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Updated November 2019
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Protein Info
Short Name:
ZNF462
Full Name:
Zinc finger protein 462
Alias:
DKFZP762N2316; Flj14960; Flj45904; Kiaa1803; Zfp462; Zinc finger protein 462; Znf462
Type:
Mass (Da):
284688
Number AA:
2506
UniProt ID:
Q96JM2
International Prot ID:
IPI00792933
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
G
C
D
F
R
A
P
S
Y
E
D
L
K
A
H
Site 2
Y16
C
D
F
R
A
P
S
Y
E
D
L
K
A
H
I
Site 3
T28
A
H
I
Q
D
V
H
T
A
F
L
Q
P
T
D
Site 4
S48
V
N
E
L
R
C
G
S
V
N
A
S
N
Q
T
Site 5
S52
R
C
G
S
V
N
A
S
N
Q
T
E
V
E
F
Site 6
S79
L
S
G
Q
N
A
T
S
L
G
T
G
G
Y
Y
Site 7
Y85
T
S
L
G
T
G
G
Y
Y
G
H
S
P
G
Y
Site 8
Y86
S
L
G
T
G
G
Y
Y
G
H
S
P
G
Y
Y
Site 9
Y92
Y
Y
G
H
S
P
G
Y
Y
G
Q
H
I
A
A
Site 10
Y93
Y
G
H
S
P
G
Y
Y
G
Q
H
I
A
A
N
Site 11
Y116
Q
C
K
F
C
V
R
Y
F
R
S
K
N
L
L
Site 12
S138
H
G
A
Q
A
E
G
S
S
S
G
P
P
V
P
Site 13
S140
A
Q
A
E
G
S
S
S
G
P
P
V
P
G
S
Site 14
S147
S
G
P
P
V
P
G
S
L
N
Y
N
I
M
M
Site 15
Y169
F
S
C
Q
F
C
T
Y
K
S
P
R
R
A
R
Site 16
T192
H
K
N
N
L
K
E
T
T
A
P
P
P
A
P
Site 17
S211
D
P
V
V
P
P
V
S
L
Q
D
P
C
K
E
Site 18
S231
V
E
R
S
I
L
E
S
M
V
K
P
L
T
K
Site 19
T237
E
S
M
V
K
P
L
T
K
S
R
G
N
F
C
Site 20
S268
H
M
M
K
K
H
R
S
M
V
K
I
L
S
S
Site 21
S274
R
S
M
V
K
I
L
S
S
L
R
Q
Q
Q
E
Site 22
S275
S
M
V
K
I
L
S
S
L
R
Q
Q
Q
E
G
Site 23
S292
L
P
D
V
P
N
K
S
A
P
S
P
T
S
N
Site 24
S295
V
P
N
K
S
A
P
S
P
T
S
N
S
T
Y
Site 25
S298
K
S
A
P
S
P
T
S
N
S
T
Y
L
T
M
Site 26
Y302
S
P
T
S
N
S
T
Y
L
T
M
N
A
A
S
Site 27
T304
T
S
N
S
T
Y
L
T
M
N
A
A
S
R
E
Site 28
T315
A
S
R
E
I
P
N
T
T
V
S
N
F
R
G
Site 29
T316
S
R
E
I
P
N
T
T
V
S
N
F
R
G
S
Site 30
S318
E
I
P
N
T
T
V
S
N
F
R
G
S
M
G
Site 31
S323
T
V
S
N
F
R
G
S
M
G
N
S
I
M
R
Site 32
S327
F
R
G
S
M
G
N
S
I
M
R
P
N
S
S
Site 33
S333
N
S
I
M
R
P
N
S
S
A
S
K
F
S
P
Site 34
S334
S
I
M
R
P
N
S
S
A
S
K
F
S
P
M
Site 35
S336
M
R
P
N
S
S
A
S
K
F
S
P
M
S
Y
Site 36
S339
N
S
S
A
S
K
F
S
P
M
S
Y
P
Q
M
Site 37
S342
A
S
K
F
S
P
M
S
Y
P
Q
M
K
P
K
Site 38
Y343
S
K
F
S
P
M
S
Y
P
Q
M
K
P
K
S
Site 39
S350
Y
P
Q
M
K
P
K
S
P
H
N
S
G
L
V
Site 40
S354
K
P
K
S
P
H
N
S
G
L
V
N
L
T
E
Site 41
T360
N
S
G
L
V
N
L
T
E
R
S
R
Y
G
M
Site 42
Y365
N
L
T
E
R
S
R
Y
G
M
T
D
M
T
N
Site 43
T371
R
Y
G
M
T
D
M
T
N
S
S
A
D
L
E
Site 44
S373
G
M
T
D
M
T
N
S
S
A
D
L
E
T
N
Site 45
S381
S
A
D
L
E
T
N
S
M
L
N
D
S
S
S
Site 46
S386
T
N
S
M
L
N
D
S
S
S
D
E
E
L
N
Site 47
S387
N
S
M
L
N
D
S
S
S
D
E
E
L
N
E
Site 48
S388
S
M
L
N
D
S
S
S
D
E
E
L
N
E
I
Site 49
S397
E
E
L
N
E
I
D
S
E
N
G
L
S
A
M
Site 50
S402
I
D
S
E
N
G
L
S
A
M
D
H
Q
T
S
Site 51
S412
D
H
Q
T
S
G
L
S
A
E
Q
L
M
G
S
Site 52
S419
S
A
E
Q
L
M
G
S
D
G
N
K
L
L
E
Site 53
S453
F
L
T
M
H
R
R
S
I
S
R
H
I
E
N
Site 54
Y470
L
S
G
K
T
A
V
Y
K
C
D
E
C
P
F
Site 55
T478
K
C
D
E
C
P
F
T
C
K
S
S
L
K
L
Site 56
S481
E
C
P
F
T
C
K
S
S
L
K
L
G
A
H
Site 57
T493
G
A
H
K
Q
C
H
T
G
T
T
S
D
W
D
Site 58
S504
S
D
W
D
A
V
N
S
Q
S
E
S
I
S
S
Site 59
S506
W
D
A
V
N
S
Q
S
E
S
I
S
S
S
L
Site 60
S508
A
V
N
S
Q
S
E
S
I
S
S
S
L
N
E
Site 61
S510
N
S
Q
S
E
S
I
S
S
S
L
N
E
G
V
Site 62
S511
S
Q
S
E
S
I
S
S
S
L
N
E
G
V
V
Site 63
S512
Q
S
E
S
I
S
S
S
L
N
E
G
V
V
S
Site 64
S519
S
L
N
E
G
V
V
S
Y
E
S
S
S
I
N
Site 65
Y520
L
N
E
G
V
V
S
Y
E
S
S
S
I
N
G
Site 66
S522
E
G
V
V
S
Y
E
S
S
S
I
N
G
R
K
Site 67
S523
G
V
V
S
Y
E
S
S
S
I
N
G
R
K
S
Site 68
S524
V
V
S
Y
E
S
S
S
I
N
G
R
K
S
G
Site 69
S530
S
S
I
N
G
R
K
S
G
V
M
L
D
P
L
Site 70
S555
P
P
P
P
P
P
P
S
Q
P
Q
P
L
Q
Q
Site 71
T580
Q
V
P
P
Q
P
Q
T
Q
P
P
P
T
Q
Q
Site 72
T585
P
Q
T
Q
P
P
P
T
Q
Q
P
Q
P
P
T
Site 73
T592
T
Q
Q
P
Q
P
P
T
Q
A
A
P
L
H
P
Site 74
S637
P
K
F
E
G
Q
P
S
S
L
P
L
E
N
E
Site 75
S638
K
F
E
G
Q
P
S
S
L
P
L
E
N
E
T
Site 76
T645
S
L
P
L
E
N
E
T
D
S
H
P
S
S
S
Site 77
S647
P
L
E
N
E
T
D
S
H
P
S
S
S
N
T
Site 78
S651
E
T
D
S
H
P
S
S
S
N
T
V
K
K
S
Site 79
S652
T
D
S
H
P
S
S
S
N
T
V
K
K
S
Q
Site 80
T654
S
H
P
S
S
S
N
T
V
K
K
S
Q
T
S
Site 81
S658
S
S
N
T
V
K
K
S
Q
T
S
I
L
G
L
Site 82
S661
T
V
K
K
S
Q
T
S
I
L
G
L
S
S
K
Site 83
S667
T
S
I
L
G
L
S
S
K
N
N
F
V
A
K
Site 84
S688
N
D
F
P
L
D
L
S
P
V
K
K
R
T
R
Site 85
S701
T
R
I
D
E
I
A
S
N
L
Q
S
K
I
N
Site 86
S705
E
I
A
S
N
L
Q
S
K
I
N
Q
T
K
Q
Site 87
T745
L
D
R
E
E
E
P
T
E
P
I
I
E
V
P
Site 88
T765
Q
Q
I
W
V
R
D
T
S
E
P
Q
K
E
P
Site 89
S766
Q
I
W
V
R
D
T
S
E
P
Q
K
E
P
N
Site 90
T778
E
P
N
F
R
N
I
T
H
D
Y
N
A
T
N
Site 91
Y781
F
R
N
I
T
H
D
Y
N
A
T
N
G
A
E
Site 92
T792
N
G
A
E
I
E
L
T
L
S
E
D
E
E
D
Site 93
S794
A
E
I
E
L
T
L
S
E
D
E
E
D
Y
Y
Site 94
Y800
L
S
E
D
E
E
D
Y
Y
G
S
S
T
N
L
Site 95
Y801
S
E
D
E
E
D
Y
Y
G
S
S
T
N
L
K
Site 96
S813
N
L
K
D
H
Q
V
S
N
T
A
L
L
N
T
Site 97
T820
S
N
T
A
L
L
N
T
Q
T
P
I
Y
G
T
Site 98
T822
T
A
L
L
N
T
Q
T
P
I
Y
G
T
E
H
Site 99
Y825
L
N
T
Q
T
P
I
Y
G
T
E
H
N
S
E
Site 100
Y843
F
G
D
S
G
R
L
Y
Y
C
K
H
C
D
F
Site 101
Y844
G
D
S
G
R
L
Y
Y
C
K
H
C
D
F
N
Site 102
S859
N
K
S
A
R
S
V
S
T
H
Y
Q
R
M
H
Site 103
Y862
A
R
S
V
S
T
H
Y
Q
R
M
H
P
Y
I
Site 104
Y886
P
N
D
H
S
A
V
Y
R
C
L
E
C
Y
I
Site 105
Y892
V
Y
R
C
L
E
C
Y
I
D
Y
T
N
F
E
Site 106
Y895
C
L
E
C
Y
I
D
Y
T
N
F
E
D
L
Q
Site 107
Y925
F
D
H
S
D
L
I
Y
R
C
R
F
C
S
Y
Site 108
Y932
Y
R
C
R
F
C
S
Y
T
S
P
N
V
R
S
Site 109
T933
R
C
R
F
C
S
Y
T
S
P
N
V
R
S
L
Site 110
S934
C
R
F
C
S
Y
T
S
P
N
V
R
S
L
M
Site 111
S939
Y
T
S
P
N
V
R
S
L
M
P
H
Y
Q
R
Site 112
Y944
V
R
S
L
M
P
H
Y
Q
R
M
H
P
T
V
Site 113
Y962
N
A
M
I
F
S
S
Y
V
V
E
Q
Q
E
G
Site 114
T972
E
Q
Q
E
G
L
N
T
E
S
Q
T
L
R
E
Site 115
T976
G
L
N
T
E
S
Q
T
L
R
E
I
L
N
S
Site 116
S983
T
L
R
E
I
L
N
S
A
P
K
N
M
A
T
Site 117
T990
S
A
P
K
N
M
A
T
S
T
P
V
A
R
G
Site 118
S991
A
P
K
N
M
A
T
S
T
P
V
A
R
G
G
Site 119
T992
P
K
N
M
A
T
S
T
P
V
A
R
G
G
G
Site 120
T1003
R
G
G
G
L
P
A
T
F
N
K
N
T
P
K
Site 121
T1008
P
A
T
F
N
K
N
T
P
K
T
F
T
P
E
Site 122
T1011
F
N
K
N
T
P
K
T
F
T
P
E
C
E
N
Site 123
T1013
K
N
T
P
K
T
F
T
P
E
C
E
N
Q
K
Site 124
T1026
Q
K
D
P
L
V
N
T
V
V
V
Y
D
C
D
Site 125
S1059
K
H
P
E
E
K
A
S
Y
F
R
I
Q
K
T
Site 126
Y1060
H
P
E
E
K
A
S
Y
F
R
I
Q
K
T
M
Site 127
T1066
S
Y
F
R
I
Q
K
T
M
R
M
V
S
V
D
Site 128
S1071
Q
K
T
M
R
M
V
S
V
D
R
G
S
A
L
Site 129
S1076
M
V
S
V
D
R
G
S
A
L
S
Q
L
S
F
Site 130
S1079
V
D
R
G
S
A
L
S
Q
L
S
F
E
V
G
Site 131
S1082
G
S
A
L
S
Q
L
S
F
E
V
G
A
P
M
Site 132
S1090
F
E
V
G
A
P
M
S
P
K
M
S
N
M
G
Site 133
S1094
A
P
M
S
P
K
M
S
N
M
G
S
P
P
P
Site 134
S1098
P
K
M
S
N
M
G
S
P
P
P
P
Q
P
P
Site 135
S1110
Q
P
P
P
P
D
L
S
T
E
L
Y
Y
C
K
Site 136
T1111
P
P
P
P
D
L
S
T
E
L
Y
Y
C
K
H
Site 137
Y1114
P
D
L
S
T
E
L
Y
Y
C
K
H
C
S
Y
Site 138
Y1115
D
L
S
T
E
L
Y
Y
C
K
H
C
S
Y
S
Site 139
Y1121
Y
Y
C
K
H
C
S
Y
S
N
R
S
V
V
G
Site 140
Y1133
V
V
G
V
L
V
H
Y
Q
K
R
H
P
E
I
Site 141
T1143
R
H
P
E
I
K
V
T
A
K
Y
I
R
Q
A
Site 142
Y1146
E
I
K
V
T
A
K
Y
I
R
Q
A
P
P
T
Site 143
T1153
Y
I
R
Q
A
P
P
T
A
A
M
M
R
G
V
Site 144
S1166
G
V
E
G
P
Q
G
S
P
R
P
P
A
P
I
Site 145
S1179
P
I
Q
Q
L
N
R
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R
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G
P
Site 146
S1180
I
Q
Q
L
N
R
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P
Site 147
S1181
Q
Q
L
N
R
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S
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G
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P
V
Site 148
Y1212
V
K
G
V
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K
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F
Site 149
T1232
V
I
R
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T
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R
Site 150
S1246
R
N
Q
K
K
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A
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C
V
L
V
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P
S
Site 151
S1251
P
A
S
C
V
L
V
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P
S
N
L
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R
D
Site 152
T1260
S
N
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R
D
K
T
K
L
R
A
L
K
C
Site 153
Y1272
L
K
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C
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Y
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Y
F
Y
A
Site 154
T1273
K
C
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T
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Y
F
Y
A
L
Site 155
Y1276
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C
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Y
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Y
A
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H
Site 156
Y1278
S
Y
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Y
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K
Site 157
T1294
D
H
P
A
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K
A
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T
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I
M
R
W
Site 158
T1322
E
W
C
I
Y
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T
E
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N
G
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L
L
Site 159
Y1331
P
N
G
L
L
L
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Y
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R
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E
H
Site 160
Y1339
Q
R
R
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E
H
Y
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Y
T
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M
A
Site 161
Y1342
H
P
E
H
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D
Y
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M
A
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Site 162
Y1344
E
H
Y
V
D
Y
T
Y
M
A
T
K
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W
A
Site 163
S1356
L
W
A
G
P
D
P
S
P
P
S
L
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M
P
Site 164
S1359
G
P
D
P
S
P
P
S
L
T
M
P
A
E
A
Site 165
Y1369
M
P
A
E
A
K
T
Y
R
C
R
D
C
V
F
Site 166
S1419
A
V
E
K
P
I
L
S
S
E
E
L
A
G
P
Site 167
T1435
N
C
E
N
S
I
P
T
P
F
P
E
Q
E
A
Site 168
S1451
C
P
E
D
A
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K
S
L
Q
L
Site 169
S1455
A
R
L
S
P
E
K
S
L
Q
L
A
S
A
N
Site 170
S1460
E
K
S
L
Q
L
A
S
A
N
P
A
I
S
S
Site 171
S1466
A
S
A
N
P
A
I
S
S
T
P
Y
Q
C
T
Site 172
Y1470
P
A
I
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S
T
P
Y
Q
C
T
V
C
Q
S
Site 173
Y1479
C
T
V
C
Q
S
E
Y
N
N
L
H
G
L
L
Site 174
T1487
N
N
L
H
G
L
L
T
H
Y
G
K
K
H
P
Site 175
Y1489
L
H
G
L
L
T
H
Y
G
K
K
H
P
G
M
Site 176
Y1515
D
I
N
P
G
A
V
Y
K
C
R
H
C
P
Y
Site 177
T1532
T
R
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Q
K
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H
P
Site 178
Y1534
I
H
G
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Y
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R
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I
Site 179
S1540
H
Y
Q
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A
E
D
Site 180
T1544
R
H
P
S
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K
V
T
A
E
D
F
V
H
D
Site 181
S1559
V
E
Q
S
A
D
I
S
Q
N
D
V
E
E
T
Site 182
Y1574
S
R
I
F
K
Q
G
Y
G
A
Y
R
C
K
L
Site 183
Y1584
Y
R
C
K
L
C
P
Y
T
H
G
T
L
E
K
Site 184
Y1599
L
K
I
H
Y
E
K
Y
H
N
Q
P
E
F
D
Site 185
S1609
E
F
C
G
R
A
F
S
Q
G
S
E
W
E
R
Site 186
S1611
E
F
D
V
F
S
Q
S
P
P
K
L
P
V
P
Site 187
T1624
V
P
L
E
P
E
M
T
T
E
V
S
P
S
Q
Site 188
S1628
P
E
M
T
T
E
V
S
P
S
Q
V
S
I
T
Site 189
S1630
M
T
T
E
V
S
P
S
Q
V
S
I
T
E
E
Site 190
S1645
E
V
G
E
E
P
V
S
T
S
H
F
S
T
S
Site 191
T1646
V
G
E
E
P
V
S
T
S
H
F
S
T
S
H
Site 192
S1647
G
E
E
P
V
S
T
S
H
F
S
T
S
H
L
Site 193
S1650
P
V
S
T
S
H
F
S
T
S
H
L
V
S
H
Site 194
T1651
V
S
T
S
H
F
S
T
S
H
L
V
S
H
T
Site 195
S1652
S
T
S
H
F
S
T
S
H
L
V
S
H
T
V
Site 196
Y1667
F
R
C
Q
L
C
K
Y
F
C
S
T
R
K
G
Site 197
Y1679
R
K
G
I
A
R
H
Y
R
I
K
H
N
N
V
Site 198
Y1704
F
K
C
A
L
C
A
Y
T
N
P
I
R
K
G
Site 199
Y1716
R
K
G
L
A
A
H
Y
Q
K
R
H
D
I
D
Site 200
Y1725
K
R
H
D
I
D
A
Y
Y
T
H
C
L
A
A
Site 201
Y1726
R
H
D
I
D
A
Y
Y
T
H
C
L
A
A
S
Site 202
T1727
H
D
I
D
A
Y
Y
T
H
C
L
A
A
S
R
Site 203
S1733
Y
T
H
C
L
A
A
S
R
T
I
S
D
K
P
Site 204
T1735
H
C
L
A
A
S
R
T
I
S
D
K
P
N
K
Site 205
S1737
L
A
A
S
R
T
I
S
D
K
P
N
K
V
I
Site 206
S1747
P
N
K
V
I
I
P
S
P
P
K
D
D
S
P
Site 207
S1753
P
S
P
P
K
D
D
S
P
Q
L
S
E
E
L
Site 208
S1757
K
D
D
S
P
Q
L
S
E
E
L
R
R
A
V
Site 209
S1770
A
V
E
K
K
K
C
S
L
C
S
F
Q
S
F
Site 210
S1773
K
K
K
C
S
L
C
S
F
Q
S
F
S
K
K
Site 211
Y1786
K
K
G
I
V
S
H
Y
M
K
R
H
P
G
V
Site 212
Y1806
H
A
S
K
L
G
G
Y
F
T
A
V
Y
A
D
Site 213
T1808
S
K
L
G
G
Y
F
T
A
V
Y
A
D
E
H
Site 214
Y1811
G
G
Y
F
T
A
V
Y
A
D
E
H
E
K
P
Site 215
Y1866
A
E
L
L
C
M
H
Y
T
D
H
H
S
R
D
Site 216
Y1892
P
R
L
Q
N
S
T
Y
Q
C
K
H
C
D
S
Site 217
S1903
H
C
D
S
K
L
Q
S
T
A
E
L
T
S
H
Site 218
S1933
E
R
R
K
Q
L
L
S
K
Q
K
Y
A
D
G
Site 219
Y1937
Q
L
L
S
K
Q
K
Y
A
D
G
A
F
A
D
Site 220
Y1968
K
E
R
K
V
V
G
Y
K
C
K
F
C
V
E
Site 221
Y1993
H
L
R
K
H
V
Q
Y
G
N
V
P
A
V
S
Site 222
S2008
A
A
V
K
G
L
R
S
H
E
R
S
H
L
A
Site 223
S2012
G
L
R
S
H
E
R
S
H
L
A
L
A
M
F
Site 224
Y2025
M
F
T
R
E
D
K
Y
S
C
Q
Y
C
S
F
Site 225
Y2029
E
D
K
Y
S
C
Q
Y
C
S
F
V
S
A
F
Site 226
S2060
P
F
R
C
K
L
C
S
F
K
S
S
Y
N
S
Site 227
S2063
C
K
L
C
S
F
K
S
S
Y
N
S
R
L
K
Site 228
S2064
K
L
C
S
F
K
S
S
Y
N
S
R
L
K
T
Site 229
S2067
S
F
K
S
S
Y
N
S
R
L
K
T
H
I
L
Site 230
T2071
S
Y
N
S
R
L
K
T
H
I
L
K
A
H
A
Site 231
Y2083
A
H
A
G
E
H
A
Y
K
C
S
W
C
S
F
Site 232
S2096
S
F
S
T
M
T
I
S
Q
L
K
E
H
S
L
Site 233
S2102
I
S
Q
L
K
E
H
S
L
K
V
H
G
K
A
Site 234
T2111
K
V
H
G
K
A
L
T
L
P
R
P
R
I
V
Site 235
S2119
L
P
R
P
R
I
V
S
L
L
S
S
H
S
H
Site 236
S2122
P
R
I
V
S
L
L
S
S
H
S
H
H
S
S
Site 237
S2123
R
I
V
S
L
L
S
S
H
S
H
H
S
S
Q
Site 238
S2125
V
S
L
L
S
S
H
S
H
H
S
S
Q
K
A
Site 239
S2129
S
S
H
S
H
H
S
S
Q
K
A
T
P
A
E
Site 240
T2133
H
H
S
S
Q
K
A
T
P
A
E
E
V
E
D
Site 241
S2141
P
A
E
E
V
E
D
S
N
D
S
S
Y
S
E
Site 242
S2144
E
V
E
D
S
N
D
S
S
Y
S
E
P
P
D
Site 243
S2145
V
E
D
S
N
D
S
S
Y
S
E
P
P
D
V
Site 244
Y2146
E
D
S
N
D
S
S
Y
S
E
P
P
D
V
Q
Site 245
S2147
D
S
N
D
S
S
Y
S
E
P
P
D
V
Q
Q
Site 246
Y2159
V
Q
Q
Q
L
N
H
Y
Q
S
A
A
L
A
R
Site 247
S2169
A
A
L
A
R
N
N
S
R
V
S
P
V
P
L
Site 248
S2172
A
R
N
N
S
R
V
S
P
V
P
L
S
G
A
Site 249
S2177
R
V
S
P
V
P
L
S
G
A
A
A
G
T
E
Site 250
S2205
F
S
S
G
Y
I
Q
S
I
R
R
H
Y
R
D
Site 251
Y2210
I
Q
S
I
R
R
H
Y
R
D
K
H
G
G
K
Site 252
Y2228
K
C
K
D
C
S
F
Y
T
G
F
K
S
A
F
Site 253
S2244
M
H
V
E
A
G
H
S
A
V
P
E
E
G
P
Site 254
Y2261
L
R
C
P
L
C
L
Y
H
T
K
Y
K
R
N
Site 255
S2289
V
P
I
E
V
C
R
S
K
L
S
K
Y
L
Q
Site 256
Y2294
C
R
S
K
L
S
K
Y
L
Q
G
V
V
F
R
Site 257
T2308
R
C
D
K
C
T
F
T
C
S
S
D
E
S
L
Site 258
S2310
D
K
C
T
F
T
C
S
S
D
E
S
L
Q
Q
Site 259
S2311
K
C
T
F
T
C
S
S
D
E
S
L
Q
Q
H
Site 260
S2314
F
T
C
S
S
D
E
S
L
Q
Q
H
I
E
K
Site 261
Y2328
K
H
N
E
L
K
P
Y
K
C
Q
L
C
Y
Y
Site 262
Y2334
P
Y
K
C
Q
L
C
Y
Y
E
T
K
H
T
E
Site 263
Y2335
Y
K
C
Q
L
C
Y
Y
E
T
K
H
T
E
E
Site 264
T2340
C
Y
Y
E
T
K
H
T
E
E
L
D
S
H
L
Site 265
S2345
K
H
T
E
E
L
D
S
H
L
R
D
E
H
K
Site 266
S2354
L
R
D
E
H
K
V
S
R
N
F
E
L
V
G
Site 267
S2377
Q
M
K
E
K
M
E
S
S
S
S
D
D
E
D
Site 268
S2378
M
K
E
K
M
E
S
S
S
S
D
D
E
D
K
Site 269
S2379
K
E
K
M
E
S
S
S
S
D
D
E
D
K
E
Site 270
S2380
E
K
M
E
S
S
S
S
D
D
E
D
K
E
E
Site 271
S2391
D
K
E
E
E
M
N
S
K
A
E
D
R
E
L
Site 272
S2402
D
R
E
L
M
R
F
S
D
H
G
A
A
L
N
Site 273
T2410
D
H
G
A
A
L
N
T
E
K
R
F
P
C
E
Site 274
S2424
E
F
C
G
R
A
F
S
Q
G
S
E
W
E
R
Site 275
T2443
H
G
M
A
L
N
D
T
K
Q
V
S
R
E
E
Site 276
S2460
P
K
E
I
M
E
N
S
V
K
M
P
S
I
E
Site 277
S2465
E
N
S
V
K
M
P
S
I
E
E
K
E
D
D
Site 278
S2496
C
V
V
T
A
D
K
S
L
L
E
N
A
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation