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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFKBIL2
Full Name:
Tonsoku-like protein
Alias:
I-kappa-B-related protein; IKBR; Inhibitor of kappa B-related protein; NF-kappa-B inhibitor-like protein 2
Type:
Transcription, coactivator/corepressor
Mass (Da):
150929
Number AA:
1378
UniProt ID:
Q96HA7
International Prot ID:
IPI00783999
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0042994
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
E
R
E
L
R
Q
L
S
K
A
K
A
K
A
Q
Site 2
Y83
R
L
A
E
M
E
D
Y
P
A
A
L
Q
H
Q
Site 3
Y93
A
L
Q
H
Q
H
Q
Y
L
E
L
A
H
S
L
Site 4
S99
Q
Y
L
E
L
A
H
S
L
R
N
H
T
E
L
Site 5
T104
A
H
S
L
R
N
H
T
E
L
Q
R
A
W
A
Site 6
Y121
G
R
T
H
L
D
I
Y
D
H
C
Q
S
R
D
Site 7
S140
A
Q
A
A
F
E
K
S
L
A
I
V
D
E
E
Site 8
T151
V
D
E
E
L
E
G
T
L
A
Q
G
E
L
N
Site 9
Y165
N
E
M
R
T
R
L
Y
L
N
L
G
L
T
F
Site 10
T178
T
F
E
S
L
Q
Q
T
A
L
C
N
D
Y
F
Site 11
Y184
Q
T
A
L
C
N
D
Y
F
R
K
S
I
F
L
Site 12
Y198
L
A
E
Q
N
H
L
Y
E
D
L
F
R
A
R
Site 13
Y206
E
D
L
F
R
A
R
Y
N
L
G
T
I
H
W
Site 14
T234
G
A
R
E
C
A
H
T
M
R
K
R
F
M
E
Site 15
S273
K
K
A
Y
R
L
G
S
Q
K
P
V
Q
R
A
Site 16
S322
E
Q
L
G
D
L
F
S
K
A
G
D
F
P
R
Site 17
Y334
F
P
R
A
A
E
A
Y
Q
K
Q
L
R
F
A
Site 18
T361
I
H
V
S
L
A
T
T
L
G
D
M
K
D
H
Site 19
Y375
H
H
G
A
V
R
H
Y
E
E
E
L
R
L
R
Site 20
S383
E
E
E
L
R
L
R
S
G
N
V
L
E
E
A
Site 21
S399
T
W
L
N
I
A
L
S
R
E
E
A
G
D
A
Site 22
Y407
R
E
E
A
G
D
A
Y
E
L
L
A
P
C
F
Site 23
S419
P
C
F
Q
K
A
L
S
C
A
Q
Q
A
Q
R
Site 24
T439
Q
V
L
Q
H
L
H
T
V
Q
L
R
L
Q
P
Site 25
T452
Q
P
Q
E
A
P
E
T
E
T
R
L
R
E
L
Site 26
S460
E
T
R
L
R
E
L
S
V
A
E
D
E
D
E
Site 27
T477
E
A
E
E
A
A
A
T
A
E
S
E
A
L
E
Site 28
S491
E
A
G
E
V
E
L
S
E
G
E
D
D
T
D
Site 29
T497
L
S
E
G
E
D
D
T
D
G
L
T
P
Q
L
Site 30
T501
E
D
D
T
D
G
L
T
P
Q
L
E
E
D
E
Site 31
S520
H
L
G
R
R
K
G
S
K
W
N
R
R
N
D
Site 32
Y560
H
P
L
N
P
R
D
Y
C
G
W
T
P
L
H
Site 33
Y572
P
L
H
E
A
C
N
Y
G
H
L
E
I
V
R
Site 34
T600
G
Q
G
C
E
G
I
T
P
L
H
D
A
L
N
Site 35
S623
L
L
L
E
R
G
A
S
V
T
L
R
T
R
K
Site 36
T625
L
E
R
G
A
S
V
T
L
R
T
R
K
G
L
Site 37
T628
G
A
S
V
T
L
R
T
R
K
G
L
S
P
L
Site 38
S633
L
R
T
R
K
G
L
S
P
L
E
T
L
Q
Q
Site 39
T637
K
G
L
S
P
L
E
T
L
Q
Q
W
V
K
L
Site 40
Y645
L
Q
Q
W
V
K
L
Y
R
R
D
L
D
L
E
Site 41
S669
M
L
L
Q
A
A
A
S
G
Q
D
P
H
S
S
Site 42
S675
A
S
G
Q
D
P
H
S
S
Q
A
F
H
T
P
Site 43
S676
S
G
Q
D
P
H
S
S
Q
A
F
H
T
P
S
Site 44
T681
H
S
S
Q
A
F
H
T
P
S
S
L
L
F
D
Site 45
S683
S
Q
A
F
H
T
P
S
S
L
L
F
D
P
E
Site 46
S684
Q
A
F
H
T
P
S
S
L
L
F
D
P
E
T
Site 47
T691
S
L
L
F
D
P
E
T
S
P
P
L
S
P
C
Site 48
S692
L
L
F
D
P
E
T
S
P
P
L
S
P
C
P
Site 49
S696
P
E
T
S
P
P
L
S
P
C
P
E
P
P
S
Site 50
S703
S
P
C
P
E
P
P
S
N
S
T
R
L
P
E
Site 51
S705
C
P
E
P
P
S
N
S
T
R
L
P
E
A
S
Site 52
S712
S
T
R
L
P
E
A
S
Q
A
H
V
R
V
S
Site 53
S719
S
Q
A
H
V
R
V
S
P
G
Q
A
A
P
A
Site 54
S733
A
M
A
R
P
R
R
S
R
H
G
P
A
S
S
Site 55
S739
R
S
R
H
G
P
A
S
S
S
S
S
S
E
G
Site 56
S740
S
R
H
G
P
A
S
S
S
S
S
S
E
G
E
Site 57
S741
R
H
G
P
A
S
S
S
S
S
S
E
G
E
D
Site 58
S742
H
G
P
A
S
S
S
S
S
S
E
G
E
D
S
Site 59
S743
G
P
A
S
S
S
S
S
S
E
G
E
D
S
A
Site 60
S744
P
A
S
S
S
S
S
S
E
G
E
D
S
A
G
Site 61
S749
S
S
S
E
G
E
D
S
A
G
P
A
R
P
S
Site 62
S756
S
A
G
P
A
R
P
S
Q
K
R
P
R
C
S
Site 63
S763
S
Q
K
R
P
R
C
S
A
T
A
Q
R
V
A
Site 64
T773
A
Q
R
V
A
A
W
T
P
G
P
A
S
N
R
Site 65
S778
A
W
T
P
G
P
A
S
N
R
E
A
A
T
A
Site 66
T784
A
S
N
R
E
A
A
T
A
S
T
S
R
A
A
Site 67
S786
N
R
E
A
A
T
A
S
T
S
R
A
A
Y
Q
Site 68
Y792
A
S
T
S
R
A
A
Y
Q
A
A
I
R
G
V
Site 69
S804
R
G
V
G
S
A
Q
S
R
L
G
P
G
P
P
Site 70
S815
P
G
P
P
R
G
H
S
K
A
L
A
P
Q
A
Site 71
T843
L
E
L
D
M
P
L
T
R
S
R
R
P
R
P
Site 72
S845
L
D
M
P
L
T
R
S
R
R
P
R
P
R
G
Site 73
T853
R
R
P
R
P
R
G
T
G
D
N
R
R
P
S
Site 74
S860
T
G
D
N
R
R
P
S
S
T
S
G
S
D
S
Site 75
S861
G
D
N
R
R
P
S
S
T
S
G
S
D
S
E
Site 76
T862
D
N
R
R
P
S
S
T
S
G
S
D
S
E
E
Site 77
S863
N
R
R
P
S
S
T
S
G
S
D
S
E
E
S
Site 78
S865
R
P
S
S
T
S
G
S
D
S
E
E
S
R
P
Site 79
S867
S
S
T
S
G
S
D
S
E
E
S
R
P
R
A
Site 80
S870
S
G
S
D
S
E
E
S
R
P
R
A
R
A
K
Site 81
T882
R
A
K
Q
V
R
L
T
C
M
Q
S
C
S
A
Site 82
S896
A
P
V
N
A
G
P
S
S
L
A
S
E
P
P
Site 83
S897
P
V
N
A
G
P
S
S
L
A
S
E
P
P
G
Site 84
S900
A
G
P
S
S
L
A
S
E
P
P
G
S
P
S
Site 85
S905
L
A
S
E
P
P
G
S
P
S
T
P
R
V
S
Site 86
S907
S
E
P
P
G
S
P
S
T
P
R
V
S
E
P
Site 87
T908
E
P
P
G
S
P
S
T
P
R
V
S
E
P
S
Site 88
S912
S
P
S
T
P
R
V
S
E
P
S
G
D
S
S
Site 89
S915
T
P
R
V
S
E
P
S
G
D
S
S
A
A
G
Site 90
S919
S
E
P
S
G
D
S
S
A
A
G
Q
P
L
G
Site 91
S952
L
I
P
V
P
H
S
S
D
T
H
S
V
A
W
Site 92
T954
P
V
P
H
S
S
D
T
H
S
V
A
W
L
A
Site 93
S956
P
H
S
S
D
T
H
S
V
A
W
L
A
E
Q
Site 94
Y969
E
Q
A
A
Q
R
Y
Y
Q
T
C
G
L
L
P
Site 95
T1016
S
W
D
L
P
P
L
T
D
R
Y
R
R
A
C
Site 96
Y1019
L
P
P
L
T
D
R
Y
R
R
A
C
Q
S
L
Site 97
S1025
R
Y
R
R
A
C
Q
S
L
G
Q
G
E
H
Q
Site 98
S1106
S
L
A
L
L
D
L
S
S
N
H
L
G
P
E
Site 99
T1127
M
G
L
P
G
Q
A
T
L
Q
S
L
E
E
L
Site 100
S1130
P
G
Q
A
T
L
Q
S
L
E
E
L
D
L
S
Site 101
S1137
S
L
E
E
L
D
L
S
M
N
P
L
G
D
G
Site 102
S1172
Q
A
C
G
F
G
P
S
F
F
L
S
H
Q
T
Site 103
T1193
Q
D
A
E
H
L
K
T
L
S
L
S
Y
N
A
Site 104
S1195
A
E
H
L
K
T
L
S
L
S
Y
N
A
L
G
Site 105
S1293
N
P
E
I
S
C
A
S
L
E
E
L
L
S
T
Site 106
S1299
A
S
L
E
E
L
L
S
T
L
Q
K
R
P
Q
Site 107
T1300
S
L
E
E
L
L
S
T
L
Q
K
R
P
Q
G
Site 108
S1309
Q
K
R
P
Q
G
L
S
F
L
G
L
S
G
C
Site 109
S1341
L
R
E
L
Q
L
C
S
R
R
L
C
A
E
D
Site 110
S1358
A
L
R
Q
L
Q
P
S
R
P
G
P
G
E
C
Site 111
T1366
R
P
G
P
G
E
C
T
L
D
H
G
S
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation