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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EME1
Full Name:
Crossover junction endonuclease EME1
Alias:
crossover junction endonuclease EME1; essential meiotic endonuclease 1 1; FLJ31364; MMS4; MMS4L
Type:
EC 3.1.22.-; Deoxyribonuclease
Mass (Da):
63252
Number AA:
570
UniProt ID:
Q96AY2
International Prot ID:
IPI00073193
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0004519
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
L
K
K
S
S
P
S
L
D
S
G
Site 2
S7
_
M
A
L
K
K
S
S
P
S
L
D
S
G
D
Site 3
S9
A
L
K
K
S
S
P
S
L
D
S
G
D
S
D
Site 4
S12
K
S
S
P
S
L
D
S
G
D
S
D
S
E
E
Site 5
S15
P
S
L
D
S
G
D
S
D
S
E
E
L
P
T
Site 6
S17
L
D
S
G
D
S
D
S
E
E
L
P
T
F
A
Site 7
T22
S
D
S
E
E
L
P
T
F
A
F
L
K
K
E
Site 8
S31
A
F
L
K
K
E
P
S
S
T
K
R
R
Q
P
Site 9
S32
F
L
K
K
E
P
S
S
T
K
R
R
Q
P
E
Site 10
T33
L
K
K
E
P
S
S
T
K
R
R
Q
P
E
R
Site 11
S55
D
I
S
D
C
E
A
S
C
P
P
A
P
E
L
Site 12
S64
P
P
A
P
E
L
F
S
P
P
V
P
E
I
A
Site 13
T73
P
V
P
E
I
A
E
T
V
T
Q
T
Q
P
V
Site 14
S84
T
Q
P
V
R
L
L
S
S
E
S
E
D
E
E
Site 15
S85
Q
P
V
R
L
L
S
S
E
S
E
D
E
E
E
Site 16
S87
V
R
L
L
S
S
E
S
E
D
E
E
E
F
I
Site 17
T106
R
L
T
C
K
F
L
T
H
K
Q
L
S
P
E
Site 18
S111
F
L
T
H
K
Q
L
S
P
E
D
S
S
S
P
Site 19
S115
K
Q
L
S
P
E
D
S
S
S
P
V
K
S
V
Site 20
S116
Q
L
S
P
E
D
S
S
S
P
V
K
S
V
L
Site 21
S117
L
S
P
E
D
S
S
S
P
V
K
S
V
L
D
Site 22
S121
D
S
S
S
P
V
K
S
V
L
D
H
Q
N
N
Site 23
T150
P
E
V
P
L
H
D
T
P
E
R
S
A
A
D
Site 24
S174
C
Q
L
P
A
Y
L
S
T
C
P
G
Q
S
S
Site 25
T175
Q
L
P
A
Y
L
S
T
C
P
G
Q
S
S
S
Site 26
S182
T
C
P
G
Q
S
S
S
L
A
V
T
K
T
N
Site 27
T186
Q
S
S
S
L
A
V
T
K
T
N
S
D
I
L
Site 28
T188
S
S
L
A
V
T
K
T
N
S
D
I
L
P
P
Site 29
S190
L
A
V
T
K
T
N
S
D
I
L
P
P
Q
K
Site 30
S202
P
Q
K
K
T
K
P
S
Q
K
V
Q
G
R
G
Site 31
S210
Q
K
V
Q
G
R
G
S
H
G
C
R
Q
Q
R
Site 32
S224
R
Q
A
R
Q
K
E
S
T
L
R
R
Q
E
R
Site 33
T225
Q
A
R
Q
K
E
S
T
L
R
R
Q
E
R
K
Site 34
S290
E
A
Q
A
V
P
C
S
V
T
W
R
R
R
A
Site 35
T292
Q
A
V
P
C
S
V
T
W
R
R
R
A
G
P
Site 36
S300
W
R
R
R
A
G
P
S
E
D
R
E
D
W
V
Site 37
S323
L
R
A
E
A
F
V
S
M
I
D
N
G
K
Q
Site 38
S332
I
D
N
G
K
Q
G
S
L
D
S
T
M
K
G
Site 39
S335
G
K
Q
G
S
L
D
S
T
M
K
G
K
E
T
Site 40
T336
K
Q
G
S
L
D
S
T
M
K
G
K
E
T
L
Site 41
T342
S
T
M
K
G
K
E
T
L
Q
G
F
V
T
D
Site 42
T351
Q
G
F
V
T
D
I
T
A
K
T
A
G
K
A
Site 43
S371
V
D
Q
E
K
C
F
S
A
Q
N
P
P
R
R
Site 44
S398
Q
Q
R
Q
P
E
A
S
I
G
S
M
V
S
R
Site 45
T455
F
K
K
L
R
D
E
T
T
F
S
F
C
L
E
Site 46
T456
K
K
L
R
D
E
T
T
F
S
F
C
L
E
S
Site 47
S458
L
R
D
E
T
T
F
S
F
C
L
E
S
D
W
Site 48
Y514
P
Q
L
L
V
Q
A
Y
Q
Q
C
F
S
D
K
Site 49
T539
V
R
R
G
E
G
V
T
S
T
S
R
R
I
G
Site 50
S540
R
R
G
E
G
V
T
S
T
S
R
R
I
G
P
Site 51
T541
R
G
E
G
V
T
S
T
S
R
R
I
G
P
E
Site 52
S542
G
E
G
V
T
S
T
S
R
R
I
G
P
E
L
Site 53
S550
R
R
I
G
P
E
L
S
R
R
I
Y
L
Q
M
Site 54
Y554
P
E
L
S
R
R
I
Y
L
Q
M
T
T
L
Q
Site 55
S565
T
T
L
Q
P
H
L
S
L
D
S
A
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation