871
Y
L
R
R
E
A
L
S
I
H
V
F
D
D
E
Site 73
S884
D
E
D
L
E
P
G
S
Y
L
G
R
A
R
V
Site 74
Y885
E
D
L
E
P
G
S
Y
L
G
R
A
R
V
P
Site 75
S901
L
P
L
A
K
N
E
S
I
K
G
D
F
N
L
Site 76
Y929
Q
L
D
W
K
F
P
Y
I
P
P
E
S
F
L
Site 77
S934
F
P
Y
I
P
P
E
S
F
L
K
P
E
A
Q
Site 78
T947
A
Q
T
K
G
K
D
T
K
D
S
S
K
I
S
Site 79
S950
K
G
K
D
T
K
D
S
S
K
I
S
S
E
E
Site 80
S951
G
K
D
T
K
D
S
S
K
I
S
S
E
E
E
Site 81
S954
T
K
D
S
S
K
I
S
S
E
E
E
K
A
S
Site 82
S955
K
D
S
S
K
I
S
S
E
E
E
K
A
S
F
Site 83
S961
S
S
E
E
E
K
A
S
F
P
S
Q
D
Q
M
Site 84
S970
P
S
Q
D
Q
M
A
S
P
E
V
P
I
E
A
Site 85
Y980
V
P
I
E
A
G
Q
Y
R
S
K
R
K
P
P
Site 86
S982
I
E
A
G
Q
Y
R
S
K
R
K
P
P
H
G
Site 87
S1001
E
K
E
H
Q
V
V
S
Y
S
R
R
K
H
G
Site 88
Y1002
K
E
H
Q
V
V
S
Y
S
R
R
K
H
G
K
Site 89
S1003
E
H
Q
V
V
S
Y
S
R
R
K
H
G
K
R
Site 90
Y1021
Q
G
K
N
R
M
E
Y
L
S
L
N
I
L
N
Site 91
S1023
K
N
R
M
E
Y
L
S
L
N
I
L
N
G
N
Site 92
T1031
L
N
I
L
N
G
N
T
P
Q
Q
V
N
Y
T
Site 93
T1038
T
P
Q
Q
V
N
Y
T
E
W
K
F
S
E
T
Site 94
S1047
W
K
F
S
E
T
N
S
F
I
G
D
G
F
K
Site 95
T1063
Q
H
E
E
E
E
M
T
L
S
H
S
A
L
K
Site 96
S1065
E
E
E
E
M
T
L
S
H
S
A
L
K
Q
K
Site 97
S1083
H
P
V
N
D
K
E
S
S
E
Q
G
S
E
V
Site 98
S1084
P
V
N
D
K
E
S
S
E
Q
G
S
E
V
S
Site 99
S1088
K
E
S
S
E
Q
G
S
E
V
S
E
A
Q
T
Site 100
S1091
S
E
Q
G
S
E
V
S
E
A
Q
T
T
D
S
Site 101
T1096
E
V
S
E
A
Q
T
T
D
S
D
D
V
I
V
Site 102
S1098
S
E
A
Q
T
T
D
S
D
D
V
I
V
P
P
Site 103
S1107
D
V
I
V
P
P
M
S
Q
K
Y
P
K
A
D
Site 104
Y1110
V
P
P
M
S
Q
K
Y
P
K
A
D
S
E
K
Site 105
S1115
Q
K
Y
P
K
A
D
S
E
K
M
C
I
E
I
Site 106
Y1143
D
E
N
I
K
Q
V
Y
V
E
Y
K
F
Y
D
Site 107
Y1149
V
Y
V
E
Y
K
F
Y
D
L
P
L
S
E
T
Site 108
S1154
K
F
Y
D
L
P
L
S
E
T
E
T
P
V
S
Site 109
T1156
Y
D
L
P
L
S
E
T
E
T
P
V
S
L
R
Site 110
T1158
L
P
L
S
E
T
E
T
P
V
S
L
R
K
P
Site 111
S1161
S
E
T
E
T
P
V
S
L
R
K
P
R
A
G
Site 112
T1210
D
Q
G
H
L
K
F
T
V
V
S
D
P
L
D
Site 113
Y1228
K
E
C
E
E
V
G
Y
A
Y
L
Q
L
W
Q
Site 114
S1239
Q
L
W
Q
I
L
E
S
G
R
D
I
L
E
Q
Site 115
S1252
E
Q
E
L
D
I
V
S
P
E
D
L
A
T
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation