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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRCH3
Full Name:
Leucine-rich repeat and calponin homology domain-containing protein 3
Alias:
Leucine-rich repeat and calponin homology domain-containing 3
Type:
Extracellular region protein
Mass (Da):
86083
Number AA:
777
UniProt ID:
Q96II8
International Prot ID:
IPI00382787
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
E
Y
S
G
T
V
A
S
G
G
N
L
P
G
V
Site 2
S33
P
G
V
H
C
G
P
S
S
G
A
G
P
G
F
Site 3
S34
G
V
H
C
G
P
S
S
G
A
G
P
G
F
G
Site 4
S44
G
P
G
F
G
P
G
S
W
S
R
S
L
D
R
Site 5
S46
G
F
G
P
G
S
W
S
R
S
L
D
R
A
L
Site 6
S48
G
P
G
S
W
S
R
S
L
D
R
A
L
E
E
Site 7
T82
G
A
A
N
H
D
L
T
D
T
T
R
A
D
L
Site 8
T84
A
N
H
D
L
T
D
T
T
R
A
D
L
S
R
Site 9
T85
N
H
D
L
T
D
T
T
R
A
D
L
S
R
N
Site 10
S90
D
T
T
R
A
D
L
S
R
N
R
L
S
E
I
Site 11
S95
D
L
S
R
N
R
L
S
E
I
P
I
E
A
C
Site 12
Y113
S
L
E
N
L
N
L
Y
Q
N
C
I
R
Y
I
Site 13
S141
N
I
S
R
N
Q
L
S
T
L
P
V
H
L
C
Site 14
T142
I
S
R
N
Q
L
S
T
L
P
V
H
L
C
N
Site 15
S164
A
S
N
N
K
L
V
S
L
P
E
E
I
G
H
Site 16
S190
N
E
I
Q
T
I
P
S
Q
I
G
N
L
E
A
Site 17
T247
L
R
H
L
Q
T
I
T
L
D
N
N
P
L
Q
Site 18
S255
L
D
N
N
P
L
Q
S
P
P
A
Q
I
C
I
Site 19
Y271
G
K
V
H
I
F
K
Y
L
N
I
Q
A
C
K
Site 20
Y286
I
A
P
D
L
P
D
Y
D
R
R
P
L
G
F
Site 21
S295
R
R
P
L
G
F
G
S
C
H
E
E
L
Y
S
Site 22
Y301
G
S
C
H
E
E
L
Y
S
S
R
P
Y
G
A
Site 23
S302
S
C
H
E
E
L
Y
S
S
R
P
Y
G
A
L
Site 24
S303
C
H
E
E
L
Y
S
S
R
P
Y
G
A
L
D
Site 25
Y306
E
L
Y
S
S
R
P
Y
G
A
L
D
S
G
F
Site 26
S311
R
P
Y
G
A
L
D
S
G
F
N
S
V
D
S
Site 27
S315
A
L
D
S
G
F
N
S
V
D
S
G
D
K
R
Site 28
S318
S
G
F
N
S
V
D
S
G
D
K
R
W
S
G
Site 29
S324
D
S
G
D
K
R
W
S
G
N
E
P
T
D
E
Site 30
T329
R
W
S
G
N
E
P
T
D
E
F
S
D
L
P
Site 31
S333
N
E
P
T
D
E
F
S
D
L
P
L
R
V
A
Site 32
T343
P
L
R
V
A
E
I
T
K
E
Q
R
L
R
R
Site 33
S352
E
Q
R
L
R
R
E
S
Q
Y
Q
E
N
R
G
Site 34
Y354
R
L
R
R
E
S
Q
Y
Q
E
N
R
G
S
L
Site 35
S360
Q
Y
Q
E
N
R
G
S
L
V
V
T
N
G
G
Site 36
T364
N
R
G
S
L
V
V
T
N
G
G
V
E
H
D
Site 37
Y377
H
D
L
D
Q
I
D
Y
I
D
S
C
T
A
E
Site 38
S380
D
Q
I
D
Y
I
D
S
C
T
A
E
E
E
E
Site 39
S400
P
K
G
P
D
P
D
S
L
S
S
Q
F
M
A
Site 40
S402
G
P
D
P
D
S
L
S
S
Q
F
M
A
Y
I
Site 41
S403
P
D
P
D
S
L
S
S
Q
F
M
A
Y
I
E
Site 42
S415
Y
I
E
Q
R
R
I
S
H
E
G
S
P
V
K
Site 43
S419
R
R
I
S
H
E
G
S
P
V
K
P
V
A
I
Site 44
T432
A
I
R
E
F
Q
K
T
E
D
M
R
R
Y
L
Site 45
Y438
K
T
E
D
M
R
R
Y
L
H
Q
N
R
V
P
Site 46
S449
N
R
V
P
A
E
P
S
S
L
L
S
L
S
A
Site 47
S450
R
V
P
A
E
P
S
S
L
L
S
L
S
A
S
Site 48
S453
A
E
P
S
S
L
L
S
L
S
A
S
H
N
Q
Site 49
S455
P
S
S
L
L
S
L
S
A
S
H
N
Q
L
S
Site 50
S457
S
L
L
S
L
S
A
S
H
N
Q
L
S
H
T
Site 51
S462
S
A
S
H
N
Q
L
S
H
T
D
L
E
L
H
Site 52
S514
D
F
V
K
Q
K
A
S
Q
S
P
Q
K
Q
H
Site 53
S516
V
K
Q
K
A
S
Q
S
P
Q
K
Q
H
P
L
Site 54
S535
D
G
E
C
P
F
P
S
R
R
S
Q
H
T
D
Site 55
S538
C
P
F
P
S
R
R
S
Q
H
T
D
D
S
A
Site 56
T541
P
S
R
R
S
Q
H
T
D
D
S
A
L
C
M
Site 57
S544
R
S
Q
H
T
D
D
S
A
L
C
M
S
L
S
Site 58
T569
L
P
H
S
S
A
F
T
P
L
K
S
D
D
R
Site 59
S573
S
A
F
T
P
L
K
S
D
D
R
P
N
A
L
Site 60
S582
D
R
P
N
A
L
L
S
S
P
A
T
E
T
V
Site 61
S583
R
P
N
A
L
L
S
S
P
A
T
E
T
V
H
Site 62
T586
A
L
L
S
S
P
A
T
E
T
V
H
H
S
P
Site 63
T588
L
S
S
P
A
T
E
T
V
H
H
S
P
A
Y
Site 64
S592
A
T
E
T
V
H
H
S
P
A
Y
S
F
P
A
Site 65
Y595
T
V
H
H
S
P
A
Y
S
F
P
A
A
I
Q
Site 66
S596
V
H
H
S
P
A
Y
S
F
P
A
A
I
Q
R
Site 67
S611
N
Q
P
Q
R
P
E
S
F
L
F
R
A
G
V
Site 68
T622
R
A
G
V
R
A
E
T
N
K
G
H
A
S
P
Site 69
S628
E
T
N
K
G
H
A
S
P
L
P
P
S
A
A
Site 70
S633
H
A
S
P
L
P
P
S
A
A
P
T
T
D
S
Site 71
T637
L
P
P
S
A
A
P
T
T
D
S
T
D
S
I
Site 72
T638
P
P
S
A
A
P
T
T
D
S
T
D
S
I
T
Site 73
S640
S
A
A
P
T
T
D
S
T
D
S
I
T
G
Q
Site 74
T641
A
A
P
T
T
D
S
T
D
S
I
T
G
Q
N
Site 75
S643
P
T
T
D
S
T
D
S
I
T
G
Q
N
S
R
Site 76
T645
T
D
S
T
D
S
I
T
G
Q
N
S
R
Q
R
Site 77
S649
D
S
I
T
G
Q
N
S
R
Q
R
E
E
E
L
Site 78
Y668
Q
L
R
K
H
I
E
Y
R
L
K
V
S
L
P
Site 79
S699
A
N
H
V
R
P
R
S
V
P
S
I
H
V
P
Site 80
S707
V
P
S
I
H
V
P
S
P
A
V
P
K
L
T
Site 81
T714
S
P
A
V
P
K
L
T
M
A
K
C
R
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation