KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SGEF
Full Name:
Rho guanine nucleotide exchange factor 26
Alias:
CSGEF; Src homology 3 domain-containing guanine nucleotide exchange factor
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
97360
Number AA:
871
UniProt ID:
Q96DR7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0001726
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
E
S
E
V
D
F
S
S
N
S
I
T
P
L
Site 2
S11
E
S
E
V
D
F
S
S
N
S
I
T
P
L
W
Site 3
S13
E
V
D
F
S
S
N
S
I
T
P
L
W
R
R
Site 4
T15
D
F
S
S
N
S
I
T
P
L
W
R
R
R
S
Site 5
S22
T
P
L
W
R
R
R
S
I
P
Q
P
H
Q
L
Site 6
S33
P
H
Q
L
L
G
R
S
K
P
R
P
Q
S
Y
Site 7
S39
R
S
K
P
R
P
Q
S
Y
Q
S
P
N
G
L
Site 8
Y40
S
K
P
R
P
Q
S
Y
Q
S
P
N
G
L
L
Site 9
S42
P
R
P
Q
S
Y
Q
S
P
N
G
L
L
I
T
Site 10
T49
S
P
N
G
L
L
I
T
D
F
P
V
E
D
G
Site 11
T70
Q
I
P
A
Q
V
P
T
A
S
D
S
R
T
V
Site 12
S72
P
A
Q
V
P
T
A
S
D
S
R
T
V
H
R
Site 13
S74
Q
V
P
T
A
S
D
S
R
T
V
H
R
S
P
Site 14
T76
P
T
A
S
D
S
R
T
V
H
R
S
P
L
L
Site 15
S80
D
S
R
T
V
H
R
S
P
L
L
L
G
A
Q
Site 16
S98
V
A
N
G
G
T
A
S
P
E
Y
R
A
A
S
Site 17
Y101
G
G
T
A
S
P
E
Y
R
A
A
S
P
R
L
Site 18
S105
S
P
E
Y
R
A
A
S
P
R
L
R
R
P
K
Site 19
S113
P
R
L
R
R
P
K
S
P
K
L
P
K
A
V
Site 20
S124
P
K
A
V
P
G
G
S
P
K
S
P
A
N
G
Site 21
S127
V
P
G
G
S
P
K
S
P
A
N
G
A
V
T
Site 22
T134
S
P
A
N
G
A
V
T
L
P
A
P
P
P
P
Site 23
T149
P
V
L
R
P
P
R
T
P
N
A
P
A
P
C
Site 24
T157
P
N
A
P
A
P
C
T
P
E
E
D
L
T
G
Site 25
T163
C
T
P
E
E
D
L
T
G
L
T
A
S
P
V
Site 26
T166
E
E
D
L
T
G
L
T
A
S
P
V
P
S
P
Site 27
S184
G
L
A
A
N
N
D
S
P
G
S
G
S
Q
S
Site 28
S187
A
N
N
D
S
P
G
S
G
S
Q
S
G
R
K
Site 29
S189
N
D
S
P
G
S
G
S
Q
S
G
R
K
A
K
Site 30
S191
S
P
G
S
G
S
Q
S
G
R
K
A
K
D
P
Site 31
S209
L
F
P
G
P
Q
K
S
S
S
E
Q
K
L
P
Site 32
S211
P
G
P
Q
K
S
S
S
E
Q
K
L
P
L
Q
Site 33
S222
L
P
L
Q
R
L
P
S
Q
E
N
E
L
L
E
Site 34
S232
N
E
L
L
E
N
P
S
V
V
L
S
T
N
S
Site 35
S236
E
N
P
S
V
V
L
S
T
N
S
P
A
A
L
Site 36
S254
K
Q
Q
I
I
P
K
S
L
A
S
E
I
K
I
Site 37
S257
I
I
P
K
S
L
A
S
E
I
K
I
S
K
S
Site 38
S262
L
A
S
E
I
K
I
S
K
S
N
N
Q
N
V
Site 39
S264
S
E
I
K
I
S
K
S
N
N
Q
N
V
E
P
Site 40
S280
K
R
L
L
K
V
R
S
M
V
E
G
L
G
G
Site 41
S296
L
G
H
A
G
E
E
S
E
V
D
N
D
V
D
Site 42
S304
E
V
D
N
D
V
D
S
P
G
S
L
R
R
G
Site 43
S307
N
D
V
D
S
P
G
S
L
R
R
G
L
R
S
Site 44
S314
S
L
R
R
G
L
R
S
T
S
Y
R
R
A
V
Site 45
T315
L
R
R
G
L
R
S
T
S
Y
R
R
A
V
V
Site 46
S316
R
R
G
L
R
S
T
S
Y
R
R
A
V
V
S
Site 47
Y317
R
G
L
R
S
T
S
Y
R
R
A
V
V
S
G
Site 48
S323
S
Y
R
R
A
V
V
S
G
F
D
F
D
S
P
Site 49
S329
V
S
G
F
D
F
D
S
P
T
S
S
K
K
K
Site 50
T331
G
F
D
F
D
S
P
T
S
S
K
K
K
N
R
Site 51
S332
F
D
F
D
S
P
T
S
S
K
K
K
N
R
M
Site 52
S333
D
F
D
S
P
T
S
S
K
K
K
N
R
M
S
Site 53
S340
S
K
K
K
N
R
M
S
Q
P
V
L
K
V
V
Site 54
S356
E
D
K
E
K
F
S
S
L
G
R
I
K
K
K
Site 55
T370
K
M
L
K
G
Q
G
T
F
D
G
E
E
N
A
Site 56
Y380
G
E
E
N
A
V
L
Y
Q
N
Y
K
E
K
A
Site 57
Y383
N
A
V
L
Y
Q
N
Y
K
E
K
A
L
D
I
Site 58
S392
E
K
A
L
D
I
D
S
D
E
E
S
E
P
K
Site 59
S396
D
I
D
S
D
E
E
S
E
P
K
E
Q
K
S
Site 60
S403
S
E
P
K
E
Q
K
S
D
E
K
I
V
I
H
Site 61
S416
I
H
H
K
P
L
R
S
T
W
S
Q
L
S
A
Site 62
T417
H
H
K
P
L
R
S
T
W
S
Q
L
S
A
V
Site 63
S419
K
P
L
R
S
T
W
S
Q
L
S
A
V
K
R
Site 64
S422
R
S
T
W
S
Q
L
S
A
V
K
R
K
G
L
Site 65
S430
A
V
K
R
K
G
L
S
Q
T
V
S
Q
E
E
Site 66
T432
K
R
K
G
L
S
Q
T
V
S
Q
E
E
R
K
Site 67
S434
K
G
L
S
Q
T
V
S
Q
E
E
R
K
R
Q
Site 68
Y454
V
I
S
S
E
H
S
Y
L
L
S
L
E
I
L
Site 69
S468
L
I
R
M
F
K
N
S
K
E
L
S
D
T
M
Site 70
S472
F
K
N
S
K
E
L
S
D
T
M
T
K
T
E
Site 71
T474
N
S
K
E
L
S
D
T
M
T
K
T
E
R
H
Site 72
T476
K
E
L
S
D
T
M
T
K
T
E
R
H
H
L
Site 73
T478
L
S
D
T
M
T
K
T
E
R
H
H
L
F
S
Site 74
T525
V
E
K
H
T
A
S
T
F
D
P
Y
V
K
Y
Site 75
Y529
T
A
S
T
F
D
P
Y
V
K
Y
C
T
N
E
Site 76
Y532
T
F
D
P
Y
V
K
Y
C
T
N
E
V
Y
Q
Site 77
Y538
K
Y
C
T
N
E
V
Y
Q
Q
R
T
L
Q
K
Site 78
S552
K
L
L
A
T
N
P
S
F
K
E
V
L
S
R
Site 79
S558
P
S
F
K
E
V
L
S
R
I
E
S
H
E
D
Site 80
S562
E
V
L
S
R
I
E
S
H
E
D
C
R
N
L
Site 81
T591
R
L
P
L
L
M
D
T
I
C
Q
K
T
P
K
Site 82
T596
M
D
T
I
C
Q
K
T
P
K
D
S
P
K
Y
Site 83
S600
C
Q
K
T
P
K
D
S
P
K
Y
E
V
C
K
Site 84
Y603
T
P
K
D
S
P
K
Y
E
V
C
K
R
A
L
Site 85
T630
G
A
R
K
M
E
R
T
E
M
M
Y
T
I
N
Site 86
Y634
M
E
R
T
E
M
M
Y
T
I
N
S
Q
L
E
Site 87
T635
E
R
T
E
M
M
Y
T
I
N
S
Q
L
E
F
Site 88
S638
E
M
M
Y
T
I
N
S
Q
L
E
F
K
I
K
Site 89
S652
K
P
F
P
L
V
S
S
S
R
W
L
V
K
R
Site 90
S653
P
F
P
L
V
S
S
S
R
W
L
V
K
R
G
Site 91
Y665
K
R
G
E
L
T
A
Y
V
E
D
T
V
L
F
Site 92
T669
L
T
A
Y
V
E
D
T
V
L
F
S
R
R
T
Site 93
S673
V
E
D
T
V
L
F
S
R
R
T
S
K
Q
Q
Site 94
T676
T
V
L
F
S
R
R
T
S
K
Q
Q
V
Y
F
Site 95
S677
V
L
F
S
R
R
T
S
K
Q
Q
V
Y
F
F
Site 96
Y682
R
T
S
K
Q
Q
V
Y
F
F
L
F
N
D
V
Site 97
S697
L
I
I
T
K
K
K
S
E
E
S
Y
N
V
N
Site 98
Y701
K
K
K
S
E
E
S
Y
N
V
N
D
Y
S
L
Site 99
Y706
E
S
Y
N
V
N
D
Y
S
L
R
D
Q
L
L
Site 100
S707
S
Y
N
V
N
D
Y
S
L
R
D
Q
L
L
V
Site 101
S716
R
D
Q
L
L
V
E
S
C
D
N
E
E
L
N
Site 102
S724
C
D
N
E
E
L
N
S
S
P
G
K
N
S
S
Site 103
S725
D
N
E
E
L
N
S
S
P
G
K
N
S
S
T
Site 104
S730
N
S
S
P
G
K
N
S
S
T
M
L
Y
S
R
Site 105
S731
S
S
P
G
K
N
S
S
T
M
L
Y
S
R
Q
Site 106
T732
S
P
G
K
N
S
S
T
M
L
Y
S
R
Q
S
Site 107
Y735
K
N
S
S
T
M
L
Y
S
R
Q
S
S
A
S
Site 108
S736
N
S
S
T
M
L
Y
S
R
Q
S
S
A
S
H
Site 109
S739
T
M
L
Y
S
R
Q
S
S
A
S
H
L
F
T
Site 110
S740
M
L
Y
S
R
Q
S
S
A
S
H
L
F
T
L
Site 111
S742
Y
S
R
Q
S
S
A
S
H
L
F
T
L
T
V
Site 112
S768
L
L
G
A
E
T
Q
S
E
R
A
R
W
I
T
Site 113
T775
S
E
R
A
R
W
I
T
A
L
G
H
S
S
G
Site 114
S780
W
I
T
A
L
G
H
S
S
G
K
P
P
A
D
Site 115
S790
K
P
P
A
D
R
T
S
L
T
Q
V
E
I
V
Site 116
T792
P
A
D
R
T
S
L
T
Q
V
E
I
V
R
S
Site 117
S799
T
Q
V
E
I
V
R
S
F
T
A
K
Q
P
D
Site 118
T801
V
E
I
V
R
S
F
T
A
K
Q
P
D
E
L
Site 119
S809
A
K
Q
P
D
E
L
S
L
Q
V
A
D
V
V
Site 120
S823
V
L
I
Y
Q
R
V
S
D
G
W
Y
E
G
E
Site 121
Y827
Q
R
V
S
D
G
W
Y
E
G
E
R
L
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation