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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INTS4
Full Name:
Integrator complex subunit 4
Alias:
INT4; Int4; MGC16733; MST093
Type:
Transcription initiation complex
Mass (Da):
108171
Number AA:
963
UniProt ID:
Q96HW7
International Prot ID:
IPI00446765
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0032039
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
A
H
L
K
K
R
V
Y
E
E
F
T
K
V
V
Site 2
T25
Q
P
Q
E
E
I
A
T
K
K
L
R
L
T
K
Site 3
T31
A
T
K
K
L
R
L
T
K
P
S
K
S
A
A
Site 4
S34
K
L
R
L
T
K
P
S
K
S
A
A
L
H
I
Site 5
S36
R
L
T
K
P
S
K
S
A
A
L
H
I
D
L
Site 6
S48
I
D
L
C
K
A
T
S
P
A
D
A
L
Q
Y
Site 7
Y55
S
P
A
D
A
L
Q
Y
L
L
Q
F
A
R
K
Site 8
Y81
R
I
L
L
E
H
Y
Y
K
E
N
D
P
S
V
Site 9
S87
Y
Y
K
E
N
D
P
S
V
R
L
K
I
A
S
Site 10
S106
L
S
K
T
A
G
F
S
P
D
C
I
M
D
D
Site 11
S123
N
I
L
Q
N
E
K
S
H
Q
V
L
A
Q
L
Site 12
T160
D
V
A
C
K
H
L
T
D
T
S
H
G
V
R
Site 13
T162
A
C
K
H
L
T
D
T
S
H
G
V
R
N
K
Site 14
S179
Q
L
L
G
N
L
G
S
L
E
K
S
V
T
K
Site 15
S183
N
L
G
S
L
E
K
S
V
T
K
D
A
E
G
Site 16
T185
G
S
L
E
K
S
V
T
K
D
A
E
G
L
A
Site 17
Y203
V
Q
K
I
I
G
D
Y
F
S
D
Q
D
P
R
Site 18
S205
K
I
I
G
D
Y
F
S
D
Q
D
P
R
V
R
Site 19
T213
D
Q
D
P
R
V
R
T
A
A
I
K
A
M
L
Site 20
T232
R
G
L
K
L
H
Q
T
I
Y
N
Q
A
C
K
Site 21
Y234
L
K
L
H
Q
T
I
Y
N
Q
A
C
K
L
L
Site 22
S242
N
Q
A
C
K
L
L
S
D
D
Y
E
Q
V
R
Site 23
Y245
C
K
L
L
S
D
D
Y
E
Q
V
R
S
A
A
Site 24
S272
E
S
I
V
P
I
P
S
S
N
E
E
I
R
L
Site 25
S292
G
K
I
C
H
M
V
S
D
G
S
W
V
V
R
Site 26
S314
G
S
M
E
Q
V
S
S
H
F
L
E
Q
T
L
Site 27
T320
S
S
H
F
L
E
Q
T
L
D
K
K
L
M
S
Site 28
S327
T
L
D
K
K
L
M
S
D
L
R
R
K
R
T
Site 29
T334
S
D
L
R
R
K
R
T
A
H
E
R
A
K
E
Site 30
Y343
H
E
R
A
K
E
L
Y
S
S
G
E
F
S
S
Site 31
S344
E
R
A
K
E
L
Y
S
S
G
E
F
S
S
G
Site 32
S345
R
A
K
E
L
Y
S
S
G
E
F
S
S
G
R
Site 33
S349
L
Y
S
S
G
E
F
S
S
G
R
K
W
G
D
Site 34
S350
Y
S
S
G
E
F
S
S
G
R
K
W
G
D
D
Site 35
T365
A
P
K
E
E
V
D
T
G
A
V
N
L
I
E
Site 36
Y388
H
G
L
E
D
E
M
Y
E
V
R
I
A
A
V
Site 37
S407
M
L
A
Q
S
S
P
S
F
A
E
K
C
L
D
Site 38
S431
I
E
E
V
R
L
Q
S
I
H
T
M
R
K
I
Site 39
T434
V
R
L
Q
S
I
H
T
M
R
K
I
S
N
N
Site 40
S439
I
H
T
M
R
K
I
S
N
N
I
T
L
R
E
Site 41
T443
R
K
I
S
N
N
I
T
L
R
E
D
Q
L
D
Site 42
T451
L
R
E
D
Q
L
D
T
V
L
A
V
L
E
D
Site 43
S459
V
L
A
V
L
E
D
S
S
R
D
I
R
E
A
Site 44
S460
L
A
V
L
E
D
S
S
R
D
I
R
E
A
L
Site 45
T494
V
E
L
L
K
N
L
T
K
Y
P
T
D
R
D
Site 46
Y496
L
L
K
N
L
T
K
Y
P
T
D
R
D
S
I
Site 47
T498
K
N
L
T
K
Y
P
T
D
R
D
S
I
W
K
Site 48
T534
S
T
H
P
F
F
D
T
A
E
P
D
M
D
D
Site 49
T569
P
A
L
F
S
D
H
T
F
R
H
Y
A
Y
L
Site 50
Y573
S
D
H
T
F
R
H
Y
A
Y
L
R
D
S
L
Site 51
Y575
H
T
F
R
H
Y
A
Y
L
R
D
S
L
S
H
Site 52
S579
H
Y
A
Y
L
R
D
S
L
S
H
L
V
P
A
Site 53
S602
V
S
S
A
V
S
P
S
I
I
P
Q
E
D
P
Site 54
S610
I
I
P
Q
E
D
P
S
Q
Q
F
L
Q
Q
S
Site 55
S617
S
Q
Q
F
L
Q
Q
S
L
E
R
V
Y
S
L
Site 56
Y622
Q
Q
S
L
E
R
V
Y
S
L
Q
H
L
D
P
Site 57
S623
Q
S
L
E
R
V
Y
S
L
Q
H
L
D
P
Q
Site 58
S651
Q
R
L
G
E
L
Q
S
E
L
A
G
V
A
D
Site 59
S660
L
A
G
V
A
D
F
S
A
T
Y
L
R
C
Q
Site 60
Y686
W
N
V
A
A
P
L
Y
L
K
Q
S
D
L
A
Site 61
S694
L
K
Q
S
D
L
A
S
A
A
A
K
Q
I
M
Site 62
Y711
T
Y
K
M
E
F
M
Y
S
G
V
E
N
K
Q
Site 63
Y764
E
V
D
F
F
Q
R
Y
F
I
A
D
L
P
H
Site 64
S775
D
L
P
H
L
Q
D
S
F
V
D
K
L
L
D
Site 65
T801
E
V
V
K
I
L
Q
T
M
L
R
Q
S
A
F
Site 66
T860
H
V
Q
D
P
Q
N
T
V
K
V
Q
V
L
Y
Site 67
Y867
T
V
K
V
Q
V
L
Y
P
D
G
Q
A
Q
M
Site 68
T894
P
G
R
H
R
L
I
T
Q
V
Y
L
S
H
T
Site 69
Y897
H
R
L
I
T
Q
V
Y
L
S
H
T
A
W
T
Site 70
S919
R
L
L
L
A
Y
N
S
S
A
R
I
P
K
C
Site 71
S935
W
M
E
G
G
E
M
S
P
Q
V
E
T
S
I
Site 72
Y955
F
S
K
P
V
K
V
Y
I
M
P
K
P
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation