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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PNPLA2
Full Name:
Patatin-like phospholipase domain-containing protein 2
Alias:
Adipose triglyceride lipase; ATGL; Calcium-independent phospholipase A2; Desnutrin; FP17548; IPLA2-zeta; Patatin-like phospholipase domain containing 2; Pigment epithelium-derived factor; PLPL2; Transport-secretion protein 2; TTS2; TTS-2.2
Type:
EC 3.1.1.3; Lipase
Mass (Da):
55320
Number AA:
UniProt ID:
Q96AD5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0012511
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004806
PhosphoSite+
KinaseNET
Biological Process:
GO:0010891
GO:0010898
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S106
L
K
V
L
P
A
D
S
H
E
H
A
S
G
R
Site 2
S111
A
D
S
H
E
H
A
S
G
R
L
G
I
S
L
Site 3
S117
A
S
G
R
L
G
I
S
L
T
R
V
S
D
G
Site 4
T119
G
R
L
G
I
S
L
T
R
V
S
D
G
E
N
Site 5
Y164
P
S
L
Q
G
V
R
Y
V
D
G
G
I
S
D
Site 6
Y176
I
S
D
N
L
P
L
Y
E
L
K
N
T
I
T
Site 7
T181
P
L
Y
E
L
K
N
T
I
T
V
S
P
F
S
Site 8
T183
Y
E
L
K
N
T
I
T
V
S
P
F
S
G
E
Site 9
S185
L
K
N
T
I
T
V
S
P
F
S
G
E
S
D
Site 10
S198
S
D
I
C
P
Q
D
S
S
T
N
I
H
E
L
Site 11
S199
D
I
C
P
Q
D
S
S
T
N
I
H
E
L
R
Site 12
T200
I
C
P
Q
D
S
S
T
N
I
H
E
L
R
V
Site 13
T208
N
I
H
E
L
R
V
T
N
T
S
I
Q
F
N
Site 14
S211
E
L
R
V
T
N
T
S
I
Q
F
N
L
R
N
Site 15
Y220
Q
F
N
L
R
N
L
Y
R
L
S
K
A
L
F
Site 16
S223
L
R
N
L
Y
R
L
S
K
A
L
F
P
P
E
Site 17
S281
D
K
D
Q
A
V
E
S
A
Q
A
E
D
Y
S
Site 18
Y287
E
S
A
Q
A
E
D
Y
S
Q
L
P
G
E
D
Site 19
S288
S
A
Q
A
E
D
Y
S
Q
L
P
G
E
D
H
Site 20
Y376
Q
T
G
S
I
C
Q
Y
L
V
M
R
A
K
R
Site 21
S404
V
E
L
R
R
V
Q
S
L
P
S
V
P
L
S
Site 22
S407
R
R
V
Q
S
L
P
S
V
P
L
S
C
A
A
Site 23
Y415
V
P
L
S
C
A
A
Y
R
E
A
L
P
G
W
Site 24
S428
G
W
M
R
N
N
L
S
L
G
D
A
L
A
K
Site 25
S476
P
A
P
A
D
P
A
S
P
Q
H
Q
L
A
G
Site 26
S489
A
G
P
A
P
L
L
S
T
P
A
P
E
A
R
Site 27
T490
G
P
A
P
L
L
S
T
P
A
P
E
A
R
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation