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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATG4C
Full Name:
Cysteine protease ATG4C
Alias:
APG4 autophagy 4 homologue C; APG4C; APG4-C; AUTL1; AUTL3; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homologue C; EC 3.4.22.-
Type:
Autophagy, Protease, Ubiquitin conjugating system
Mass (Da):
52497
Number AA:
458
UniProt ID:
Q96DT6
International Prot ID:
IPI00156979
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005576
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0000045
GO:0019941
GO:0006612
Phosida
TranscriptoNet
STRING
Kinexus Products
Cysteine protease ATG4C pan-specific antibody AB-NN210-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN210-1#AUT like 1cysteine endopeptidase (S. cerevisiae) pan-specific antibody AB-NN210-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN210-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
A
T
G
T
D
E
V
D
K
L
K
Site 2
T14
D
E
V
D
K
L
K
T
K
F
I
S
A
W
N
Site 3
Y25
S
A
W
N
N
M
K
Y
S
W
V
L
K
T
K
Site 4
T31
K
Y
S
W
V
L
K
T
K
T
Y
F
S
R
N
Site 5
T33
S
W
V
L
K
T
K
T
Y
F
S
R
N
S
P
Site 6
Y34
W
V
L
K
T
K
T
Y
F
S
R
N
S
P
V
Site 7
S39
K
T
Y
F
S
R
N
S
P
V
L
L
L
G
K
Site 8
Y52
G
K
C
Y
H
F
K
Y
E
D
E
D
K
T
L
Site 9
T58
K
Y
E
D
E
D
K
T
L
P
A
E
S
G
C
Site 10
T90
F
I
S
R
I
W
L
T
Y
R
E
E
F
P
Q
Site 11
Y91
I
S
R
I
W
L
T
Y
R
E
E
F
P
Q
I
Site 12
S144
D
A
L
N
I
E
N
S
D
S
E
S
W
T
S
Site 13
S146
L
N
I
E
N
S
D
S
E
S
W
T
S
H
T
Site 14
S148
I
E
N
S
D
S
E
S
W
T
S
H
T
V
K
Site 15
T150
N
S
D
S
E
S
W
T
S
H
T
V
K
K
F
Site 16
S151
S
D
S
E
S
W
T
S
H
T
V
K
K
F
T
Site 17
T153
S
E
S
W
T
S
H
T
V
K
K
F
T
A
S
Site 18
S160
T
V
K
K
F
T
A
S
F
E
A
S
L
S
G
Site 19
S164
F
T
A
S
F
E
A
S
L
S
G
E
R
E
F
Site 20
S166
A
S
F
E
A
S
L
S
G
E
R
E
F
K
T
Site 21
T173
S
G
E
R
E
F
K
T
P
T
I
S
L
K
E
Site 22
S177
E
F
K
T
P
T
I
S
L
K
E
T
I
G
K
Site 23
T181
P
T
I
S
L
K
E
T
I
G
K
Y
S
D
D
Site 24
Y185
L
K
E
T
I
G
K
Y
S
D
D
H
E
M
R
Site 25
S186
K
E
T
I
G
K
Y
S
D
D
H
E
M
R
N
Site 26
Y196
H
E
M
R
N
E
V
Y
H
R
K
I
I
S
W
Site 27
Y220
G
L
H
Q
L
I
E
Y
G
K
K
S
G
K
K
Site 28
S224
L
I
E
Y
G
K
K
S
G
K
K
A
G
D
W
Site 29
Y232
G
K
K
A
G
D
W
Y
G
P
A
V
V
A
H
Site 30
Y267
V
A
Q
D
C
T
V
Y
N
S
D
V
I
D
K
Site 31
S276
S
D
V
I
D
K
Q
S
A
S
M
T
S
D
N
Site 32
S278
V
I
D
K
Q
S
A
S
M
T
S
D
N
A
D
Site 33
T280
D
K
Q
S
A
S
M
T
S
D
N
A
D
D
K
Site 34
T302
V
R
L
G
G
E
R
T
N
T
D
Y
L
E
F
Site 35
T304
L
G
G
E
R
T
N
T
D
Y
L
E
F
V
K
Site 36
Y306
G
E
R
T
N
T
D
Y
L
E
F
V
K
G
I
Site 37
Y331
G
G
K
P
K
Q
S
Y
Y
F
A
G
F
Q
D
Site 38
Y332
G
K
P
K
Q
S
Y
Y
F
A
G
F
Q
D
D
Site 39
Y343
F
Q
D
D
S
L
I
Y
M
D
P
H
Y
C
Q
Site 40
T364
I
K
D
F
P
L
E
T
F
H
C
P
S
P
K
Site 41
S369
L
E
T
F
H
C
P
S
P
K
K
M
S
F
R
Site 42
S374
C
P
S
P
K
K
M
S
F
R
K
M
D
P
S
Site 43
S381
S
F
R
K
M
D
P
S
C
T
I
G
F
Y
C
Site 44
T383
R
K
M
D
P
S
C
T
I
G
F
Y
C
R
N
Site 45
Y387
P
S
C
T
I
G
F
Y
C
R
N
V
Q
D
F
Site 46
S398
V
Q
D
F
K
R
A
S
E
E
I
T
K
M
L
Site 47
T402
K
R
A
S
E
E
I
T
K
M
L
K
F
S
S
Site 48
S409
T
K
M
L
K
F
S
S
K
E
K
Y
P
L
F
Site 49
Y413
K
F
S
S
K
E
K
Y
P
L
F
T
F
V
N
Site 50
T417
K
E
K
Y
P
L
F
T
F
V
N
G
H
S
R
Site 51
Y426
V
N
G
H
S
R
D
Y
D
F
T
S
T
T
T
Site 52
T429
H
S
R
D
Y
D
F
T
S
T
T
T
N
E
E
Site 53
S430
S
R
D
Y
D
F
T
S
T
T
T
N
E
E
D
Site 54
S440
T
N
E
E
D
L
F
S
E
D
E
K
K
Q
L
Site 55
S451
K
K
Q
L
K
R
F
S
T
E
E
F
V
L
L
Site 56
T452
K
Q
L
K
R
F
S
T
E
E
F
V
L
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation