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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHA8
Full Name:
Pleckstrin homology domain-containing family A member 8
Alias:
Phosphatidylinositol-four-phosphate adapter protein 2;Serologically defined breast cancer antigen NY-BR-86
Type:
Mass (Da):
58306
Number AA:
519
UniProt ID:
Q96JA3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
V
L
Y
K
W
T
N
Y
L
S
G
W
Q
P
R
Site 2
S28
L
L
C
G
G
I
L
S
Y
Y
D
S
P
E
D
Site 3
Y30
C
G
G
I
L
S
Y
Y
D
S
P
E
D
A
W
Site 4
S32
G
I
L
S
Y
Y
D
S
P
E
D
A
W
K
G
Site 5
T59
Q
V
H
S
V
D
N
T
R
M
D
L
I
I
P
Site 6
Y70
L
I
I
P
G
E
Q
Y
F
Y
L
K
A
R
S
Site 7
Y72
I
P
G
E
Q
Y
F
Y
L
K
A
R
S
V
A
Site 8
S77
Y
F
Y
L
K
A
R
S
V
A
E
R
Q
R
W
Site 9
T96
G
S
A
K
A
C
L
T
D
S
R
T
Q
K
E
Site 10
S98
A
K
A
C
L
T
D
S
R
T
Q
K
E
K
E
Site 11
T100
A
C
L
T
D
S
R
T
Q
K
E
K
E
F
A
Site 12
T115
E
N
T
E
N
L
K
T
K
M
S
E
L
R
L
Site 13
S118
E
N
L
K
T
K
M
S
E
L
R
L
Y
C
D
Site 14
Y123
K
M
S
E
L
R
L
Y
C
D
L
L
V
Q
Q
Site 15
T134
L
V
Q
Q
V
D
K
T
K
E
V
T
T
T
G
Site 16
T140
K
T
K
E
V
T
T
T
G
V
S
N
S
E
E
Site 17
S143
E
V
T
T
T
G
V
S
N
S
E
E
G
I
D
Site 18
S145
T
T
T
G
V
S
N
S
E
E
G
I
D
V
G
Site 19
T153
E
E
G
I
D
V
G
T
L
L
K
S
T
C
N
Site 20
T161
L
L
K
S
T
C
N
T
F
L
K
T
L
E
E
Site 21
Y183
A
F
T
S
E
L
L
Y
R
T
P
P
G
S
P
Site 22
T185
T
S
E
L
L
Y
R
T
P
P
G
S
P
Q
L
Site 23
S189
L
Y
R
T
P
P
G
S
P
Q
L
A
M
L
K
Site 24
S197
P
Q
L
A
M
L
K
S
S
K
M
K
H
P
I
Site 25
S210
P
I
I
P
I
H
N
S
L
E
R
Q
M
E
L
Site 26
S218
L
E
R
Q
M
E
L
S
T
C
E
N
G
S
L
Site 27
S224
L
S
T
C
E
N
G
S
L
N
M
E
I
N
G
Site 28
S242
I
L
M
K
N
K
N
S
L
Y
L
K
S
A
E
Site 29
Y244
M
K
N
K
N
S
L
Y
L
K
S
A
E
I
D
Site 30
S253
K
S
A
E
I
D
C
S
I
S
S
E
E
N
T
Site 31
S255
A
E
I
D
C
S
I
S
S
E
E
N
T
D
D
Site 32
T260
S
I
S
S
E
E
N
T
D
D
N
I
T
V
Q
Site 33
T265
E
N
T
D
D
N
I
T
V
Q
G
E
I
R
K
Site 34
T287
K
N
H
D
N
N
L
T
Q
S
G
S
D
S
S
Site 35
S289
H
D
N
N
L
T
Q
S
G
S
D
S
S
C
S
Site 36
S291
N
N
L
T
Q
S
G
S
D
S
S
C
S
P
E
Site 37
S293
L
T
Q
S
G
S
D
S
S
C
S
P
E
C
L
Site 38
S294
T
Q
S
G
S
D
S
S
C
S
P
E
C
L
W
Site 39
S296
S
G
S
D
S
S
C
S
P
E
C
L
W
E
E
Site 40
T310
E
G
K
E
V
I
P
T
F
F
S
T
M
N
T
Site 41
S320
S
T
M
N
T
S
F
S
D
I
E
L
L
E
D
Site 42
S328
D
I
E
L
L
E
D
S
G
I
P
T
E
A
F
Site 43
Y372
I
K
K
V
N
Q
K
Y
I
T
N
K
E
E
F
Site 44
T380
I
T
N
K
E
E
F
T
T
L
Q
K
I
V
L
Site 45
T381
T
N
K
E
E
F
T
T
L
Q
K
I
V
L
H
Site 46
S400
D
V
A
Q
V
R
N
S
A
T
E
A
L
L
W
Site 47
T420
K
F
L
K
G
F
L
T
E
V
K
N
G
E
K
Site 48
T431
N
G
E
K
D
I
Q
T
A
L
N
N
A
Y
G
Site 49
Y437
Q
T
A
L
N
N
A
Y
G
K
T
L
R
Q
H
Site 50
T471
E
D
F
V
A
A
L
T
V
K
E
G
D
H
R
Site 51
S483
D
H
R
K
E
A
F
S
I
G
M
Q
R
D
L
Site 52
Y493
M
Q
R
D
L
S
L
Y
L
P
A
M
K
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation