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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALKBH8
Full Name:
Alkylated DNA repair protein alkB homolog 8
Alias:
Probable alpha-ketoglutarate-dependent dioxygenase ABH8;S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8
Type:
Mass (Da):
75208
Number AA:
664
UniProt ID:
Q96BT7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
S
N
Y
K
L
S
K
T
E
K
K
F
L
R
K
Site 2
T37
L
R
H
E
G
I
E
T
V
S
Y
A
T
Q
S
Site 3
S39
H
E
G
I
E
T
V
S
Y
A
T
Q
S
L
V
Site 4
S57
G
G
L
G
N
G
V
S
R
N
Q
L
L
P
V
Site 5
S83
M
P
P
N
K
P
Y
S
F
A
R
Y
R
T
T
Site 6
Y87
K
P
Y
S
F
A
R
Y
R
T
T
E
E
S
K
Site 7
T89
Y
S
F
A
R
Y
R
T
T
E
E
S
K
R
A
Site 8
T90
S
F
A
R
Y
R
T
T
E
E
S
K
R
A
Y
Site 9
S93
R
Y
R
T
T
E
E
S
K
R
A
Y
V
T
L
Site 10
Y97
T
E
E
S
K
R
A
Y
V
T
L
N
G
K
E
Site 11
S145
M
V
V
E
E
I
I
S
S
E
E
E
K
M
L
Site 12
S155
E
E
K
M
L
L
E
S
V
D
W
T
E
D
T
Site 13
T159
L
L
E
S
V
D
W
T
E
D
T
D
N
Q
N
Site 14
T162
S
V
D
W
T
E
D
T
D
N
Q
N
S
Q
K
Site 15
S167
E
D
T
D
N
Q
N
S
Q
K
S
L
K
H
R
Site 16
S170
D
N
Q
N
S
Q
K
S
L
K
H
R
R
V
K
Site 17
Y181
R
R
V
K
H
F
G
Y
E
F
H
Y
E
N
N
Site 18
Y185
H
F
G
Y
E
F
H
Y
E
N
N
N
V
D
K
Site 19
S197
V
D
K
D
K
P
L
S
G
G
L
P
D
I
C
Site 20
S206
G
L
P
D
I
C
E
S
F
L
E
K
W
L
R
Site 21
Y216
E
K
W
L
R
K
G
Y
I
K
H
K
P
D
Q
Site 22
T225
K
H
K
P
D
Q
M
T
I
N
Q
Y
E
P
G
Site 23
Y229
D
Q
M
T
I
N
Q
Y
E
P
G
Q
G
I
P
Site 24
T241
G
I
P
A
H
I
D
T
H
S
A
F
E
D
E
Site 25
S243
P
A
H
I
D
T
H
S
A
F
E
D
E
I
V
Site 26
Y288
V
M
T
G
E
S
R
Y
L
W
T
H
G
I
T
Site 27
T301
I
T
C
R
K
F
D
T
V
Q
A
S
E
S
L
Site 28
S305
K
F
D
T
V
Q
A
S
E
S
L
K
S
G
I
Site 29
S307
D
T
V
Q
A
S
E
S
L
K
S
G
I
I
T
Site 30
S310
Q
A
S
E
S
L
K
S
G
I
I
T
S
D
V
Site 31
T321
T
S
D
V
G
D
L
T
L
S
K
R
G
L
R
Site 32
S323
D
V
G
D
L
T
L
S
K
R
G
L
R
T
S
Site 33
S330
S
K
R
G
L
R
T
S
F
T
F
R
K
V
R
Site 34
T332
R
G
L
R
T
S
F
T
F
R
K
V
R
Q
T
Site 35
T339
T
F
R
K
V
R
Q
T
P
C
N
C
S
Y
P
Site 36
Y345
Q
T
P
C
N
C
S
Y
P
L
V
C
D
S
Q
Site 37
S351
S
Y
P
L
V
C
D
S
Q
R
K
E
T
P
P
Site 38
T356
C
D
S
Q
R
K
E
T
P
P
S
F
P
E
S
Site 39
S359
Q
R
K
E
T
P
P
S
F
P
E
S
D
K
E
Site 40
S363
T
P
P
S
F
P
E
S
D
K
E
A
S
R
L
Site 41
Y374
A
S
R
L
E
Q
E
Y
V
H
Q
V
Y
E
E
Site 42
Y379
Q
E
Y
V
H
Q
V
Y
E
E
I
A
G
H
F
Site 43
S388
E
I
A
G
H
F
S
S
T
R
H
T
P
W
P
Site 44
T392
H
F
S
S
T
R
H
T
P
W
P
H
I
V
E
Site 45
Y420
I
G
C
G
N
G
K
Y
L
G
I
N
K
E
L
Site 46
Y428
L
G
I
N
K
E
L
Y
M
I
G
C
D
R
S
Site 47
Y502
P
G
G
K
A
L
I
Y
V
W
A
M
E
Q
E
Site 48
Y510
V
W
A
M
E
Q
E
Y
N
K
Q
K
S
K
Y
Site 49
S515
Q
E
Y
N
K
Q
K
S
K
Y
L
R
G
N
R
Site 50
Y517
Y
N
K
Q
K
S
K
Y
L
R
G
N
R
N
S
Site 51
S524
Y
L
R
G
N
R
N
S
Q
G
K
K
E
E
M
Site 52
S533
G
K
K
E
E
M
N
S
D
T
S
V
Q
R
S
Site 53
T535
K
E
E
M
N
S
D
T
S
V
Q
R
S
L
V
Site 54
S536
E
E
M
N
S
D
T
S
V
Q
R
S
L
V
E
Site 55
S540
S
D
T
S
V
Q
R
S
L
V
E
Q
M
R
D
Site 56
S550
E
Q
M
R
D
M
G
S
R
D
S
A
S
S
V
Site 57
S553
R
D
M
G
S
R
D
S
A
S
S
V
P
R
I
Site 58
S555
M
G
S
R
D
S
A
S
S
V
P
R
I
N
D
Site 59
S556
G
S
R
D
S
A
S
S
V
P
R
I
N
D
S
Site 60
S563
S
V
P
R
I
N
D
S
Q
E
G
G
C
N
S
Site 61
S570
S
Q
E
G
G
C
N
S
R
Q
V
S
N
S
K
Site 62
S574
G
C
N
S
R
Q
V
S
N
S
K
L
P
V
H
Site 63
S576
N
S
R
Q
V
S
N
S
K
L
P
V
H
V
N
Site 64
S586
P
V
H
V
N
R
T
S
F
Y
S
Q
D
V
L
Site 65
S589
V
N
R
T
S
F
Y
S
Q
D
V
L
V
P
W
Site 66
S616
E
P
F
G
P
I
G
S
Q
D
P
S
P
V
F
Site 67
S620
P
I
G
S
Q
D
P
S
P
V
F
H
R
Y
Y
Site 68
Y626
P
S
P
V
F
H
R
Y
Y
H
V
F
R
E
G
Site 69
Y627
S
P
V
F
H
R
Y
Y
H
V
F
R
E
G
E
Site 70
S643
E
G
A
C
R
T
V
S
D
V
R
I
L
Q
S
Site 71
Y651
D
V
R
I
L
Q
S
Y
Y
D
Q
G
N
W
C
Site 72
Y652
V
R
I
L
Q
S
Y
Y
D
Q
G
N
W
C
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation