KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TOE1
Full Name:
Target of EGR1 protein 1
Alias:
target of EGR1, member 1 (nuclear)
Type:
Mass (Da):
56548
Number AA:
510
UniProt ID:
Q96GM8
International Prot ID:
IPI00549516
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0016604
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005488
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
A
D
S
D
D
G
A
V
S
A
Site 2
S11
D
S
D
D
G
A
V
S
A
P
A
A
S
D
G
Site 3
S23
S
D
G
G
V
S
K
S
T
T
S
G
E
E
L
Site 4
T25
G
G
V
S
K
S
T
T
S
G
E
E
L
V
V
Site 5
S75
S
G
L
G
D
R
K
S
L
L
N
Q
C
I
E
Site 6
Y116
P
D
K
G
E
H
S
Y
L
A
Q
V
F
N
L
Site 7
Y152
G
F
N
F
N
Q
Q
Y
A
Q
G
I
P
Y
H
Site 8
S168
G
N
D
K
G
D
E
S
Q
S
Q
S
V
R
T
Site 9
S170
D
K
G
D
E
S
Q
S
Q
S
V
R
T
L
F
Site 10
S172
G
D
E
S
Q
S
Q
S
V
R
T
L
F
L
E
Site 11
S210
F
Y
A
H
L
P
E
S
L
G
T
F
T
A
D
Site 12
T213
H
L
P
E
S
L
G
T
F
T
A
D
L
C
E
Site 13
Y231
A
G
I
Y
D
T
K
Y
A
A
E
F
H
A
R
Site 14
Y243
H
A
R
F
V
A
S
Y
L
E
Y
A
F
R
K
Site 15
Y246
F
V
A
S
Y
L
E
Y
A
F
R
K
C
E
R
Site 16
S263
G
K
Q
R
A
A
G
S
P
H
L
T
L
E
F
Site 17
T267
A
A
G
S
P
H
L
T
L
E
F
C
N
Y
P
Site 18
Y273
L
T
L
E
F
C
N
Y
P
S
S
M
R
D
H
Site 19
Y283
S
M
R
D
H
I
D
Y
R
C
C
L
P
P
A
Site 20
T291
R
C
C
L
P
P
A
T
H
R
P
H
P
T
S
Site 21
S298
T
H
R
P
H
P
T
S
I
C
D
N
F
S
A
Site 22
Y306
I
C
D
N
F
S
A
Y
G
W
C
P
L
G
P
Site 23
T327
D
I
D
L
I
I
D
T
D
E
A
A
A
E
D
Site 24
T355
A
L
L
N
L
P
G
T
Q
T
S
G
E
A
K
Site 25
T357
L
N
L
P
G
T
Q
T
S
G
E
A
K
D
G
Site 26
S358
N
L
P
G
T
Q
T
S
G
E
A
K
D
G
P
Site 27
S374
K
K
Q
V
C
G
D
S
I
K
P
E
E
T
E
Site 28
S395
E
T
R
N
L
P
H
S
K
Q
G
N
K
N
D
Site 29
T419
P
E
I
A
D
R
A
T
S
E
V
P
G
S
Q
Site 30
S420
E
I
A
D
R
A
T
S
E
V
P
G
S
Q
A
Site 31
S425
A
T
S
E
V
P
G
S
Q
A
S
P
N
P
V
Site 32
S428
E
V
P
G
S
Q
A
S
P
N
P
V
P
G
D
Site 33
S457
V
M
A
Y
V
E
V
S
Q
G
P
Q
P
C
S
Site 34
S464
S
Q
G
P
Q
P
C
S
S
G
P
W
L
P
E
Site 35
S465
Q
G
P
Q
P
C
S
S
G
P
W
L
P
E
C
Site 36
Y477
P
E
C
H
N
K
V
Y
L
S
G
K
A
V
P
Site 37
T486
S
G
K
A
V
P
L
T
V
A
K
S
Q
F
S
Site 38
S490
V
P
L
T
V
A
K
S
Q
F
S
R
S
S
K
Site 39
S493
T
V
A
K
S
Q
F
S
R
S
S
K
A
H
N
Site 40
S495
A
K
S
Q
F
S
R
S
S
K
A
H
N
Q
K
Site 41
S496
K
S
Q
F
S
R
S
S
K
A
H
N
Q
K
M
Site 42
T506
H
N
Q
K
M
K
L
T
W
G
S
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation