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Updated November 2019
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Protein Info
Short Name:
VCPIP1
Full Name:
Deubiquitinating protein VCIP135
Alias:
DUBA3; FLJ23132; KIAA1850; Valosin containing protein (p97)/p47 complex interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCIP; VCIP1; VCIP135
Type:
EC 3.4.22.-; Cell cycle regulation; Ubiquitin conjugating system; Protease
Mass (Da):
134321
Number AA:
1222
UniProt ID:
Q96JH7
International Prot ID:
IPI00064162
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005783
GO:0005794
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004843
GO:0008233
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006508
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
P
P
P
E
A
P
Q
T
P
S
S
L
A
S
A
Site 2
S25
P
E
A
P
Q
T
P
S
S
L
A
S
A
A
A
Site 3
S26
E
A
P
Q
T
P
S
S
L
A
S
A
A
A
S
Site 4
S33
S
L
A
S
A
A
A
S
G
G
L
L
K
R
R
Site 5
S46
R
R
D
R
R
I
L
S
G
S
C
P
D
P
K
Site 6
S48
D
R
R
I
L
S
G
S
C
P
D
P
K
C
Q
Site 7
T71
G
S
V
S
I
E
C
T
E
C
G
Q
R
H
E
Site 8
Y125
K
V
M
G
L
S
N
Y
H
C
K
L
L
S
P
Site 9
S131
N
Y
H
C
K
L
L
S
P
I
L
A
R
Y
G
Site 10
Y137
L
S
P
I
L
A
R
Y
G
M
D
K
Q
T
G
Site 11
T143
R
Y
G
M
D
K
Q
T
G
R
A
K
L
L
R
Site 12
T177
I
E
P
E
H
V
N
T
V
G
Y
G
K
D
R
Site 13
S185
V
G
Y
G
K
D
R
S
G
S
L
L
Y
L
H
Site 14
S187
Y
G
K
D
R
S
G
S
L
L
Y
L
H
D
T
Site 15
Y190
D
R
S
G
S
L
L
Y
L
H
D
T
L
E
D
Site 16
T194
S
L
L
Y
L
H
D
T
L
E
D
I
K
R
A
Site 17
S204
D
I
K
R
A
N
K
S
Q
E
C
L
I
P
V
Site 18
Y253
F
Q
Q
H
L
A
R
Y
Q
A
L
F
H
D
F
Site 19
S314
D
S
L
S
G
M
R
S
S
G
D
Y
S
A
T
Site 20
S315
S
L
S
G
M
R
S
S
G
D
Y
S
A
T
F
Site 21
Y318
G
M
R
S
S
G
D
Y
S
A
T
F
L
P
G
Site 22
S319
M
R
S
S
G
D
Y
S
A
T
F
L
P
G
L
Site 23
Y355
S
S
S
G
R
N
H
Y
I
P
L
V
G
I
K
Site 24
Y388
P
Q
D
L
I
K
K
Y
I
K
L
E
E
D
G
Site 25
S404
C
V
I
G
G
D
R
S
L
Q
D
K
Y
L
L
Site 26
Y409
D
R
S
L
Q
D
K
Y
L
L
R
L
V
A
A
Site 27
S430
D
K
H
G
I
H
P
S
L
V
A
D
V
H
Q
Site 28
Y438
L
V
A
D
V
H
Q
Y
F
Y
R
R
T
G
V
Site 29
Y440
A
D
V
H
Q
Y
F
Y
R
R
T
G
V
I
G
Site 30
T443
H
Q
Y
F
Y
R
R
T
G
V
I
G
V
Q
P
Site 31
Y492
L
A
P
G
G
K
L
Y
N
L
A
K
S
T
H
Site 32
S497
K
L
Y
N
L
A
K
S
T
H
G
Q
L
R
T
Site 33
T504
S
T
H
G
Q
L
R
T
D
K
N
Y
S
F
P
Site 34
Y508
Q
L
R
T
D
K
N
Y
S
F
P
L
N
N
L
Site 35
S509
L
R
T
D
K
N
Y
S
F
P
L
N
N
L
V
Site 36
Y530
K
D
V
L
V
P
D
Y
G
M
S
N
L
T
A
Site 37
S554
R
K
V
R
G
D
G
S
I
V
Y
L
D
G
D
Site 38
Y557
R
G
D
G
S
I
V
Y
L
D
G
D
R
T
N
Site 39
T563
V
Y
L
D
G
D
R
T
N
S
R
S
T
G
G
Site 40
S565
L
D
G
D
R
T
N
S
R
S
T
G
G
K
C
Site 41
S567
G
D
R
T
N
S
R
S
T
G
G
K
C
G
C
Site 42
T568
D
R
T
N
S
R
S
T
G
G
K
C
G
C
G
Site 43
Y608
R
V
V
R
E
T
V
Y
W
F
Q
Y
E
S
D
Site 44
Y612
E
T
V
Y
W
F
Q
Y
E
S
D
S
S
L
N
Site 45
S614
V
Y
W
F
Q
Y
E
S
D
S
S
L
N
S
N
Site 46
S616
W
F
Q
Y
E
S
D
S
S
L
N
S
N
V
Y
Site 47
S617
F
Q
Y
E
S
D
S
S
L
N
S
N
V
Y
D
Site 48
S620
E
S
D
S
S
L
N
S
N
V
Y
D
V
A
M
Site 49
Y663
A
K
K
N
P
D
D
Y
T
P
V
N
I
D
G
Site 50
T664
K
K
N
P
D
D
Y
T
P
V
N
I
D
G
A
Site 51
S686
V
Q
G
Q
E
S
E
S
Q
L
P
T
K
I
I
Site 52
T690
E
S
E
S
Q
L
P
T
K
I
I
L
T
G
Q
Site 53
T701
L
T
G
Q
K
T
K
T
L
H
K
E
E
L
N
Site 54
S710
H
K
E
E
L
N
M
S
K
T
E
R
T
I
Q
Site 55
T712
E
E
L
N
M
S
K
T
E
R
T
I
Q
Q
N
Site 56
T721
R
T
I
Q
Q
N
I
T
E
Q
A
S
V
M
Q
Site 57
T732
S
V
M
Q
K
R
K
T
E
K
L
K
Q
E
Q
Site 58
T745
E
Q
K
G
Q
P
R
T
V
S
P
S
T
I
R
Site 59
S747
K
G
Q
P
R
T
V
S
P
S
T
I
R
D
G
Site 60
S749
Q
P
R
T
V
S
P
S
T
I
R
D
G
P
S
Site 61
T750
P
R
T
V
S
P
S
T
I
R
D
G
P
S
S
Site 62
S756
S
T
I
R
D
G
P
S
S
A
P
A
T
P
T
Site 63
S757
T
I
R
D
G
P
S
S
A
P
A
T
P
T
K
Site 64
T761
G
P
S
S
A
P
A
T
P
T
K
A
P
Y
S
Site 65
T763
S
S
A
P
A
T
P
T
K
A
P
Y
S
P
T
Site 66
Y767
A
T
P
T
K
A
P
Y
S
P
T
T
S
K
E
Site 67
S768
T
P
T
K
A
P
Y
S
P
T
T
S
K
E
K
Site 68
T770
T
K
A
P
Y
S
P
T
T
S
K
E
K
K
I
Site 69
T771
K
A
P
Y
S
P
T
T
S
K
E
K
K
I
R
Site 70
S772
A
P
Y
S
P
T
T
S
K
E
K
K
I
R
I
Site 71
T780
K
E
K
K
I
R
I
T
T
N
D
G
R
Q
S
Site 72
T781
E
K
K
I
R
I
T
T
N
D
G
R
Q
S
M
Site 73
S787
T
T
N
D
G
R
Q
S
M
V
T
L
K
S
S
Site 74
T790
D
G
R
Q
S
M
V
T
L
K
S
S
T
T
F
Site 75
T796
V
T
L
K
S
S
T
T
F
F
E
L
Q
E
S
Site 76
S803
T
F
F
E
L
Q
E
S
I
A
R
E
F
N
I
Site 77
Y813
R
E
F
N
I
P
P
Y
L
Q
C
I
R
Y
G
Site 78
Y819
P
Y
L
Q
C
I
R
Y
G
F
P
P
K
E
L
Site 79
T847
L
Q
H
G
D
R
I
T
I
E
I
L
K
S
K
Site 80
S853
I
T
I
E
I
L
K
S
K
A
E
G
G
Q
S
Site 81
S860
S
K
A
E
G
G
Q
S
A
A
A
H
S
A
H
Site 82
Y894
E
Q
A
E
K
E
M
Y
S
L
C
L
L
A
T
Site 83
Y910
M
G
E
D
V
W
S
Y
A
K
G
L
P
H
M
Site 84
T949
F
P
H
L
P
G
K
T
F
V
Y
N
A
S
E
Site 85
Y952
L
P
G
K
T
F
V
Y
N
A
S
E
D
R
L
Site 86
S984
D
L
V
K
E
A
V
S
Q
V
R
A
E
A
T
Site 87
T991
S
Q
V
R
A
E
A
T
T
R
S
R
E
S
S
Site 88
T992
Q
V
R
A
E
A
T
T
R
S
R
E
S
S
P
Site 89
S994
R
A
E
A
T
T
R
S
R
E
S
S
P
S
H
Site 90
S997
A
T
T
R
S
R
E
S
S
P
S
H
G
L
L
Site 91
S998
T
T
R
S
R
E
S
S
P
S
H
G
L
L
K
Site 92
S1000
R
S
R
E
S
S
P
S
H
G
L
L
K
L
G
Site 93
S1008
H
G
L
L
K
L
G
S
G
G
V
V
K
K
K
Site 94
S1016
G
G
V
V
K
K
K
S
E
Q
L
H
N
V
T
Site 95
S1031
A
F
Q
G
K
G
H
S
L
G
T
A
S
G
N
Site 96
T1034
G
K
G
H
S
L
G
T
A
S
G
N
P
H
L
Site 97
S1036
G
H
S
L
G
T
A
S
G
N
P
H
L
D
P
Site 98
T1048
L
D
P
R
A
R
E
T
S
V
V
R
K
H
N
Site 99
S1049
D
P
R
A
R
E
T
S
V
V
R
K
H
N
T
Site 100
T1058
V
R
K
H
N
T
G
T
D
F
S
N
S
S
T
Site 101
S1061
H
N
T
G
T
D
F
S
N
S
S
T
K
T
E
Site 102
S1063
T
G
T
D
F
S
N
S
S
T
K
T
E
P
S
Site 103
S1064
G
T
D
F
S
N
S
S
T
K
T
E
P
S
V
Site 104
T1065
T
D
F
S
N
S
S
T
K
T
E
P
S
V
F
Site 105
T1067
F
S
N
S
S
T
K
T
E
P
S
V
F
T
A
Site 106
S1070
S
S
T
K
T
E
P
S
V
F
T
A
S
S
S
Site 107
T1073
K
T
E
P
S
V
F
T
A
S
S
S
N
S
E
Site 108
S1075
E
P
S
V
F
T
A
S
S
S
N
S
E
L
I
Site 109
S1076
P
S
V
F
T
A
S
S
S
N
S
E
L
I
R
Site 110
S1079
F
T
A
S
S
S
N
S
E
L
I
R
I
A
P
Site 111
T1090
R
I
A
P
G
V
V
T
M
R
D
G
R
Q
L
Site 112
S1114
K
K
L
Q
E
M
V
S
S
I
Q
A
S
M
D
Site 113
S1115
K
L
Q
E
M
V
S
S
I
Q
A
S
M
D
R
Site 114
S1119
M
V
S
S
I
Q
A
S
M
D
R
H
L
R
D
Site 115
S1128
D
R
H
L
R
D
Q
S
T
E
Q
S
P
S
D
Site 116
T1129
R
H
L
R
D
Q
S
T
E
Q
S
P
S
D
L
Site 117
S1132
R
D
Q
S
T
E
Q
S
P
S
D
L
P
Q
R
Site 118
S1134
Q
S
T
E
Q
S
P
S
D
L
P
Q
R
K
T
Site 119
T1141
S
D
L
P
Q
R
K
T
E
V
V
S
S
S
A
Site 120
S1145
Q
R
K
T
E
V
V
S
S
S
A
K
S
G
S
Site 121
S1146
R
K
T
E
V
V
S
S
S
A
K
S
G
S
L
Site 122
S1147
K
T
E
V
V
S
S
S
A
K
S
G
S
L
Q
Site 123
S1152
S
S
S
A
K
S
G
S
L
Q
T
G
L
P
E
Site 124
S1160
L
Q
T
G
L
P
E
S
F
P
L
T
G
G
T
Site 125
T1164
L
P
E
S
F
P
L
T
G
G
T
E
N
L
N
Site 126
T1172
G
G
T
E
N
L
N
T
E
T
T
D
G
C
V
Site 127
S1191
G
A
A
F
A
T
R
S
K
A
Q
R
G
N
S
Site 128
S1198
S
K
A
Q
R
G
N
S
V
E
E
L
E
E
M
Site 129
S1207
E
E
L
E
E
M
D
S
Q
D
A
E
M
T
N
Site 130
T1215
Q
D
A
E
M
T
N
T
T
E
P
M
D
H
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation