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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VWCE
Full Name:
von Willebrand factor C and EGF domain-containing protein
Alias:
HBV X protein up-regulated gene 11 protein;HBxAg up-regulated gene 11 protein
Type:
Mass (Da):
99915
Number AA:
955
UniProt ID:
Q96DN2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
P
G
A
P
A
R
G
Y
T
G
R
K
P
P
G
Site 2
T25
G
A
P
A
R
G
Y
T
G
R
K
P
P
G
H
Site 3
T96
Q
D
G
E
Q
G
A
T
C
P
E
T
H
G
P
Site 4
T100
Q
G
A
T
C
P
E
T
H
G
P
C
G
E
Y
Site 5
Y107
T
H
G
P
C
G
E
Y
G
C
D
L
T
C
N
Site 6
S173
C
G
P
G
M
Q
L
S
A
D
R
H
S
C
Q
Site 7
S178
Q
L
S
A
D
R
H
S
C
Q
D
T
D
E
C
Site 8
T182
D
R
H
S
C
Q
D
T
D
E
C
L
G
T
P
Site 9
T188
D
T
D
E
C
L
G
T
P
C
Q
Q
R
C
K
Site 10
S197
C
Q
Q
R
C
K
N
S
I
G
S
Y
K
C
S
Site 11
S200
R
C
K
N
S
I
G
S
Y
K
C
S
C
R
T
Site 12
Y201
C
K
N
S
I
G
S
Y
K
C
S
C
R
T
G
Site 13
S204
S
I
G
S
Y
K
C
S
C
R
T
G
F
H
L
Site 14
S260
R
L
R
A
D
R
V
S
C
E
A
F
P
K
A
Site 15
S282
L
Q
P
R
Q
H
P
S
K
M
L
L
L
L
P
Site 16
S297
E
A
G
R
P
A
L
S
P
G
H
S
P
P
S
Site 17
S301
P
A
L
S
P
G
H
S
P
P
S
G
A
P
G
Site 18
S304
S
P
G
H
S
P
P
S
G
A
P
G
P
P
A
Site 19
T315
G
P
P
A
G
V
R
T
T
R
L
P
S
P
T
Site 20
T316
P
P
A
G
V
R
T
T
R
L
P
S
P
T
P
Site 21
S320
V
R
T
T
R
L
P
S
P
T
P
R
L
P
T
Site 22
T322
T
T
R
L
P
S
P
T
P
R
L
P
T
S
S
Site 23
T327
S
P
T
P
R
L
P
T
S
S
P
S
A
P
V
Site 24
S328
P
T
P
R
L
P
T
S
S
P
S
A
P
V
W
Site 25
S329
T
P
R
L
P
T
S
S
P
S
A
P
V
W
L
Site 26
S331
R
L
P
T
S
S
P
S
A
P
V
W
L
L
S
Site 27
T367
L
Q
G
E
V
M
G
T
P
S
S
P
R
G
P
Site 28
S369
G
E
V
M
G
T
P
S
S
P
R
G
P
E
S
Site 29
S370
E
V
M
G
T
P
S
S
P
R
G
P
E
S
P
Site 30
S376
S
S
P
R
G
P
E
S
P
R
L
A
A
G
P
Site 31
S384
P
R
L
A
A
G
P
S
P
C
W
H
L
G
A
Site 32
T400
H
E
S
R
S
R
W
T
E
P
G
C
S
Q
C
Site 33
S426
V
R
C
E
A
A
C
S
H
P
I
P
S
R
D
Site 34
S431
A
C
S
H
P
I
P
S
R
D
G
G
C
C
P
Site 35
S439
R
D
G
G
C
C
P
S
C
T
G
C
F
H
S
Site 36
T441
G
G
C
C
P
S
C
T
G
C
F
H
S
G
V
Site 37
S446
S
C
T
G
C
F
H
S
G
V
V
R
A
E
G
Site 38
S457
R
A
E
G
D
V
F
S
P
P
N
E
N
C
T
Site 39
S477
A
G
N
V
S
C
I
S
P
E
C
P
S
G
P
Site 40
S482
C
I
S
P
E
C
P
S
G
P
C
Q
T
P
P
Site 41
T487
C
P
S
G
P
C
Q
T
P
P
Q
T
D
C
C
Site 42
T563
C
F
T
C
Q
E
P
T
P
S
T
G
C
S
L
Site 43
S565
T
C
Q
E
P
T
P
S
T
G
C
S
L
D
D
Site 44
S569
P
T
P
S
T
G
C
S
L
D
D
N
G
V
E
Site 45
S584
F
P
I
G
Q
I
W
S
P
G
D
P
C
E
L
Site 46
T605
G
S
V
S
C
K
R
T
D
C
V
D
S
C
P
Site 47
Y637
T
Y
T
G
R
I
F
Y
N
N
E
T
F
P
S
Site 48
T641
R
I
F
Y
N
N
E
T
F
P
S
V
L
D
P
Site 49
S644
Y
N
N
E
T
F
P
S
V
L
D
P
C
L
S
Site 50
Y689
P
V
C
R
D
C
N
Y
E
G
R
K
V
A
N
Site 51
S741
L
P
G
D
C
C
S
S
C
P
D
S
L
S
P
Site 52
S745
C
C
S
S
C
P
D
S
L
S
P
L
E
E
K
Site 53
S747
S
S
C
P
D
S
L
S
P
L
E
E
K
Q
G
Site 54
S756
L
E
E
K
Q
G
L
S
P
H
G
N
V
A
F
Site 55
S764
P
H
G
N
V
A
F
S
K
A
G
R
S
L
H
Site 56
S769
A
F
S
K
A
G
R
S
L
H
G
D
T
E
A
Site 57
T774
G
R
S
L
H
G
D
T
E
A
P
V
N
C
S
Site 58
S782
E
A
P
V
N
C
S
S
C
P
G
P
P
T
A
Site 59
T788
S
S
C
P
G
P
P
T
A
S
P
S
R
P
V
Site 60
S790
C
P
G
P
P
T
A
S
P
S
R
P
V
L
H
Site 61
S792
G
P
P
T
A
S
P
S
R
P
V
L
H
L
L
Site 62
T810
L
R
T
N
L
M
K
T
Q
T
L
P
T
S
P
Site 63
T812
T
N
L
M
K
T
Q
T
L
P
T
S
P
A
G
Site 64
S816
K
T
Q
T
L
P
T
S
P
A
G
A
H
G
P
Site 65
S841
F
P
G
E
P
G
A
S
P
R
L
S
P
G
P
Site 66
S845
P
G
A
S
P
R
L
S
P
G
P
S
T
P
P
Site 67
S849
P
R
L
S
P
G
P
S
T
P
P
G
A
P
T
Site 68
T850
R
L
S
P
G
P
S
T
P
P
G
A
P
T
L
Site 69
T856
S
T
P
P
G
A
P
T
L
P
L
A
S
P
G
Site 70
S861
A
P
T
L
P
L
A
S
P
G
A
P
Q
P
P
Site 71
T871
A
P
Q
P
P
P
V
T
P
E
R
S
F
S
A
Site 72
S875
P
P
V
T
P
E
R
S
F
S
A
S
G
A
Q
Site 73
S877
V
T
P
E
R
S
F
S
A
S
G
A
Q
I
V
Site 74
S879
P
E
R
S
F
S
A
S
G
A
Q
I
V
S
R
Site 75
S885
A
S
G
A
Q
I
V
S
R
W
P
P
L
P
G
Site 76
T893
R
W
P
P
L
P
G
T
L
L
T
E
A
S
A
Site 77
S902
L
T
E
A
S
A
L
S
M
M
D
P
S
P
S
Site 78
S907
A
L
S
M
M
D
P
S
P
S
K
T
P
I
T
Site 79
S909
S
M
M
D
P
S
P
S
K
T
P
I
T
L
L
Site 80
T911
M
D
P
S
P
S
K
T
P
I
T
L
L
G
P
Site 81
T924
G
P
R
V
L
S
P
T
T
S
R
L
S
T
A
Site 82
T925
P
R
V
L
S
P
T
T
S
R
L
S
T
A
L
Site 83
S929
S
P
T
T
S
R
L
S
T
A
L
A
A
T
T
Site 84
T930
P
T
T
S
R
L
S
T
A
L
A
A
T
T
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation