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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TOP1MT
Full Name:
DNA topoisomerase I, mitochondrial
Alias:
EC 5.99.1.2; TOP1M; TOP1mt
Type:
Mitochondrial; EC 5.99.1.2; Topoisomerase
Mass (Da):
69872
Number AA:
601
UniProt ID:
Q969P6
International Prot ID:
IPI00787825
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005739
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006259
GO:0006265
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
E
V
P
R
R
P
A
S
R
G
V
P
G
S
R
Site 2
S31
A
S
R
G
V
P
G
S
R
R
T
Q
K
G
S
Site 3
T34
G
V
P
G
S
R
R
T
Q
K
G
S
G
A
R
Site 4
S38
S
R
R
T
Q
K
G
S
G
A
R
W
E
K
E
Site 5
Y62
Q
L
E
H
K
G
P
Y
F
A
P
P
Y
E
P
Site 6
Y67
G
P
Y
F
A
P
P
Y
E
P
L
P
D
G
V
Site 7
Y78
P
D
G
V
R
F
F
Y
E
G
R
P
V
R
L
Site 8
S86
E
G
R
P
V
R
L
S
V
A
A
E
E
V
A
Site 9
Y96
A
E
E
V
A
T
F
Y
G
R
M
L
D
H
E
Site 10
Y104
G
R
M
L
D
H
E
Y
T
T
K
E
V
F
R
Site 11
S132
E
E
R
E
V
I
K
S
L
D
K
C
D
F
T
Site 12
Y144
D
F
T
E
I
H
R
Y
F
V
D
K
A
A
A
Site 13
S156
A
A
A
R
K
V
L
S
R
E
E
K
Q
K
L
Site 14
Y176
K
L
Q
Q
E
F
G
Y
C
I
L
D
G
H
Q
Site 15
T214
G
M
L
K
R
R
I
T
P
E
D
V
V
I
N
Site 16
S226
V
I
N
C
S
R
D
S
K
I
P
E
P
P
A
Site 17
S242
H
Q
W
K
E
V
R
S
D
N
T
V
T
W
L
Site 18
T245
K
E
V
R
S
D
N
T
V
T
W
L
A
A
W
Site 19
T247
V
R
S
D
N
T
V
T
W
L
A
A
W
T
E
Site 20
Y262
S
V
Q
N
S
I
K
Y
I
M
L
N
P
C
S
Site 21
S269
Y
I
M
L
N
P
C
S
K
L
K
G
E
T
A
Site 22
T282
T
A
W
Q
K
F
E
T
A
R
R
L
R
G
F
Site 23
S295
G
F
V
D
E
I
R
S
Q
Y
R
A
D
W
K
Site 24
Y297
V
D
E
I
R
S
Q
Y
R
A
D
W
K
S
R
Site 25
T337
E
D
G
E
A
A
D
T
V
G
C
C
S
L
R
Site 26
Y373
L
G
K
D
C
I
R
Y
Y
N
R
V
P
V
E
Site 27
Y374
G
K
D
C
I
R
Y
Y
N
R
V
P
V
E
K
Site 28
Y384
V
P
V
E
K
P
V
Y
K
N
L
Q
L
F
M
Site 29
T405
D
D
L
F
D
R
L
T
T
T
S
L
N
K
H
Site 30
T406
D
L
F
D
R
L
T
T
T
S
L
N
K
H
L
Site 31
S408
F
D
R
L
T
T
T
S
L
N
K
H
L
Q
E
Site 32
T421
Q
E
L
M
D
G
L
T
A
K
V
F
R
T
Y
Site 33
Y428
T
A
K
V
F
R
T
Y
N
A
S
I
T
L
Q
Site 34
S431
V
F
R
T
Y
N
A
S
I
T
L
Q
E
Q
L
Site 35
T433
R
T
Y
N
A
S
I
T
L
Q
E
Q
L
R
A
Site 36
T442
Q
E
Q
L
R
A
L
T
R
A
E
D
S
I
A
Site 37
S454
S
I
A
A
K
I
L
S
Y
N
R
A
N
R
V
Site 38
Y455
I
A
A
K
I
L
S
Y
N
R
A
N
R
V
V
Site 39
T472
L
C
N
H
Q
R
A
T
P
S
T
F
E
K
S
Site 40
T475
H
Q
R
A
T
P
S
T
F
E
K
S
M
Q
N
Site 41
S516
K
A
Q
G
D
G
K
S
R
S
V
L
E
K
K
Site 42
S518
Q
G
D
G
K
S
R
S
V
L
E
K
K
R
R
Site 43
T542
A
Q
L
S
V
Q
A
T
D
K
E
E
N
K
Q
Site 44
Y559
L
G
T
S
K
L
N
Y
L
D
P
R
I
S
I
Site 45
S581
V
P
V
E
K
I
Y
S
K
T
Q
R
E
R
F
Site 46
T583
V
E
K
I
Y
S
K
T
Q
R
E
R
F
A
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation