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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF521
Full Name:
Zinc finger protein 521
Alias:
Early hematopoietic zinc finger protein; LYST-interacting protein 3
Type:
Mass (Da):
147848
Number AA:
1311
UniProt ID:
Q96K83
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0019904
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007275
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
K
Q
A
K
P
R
S
L
K
D
P
N
C
K
Site 2
T23
N
C
K
L
E
D
K
T
E
D
G
E
A
L
D
Site 3
S48
L
E
D
E
A
V
H
S
C
D
S
C
L
Q
V
Site 4
S58
S
C
L
Q
V
F
E
S
L
S
D
I
T
E
H
Site 5
S60
L
Q
V
F
E
S
L
S
D
I
T
E
H
K
I
Site 6
T83
V
D
V
E
D
D
P
T
C
S
W
P
A
S
S
Site 7
S85
V
E
D
D
P
T
C
S
W
P
A
S
S
P
S
Site 8
S89
P
T
C
S
W
P
A
S
S
P
S
S
K
D
Q
Site 9
S90
T
C
S
W
P
A
S
S
P
S
S
K
D
Q
T
Site 10
S92
S
W
P
A
S
S
P
S
S
K
D
Q
T
S
P
Site 11
S93
W
P
A
S
S
P
S
S
K
D
Q
T
S
P
S
Site 12
T97
S
P
S
S
K
D
Q
T
S
P
S
H
G
E
G
Site 13
S98
P
S
S
K
D
Q
T
S
P
S
H
G
E
G
C
Site 14
S100
S
K
D
Q
T
S
P
S
H
G
E
G
C
D
F
Site 15
Y118
E
G
G
P
G
L
P
Y
P
C
Q
F
C
D
K
Site 16
S126
P
C
Q
F
C
D
K
S
F
S
R
L
S
Y
L
Site 17
S128
Q
F
C
D
K
S
F
S
R
L
S
Y
L
K
H
Site 18
S131
D
K
S
F
S
R
L
S
Y
L
K
H
H
E
Q
Site 19
Y132
K
S
F
S
R
L
S
Y
L
K
H
H
E
Q
S
Site 20
S139
Y
L
K
H
H
E
Q
S
H
S
D
K
L
P
F
Site 21
S141
K
H
H
E
Q
S
H
S
D
K
L
P
F
K
C
Site 22
Y150
K
L
P
F
K
C
T
Y
C
S
R
L
F
K
H
Site 23
S160
R
L
F
K
H
K
R
S
R
D
R
H
I
K
L
Site 24
T169
D
R
H
I
K
L
H
T
G
D
K
K
Y
H
C
Site 25
Y174
L
H
T
G
D
K
K
Y
H
C
S
E
C
D
A
Site 26
S184
S
E
C
D
A
A
F
S
R
S
D
H
L
K
I
Site 27
Y202
T
H
T
S
N
K
P
Y
K
C
A
I
C
R
R
Site 28
S213
I
C
R
R
G
F
L
S
S
S
S
L
H
G
H
Site 29
S214
C
R
R
G
F
L
S
S
S
S
L
H
G
H
M
Site 30
S215
R
R
G
F
L
S
S
S
S
L
H
G
H
M
Q
Site 31
S216
R
G
F
L
S
S
S
S
L
H
G
H
M
Q
V
Site 32
S231
H
E
R
N
K
D
G
S
Q
S
G
S
R
M
E
Site 33
S233
R
N
K
D
G
S
Q
S
G
S
R
M
E
D
W
Site 34
S235
K
D
G
S
Q
S
G
S
R
M
E
D
W
K
M
Site 35
S273
A
E
C
H
P
E
C
S
P
N
E
D
R
A
A
Site 36
S311
H
S
G
E
K
K
N
S
C
S
I
C
S
E
S
Site 37
S313
G
E
K
K
N
S
C
S
I
C
S
E
S
F
H
Site 38
S318
S
C
S
I
C
S
E
S
F
H
T
V
E
E
L
Site 39
T321
I
C
S
E
S
F
H
T
V
E
E
L
Y
S
H
Site 40
Y326
F
H
T
V
E
E
L
Y
S
H
M
D
S
H
Q
Site 41
S331
E
L
Y
S
H
M
D
S
H
Q
Q
P
E
S
C
Site 42
S337
D
S
H
Q
Q
P
E
S
C
N
H
S
N
S
P
Site 43
S341
Q
P
E
S
C
N
H
S
N
S
P
S
L
V
T
Site 44
S343
E
S
C
N
H
S
N
S
P
S
L
V
T
V
G
Site 45
S345
C
N
H
S
N
S
P
S
L
V
T
V
G
Y
T
Site 46
T348
S
N
S
P
S
L
V
T
V
G
Y
T
S
V
S
Site 47
S356
V
G
Y
T
S
V
S
S
T
T
P
D
S
N
L
Site 48
T357
G
Y
T
S
V
S
S
T
T
P
D
S
N
L
S
Site 49
T358
Y
T
S
V
S
S
T
T
P
D
S
N
L
S
V
Site 50
S361
V
S
S
T
T
P
D
S
N
L
S
V
D
S
S
Site 51
S364
T
T
P
D
S
N
L
S
V
D
S
S
T
M
V
Site 52
S368
S
N
L
S
V
D
S
S
T
M
V
E
A
A
P
Site 53
S380
A
A
P
P
I
P
K
S
R
G
R
K
R
A
A
Site 54
T390
R
K
R
A
A
Q
Q
T
P
D
M
T
G
P
S
Site 55
T394
A
Q
Q
T
P
D
M
T
G
P
S
S
K
Q
A
Site 56
S398
P
D
M
T
G
P
S
S
K
Q
A
K
V
T
Y
Site 57
Y405
S
K
Q
A
K
V
T
Y
S
C
I
Y
C
N
K
Site 58
Y409
K
V
T
Y
S
C
I
Y
C
N
K
Q
L
F
S
Site 59
S448
Y
C
L
E
V
L
P
S
L
Y
N
L
N
E
H
Site 60
Y450
L
E
V
L
P
S
L
Y
N
L
N
E
H
L
K
Site 61
T491
E
V
V
N
D
L
N
T
L
Q
E
H
I
R
C
Site 62
T524
H
C
Y
M
G
F
L
T
D
S
S
L
E
E
H
Site 63
S526
Y
M
G
F
L
T
D
S
S
L
E
E
H
I
R
Site 64
S527
M
G
F
L
T
D
S
S
L
E
E
H
I
R
Q
Site 65
S540
R
Q
V
H
C
D
L
S
G
S
R
F
G
S
P
Site 66
S546
L
S
G
S
R
F
G
S
P
V
L
G
T
P
K
Site 67
T551
F
G
S
P
V
L
G
T
P
K
E
P
V
V
E
Site 68
S573
T
N
S
P
I
F
N
S
V
L
K
L
N
K
H
Site 69
S601
Y
I
H
N
G
K
K
S
R
A
L
S
P
L
S
Site 70
S605
G
K
K
S
R
A
L
S
P
L
S
P
V
A
I
Site 71
S608
S
R
A
L
S
P
L
S
P
V
A
I
E
Q
T
Site 72
T631
G
G
A
P
A
R
P
T
G
E
Y
I
C
N
Q
Site 73
Y634
P
A
R
P
T
G
E
Y
I
C
N
Q
C
G
A
Site 74
Y643
C
N
Q
C
G
A
K
Y
T
S
L
D
S
F
Q
Site 75
S645
Q
C
G
A
K
Y
T
S
L
D
S
F
Q
T
H
Site 76
S648
A
K
Y
T
S
L
D
S
F
Q
T
H
L
K
T
Site 77
T655
S
F
Q
T
H
L
K
T
H
L
D
T
V
L
P
Site 78
T659
H
L
K
T
H
L
D
T
V
L
P
K
L
T
C
Site 79
S705
S
C
D
K
Q
F
T
S
V
D
D
L
Q
K
H
Site 80
S746
L
H
L
A
V
K
H
S
N
E
K
K
V
Y
R
Site 81
Y752
H
S
N
E
K
K
V
Y
R
C
T
S
C
N
W
Site 82
Y809
I
T
T
H
S
K
K
Y
N
C
K
F
C
S
K
Site 83
T863
V
E
L
Q
T
L
L
T
N
S
Q
E
S
H
N
Site 84
S865
L
Q
T
L
L
T
N
S
Q
E
S
H
N
S
H
Site 85
S871
N
S
Q
E
S
H
N
S
H
D
G
S
E
E
D
Site 86
S875
S
H
N
S
H
D
G
S
E
E
D
V
D
T
S
Site 87
T881
G
S
E
E
D
V
D
T
S
E
P
M
Y
G
C
Site 88
S882
S
E
E
D
V
D
T
S
E
P
M
Y
G
C
D
Site 89
Y930
A
E
L
I
K
G
N
Y
K
C
N
V
C
S
R
Site 90
T938
K
C
N
V
C
S
R
T
F
F
S
E
N
G
L
Site 91
S941
V
C
S
R
T
F
F
S
E
N
G
L
R
E
H
Site 92
T951
G
L
R
E
H
M
Q
T
H
L
G
P
V
K
H
Site 93
Y959
H
L
G
P
V
K
H
Y
M
C
P
I
C
G
E
Site 94
S970
I
C
G
E
R
F
P
S
L
L
T
L
T
E
H
Site 95
T975
F
P
S
L
L
T
L
T
E
H
K
V
T
H
S
Site 96
T980
T
L
T
E
H
K
V
T
H
S
K
S
L
D
T
Site 97
S984
H
K
V
T
H
S
K
S
L
D
T
G
N
C
R
Site 98
S999
I
C
K
M
P
L
Q
S
E
E
E
F
L
E
H
Site 99
S1016
M
H
P
D
L
R
N
S
L
T
G
F
R
C
V
Site 100
T1040
L
E
L
K
I
H
G
T
F
H
M
Q
K
T
G
Site 101
T1046
G
T
F
H
M
Q
K
T
G
N
G
S
A
V
Q
Site 102
S1050
M
Q
K
T
G
N
G
S
A
V
Q
T
T
G
R
Site 103
T1054
G
N
G
S
A
V
Q
T
T
G
R
G
Q
H
V
Site 104
Y1065
G
Q
H
V
Q
K
L
Y
K
C
A
S
C
L
K
Site 105
S1069
Q
K
L
Y
K
C
A
S
C
L
K
E
F
R
S
Site 106
S1076
S
C
L
K
E
F
R
S
K
Q
D
L
V
K
L
Site 107
S1104
V
N
L
S
K
S
A
S
P
G
I
N
V
P
P
Site 108
T1113
G
I
N
V
P
P
G
T
N
R
P
G
L
G
Q
Site 109
S1125
L
G
Q
N
E
N
L
S
A
I
E
G
K
G
K
Site 110
T1138
G
K
V
G
G
L
K
T
R
C
S
S
C
N
V
Site 111
S1141
G
G
L
K
T
R
C
S
S
C
N
V
K
F
E
Site 112
S1142
G
L
K
T
R
C
S
S
C
N
V
K
F
E
S
Site 113
S1149
S
C
N
V
K
F
E
S
E
S
E
L
Q
N
H
Site 114
S1168
H
R
E
L
V
P
D
S
N
S
T
Q
L
K
T
Site 115
S1170
E
L
V
P
D
S
N
S
T
Q
L
K
T
P
Q
Site 116
T1175
S
N
S
T
Q
L
K
T
P
Q
V
S
P
M
P
Site 117
S1179
Q
L
K
T
P
Q
V
S
P
M
P
R
I
S
P
Site 118
S1185
V
S
P
M
P
R
I
S
P
S
Q
S
D
E
K
Site 119
S1187
P
M
P
R
I
S
P
S
Q
S
D
E
K
K
T
Site 120
S1189
P
R
I
S
P
S
Q
S
D
E
K
K
T
Y
Q
Site 121
Y1195
Q
S
D
E
K
K
T
Y
Q
C
I
K
C
Q
M
Site 122
S1231
N
H
E
C
K
L
C
S
Q
T
F
D
S
P
A
Site 123
T1233
E
C
K
L
C
S
Q
T
F
D
S
P
A
K
L
Site 124
S1236
L
C
S
Q
T
F
D
S
P
A
K
L
Q
C
H
Site 125
Y1286
H
G
Q
E
D
K
I
Y
D
C
T
Q
C
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation