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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RHBDF1
Full Name:
Rhomboid family member 1
Alias:
16pHQG;5; Rhomboid family 1
Type:
Uncharacterized protein
Mass (Da):
98157
Number AA:
862
UniProt ID:
Q96CC6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005507
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
E
A
R
R
D
S
T
S
S
L
Q
R
K
Site 2
T9
S
E
A
R
R
D
S
T
S
S
L
Q
R
K
K
Site 3
S10
E
A
R
R
D
S
T
S
S
L
Q
R
K
K
P
Site 4
S11
A
R
R
D
S
T
S
S
L
Q
R
K
K
P
P
Site 5
S36
P
L
T
A
E
E
P
S
F
L
Q
P
L
R
R
Site 6
S49
R
R
Q
A
F
L
R
S
V
S
M
P
A
E
T
Site 7
S51
Q
A
F
L
R
S
V
S
M
P
A
E
T
A
H
Site 8
T56
S
V
S
M
P
A
E
T
A
H
I
S
S
P
H
Site 9
S60
P
A
E
T
A
H
I
S
S
P
H
H
E
L
R
Site 10
S61
A
E
T
A
H
I
S
S
P
H
H
E
L
R
R
Site 11
T75
R
P
V
L
Q
R
Q
T
S
I
T
Q
T
I
R
Site 12
S76
P
V
L
Q
R
Q
T
S
I
T
Q
T
I
R
R
Site 13
T78
L
Q
R
Q
T
S
I
T
Q
T
I
R
R
G
T
Site 14
T80
R
Q
T
S
I
T
Q
T
I
R
R
G
T
A
D
Site 15
T85
T
Q
T
I
R
R
G
T
A
D
W
F
G
V
S
Site 16
S92
T
A
D
W
F
G
V
S
K
D
S
D
S
T
Q
Site 17
S95
W
F
G
V
S
K
D
S
D
S
T
Q
K
W
Q
Site 18
S97
G
V
S
K
D
S
D
S
T
Q
K
W
Q
R
K
Site 19
S110
R
K
S
I
R
H
C
S
Q
R
Y
G
K
L
K
Site 20
S128
L
R
E
L
D
L
P
S
Q
D
N
V
S
L
T
Site 21
S133
L
P
S
Q
D
N
V
S
L
T
S
T
E
T
P
Site 22
T135
S
Q
D
N
V
S
L
T
S
T
E
T
P
P
P
Site 23
T137
D
N
V
S
L
T
S
T
E
T
P
P
P
L
Y
Site 24
T139
V
S
L
T
S
T
E
T
P
P
P
L
Y
V
G
Site 25
Y144
T
E
T
P
P
P
L
Y
V
G
P
C
Q
L
G
Site 26
T171
A
F
R
V
A
D
D
T
A
E
G
L
S
A
P
Site 27
S176
D
D
T
A
E
G
L
S
A
P
H
T
P
V
T
Site 28
T180
E
G
L
S
A
P
H
T
P
V
T
P
G
A
A
Site 29
T183
S
A
P
H
T
P
V
T
P
G
A
A
S
L
C
Site 30
S188
P
V
T
P
G
A
A
S
L
C
S
F
S
S
S
Site 31
S191
P
G
A
A
S
L
C
S
F
S
S
S
R
S
G
Site 32
S193
A
A
S
L
C
S
F
S
S
S
R
S
G
F
H
Site 33
S194
A
S
L
C
S
F
S
S
S
R
S
G
F
H
R
Site 34
S195
S
L
C
S
F
S
S
S
R
S
G
F
H
R
L
Site 35
S197
C
S
F
S
S
S
R
S
G
F
H
R
L
P
R
Site 36
S210
P
R
R
R
K
R
E
S
V
A
K
M
S
F
R
Site 37
S227
A
A
L
M
K
G
R
S
V
R
D
G
T
F
R
Site 38
T232
G
R
S
V
R
D
G
T
F
R
R
A
Q
R
R
Site 39
S240
F
R
R
A
Q
R
R
S
F
T
P
A
S
F
L
Site 40
T242
R
A
Q
R
R
S
F
T
P
A
S
F
L
E
E
Site 41
S245
R
R
S
F
T
P
A
S
F
L
E
E
D
T
T
Site 42
T252
S
F
L
E
E
D
T
T
D
F
P
D
E
L
D
Site 43
S261
F
P
D
E
L
D
T
S
F
F
A
R
E
G
I
Site 44
S274
G
I
L
H
E
E
L
S
T
Y
P
D
E
V
F
Site 45
T275
I
L
H
E
E
L
S
T
Y
P
D
E
V
F
E
Site 46
Y276
L
H
E
E
L
S
T
Y
P
D
E
V
F
E
S
Site 47
S283
Y
P
D
E
V
F
E
S
P
S
E
A
A
L
K
Site 48
S285
D
E
V
F
E
S
P
S
E
A
A
L
K
D
W
Site 49
T302
A
P
E
Q
A
D
L
T
G
G
A
L
D
R
S
Site 50
S309
T
G
G
A
L
D
R
S
E
L
E
R
S
H
L
Site 51
S314
D
R
S
E
L
E
R
S
H
L
M
L
P
L
E
Site 52
S346
R
L
R
Q
E
V
V
S
T
A
G
P
R
R
G
Site 53
T347
L
R
Q
E
V
V
S
T
A
G
P
R
R
G
Q
Site 54
Y371
F
A
R
E
K
R
P
Y
G
L
G
M
V
G
R
Site 55
T380
L
G
M
V
G
R
L
T
N
R
T
Y
R
K
R
Site 56
T383
V
G
R
L
T
N
R
T
Y
R
K
R
I
D
S
Site 57
Y384
G
R
L
T
N
R
T
Y
R
K
R
I
D
S
F
Site 58
S390
T
Y
R
K
R
I
D
S
F
V
K
R
Q
I
E
Site 59
T437
V
G
F
S
Q
H
E
T
V
D
S
V
L
R
N
Site 60
S440
S
Q
H
E
T
V
D
S
V
L
R
N
R
G
V
Site 61
Y448
V
L
R
N
R
G
V
Y
E
N
V
K
Y
V
Q
Site 62
Y453
G
V
Y
E
N
V
K
Y
V
Q
Q
E
N
F
W
Site 63
S476
I
H
L
G
A
K
F
S
P
C
M
R
Q
D
P
Site 64
S487
R
Q
D
P
Q
V
H
S
F
I
R
S
A
R
E
Site 65
S491
Q
V
H
S
F
I
R
S
A
R
E
R
E
K
H
Site 66
S514
R
S
G
C
V
Q
T
S
E
E
E
C
S
S
T
Site 67
S519
Q
T
S
E
E
E
C
S
S
T
L
A
V
W
V
Site 68
S520
T
S
E
E
E
C
S
S
T
L
A
V
W
V
K
Site 69
T521
S
E
E
E
C
S
S
T
L
A
V
W
V
K
W
Site 70
S546
G
H
K
R
Q
F
G
S
V
C
H
Q
D
P
R
Site 71
S559
P
R
V
C
D
E
P
S
S
E
D
P
H
E
W
Site 72
S560
R
V
C
D
E
P
S
S
E
D
P
H
E
W
P
Site 73
Y614
C
E
I
T
S
R
E
Y
C
D
F
M
R
G
Y
Site 74
Y621
Y
C
D
F
M
R
G
Y
F
H
E
E
A
T
L
Site 75
Y654
P
E
V
P
D
Q
F
Y
R
L
W
L
S
L
F
Site 76
Y798
S
F
G
K
F
D
L
Y
R
K
R
C
Q
I
I
Site 77
Y848
T
D
K
F
C
E
K
Y
E
L
D
A
Q
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation