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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOCK10
Full Name:
Dedicator of cytokinesis protein 10
Alias:
Dedicator of cytokinesis 10; Dedicator of cytokinesis protein 10;Zizimin-3;Dedicator of cytokinesis protein 10;Zizimin-3; DOC10; Dopamine receptor interacting 2; DRIP2; KIAA0694; Nbla10300; ZIZ3; Zizimin 3; Zizimin3
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
249312
Number AA:
2183
UniProt ID:
Q96BY6
International Prot ID:
IPI00333770
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0051020
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
G
E
R
T
R
R
F
T
R
S
L
L
R
P
G
Site 2
S12
R
T
R
R
F
T
R
S
L
L
R
P
G
Q
A
Site 3
S35
S
A
A
A
V
A
V
S
S
R
Q
Q
Q
R
Q
Site 4
Y53
R
L
L
E
P
L
D
Y
E
T
V
I
E
E
L
Site 5
T55
L
E
P
L
D
Y
E
T
V
I
E
E
L
E
K
Site 6
T63
V
I
E
E
L
E
K
T
Y
R
N
D
P
L
Q
Site 7
S77
Q
D
L
L
F
F
P
S
D
D
F
S
A
A
T
Site 8
S81
F
F
P
S
D
D
F
S
A
A
T
V
S
W
D
Site 9
T84
S
D
D
F
S
A
A
T
V
S
W
D
I
R
T
Site 10
T91
T
V
S
W
D
I
R
T
L
Y
S
T
V
P
E
Site 11
Y93
S
W
D
I
R
T
L
Y
S
T
V
P
E
D
A
Site 12
S94
W
D
I
R
T
L
Y
S
T
V
P
E
D
A
E
Site 13
T95
D
I
R
T
L
Y
S
T
V
P
E
D
A
E
H
Site 14
Y125
S
Q
W
H
V
V
N
Y
K
Y
E
Q
Y
S
G
Site 15
Y127
W
H
V
V
N
Y
K
Y
E
Q
Y
S
G
D
I
Site 16
Y142
R
Q
L
P
R
A
E
Y
K
P
E
K
L
P
S
Site 17
S149
Y
K
P
E
K
L
P
S
H
S
F
E
I
D
H
Site 18
S151
P
E
K
L
P
S
H
S
F
E
I
D
H
E
D
Site 19
T165
D
A
D
K
D
E
D
T
T
S
H
S
S
S
K
Site 20
T166
A
D
K
D
E
D
T
T
S
H
S
S
S
K
G
Site 21
S167
D
K
D
E
D
T
T
S
H
S
S
S
K
G
G
Site 22
S169
D
E
D
T
T
S
H
S
S
S
K
G
G
G
G
Site 23
S170
E
D
T
T
S
H
S
S
S
K
G
G
G
G
A
Site 24
S171
D
T
T
S
H
S
S
S
K
G
G
G
G
A
G
Site 25
T180
G
G
G
G
A
G
G
T
G
V
F
K
S
G
W
Site 26
Y189
V
F
K
S
G
W
L
Y
K
G
N
F
N
S
T
Site 27
S195
L
Y
K
G
N
F
N
S
T
V
N
N
T
V
T
Site 28
T196
Y
K
G
N
F
N
S
T
V
N
N
T
V
T
V
Site 29
T200
F
N
S
T
V
N
N
T
V
T
V
R
S
F
K
Site 30
T202
S
T
V
N
N
T
V
T
V
R
S
F
K
K
R
Site 31
S205
N
N
T
V
T
V
R
S
F
K
K
R
Y
F
Q
Site 32
Y210
V
R
S
F
K
K
R
Y
F
Q
L
T
Q
L
P
Site 33
T214
K
K
R
Y
F
Q
L
T
Q
L
P
D
N
S
Y
Site 34
Y221
T
Q
L
P
D
N
S
Y
I
M
N
F
Y
K
D
Site 35
Y256
Q
N
N
R
L
R
K
Y
A
F
E
L
K
M
N
Site 36
S276
V
L
A
A
E
T
E
S
D
M
D
E
W
I
H
Site 37
S292
L
N
R
I
L
Q
I
S
P
E
G
P
L
Q
G
Site 38
S302
G
P
L
Q
G
R
R
S
T
E
L
T
D
L
G
Site 39
T303
P
L
Q
G
R
R
S
T
E
L
T
D
L
G
L
Site 40
T306
G
R
R
S
T
E
L
T
D
L
G
L
D
S
L
Site 41
S316
G
L
D
S
L
D
N
S
V
T
C
E
C
T
P
Site 42
T318
D
S
L
D
N
S
V
T
C
E
C
T
P
E
E
Site 43
T322
N
S
V
T
C
E
C
T
P
E
E
T
D
S
S
Site 44
S328
C
T
P
E
E
T
D
S
S
E
N
N
L
H
A
Site 45
S329
T
P
E
E
T
D
S
S
E
N
N
L
H
A
D
Site 46
Y340
L
H
A
D
F
A
K
Y
L
T
E
T
E
D
T
Site 47
T347
Y
L
T
E
T
E
D
T
V
K
T
T
R
N
M
Site 48
T350
E
T
E
D
T
V
K
T
T
R
N
M
E
R
L
Site 49
S361
M
E
R
L
N
L
F
S
L
D
P
D
I
D
T
Site 50
T368
S
L
D
P
D
I
D
T
L
K
L
Q
K
K
D
Site 51
S381
K
D
L
L
E
P
E
S
V
I
K
P
F
E
E
Site 52
T418
E
N
E
N
D
P
I
T
N
I
E
P
F
F
V
Site 53
Y430
F
F
V
S
V
A
L
Y
D
L
R
D
S
R
K
Site 54
S435
A
L
Y
D
L
R
D
S
R
K
I
S
A
D
F
Site 55
S439
L
R
D
S
R
K
I
S
A
D
F
H
V
D
L
Site 56
S459
R
Q
M
L
L
G
A
S
V
A
L
E
N
G
N
Site 57
T469
L
E
N
G
N
I
D
T
I
T
P
R
Q
S
E
Site 58
T471
N
G
N
I
D
T
I
T
P
R
Q
S
E
E
P
Site 59
S475
D
T
I
T
P
R
Q
S
E
E
P
H
I
K
G
Site 60
S497
F
P
K
Q
A
V
F
S
V
S
N
P
H
S
E
Site 61
S499
K
Q
A
V
F
S
V
S
N
P
H
S
E
I
V
Site 62
Y526
I
A
S
G
A
E
P
Y
I
K
N
P
D
S
N
Site 63
S532
P
Y
I
K
N
P
D
S
N
K
Y
A
Q
K
I
Site 64
Y535
K
N
P
D
S
N
K
Y
A
Q
K
I
L
K
S
Site 65
S548
K
S
N
R
Q
F
C
S
K
L
G
K
Y
R
M
Site 66
Y553
F
C
S
K
L
G
K
Y
R
M
P
F
A
W
A
Site 67
Y563
P
F
A
W
A
V
R
Y
V
F
K
D
N
Q
G
Site 68
S576
Q
G
N
V
D
R
D
S
R
F
S
P
L
F
R
Site 69
S579
V
D
R
D
S
R
F
S
P
L
F
R
Q
E
S
Site 70
S586
S
P
L
F
R
Q
E
S
S
K
I
S
T
E
D
Site 71
S590
R
Q
E
S
S
K
I
S
T
E
D
L
V
K
L
Site 72
T591
Q
E
S
S
K
I
S
T
E
D
L
V
K
L
V
Site 73
S599
E
D
L
V
K
L
V
S
D
Y
R
R
A
D
R
Site 74
Y601
L
V
K
L
V
S
D
Y
R
R
A
D
R
I
S
Site 75
S608
Y
R
R
A
D
R
I
S
K
M
Q
T
I
P
G
Site 76
T612
D
R
I
S
K
M
Q
T
I
P
G
S
L
D
I
Site 77
S616
K
M
Q
T
I
P
G
S
L
D
I
A
V
D
N
Site 78
T651
M
M
A
Q
T
E
P
T
V
E
V
E
E
F
V
Site 79
Y659
V
E
V
E
E
F
V
Y
D
S
T
K
Y
C
R
Site 80
Y664
F
V
Y
D
S
T
K
Y
C
R
P
Y
R
V
Y
Site 81
Y668
S
T
K
Y
C
R
P
Y
R
V
Y
K
N
Q
I
Site 82
Y671
Y
C
R
P
Y
R
V
Y
K
N
Q
I
Y
I
Y
Site 83
Y676
R
V
Y
K
N
Q
I
Y
I
Y
P
K
H
L
K
Site 84
Y678
Y
K
N
Q
I
Y
I
Y
P
K
H
L
K
Y
D
Site 85
Y684
I
Y
P
K
H
L
K
Y
D
S
Q
K
C
F
N
Site 86
S686
P
K
H
L
K
Y
D
S
Q
K
C
F
N
K
A
Site 87
T697
F
N
K
A
R
N
I
T
V
C
I
E
F
K
N
Site 88
S705
V
C
I
E
F
K
N
S
D
E
E
S
A
K
P
Site 89
S709
F
K
N
S
D
E
E
S
A
K
P
L
K
C
I
Site 90
Y717
A
K
P
L
K
C
I
Y
G
K
P
G
G
P
L
Site 91
S737
Y
T
A
V
L
H
H
S
Q
N
P
D
F
S
D
Site 92
S743
H
S
Q
N
P
D
F
S
D
E
V
K
I
E
L
Site 93
Y765
H
H
I
L
F
S
F
Y
H
V
T
C
D
I
N
Site 94
T785
K
K
K
E
A
L
E
T
S
V
G
Y
A
W
L
Site 95
Y805
D
Q
I
A
S
Q
E
Y
N
I
P
I
A
T
S
Site 96
S812
Y
N
I
P
I
A
T
S
L
P
P
N
Y
L
S
Site 97
Y817
A
T
S
L
P
P
N
Y
L
S
F
Q
D
S
A
Site 98
S819
S
L
P
P
N
Y
L
S
F
Q
D
S
A
S
H
Site 99
S823
N
Y
L
S
F
Q
D
S
A
S
H
G
G
S
D
Site 100
S825
L
S
F
Q
D
S
A
S
H
G
G
S
D
I
K
Site 101
S829
D
S
A
S
H
G
G
S
D
I
K
W
V
D
G
Site 102
T853
F
V
V
S
T
V
N
T
Q
D
P
H
V
N
A
Site 103
S873
Q
K
R
E
K
D
M
S
Q
S
P
T
S
N
F
Site 104
S875
R
E
K
D
M
S
Q
S
P
T
S
N
F
I
R
Site 105
T877
K
D
M
S
Q
S
P
T
S
N
F
I
R
S
C
Site 106
S878
D
M
S
Q
S
P
T
S
N
F
I
R
S
C
K
Site 107
T920
Q
N
E
E
D
E
I
T
T
T
V
T
R
V
L
Site 108
T922
E
E
D
E
I
T
T
T
V
T
R
V
L
T
D
Site 109
S942
H
E
E
Q
L
D
H
S
V
Q
S
Y
I
K
F
Site 110
Y946
L
D
H
S
V
Q
S
Y
I
K
F
V
F
K
T
Site 111
T960
T
R
A
C
K
E
R
T
V
H
E
E
L
A
K
Site 112
S975
N
V
T
G
L
L
K
S
N
D
S
T
T
V
K
Site 113
S978
G
L
L
K
S
N
D
S
T
T
V
K
H
V
L
Site 114
T979
L
L
K
S
N
D
S
T
T
V
K
H
V
L
E
Site 115
T980
L
K
S
N
D
S
T
T
V
K
H
V
L
E
H
Site 116
T1006
M
A
Q
H
L
I
D
T
N
K
I
Q
L
P
R
Site 117
S1020
R
P
Q
R
F
P
E
S
Y
Q
N
E
L
D
N
Site 118
Y1021
P
Q
R
F
P
E
S
Y
Q
N
E
L
D
N
L
Site 119
Y1040
S
D
H
V
I
W
K
Y
K
D
A
L
E
E
T
Site 120
S1053
E
T
R
R
A
N
H
S
V
A
R
F
L
K
R
Site 121
Y1069
F
T
F
M
D
R
G
Y
V
F
K
M
V
N
N
Site 122
Y1092
D
F
Q
T
L
C
Q
Y
K
F
D
F
L
Q
E
Site 123
T1123
A
N
I
P
D
P
L
T
P
S
E
S
T
Q
E
Site 124
S1125
I
P
D
P
L
T
P
S
E
S
T
Q
E
L
H
Site 125
S1127
D
P
L
T
P
S
E
S
T
Q
E
L
H
A
S
Site 126
S1134
S
T
Q
E
L
H
A
S
D
M
P
E
Y
S
V
Site 127
Y1139
H
A
S
D
M
P
E
Y
S
V
T
N
E
F
C
Site 128
S1140
A
S
D
M
P
E
Y
S
V
T
N
E
F
C
R
Site 129
S1185
K
N
L
M
A
K
H
S
F
D
D
R
Y
R
E
Site 130
Y1190
K
H
S
F
D
D
R
Y
R
E
R
K
Q
A
Q
Site 131
S1200
R
K
Q
A
Q
I
A
S
L
Y
M
P
L
Y
G
Site 132
Y1217
L
D
N
M
P
R
I
Y
L
K
D
L
Y
P
F
Site 133
Y1222
R
I
Y
L
K
D
L
Y
P
F
T
V
N
T
S
Site 134
T1225
L
K
D
L
Y
P
F
T
V
N
T
S
N
Q
G
Site 135
T1228
L
Y
P
F
T
V
N
T
S
N
Q
G
S
R
D
Site 136
S1229
Y
P
F
T
V
N
T
S
N
Q
G
S
R
D
D
Site 137
S1233
V
N
T
S
N
Q
G
S
R
D
D
L
S
T
N
Site 138
S1238
Q
G
S
R
D
D
L
S
T
N
G
G
F
Q
S
Site 139
T1239
G
S
R
D
D
L
S
T
N
G
G
F
Q
S
Q
Site 140
S1245
S
T
N
G
G
F
Q
S
Q
T
A
I
K
H
A
Site 141
S1254
T
A
I
K
H
A
N
S
V
D
T
S
F
S
K
Site 142
T1257
K
H
A
N
S
V
D
T
S
F
S
K
D
V
L
Site 143
S1258
H
A
N
S
V
D
T
S
F
S
K
D
V
L
N
Site 144
S1260
N
S
V
D
T
S
F
S
K
D
V
L
N
S
I
Site 145
S1283
S
T
V
N
H
A
D
S
R
A
S
L
A
S
L
Site 146
S1286
N
H
A
D
S
R
A
S
L
A
S
L
D
S
N
Site 147
S1289
D
S
R
A
S
L
A
S
L
D
S
N
P
S
T
Site 148
S1292
A
S
L
A
S
L
D
S
N
P
S
T
N
E
K
Site 149
S1295
A
S
L
A
S
L
D
S
N
P
S
T
N
E
K
Site 150
T1296
S
L
D
S
N
P
S
T
N
E
K
S
S
E
K
Site 151
S1300
N
P
S
T
N
E
K
S
S
E
K
T
D
N
C
Site 152
T1304
N
E
K
S
S
E
K
T
D
N
C
E
K
V
P
Site 153
S1315
E
K
V
P
R
P
L
S
L
I
G
S
T
L
R
Site 154
S1319
R
P
L
S
L
I
G
S
T
L
R
F
D
K
L
Site 155
Y1353
S
D
E
T
L
I
A
Y
W
Q
R
A
P
S
P
Site 156
S1359
A
Y
W
Q
R
A
P
S
P
E
V
S
D
F
F
Site 157
S1363
R
A
P
S
P
E
V
S
D
F
F
S
I
L
E
Site 158
T1403
Q
S
T
Q
N
N
G
T
L
K
G
S
N
P
S
Site 159
S1410
T
L
K
G
S
N
P
S
C
Q
T
S
G
L
L
Site 160
T1413
G
S
N
P
S
C
Q
T
S
G
L
L
S
Q
W
Site 161
S1414
S
N
P
S
C
Q
T
S
G
L
L
S
Q
W
M
Site 162
S1418
C
Q
T
S
G
L
L
S
Q
W
M
H
S
T
S
Site 163
S1423
L
L
S
Q
W
M
H
S
T
S
S
H
E
G
H
Site 164
S1425
S
Q
W
M
H
S
T
S
S
H
E
G
H
K
Q
Site 165
S1435
E
G
H
K
Q
H
R
S
Q
T
L
P
I
I
R
Site 166
T1437
H
K
Q
H
R
S
Q
T
L
P
I
I
R
G
K
Site 167
S1448
I
R
G
K
N
A
L
S
N
P
K
L
L
Q
M
Site 168
S1573
L
K
C
C
N
H
R
S
R
S
T
Q
T
E
A
Site 169
S1575
C
C
N
H
R
S
R
S
T
Q
T
E
A
S
A
Site 170
T1576
C
N
H
R
S
R
S
T
Q
T
E
A
S
A
L
Site 171
S1599
F
E
F
N
K
Q
K
S
I
V
R
S
H
L
Q
Site 172
S1603
K
Q
K
S
I
V
R
S
H
L
Q
L
I
K
A
Site 173
S1628
G
G
S
R
F
Q
H
S
L
A
I
T
N
N
F
Site 174
T1632
F
Q
H
S
L
A
I
T
N
N
F
A
N
G
D
Site 175
T1655
P
A
E
V
K
D
L
T
K
R
I
R
T
V
L
Site 176
T1660
D
L
T
K
R
I
R
T
V
L
M
A
T
A
Q
Site 177
S1688
L
Q
Y
S
L
A
N
S
Y
A
S
T
P
E
L
Site 178
T1692
L
A
N
S
Y
A
S
T
P
E
L
R
R
T
W
Site 179
T1698
S
T
P
E
L
R
R
T
W
L
E
S
M
A
K
Site 180
S1702
L
R
R
T
W
L
E
S
M
A
K
I
H
A
R
Site 181
Y1736
E
Y
L
K
R
K
G
Y
W
K
V
E
K
I
C
Site 182
T1744
W
K
V
E
K
I
C
T
A
S
L
L
S
E
D
Site 183
S1746
V
E
K
I
C
T
A
S
L
L
S
E
D
T
H
Site 184
T1752
A
S
L
L
S
E
D
T
H
P
C
D
S
N
S
Site 185
S1757
E
D
T
H
P
C
D
S
N
S
L
L
T
T
P
Site 186
S1759
T
H
P
C
D
S
N
S
L
L
T
T
P
S
G
Site 187
T1762
C
D
S
N
S
L
L
T
T
P
S
G
G
S
M
Site 188
T1763
D
S
N
S
L
L
T
T
P
S
G
G
S
M
F
Site 189
S1765
N
S
L
L
T
T
P
S
G
G
S
M
F
S
M
Site 190
S1768
L
T
T
P
S
G
G
S
M
F
S
M
G
W
P
Site 191
T1781
W
P
A
F
L
S
I
T
P
N
I
K
E
E
G
Site 192
S1794
E
G
A
M
K
E
D
S
G
M
Q
D
T
P
Y
Site 193
T1799
E
D
S
G
M
Q
D
T
P
Y
N
E
N
I
L
Site 194
Y1801
S
G
M
Q
D
T
P
Y
N
E
N
I
L
V
E
Site 195
S1847
Q
R
D
F
K
K
L
S
D
L
Y
Y
D
I
H
Site 196
Y1850
F
K
K
L
S
D
L
Y
Y
D
I
H
R
S
Y
Site 197
Y1851
K
K
L
S
D
L
Y
Y
D
I
H
R
S
Y
L
Site 198
Y1857
Y
Y
D
I
H
R
S
Y
L
K
V
A
E
V
V
Site 199
S1866
K
V
A
E
V
V
N
S
E
K
R
L
F
G
R
Site 200
Y1874
E
K
R
L
F
G
R
Y
Y
R
V
A
F
Y
G
Site 201
Y1875
K
R
L
F
G
R
Y
Y
R
V
A
F
Y
G
Q
Site 202
Y1893
E
E
E
E
G
K
E
Y
I
Y
K
E
P
K
L
Site 203
Y1895
E
E
G
K
E
Y
I
Y
K
E
P
K
L
T
G
Site 204
T1901
I
Y
K
E
P
K
L
T
G
L
S
E
I
S
Q
Site 205
S1904
E
P
K
L
T
G
L
S
E
I
S
Q
R
L
L
Site 206
Y1914
S
Q
R
L
L
K
L
Y
A
D
K
F
G
A
D
Site 207
Y1941
P
K
D
L
D
P
K
Y
A
Y
I
Q
V
T
Y
Site 208
T1950
Y
I
Q
V
T
Y
V
T
P
F
F
E
E
K
E
Site 209
T1978
I
N
R
F
V
F
E
T
P
F
T
L
S
G
K
Site 210
T1981
F
V
F
E
T
P
F
T
L
S
G
K
K
H
G
Site 211
S1983
F
E
T
P
F
T
L
S
G
K
K
H
G
G
V
Site 212
T1998
A
E
Q
C
K
R
R
T
I
L
T
T
S
H
L
Site 213
T2001
C
K
R
R
T
I
L
T
T
S
H
L
F
P
Y
Site 214
T2002
K
R
R
T
I
L
T
T
S
H
L
F
P
Y
V
Site 215
Y2008
T
T
S
H
L
F
P
Y
V
K
K
R
I
Q
V
Site 216
S2017
K
K
R
I
Q
V
I
S
Q
S
S
T
E
L
N
Site 217
S2019
R
I
Q
V
I
S
Q
S
S
T
E
L
N
P
I
Site 218
T2021
Q
V
I
S
Q
S
S
T
E
L
N
P
I
E
V
Site 219
S2034
E
V
A
I
D
E
M
S
K
K
V
S
E
L
N
Site 220
S2038
D
E
M
S
K
K
V
S
E
L
N
Q
L
C
T
Site 221
T2045
S
E
L
N
Q
L
C
T
M
E
E
V
D
M
I
Site 222
Y2073
V
N
A
G
P
M
A
Y
A
R
A
F
L
E
E
Site 223
Y2086
E
E
T
N
A
K
K
Y
P
D
N
Q
V
K
L
Site 224
Y2123
I
K
E
D
Q
L
E
Y
Q
E
E
L
R
S
H
Site 225
S2129
E
Y
Q
E
E
L
R
S
H
Y
K
D
M
L
S
Site 226
Y2131
Q
E
E
L
R
S
H
Y
K
D
M
L
S
E
L
Site 227
S2136
S
H
Y
K
D
M
L
S
E
L
S
T
V
M
N
Site 228
T2140
D
M
L
S
E
L
S
T
V
M
N
E
Q
I
T
Site 229
S2153
I
T
G
R
D
D
L
S
K
R
G
V
D
Q
T
Site 230
T2160
S
K
R
G
V
D
Q
T
C
T
R
V
I
S
K
Site 231
T2162
R
G
V
D
Q
T
C
T
R
V
I
S
K
A
T
Site 232
S2166
Q
T
C
T
R
V
I
S
K
A
T
P
A
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation