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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHTKD1
Full Name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Alias:
2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; Dehydrogenase E1 and transketolase domain containing 1; Dehydrogenase E1 and transketolase domain-containing protein 1; DHTK1; DKFZP762M115; EC 1.2.4.2; KIAA1630; MGC3090
Type:
EC 1.2.4.2; Oxidoreductase
Mass (Da):
103043
Number AA:
919
UniProt ID:
Q96HY7
International Prot ID:
IPI00063408
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004591
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0005996
GO:0006006
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
L
P
L
L
W
R
G
Y
Q
T
E
R
G
V
Y
Site 2
T26
L
L
W
R
G
Y
Q
T
E
R
G
V
Y
G
Y
Site 3
Y31
Y
Q
T
E
R
G
V
Y
G
Y
R
P
R
K
P
Site 4
Y33
T
E
R
G
V
Y
G
Y
R
P
R
K
P
E
S
Site 5
S40
Y
R
P
R
K
P
E
S
R
E
P
Q
G
A
L
Site 6
T61
H
G
L
A
R
L
V
T
V
Y
C
E
H
G
H
Site 7
S114
N
M
G
K
E
E
A
S
L
E
E
V
L
V
Y
Site 8
S131
Q
I
Y
C
G
Q
I
S
I
E
T
S
Q
L
Q
Site 9
S135
G
Q
I
S
I
E
T
S
Q
L
Q
S
Q
D
E
Site 10
S139
I
E
T
S
Q
L
Q
S
Q
D
E
K
D
W
F
Site 11
T160
L
Q
K
E
T
F
T
T
E
E
R
K
H
L
S
Site 12
S167
T
E
E
R
K
H
L
S
K
L
M
L
E
S
Q
Site 13
S173
L
S
K
L
M
L
E
S
Q
E
F
D
H
F
L
Site 14
S185
H
F
L
A
T
K
F
S
T
V
K
R
Y
G
G
Site 15
T186
F
L
A
T
K
F
S
T
V
K
R
Y
G
G
E
Site 16
S249
F
R
K
M
R
G
L
S
E
F
P
E
N
F
S
Site 17
T258
F
P
E
N
F
S
A
T
G
D
V
L
S
H
L
Site 18
S263
S
A
T
G
D
V
L
S
H
L
T
S
S
V
D
Site 19
T282
A
H
H
P
L
H
V
T
M
L
P
N
P
S
H
Site 20
S307
K
T
R
G
R
Q
Q
S
R
Q
D
G
D
Y
S
Site 21
Y313
Q
S
R
Q
D
G
D
Y
S
P
D
N
S
A
Q
Site 22
S314
S
R
Q
D
G
D
Y
S
P
D
N
S
A
Q
P
Site 23
S318
G
D
Y
S
P
D
N
S
A
Q
P
G
D
R
V
Site 24
Y370
I
V
N
N
Q
L
G
Y
T
T
P
A
E
R
G
Site 25
T372
N
N
Q
L
G
Y
T
T
P
A
E
R
G
R
S
Site 26
S379
T
P
A
E
R
G
R
S
S
L
Y
C
S
D
I
Site 27
S380
P
A
E
R
G
R
S
S
L
Y
C
S
D
I
G
Site 28
Y382
E
R
G
R
S
S
L
Y
C
S
D
I
G
K
L
Site 29
S384
G
R
S
S
L
Y
C
S
D
I
G
K
L
V
G
Site 30
S401
I
I
H
V
N
G
D
S
P
E
E
V
V
R
A
Site 31
T409
P
E
E
V
V
R
A
T
R
L
A
F
E
Y
Q
Site 32
Y415
A
T
R
L
A
F
E
Y
Q
R
Q
F
R
K
D
Site 33
Y443
N
E
L
D
E
P
F
Y
T
N
P
I
M
Y
K
Site 34
T444
E
L
D
E
P
F
Y
T
N
P
I
M
Y
K
I
Site 35
Y449
F
Y
T
N
P
I
M
Y
K
I
I
R
A
R
K
Site 36
S457
K
I
I
R
A
R
K
S
I
P
D
T
Y
A
E
Site 37
T461
A
R
K
S
I
P
D
T
Y
A
E
H
L
I
A
Site 38
Y462
R
K
S
I
P
D
T
Y
A
E
H
L
I
A
G
Site 39
S478
L
M
T
Q
E
E
V
S
E
I
K
S
S
Y
Y
Site 40
S482
E
E
V
S
E
I
K
S
S
Y
Y
A
K
L
N
Site 41
S483
E
V
S
E
I
K
S
S
Y
Y
A
K
L
N
D
Site 42
Y485
S
E
I
K
S
S
Y
Y
A
K
L
N
D
H
L
Site 43
Y498
H
L
N
N
M
A
H
Y
R
P
P
A
L
N
L
Site 44
T520
A
Q
P
E
A
Q
I
T
T
W
S
T
G
V
P
Site 45
T554
M
H
S
H
L
L
K
T
H
V
Q
S
R
M
E
Site 46
S592
Q
G
F
N
V
R
L
S
G
Q
D
V
G
R
G
Site 47
T600
G
Q
D
V
G
R
G
T
F
S
Q
R
H
A
I
Site 48
S602
D
V
G
R
G
T
F
S
Q
R
H
A
I
V
V
Site 49
Y617
C
Q
E
T
D
D
T
Y
I
P
L
N
H
M
D
Site 50
S634
Q
K
G
F
L
E
V
S
N
S
P
L
S
E
E
Site 51
S636
G
F
L
E
V
S
N
S
P
L
S
E
E
A
V
Site 52
S639
E
V
S
N
S
P
L
S
E
E
A
V
L
G
F
Site 53
S654
E
Y
G
M
S
I
E
S
P
K
L
L
P
L
W
Site 54
Y701
V
I
L
L
P
H
G
Y
D
G
A
G
P
D
H
Site 55
S709
D
G
A
G
P
D
H
S
S
C
R
I
E
R
F
Site 56
S710
G
A
G
P
D
H
S
S
C
R
I
E
R
F
L
Site 57
S722
R
F
L
Q
M
C
D
S
A
E
E
G
V
D
G
Site 58
T731
E
E
G
V
D
G
D
T
V
N
M
F
V
V
H
Site 59
T786
L
Q
E
M
A
P
G
T
T
F
N
P
V
I
G
Site 60
T787
Q
E
M
A
P
G
T
T
F
N
P
V
I
G
D
Site 61
S795
F
N
P
V
I
G
D
S
S
V
D
P
K
K
V
Site 62
S796
N
P
V
I
G
D
S
S
V
D
P
K
K
V
K
Site 63
T804
V
D
P
K
K
V
K
T
L
V
F
C
S
G
K
Site 64
S809
V
K
T
L
V
F
C
S
G
K
H
F
Y
S
L
Site 65
S815
C
S
G
K
H
F
Y
S
L
V
K
Q
R
E
S
Site 66
S822
S
L
V
K
Q
R
E
S
L
G
A
K
K
H
D
Site 67
S845
L
C
P
F
P
L
D
S
L
Q
Q
E
M
S
K
Site 68
S851
D
S
L
Q
Q
E
M
S
K
Y
K
H
V
K
D
Site 69
Y853
L
Q
Q
E
M
S
K
Y
K
H
V
K
D
H
I
Site 70
S873
P
Q
N
M
G
P
W
S
F
V
S
P
R
F
E
Site 71
S876
M
G
P
W
S
F
V
S
P
R
F
E
K
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation