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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIWIL1
Full Name:
Piwi-like protein 1
Alias:
HIWI; PIWI; Piwi-like 1; PIWL1
Type:
Membrane protein, peripheral
Mass (Da):
98603
Number AA:
861
UniProt ID:
Q96J94
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043186
GO:0033391
Uniprot
OncoNet
Molecular Function:
GO:0003729
GO:0034584
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031047
GO:0007126
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
E
T
A
Q
L
V
G
S
T
A
S
Q
Q
P
G
Site 2
S27
Q
L
V
G
S
T
A
S
Q
Q
P
G
Y
I
Q
Site 3
Y32
T
A
S
Q
Q
P
G
Y
I
Q
P
R
P
Q
P
Site 4
T55
G
R
G
R
Q
R
G
T
A
G
G
T
A
K
S
Site 5
S62
T
A
G
G
T
A
K
S
Q
G
L
Q
I
S
A
Site 6
S68
K
S
Q
G
L
Q
I
S
A
G
F
Q
E
L
S
Site 7
S75
S
A
G
F
Q
E
L
S
L
A
E
R
G
G
R
Site 8
S103
N
L
D
H
V
K
E
S
K
T
G
S
S
G
I
Site 9
S107
V
K
E
S
K
T
G
S
S
G
I
I
V
R
L
Site 10
T122
S
T
N
H
F
R
L
T
S
R
P
Q
W
A
L
Site 11
S123
T
N
H
F
R
L
T
S
R
P
Q
W
A
L
Y
Site 12
Y130
S
R
P
Q
W
A
L
Y
Q
Y
H
I
D
Y
N
Site 13
Y132
P
Q
W
A
L
Y
Q
Y
H
I
D
Y
N
P
L
Site 14
Y136
L
Y
Q
Y
H
I
D
Y
N
P
L
M
E
A
R
Site 15
S147
M
E
A
R
R
L
R
S
A
L
L
F
Q
H
E
Site 16
T166
K
C
H
A
F
D
G
T
I
L
F
L
P
K
R
Site 17
T179
K
R
L
Q
Q
K
V
T
E
V
F
S
K
T
R
Site 18
S183
Q
K
V
T
E
V
F
S
K
T
R
N
G
E
D
Site 19
T194
N
G
E
D
V
R
I
T
I
T
L
T
N
E
L
Site 20
T196
E
D
V
R
I
T
I
T
L
T
N
E
L
P
P
Site 21
T204
L
T
N
E
L
P
P
T
S
P
T
C
L
Q
F
Site 22
S205
T
N
E
L
P
P
T
S
P
T
C
L
Q
F
Y
Site 23
Y232
L
Q
Q
I
G
R
N
Y
Y
N
P
N
D
P
I
Site 24
Y233
Q
Q
I
G
R
N
Y
Y
N
P
N
D
P
I
D
Site 25
T278
H
K
V
L
R
S
E
T
V
L
D
F
M
F
N
Site 26
Y287
L
D
F
M
F
N
F
Y
H
Q
T
E
E
H
K
Site 27
Y312
G
L
V
V
L
T
K
Y
N
N
K
T
Y
R
V
Site 28
T316
L
T
K
Y
N
N
K
T
Y
R
V
D
D
I
D
Site 29
S330
D
W
D
Q
N
P
K
S
T
F
K
K
A
D
G
Site 30
S338
T
F
K
K
A
D
G
S
E
V
S
F
L
E
Y
Site 31
S341
K
A
D
G
S
E
V
S
F
L
E
Y
Y
R
K
Site 32
Y345
S
E
V
S
F
L
E
Y
Y
R
K
Q
Y
N
Q
Site 33
Y350
L
E
Y
Y
R
K
Q
Y
N
Q
E
I
T
D
L
Site 34
S364
L
K
Q
P
V
L
V
S
Q
P
K
R
R
R
G
Site 35
T375
R
R
R
G
P
G
G
T
L
P
G
P
A
M
L
Site 36
T413
L
A
V
H
T
R
L
T
P
E
Q
R
Q
R
E
Site 37
Y427
E
V
G
R
L
I
D
Y
I
H
K
N
D
N
V
Site 38
S444
E
L
R
D
W
G
L
S
F
D
S
N
L
L
S
Site 39
S447
D
W
G
L
S
F
D
S
N
L
L
S
F
S
G
Site 40
S451
S
F
D
S
N
L
L
S
F
S
G
R
I
L
Q
Site 41
S453
D
S
N
L
L
S
F
S
G
R
I
L
Q
T
E
Site 42
T468
K
I
H
Q
G
G
K
T
F
D
Y
N
P
Q
F
Site 43
Y471
Q
G
G
K
T
F
D
Y
N
P
Q
F
A
D
W
Site 44
S479
N
P
Q
F
A
D
W
S
K
E
T
R
G
A
P
Site 45
S489
T
R
G
A
P
L
I
S
V
K
P
L
D
N
W
Site 46
Y500
L
D
N
W
L
L
I
Y
T
R
R
N
Y
E
A
Site 47
Y505
L
I
Y
T
R
R
N
Y
E
A
A
N
S
L
I
Site 48
S510
R
N
Y
E
A
A
N
S
L
I
Q
N
L
F
K
Site 49
T538
M
I
E
V
D
D
R
T
E
A
Y
L
R
V
L
Site 50
Y541
V
D
D
R
T
E
A
Y
L
R
V
L
Q
Q
K
Site 51
S561
Q
I
V
V
C
L
L
S
S
N
R
K
D
K
Y
Site 52
S562
I
V
V
C
L
L
S
S
N
R
K
D
K
Y
D
Site 53
Y568
S
S
N
R
K
D
K
Y
D
A
I
K
K
Y
L
Site 54
Y574
K
Y
D
A
I
K
K
Y
L
C
T
D
C
P
T
Site 55
T577
A
I
K
K
Y
L
C
T
D
C
P
T
P
S
Q
Site 56
T596
R
T
L
G
K
Q
Q
T
V
M
A
I
A
T
K
Site 57
Y692
A
W
N
S
C
N
E
Y
M
P
S
R
I
I
V
Site 58
T711
V
G
D
G
Q
L
K
T
L
V
N
Y
E
V
P
Site 59
Y715
Q
L
K
T
L
V
N
Y
E
V
P
Q
F
L
D
Site 60
S726
Q
F
L
D
C
L
K
S
I
G
R
G
Y
N
P
Site 61
Y731
L
K
S
I
G
R
G
Y
N
P
R
L
T
V
I
Site 62
T736
R
G
Y
N
P
R
L
T
V
I
V
V
K
K
R
Site 63
T746
V
V
K
K
R
V
N
T
R
F
F
A
Q
S
G
Site 64
S752
N
T
R
F
F
A
Q
S
G
G
R
L
Q
N
P
Site 65
S786
I
V
S
Q
A
V
R
S
G
S
V
S
P
T
H
Site 66
S788
S
Q
A
V
R
S
G
S
V
S
P
T
H
Y
N
Site 67
S790
A
V
R
S
G
S
V
S
P
T
H
Y
N
V
I
Site 68
T792
R
S
G
S
V
S
P
T
H
Y
N
V
I
Y
D
Site 69
Y794
G
S
V
S
P
T
H
Y
N
V
I
Y
D
N
S
Site 70
Y798
P
T
H
Y
N
V
I
Y
D
N
S
G
L
K
P
Site 71
Y813
D
H
I
Q
R
L
T
Y
K
L
C
H
I
Y
Y
Site 72
S853
I
H
R
E
P
N
L
S
L
S
N
R
L
Y
Y
Site 73
S855
R
E
P
N
L
S
L
S
N
R
L
Y
Y
L
_
Site 74
Y860
S
L
S
N
R
L
Y
Y
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation