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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYFIP2
Full Name:
Cytoplasmic FMR1-interacting protein 2
Alias:
CYFP2; cytoplasmic FMR1 interacting protein 2; p53 inducible protein; PIR121
Type:
Adhesion
Mass (Da):
148400
Number AA:
UniProt ID:
Q96F07
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0048471
GO:0045202
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0016337
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
P
C
I
E
P
P
P
S
S
I
M
Y
Q
A
N
Site 2
Y38
P
P
P
S
S
I
M
Y
Q
A
N
F
D
T
N
Site 3
T54
E
D
R
N
A
F
V
T
G
I
A
R
Y
I
E
Site 4
T64
A
R
Y
I
E
Q
A
T
V
H
S
S
M
N
E
Site 5
S68
E
Q
A
T
V
H
S
S
M
N
E
M
L
E
E
Site 6
Y79
M
L
E
E
G
H
E
Y
A
V
M
L
Y
T
W
Site 7
Y84
H
E
Y
A
V
M
L
Y
T
W
R
S
C
S
R
Site 8
S90
L
Y
T
W
R
S
C
S
R
A
I
P
Q
V
K
Site 9
Y108
Q
P
N
R
V
E
I
Y
E
K
T
V
E
V
L
Site 10
T111
R
V
E
I
Y
E
K
T
V
E
V
L
E
P
E
Site 11
Y127
T
K
L
M
K
F
M
Y
F
Q
R
K
A
I
E
Site 12
S138
K
A
I
E
R
F
C
S
E
V
K
R
L
C
H
Site 13
S154
E
R
R
K
D
F
V
S
E
A
Y
L
L
T
L
Site 14
Y188
V
K
N
D
H
S
A
Y
K
R
A
A
Q
F
L
Site 15
S203
R
K
M
A
D
P
Q
S
I
Q
E
S
Q
N
L
Site 16
S207
D
P
Q
S
I
Q
E
S
Q
N
L
S
M
F
L
Site 17
Y249
V
N
I
C
V
D
Y
Y
E
N
K
M
Y
L
T
Site 18
Y254
D
Y
Y
E
N
K
M
Y
L
T
P
S
E
K
H
Site 19
T256
Y
E
N
K
M
Y
L
T
P
S
E
K
H
M
L
Site 20
Y282
D
G
N
V
S
N
I
Y
K
L
D
A
K
K
R
Site 21
S293
A
K
K
R
I
N
L
S
K
I
D
K
F
F
K
Site 22
Y318
M
Q
I
E
L
A
R
Y
I
K
T
S
A
H
Y
Site 23
S322
L
A
R
Y
I
K
T
S
A
H
Y
E
E
N
K
Site 24
T333
E
E
N
K
S
K
W
T
C
T
Q
S
S
I
S
Site 25
T335
N
K
S
K
W
T
C
T
Q
S
S
I
S
P
Q
Site 26
S340
T
C
T
Q
S
S
I
S
P
Q
Y
N
I
C
E
Site 27
Y343
Q
S
S
I
S
P
Q
Y
N
I
C
E
Q
M
V
Site 28
S361
D
D
H
I
R
F
I
S
E
L
A
R
Y
S
N
Site 29
Y366
F
I
S
E
L
A
R
Y
S
N
S
E
V
V
T
Site 30
S367
I
S
E
L
A
R
Y
S
N
S
E
V
V
T
G
Site 31
S369
E
L
A
R
Y
S
N
S
E
V
V
T
G
S
G
Site 32
T373
Y
S
N
S
E
V
V
T
G
S
G
L
D
S
Q
Site 33
S375
N
S
E
V
V
T
G
S
G
L
D
S
Q
K
S
Site 34
S379
V
T
G
S
G
L
D
S
Q
K
S
D
E
E
Y
Site 35
S382
S
G
L
D
S
Q
K
S
D
E
E
Y
R
E
L
Site 36
Y386
S
Q
K
S
D
E
E
Y
R
E
L
F
D
L
A
Site 37
Y411
S
A
H
V
M
E
V
Y
S
W
K
L
V
H
P
Site 38
Y434
C
P
G
T
A
E
E
Y
E
R
A
T
R
Y
N
Site 39
T438
A
E
E
Y
E
R
A
T
R
Y
N
Y
T
S
E
Site 40
Y440
E
Y
E
R
A
T
R
Y
N
Y
T
S
E
E
K
Site 41
Y442
E
R
A
T
R
Y
N
Y
T
S
E
E
K
F
A
Site 42
S444
A
T
R
Y
N
Y
T
S
E
E
K
F
A
F
V
Site 43
T478
F
N
Q
A
I
R
N
T
I
Y
A
A
L
Q
D
Site 44
T490
L
Q
D
F
A
Q
V
T
L
R
E
P
L
R
Q
Site 45
S508
K
K
K
N
V
L
I
S
V
L
Q
A
I
R
K
Site 46
T516
V
L
Q
A
I
R
K
T
I
C
D
W
E
G
G
Site 47
S554
P
R
R
A
V
G
P
S
S
T
Q
A
C
Q
W
Site 48
S555
R
R
A
V
G
P
S
S
T
Q
A
C
Q
W
S
Site 49
S562
S
T
Q
A
C
Q
W
S
P
R
A
L
F
H
P
Site 50
S581
Q
G
R
R
G
C
R
S
L
L
Y
M
V
R
T
Site 51
S592
M
V
R
T
M
L
E
S
L
I
A
D
K
S
G
Site 52
S598
E
S
L
I
A
D
K
S
G
S
K
K
T
L
R
Site 53
T603
D
K
S
G
S
K
K
T
L
R
S
S
L
D
G
Site 54
S606
G
S
K
K
T
L
R
S
S
L
D
G
P
I
V
Site 55
S607
S
K
K
T
L
R
S
S
L
D
G
P
I
V
L
Site 56
T627
H
K
Q
S
F
F
F
T
H
L
L
N
I
S
E
Site 57
T655
R
E
F
F
L
E
L
T
M
G
R
R
I
Q
F
Site 58
T679
L
T
D
H
I
L
E
T
K
E
P
S
M
M
E
Site 59
Y687
K
E
P
S
M
M
E
Y
V
L
Y
P
L
D
L
Site 60
Y690
S
M
M
E
Y
V
L
Y
P
L
D
L
Y
N
D
Site 61
Y695
V
L
Y
P
L
D
L
Y
N
D
S
A
Y
Y
A
Site 62
S698
P
L
D
L
Y
N
D
S
A
Y
Y
A
L
T
K
Site 63
Y700
D
L
Y
N
D
S
A
Y
Y
A
L
T
K
F
K
Site 64
Y712
K
F
K
K
Q
F
L
Y
D
E
I
E
A
E
V
Site 65
Y758
F
R
A
E
C
K
N
Y
G
V
I
I
P
Y
P
Site 66
Y764
N
Y
G
V
I
I
P
Y
P
P
S
N
R
Y
E
Site 67
S767
V
I
I
P
Y
P
P
S
N
R
Y
E
T
L
L
Site 68
T772
P
P
S
N
R
Y
E
T
L
L
K
Q
R
H
V
Site 69
S797
R
L
I
T
Q
R
I
S
A
A
M
Y
K
S
L
Site 70
Y801
Q
R
I
S
A
A
M
Y
K
S
L
D
Q
A
I
Site 71
S803
I
S
A
A
M
Y
K
S
L
D
Q
A
I
S
R
Site 72
S809
K
S
L
D
Q
A
I
S
R
F
E
S
E
D
L
Site 73
S813
Q
A
I
S
R
F
E
S
E
D
L
T
S
I
V
Site 74
T817
R
F
E
S
E
D
L
T
S
I
V
E
L
E
W
Site 75
T832
L
L
E
I
N
R
L
T
H
R
L
L
C
K
H
Site 76
S857
R
E
A
N
H
N
V
S
A
P
Y
G
R
I
T
Site 77
Y860
N
H
N
V
S
A
P
Y
G
R
I
T
L
H
V
Site 78
Y879
N
F
D
F
L
P
N
Y
C
Y
N
G
S
T
N
Site 79
Y881
D
F
L
P
N
Y
C
Y
N
G
S
T
N
R
F
Site 80
T891
S
T
N
R
F
V
R
T
A
I
P
F
T
Q
E
Site 81
T896
V
R
T
A
I
P
F
T
Q
E
P
Q
R
D
K
Site 82
Y910
K
P
A
N
V
Q
P
Y
Y
L
Y
G
S
K
P
Site 83
Y911
P
A
N
V
Q
P
Y
Y
L
Y
G
S
K
P
L
Site 84
Y913
N
V
Q
P
Y
Y
L
Y
G
S
K
P
L
N
I
Site 85
Y922
S
K
P
L
N
I
A
Y
S
H
I
Y
S
S
Y
Site 86
S923
K
P
L
N
I
A
Y
S
H
I
Y
S
S
Y
R
Site 87
Y929
Y
S
H
I
Y
S
S
Y
R
N
F
V
G
P
P
Site 88
Y991
C
R
L
P
R
H
E
Y
G
S
P
G
I
L
E
Site 89
S993
L
P
R
H
E
Y
G
S
P
G
I
L
E
F
F
Site 90
T1015
I
E
Y
A
E
L
K
T
D
V
F
Q
S
L
R
Site 91
S1020
L
K
T
D
V
F
Q
S
L
R
E
V
G
N
A
Site 92
Y1060
Q
N
I
L
P
R
V
Y
I
K
E
G
E
R
L
Site 93
Y1078
M
K
R
L
E
A
K
Y
A
P
L
H
L
V
P
Site 94
T1092
P
L
I
E
R
L
G
T
P
Q
Q
I
A
I
A
Site 95
T1106
A
R
E
G
D
L
L
T
K
E
R
L
C
C
G
Site 96
Y1127
I
L
T
R
I
R
S
Y
L
Q
D
P
I
W
R
Site 97
Y1235
M
A
D
R
I
R
K
Y
Q
I
L
N
N
E
V
Site 98
S1252
I
L
N
K
Y
M
K
S
V
E
T
D
S
S
T
Site 99
S1257
M
K
S
V
E
T
D
S
S
T
V
E
H
V
R
Site 100
S1258
K
S
V
E
T
D
S
S
T
V
E
H
V
R
C
Site 101
T1259
S
V
E
T
D
S
S
T
V
E
H
V
R
C
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation