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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HPS3
Full Name:
Hermansky-Pudlak syndrome 3 protein
Alias:
FLJ22704; Hermansky-Pudlak syndrome 3; SUTAL
Type:
Vesicle protein
Mass (Da):
113736
Number AA:
1004
UniProt ID:
Q969F9
International Prot ID:
IPI00056324
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y69
G
R
V
L
R
L
A
Y
S
E
A
G
D
Y
L
Site 2
Y75
A
Y
S
E
A
G
D
Y
L
V
A
I
E
E
K
Site 3
T86
I
E
E
K
N
K
A
T
F
L
R
A
Y
V
N
Site 4
Y91
K
A
T
F
L
R
A
Y
V
N
W
R
N
K
R
Site 5
Y126
K
A
F
R
D
Q
M
Y
I
I
E
M
P
L
S
Site 6
S171
Q
I
I
N
E
E
F
S
L
L
D
F
E
R
S
Site 7
T228
V
H
H
H
P
H
K
T
N
N
R
I
R
R
T
Site 8
T235
T
N
N
R
I
R
R
T
E
E
G
I
S
N
E
Site 9
S240
R
R
T
E
E
G
I
S
N
E
I
S
Q
L
E
Site 10
S244
E
G
I
S
N
E
I
S
Q
L
E
S
D
D
F
Site 11
S248
N
E
I
S
Q
L
E
S
D
D
F
V
I
C
Q
Site 12
S265
L
E
L
L
G
E
K
S
E
Q
S
G
L
S
V
Site 13
S271
K
S
E
Q
S
G
L
S
V
T
L
E
S
T
G
Site 14
T273
E
Q
S
G
L
S
V
T
L
E
S
T
G
L
A
Site 15
Y286
L
A
D
E
K
R
K
Y
S
H
F
Q
H
L
L
Site 16
S287
A
D
E
K
R
K
Y
S
H
F
Q
H
L
L
Y
Site 17
Y294
S
H
F
Q
H
L
L
Y
R
R
F
A
P
D
I
Site 18
S302
R
R
F
A
P
D
I
S
S
Y
V
L
S
D
D
Site 19
S303
R
F
A
P
D
I
S
S
Y
V
L
S
D
D
I
Site 20
Y304
F
A
P
D
I
S
S
Y
V
L
S
D
D
I
K
Site 21
S307
D
I
S
S
Y
V
L
S
D
D
I
K
L
H
S
Site 22
S314
S
D
D
I
K
L
H
S
L
Q
L
L
P
I
Y
Site 23
S325
L
P
I
Y
Q
T
G
S
L
T
S
D
G
K
N
Site 24
S334
T
S
D
G
K
N
L
S
Q
E
K
E
L
L
S
Site 25
S365
V
K
S
V
E
L
M
S
V
Y
Q
Y
P
E
K
Site 26
Y367
S
V
E
L
M
S
V
Y
Q
Y
P
E
K
S
Q
Site 27
Y369
E
L
M
S
V
Y
Q
Y
P
E
K
S
Q
Q
A
Site 28
S373
V
Y
Q
Y
P
E
K
S
Q
Q
A
V
L
T
P
Site 29
S399
Q
C
F
T
V
R
C
S
A
A
A
A
R
E
E
Site 30
Y409
A
A
R
E
E
D
P
Y
M
D
T
T
L
K
A
Site 31
T413
E
D
P
Y
M
D
T
T
L
K
A
C
P
P
V
Site 32
S462
A
I
P
E
R
R
Q
S
P
K
R
L
L
S
R
Site 33
S468
Q
S
P
K
R
L
L
S
R
K
D
T
S
V
K
Site 34
T472
R
L
L
S
R
K
D
T
S
V
K
I
K
I
P
Site 35
S473
L
L
S
R
K
D
T
S
V
K
I
K
I
P
P
Site 36
Y500
T
I
S
P
V
Q
L
Y
K
E
M
V
D
Y
S
Site 37
Y506
L
Y
K
E
M
V
D
Y
S
N
T
Y
K
T
V
Site 38
T512
D
Y
S
N
T
Y
K
T
V
K
T
Q
S
C
I
Site 39
T515
N
T
Y
K
T
V
K
T
Q
S
C
I
H
L
L
Site 40
S517
Y
K
T
V
K
T
Q
S
C
I
H
L
L
S
E
Site 41
S537
R
A
A
L
M
D
A
S
Q
L
E
P
G
E
K
Site 42
Y562
C
G
H
L
G
D
C
Y
S
R
L
D
S
Q
H
Site 43
S563
G
H
L
G
D
C
Y
S
R
L
D
S
Q
H
S
Site 44
S567
D
C
Y
S
R
L
D
S
Q
H
S
H
L
T
L
Site 45
S570
S
R
L
D
S
Q
H
S
H
L
T
L
P
Y
Y
Site 46
T573
D
S
Q
H
S
H
L
T
L
P
Y
Y
K
M
S
Site 47
Y576
H
S
H
L
T
L
P
Y
Y
K
M
S
G
L
S
Site 48
Y577
S
H
L
T
L
P
Y
Y
K
M
S
G
L
S
M
Site 49
T594
V
L
A
R
T
D
W
T
V
E
D
G
L
Q
K
Site 50
Y602
V
E
D
G
L
Q
K
Y
E
R
G
L
I
F
Y
Site 51
Y609
Y
E
R
G
L
I
F
Y
I
N
H
S
L
Y
E
Site 52
Y615
F
Y
I
N
H
S
L
Y
E
N
L
D
E
E
L
Site 53
S648
Q
V
P
H
I
L
C
S
P
S
M
K
N
I
N
Site 54
S650
P
H
I
L
C
S
P
S
M
K
N
I
N
P
L
Site 55
T658
M
K
N
I
N
P
L
T
A
M
S
Y
L
R
K
Site 56
Y662
N
P
L
T
A
M
S
Y
L
R
K
L
D
T
S
Site 57
T668
S
Y
L
R
K
L
D
T
S
G
F
S
S
I
L
Site 58
S699
M
H
R
N
E
M
K
S
H
S
E
M
K
L
V
Site 59
S701
R
N
E
M
K
S
H
S
E
M
K
L
V
C
G
Site 60
S804
E
L
F
F
K
L
T
S
Q
Y
I
W
R
L
S
Site 61
Y806
F
F
K
L
T
S
Q
Y
I
W
R
L
S
K
R
Site 62
S811
S
Q
Y
I
W
R
L
S
K
R
Q
P
P
D
T
Site 63
T818
S
K
R
Q
P
P
D
T
T
P
L
R
T
S
E
Site 64
T819
K
R
Q
P
P
D
T
T
P
L
R
T
S
E
D
Site 65
S824
D
T
T
P
L
R
T
S
E
D
L
I
N
A
C
Site 66
S849
H
V
V
I
S
S
D
S
L
A
D
K
N
Y
T
Site 67
Y855
D
S
L
A
D
K
N
Y
T
E
D
L
S
K
L
Site 68
S860
K
N
Y
T
E
D
L
S
K
L
Q
S
L
I
C
Site 69
S864
E
D
L
S
K
L
Q
S
L
I
C
G
P
S
F
Site 70
Y922
C
P
E
A
V
I
P
Y
A
N
H
E
L
K
E
Site 71
T933
E
L
K
E
E
N
R
T
L
W
W
K
K
L
L
Site 72
Y954
I
K
C
G
G
E
K
Y
Q
L
Y
L
S
S
L
Site 73
Y957
G
G
E
K
Y
Q
L
Y
L
S
S
L
K
E
T
Site 74
S959
E
K
Y
Q
L
Y
L
S
S
L
K
E
T
L
S
Site 75
S960
K
Y
Q
L
Y
L
S
S
L
K
E
T
L
S
I
Site 76
Y996
F
F
L
P
Y
L
L
Y
C
S
R
K
K
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation