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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPWD1
Full Name:
Peptidylprolyl isomerase domain and WD repeat-containing protein 1
Alias:
Spliceosome-associated cyclophilin
Type:
Mass (Da):
73575
Number AA:
646
UniProt ID:
Q96BP3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0003755
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
D
P
E
E
P
E
K
T
E
L
S
E
R
E
L
Site 2
S28
E
P
E
K
T
E
L
S
E
R
E
L
A
V
A
Site 3
T59
G
P
L
P
V
E
A
T
L
A
K
K
R
K
V
Site 4
S79
V
Y
L
D
N
L
P
S
A
S
M
Y
E
R
S
Site 5
S81
L
D
N
L
P
S
A
S
M
Y
E
R
S
Y
M
Site 6
Y83
N
L
P
S
A
S
M
Y
E
R
S
Y
M
H
R
Site 7
Y87
A
S
M
Y
E
R
S
Y
M
H
R
D
V
I
T
Site 8
T99
V
I
T
H
V
V
C
T
K
T
D
F
I
I
T
Site 9
S131
E
F
V
K
H
F
R
S
H
L
G
V
I
E
S
Site 10
S150
S
E
G
A
L
F
C
S
V
G
D
D
K
A
M
Site 11
Y175
I
N
M
L
K
L
G
Y
F
P
G
Q
C
E
W
Site 12
S191
Y
C
P
G
D
A
I
S
S
V
A
A
S
E
K
Site 13
S192
C
P
G
D
A
I
S
S
V
A
A
S
E
K
S
Site 14
S196
A
I
S
S
V
A
A
S
E
K
S
T
G
K
I
Site 15
T200
V
A
A
S
E
K
S
T
G
K
I
F
I
Y
D
Site 16
Y206
S
T
G
K
I
F
I
Y
D
G
R
G
D
N
Q
Site 17
S224
I
F
D
K
L
H
T
S
P
L
T
Q
I
R
L
Site 18
T227
K
L
H
T
S
P
L
T
Q
I
R
L
N
P
V
Site 19
Y235
Q
I
R
L
N
P
V
Y
K
A
V
V
S
S
D
Site 20
S241
V
Y
K
A
V
V
S
S
D
K
S
G
M
I
E
Site 21
S244
A
V
V
S
S
D
K
S
G
M
I
E
Y
W
T
Site 22
Y249
D
K
S
G
M
I
E
Y
W
T
G
P
P
H
E
Site 23
Y257
W
T
G
P
P
H
E
Y
K
F
P
K
N
V
N
Site 24
Y267
P
K
N
V
N
W
E
Y
K
T
D
T
D
L
Y
Site 25
T271
N
W
E
Y
K
T
D
T
D
L
Y
E
F
A
K
Site 26
Y274
Y
K
T
D
T
D
L
Y
E
F
A
K
C
K
A
Site 27
Y282
E
F
A
K
C
K
A
Y
P
T
S
V
C
F
S
Site 28
T284
A
K
C
K
A
Y
P
T
S
V
C
F
S
P
D
Site 29
S285
K
C
K
A
Y
P
T
S
V
C
F
S
P
D
G
Site 30
S289
Y
P
T
S
V
C
F
S
P
D
G
K
K
I
A
Site 31
S300
K
K
I
A
T
I
G
S
D
R
K
V
R
I
F
Site 32
S323
R
V
F
D
E
S
L
S
M
F
T
E
L
Q
Q
Site 33
T417
A
K
K
H
R
A
A
T
T
I
E
M
K
A
S
Site 34
S424
T
T
I
E
M
K
A
S
E
N
P
V
L
Q
N
Site 35
T437
Q
N
I
Q
A
D
P
T
I
V
C
T
S
F
K
Site 36
Y449
S
F
K
K
N
R
F
Y
M
F
T
K
R
E
P
Site 37
T452
K
N
R
F
Y
M
F
T
K
R
E
P
E
D
T
Site 38
T459
T
K
R
E
P
E
D
T
K
S
A
D
S
D
R
Site 39
S461
R
E
P
E
D
T
K
S
A
D
S
D
R
D
V
Site 40
S464
E
D
T
K
S
A
D
S
D
R
D
V
F
N
E
Site 41
S491
A
E
G
P
K
R
V
S
D
S
A
I
I
H
T
Site 42
S493
G
P
K
R
V
S
D
S
A
I
I
H
T
S
M
Site 43
Y528
V
H
S
R
N
G
Y
Y
N
G
H
T
F
H
R
Site 44
T544
I
K
G
F
M
I
Q
T
G
D
P
T
G
T
G
Site 45
T548
M
I
Q
T
G
D
P
T
G
T
G
M
G
G
E
Site 46
S556
G
T
G
M
G
G
E
S
I
W
G
G
E
F
E
Site 47
T569
F
E
D
E
F
H
S
T
L
R
H
D
R
P
Y
Site 48
Y576
T
L
R
H
D
R
P
Y
T
L
S
M
A
N
A
Site 49
T577
L
R
H
D
R
P
Y
T
L
S
M
A
N
A
G
Site 50
S579
H
D
R
P
Y
T
L
S
M
A
N
A
G
S
N
Site 51
S585
L
S
M
A
N
A
G
S
N
T
N
G
S
Q
F
Site 52
T607
P
W
L
D
N
K
H
T
V
F
G
R
V
T
K
Site 53
S623
M
E
V
V
Q
R
I
S
N
V
K
V
N
P
K
Site 54
T631
N
V
K
V
N
P
K
T
D
K
P
Y
E
D
V
Site 55
Y635
N
P
K
T
D
K
P
Y
E
D
V
S
I
I
N
Site 56
S639
D
K
P
Y
E
D
V
S
I
I
N
I
T
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation