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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSH2D
Full Name:
Hematopoietic SH2 domain-containing protein
Alias:
ALX; FLJ14886; Hematopoietic SH2 domain containing; HSH2
Type:
Adaptor/scaffold
Mass (Da):
39002
Number AA:
352
UniProt ID:
Q96JZ2
International Prot ID:
IPI00396593
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
R
L
D
W
F
V
H
T
Q
M
G
Q
L
A
Q
Site 2
S50
D
A
E
N
L
L
E
S
Q
P
L
G
S
F
L
Site 3
T68
S
H
S
H
V
G
Y
T
L
S
Y
K
A
Q
S
Site 4
S70
S
H
V
G
Y
T
L
S
Y
K
A
Q
S
S
C
Site 5
Y71
H
V
G
Y
T
L
S
Y
K
A
Q
S
S
C
C
Site 6
T89
V
K
L
L
D
D
G
T
F
M
I
P
G
E
K
Site 7
T107
T
S
L
D
A
L
V
T
F
H
Q
Q
K
P
I
Site 8
T122
E
P
R
R
E
L
L
T
Q
P
C
R
Q
K
D
Site 9
Y135
K
D
P
A
N
V
D
Y
E
D
L
F
L
Y
S
Site 10
Y141
D
Y
E
D
L
F
L
Y
S
N
A
V
A
E
E
Site 11
S154
E
E
A
A
C
P
V
S
A
P
E
E
A
S
P
Site 12
S160
V
S
A
P
E
E
A
S
P
K
P
V
L
C
H
Site 13
S169
K
P
V
L
C
H
Q
S
K
E
R
K
P
S
A
Site 14
S175
Q
S
K
E
R
K
P
S
A
E
M
N
R
I
T
Site 15
T182
S
A
E
M
N
R
I
T
T
K
E
A
T
S
S
Site 16
T183
A
E
M
N
R
I
T
T
K
E
A
T
S
S
C
Site 17
S188
I
T
T
K
E
A
T
S
S
C
P
P
K
S
P
Site 18
S189
T
T
K
E
A
T
S
S
C
P
P
K
S
P
L
Site 19
S194
T
S
S
C
P
P
K
S
P
L
G
E
T
R
Q
Site 20
S206
T
R
Q
K
L
W
R
S
L
K
M
L
P
E
R
Site 21
S223
R
V
R
Q
Q
L
K
S
H
L
A
T
V
N
L
Site 22
S239
S
L
L
D
V
R
R
S
T
V
I
S
G
P
G
Site 23
S243
V
R
R
S
T
V
I
S
G
P
G
T
G
K
G
Site 24
T247
T
V
I
S
G
P
G
T
G
K
G
S
Q
D
H
Site 25
S251
G
P
G
T
G
K
G
S
Q
D
H
S
G
D
P
Site 26
S255
G
K
G
S
Q
D
H
S
G
D
P
T
S
G
D
Site 27
T259
Q
D
H
S
G
D
P
T
S
G
D
R
G
Y
T
Site 28
S260
D
H
S
G
D
P
T
S
G
D
R
G
Y
T
D
Site 29
Y265
P
T
S
G
D
R
G
Y
T
D
P
C
V
A
T
Site 30
T266
T
S
G
D
R
G
Y
T
D
P
C
V
A
T
S
Site 31
T272
Y
T
D
P
C
V
A
T
S
L
K
S
P
S
Q
Site 32
S273
T
D
P
C
V
A
T
S
L
K
S
P
S
Q
P
Site 33
S276
C
V
A
T
S
L
K
S
P
S
Q
P
Q
A
P
Site 34
S278
A
T
S
L
K
S
P
S
Q
P
Q
A
P
K
D
Site 35
S296
P
T
R
K
A
E
R
S
V
S
C
I
E
V
T
Site 36
S298
R
K
A
E
R
S
V
S
C
I
E
V
T
P
G
Site 37
T303
S
V
S
C
I
E
V
T
P
G
D
R
S
W
H
Site 38
S318
Q
M
V
V
R
A
L
S
S
Q
E
S
K
P
E
Site 39
S319
M
V
V
R
A
L
S
S
Q
E
S
K
P
E
H
Site 40
S322
R
A
L
S
S
Q
E
S
K
P
E
H
Q
G
L
Site 41
Y341
N
D
Q
L
P
E
E
Y
Q
Q
P
P
P
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation