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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAML3
Full Name:
Mastermind-like protein 3
Alias:
Type:
Mass (Da):
121780
Number AA:
1134
UniProt ID:
Q96JK9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T36
A
G
I
G
V
N
N
T
P
N
S
T
P
A
A
Site 2
S39
G
V
N
N
T
P
N
S
T
P
A
A
P
S
S
Site 3
T40
V
N
N
T
P
N
S
T
P
A
A
P
S
S
N
Site 4
S46
S
T
P
A
A
P
S
S
N
H
P
A
A
G
G
Site 5
S57
A
A
G
G
C
G
G
S
G
G
P
G
G
G
S
Site 6
S64
S
G
G
P
G
G
G
S
A
A
V
P
K
H
S
Site 7
T72
A
A
V
P
K
H
S
T
V
V
E
R
L
R
Q
Site 8
T110
L
E
L
E
R
R
D
T
V
S
L
Y
Q
R
T
Site 9
S112
L
E
R
R
D
T
V
S
L
Y
Q
R
T
L
E
Site 10
Y114
R
R
D
T
V
S
L
Y
Q
R
T
L
E
Q
R
Site 11
S125
L
E
Q
R
A
K
K
S
G
A
G
T
G
K
Q
Site 12
T153
S
A
E
Q
R
N
H
T
L
I
M
L
Q
E
T
Site 13
T160
T
L
I
M
L
Q
E
T
V
K
R
K
L
E
G
Site 14
S170
R
K
L
E
G
A
R
S
P
L
N
G
D
Q
Q
Site 15
S186
G
A
C
D
G
N
F
S
P
T
S
K
R
I
R
Site 16
S189
D
G
N
F
S
P
T
S
K
R
I
R
K
D
I
Site 17
S208
E
A
I
N
N
L
P
S
N
M
P
L
P
S
A
Site 18
S214
P
S
N
M
P
L
P
S
A
S
P
L
H
Q
L
Site 19
S216
N
M
P
L
P
S
A
S
P
L
H
Q
L
D
L
Site 20
S226
H
Q
L
D
L
K
P
S
L
P
L
Q
N
S
G
Site 21
S232
P
S
L
P
L
Q
N
S
G
T
H
T
P
G
L
Site 22
T234
L
P
L
Q
N
S
G
T
H
T
P
G
L
L
E
Site 23
T236
L
Q
N
S
G
T
H
T
P
G
L
L
E
D
L
Site 24
S244
P
G
L
L
E
D
L
S
K
N
G
R
L
P
E
Site 25
S260
K
L
P
V
N
G
C
S
D
L
E
D
S
F
T
Site 26
S265
G
C
S
D
L
E
D
S
F
T
I
L
Q
S
K
Site 27
T267
S
D
L
E
D
S
F
T
I
L
Q
S
K
D
L
Site 28
T283
Q
E
P
L
D
D
P
T
C
I
D
T
S
E
T
Site 29
T287
D
D
P
T
C
I
D
T
S
E
T
S
L
S
N
Site 30
S288
D
P
T
C
I
D
T
S
E
T
S
L
S
N
Q
Site 31
S291
C
I
D
T
S
E
T
S
L
S
N
Q
N
K
L
Site 32
S293
D
T
S
E
T
S
L
S
N
Q
N
K
L
F
S
Site 33
T319
L
I
D
E
L
A
N
T
V
P
E
D
D
I
Q
Site 34
S342
E
K
K
E
P
E
F
S
Q
P
A
T
E
T
P
Site 35
T346
P
E
F
S
Q
P
A
T
E
T
P
L
S
Q
E
Site 36
T348
F
S
Q
P
A
T
E
T
P
L
S
Q
E
S
A
Site 37
S351
P
A
T
E
T
P
L
S
Q
E
S
A
S
V
K
Site 38
S354
E
T
P
L
S
Q
E
S
A
S
V
K
S
D
P
Site 39
S356
P
L
S
Q
E
S
A
S
V
K
S
D
P
S
H
Site 40
S359
Q
E
S
A
S
V
K
S
D
P
S
H
S
P
F
Site 41
S362
A
S
V
K
S
D
P
S
H
S
P
F
A
H
V
Site 42
S364
V
K
S
D
P
S
H
S
P
F
A
H
V
S
M
Site 43
S370
H
S
P
F
A
H
V
S
M
G
S
P
Q
A
R
Site 44
S373
F
A
H
V
S
M
G
S
P
Q
A
R
P
S
S
Site 45
S379
G
S
P
Q
A
R
P
S
S
S
G
P
P
F
S
Site 46
S380
S
P
Q
A
R
P
S
S
S
G
P
P
F
S
T
Site 47
S381
P
Q
A
R
P
S
S
S
G
P
P
F
S
T
V
Site 48
S386
S
S
S
G
P
P
F
S
T
V
S
T
A
T
S
Site 49
T387
S
S
G
P
P
F
S
T
V
S
T
A
T
S
L
Site 50
S389
G
P
P
F
S
T
V
S
T
A
T
S
L
P
S
Site 51
S399
T
S
L
P
S
V
A
S
T
P
A
A
P
N
P
Site 52
T400
S
L
P
S
V
A
S
T
P
A
A
P
N
P
A
Site 53
S408
P
A
A
P
N
P
A
S
S
P
A
N
C
A
V
Site 54
S409
A
A
P
N
P
A
S
S
P
A
N
C
A
V
Q
Site 55
S417
P
A
N
C
A
V
Q
S
P
Q
T
P
N
Q
A
Site 56
T420
C
A
V
Q
S
P
Q
T
P
N
Q
A
H
T
P
Site 57
T426
Q
T
P
N
Q
A
H
T
P
G
Q
A
P
P
R
Site 58
Y438
P
P
R
P
G
N
G
Y
L
L
N
P
A
A
V
Site 59
S459
S
G
P
V
A
V
P
S
S
D
M
S
P
A
E
Site 60
S460
G
P
V
A
V
P
S
S
D
M
S
P
A
E
Q
Site 61
S463
A
V
P
S
S
D
M
S
P
A
E
Q
L
K
Q
Site 62
S512
Q
Q
H
S
N
Q
T
S
N
W
S
P
L
G
P
Site 63
S515
S
N
Q
T
S
N
W
S
P
L
G
P
P
S
S
Site 64
S521
W
S
P
L
G
P
P
S
S
P
Y
G
A
A
F
Site 65
S522
S
P
L
G
P
P
S
S
P
Y
G
A
A
F
T
Site 66
Y524
L
G
P
P
S
S
P
Y
G
A
A
F
T
A
E
Site 67
S535
F
T
A
E
K
P
N
S
P
M
M
Y
P
Q
A
Site 68
Y539
K
P
N
S
P
M
M
Y
P
Q
A
F
N
N
Q
Site 69
Y565
Q
K
T
T
M
N
N
Y
L
P
Q
N
H
M
N
Site 70
S585
P
N
N
L
G
T
N
S
L
N
K
Q
H
N
I
Site 71
T602
Y
G
N
T
K
P
L
T
H
F
N
A
D
L
S
Site 72
S609
T
H
F
N
A
D
L
S
Q
R
M
T
P
P
V
Site 73
T613
A
D
L
S
Q
R
M
T
P
P
V
A
N
P
N
Site 74
S660
Q
A
P
R
A
H
L
S
E
D
Q
K
R
L
L
Site 75
Y681
V
M
N
Q
P
M
A
Y
A
A
L
P
S
H
G
Site 76
T699
H
P
V
G
L
P
R
T
T
G
P
M
Q
S
S
Site 77
T700
P
V
G
L
P
R
T
T
G
P
M
Q
S
S
V
Site 78
S705
R
T
T
G
P
M
Q
S
S
V
P
P
G
S
G
Site 79
S706
T
T
G
P
M
Q
S
S
V
P
P
G
S
G
G
Site 80
S711
Q
S
S
V
P
P
G
S
G
G
M
V
S
G
A
Site 81
S716
P
G
S
G
G
M
V
S
G
A
S
P
A
G
P
Site 82
Y792
L
Q
P
Q
R
N
P
Y
P
V
Q
Q
V
N
Q
Site 83
S803
Q
V
N
Q
F
Q
G
S
P
Q
D
I
A
A
V
Site 84
S812
Q
D
I
A
A
V
R
S
Q
A
A
L
Q
S
M
Site 85
S818
R
S
Q
A
A
L
Q
S
M
R
T
S
R
L
M
Site 86
S822
A
L
Q
S
M
R
T
S
R
L
M
A
Q
N
A
Site 87
S837
G
M
M
G
I
G
P
S
Q
N
P
G
T
M
A
Site 88
S858
E
M
G
L
A
P
Y
S
T
T
P
T
S
Q
P
Site 89
T859
M
G
L
A
P
Y
S
T
T
P
T
S
Q
P
G
Site 90
T860
G
L
A
P
Y
S
T
T
P
T
S
Q
P
G
M
Site 91
T862
A
P
Y
S
T
T
P
T
S
Q
P
G
M
Y
N
Site 92
S863
P
Y
S
T
T
P
T
S
Q
P
G
M
Y
N
M
Site 93
Y868
P
T
S
Q
P
G
M
Y
N
M
S
T
G
M
T
Site 94
S901
Q
G
P
R
Q
P
A
S
G
Q
G
V
G
M
V
Site 95
S919
G
Q
S
M
L
V
N
S
A
I
T
Q
Q
H
P
Site 96
S947
Q
A
P
P
R
L
Q
S
L
M
G
T
V
Q
Q
Site 97
T951
R
L
Q
S
L
M
G
T
V
Q
Q
G
A
Q
S
Site 98
S963
A
Q
S
W
Q
Q
R
S
L
Q
G
M
P
G
R
Site 99
S972
Q
G
M
P
G
R
T
S
G
E
L
G
P
F
N
Site 100
S983
G
P
F
N
N
G
A
S
Y
P
L
Q
A
G
Q
Site 101
Y984
P
F
N
N
G
A
S
Y
P
L
Q
A
G
Q
P
Site 102
T994
Q
A
G
Q
P
R
L
T
K
Q
H
F
P
Q
G
Site 103
S1003
Q
H
F
P
Q
G
L
S
Q
S
V
V
D
A
N
Site 104
S1005
F
P
Q
G
L
S
Q
S
V
V
D
A
N
T
G
Site 105
T1016
A
N
T
G
T
V
R
T
L
N
P
A
A
M
G
Site 106
S1029
M
G
R
Q
M
M
P
S
L
P
G
Q
Q
G
T
Site 107
S1037
L
P
G
Q
Q
G
T
S
Q
A
R
P
M
V
M
Site 108
S1045
Q
A
R
P
M
V
M
S
G
L
S
Q
G
V
P
Site 109
S1058
V
P
G
M
P
A
F
S
Q
P
P
A
Q
Q
Q
Site 110
S1068
P
A
Q
Q
Q
I
P
S
G
S
F
A
P
S
S
Site 111
S1070
Q
Q
Q
I
P
S
G
S
F
A
P
S
S
Q
S
Site 112
S1074
P
S
G
S
F
A
P
S
S
Q
S
Q
A
Y
E
Site 113
S1075
S
G
S
F
A
P
S
S
Q
S
Q
A
Y
E
R
Site 114
S1077
S
F
A
P
S
S
Q
S
Q
A
Y
E
R
N
A
Site 115
Y1080
P
S
S
Q
S
Q
A
Y
E
R
N
A
P
Q
D
Site 116
S1089
R
N
A
P
Q
D
V
S
Y
N
Y
S
G
D
G
Site 117
Y1090
N
A
P
Q
D
V
S
Y
N
Y
S
G
D
G
A
Site 118
Y1092
P
Q
D
V
S
Y
N
Y
S
G
D
G
A
G
G
Site 119
S1093
Q
D
V
S
Y
N
Y
S
G
D
G
A
G
G
S
Site 120
S1100
S
G
D
G
A
G
G
S
F
P
G
L
P
D
G
Site 121
S1113
D
G
A
D
L
V
D
S
I
I
K
G
G
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation