KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PHKB
Full Name:
Phosphorylase b kinase regulatory subunit beta
Alias:
KPBB
Type:
Protein-serine kinase, regulatory subunit
Mass (Da):
124884
Number AA:
1093
UniProt ID:
Q93100
International Prot ID:
IPI00218571
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
GO:0016020
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0005977
GO:0005976
GO:0005977
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
G
A
A
G
L
T
A
E
V
S
W
K
V
Site 2
S12
A
G
L
T
A
E
V
S
W
K
V
L
E
R
R
Site 3
T22
V
L
E
R
R
A
R
T
K
R
S
G
S
V
Y
Site 4
S25
R
R
A
R
T
K
R
S
G
S
V
Y
E
P
L
Site 5
S27
A
R
T
K
R
S
G
S
V
Y
E
P
L
K
S
Site 6
Y29
T
K
R
S
G
S
V
Y
E
P
L
K
S
I
N
Site 7
S34
S
V
Y
E
P
L
K
S
I
N
L
P
R
P
D
Site 8
T44
L
P
R
P
D
N
E
T
L
W
D
K
L
D
H
Site 9
Y52
L
W
D
K
L
D
H
Y
Y
R
I
V
K
S
T
Site 10
Y53
W
D
K
L
D
H
Y
Y
R
I
V
K
S
T
L
Site 11
S58
H
Y
Y
R
I
V
K
S
T
L
L
L
Y
Q
S
Site 12
T59
Y
Y
R
I
V
K
S
T
L
L
L
Y
Q
S
P
Site 13
T75
T
G
L
F
P
T
K
T
C
G
G
D
Q
K
A
Site 14
S117
R
T
H
E
L
E
H
S
A
I
K
C
M
R
G
Site 15
Y127
K
C
M
R
G
I
L
Y
C
Y
M
R
Q
A
D
Site 16
Y129
M
R
G
I
L
Y
C
Y
M
R
Q
A
D
K
V
Site 17
T146
F
K
Q
D
P
R
P
T
T
C
L
H
S
V
F
Site 18
T147
K
Q
D
P
R
P
T
T
C
L
H
S
V
F
N
Site 19
S163
H
T
G
D
E
L
L
S
Y
E
E
Y
G
H
L
Site 20
Y164
T
G
D
E
L
L
S
Y
E
E
Y
G
H
L
Q
Site 21
Y167
E
L
L
S
Y
E
E
Y
G
H
L
Q
I
N
A
Site 22
Y194
S
S
G
L
Q
I
I
Y
N
T
D
E
V
S
F
Site 23
S225
F
G
V
W
E
R
G
S
K
Y
N
N
G
S
T
Site 24
Y227
V
W
E
R
G
S
K
Y
N
N
G
S
T
E
L
Site 25
S231
G
S
K
Y
N
N
G
S
T
E
L
H
S
S
S
Site 26
T232
S
K
Y
N
N
G
S
T
E
L
H
S
S
S
V
Site 27
S236
N
G
S
T
E
L
H
S
S
S
V
G
L
A
K
Site 28
S238
S
T
E
L
H
S
S
S
V
G
L
A
K
A
A
Site 29
T278
A
H
N
R
N
R
Q
T
L
C
S
L
L
P
R
Site 30
S281
R
N
R
Q
T
L
C
S
L
L
P
R
E
S
R
Site 31
S287
C
S
L
L
P
R
E
S
R
S
H
N
T
D
A
Site 32
Y338
K
R
F
L
R
D
G
Y
R
T
S
L
E
D
P
Site 33
T340
F
L
R
D
G
Y
R
T
S
L
E
D
P
N
R
Site 34
S341
L
R
D
G
Y
R
T
S
L
E
D
P
N
R
C
Site 35
Y349
L
E
D
P
N
R
C
Y
Y
K
P
A
E
I
K
Site 36
Y350
E
D
P
N
R
C
Y
Y
K
P
A
E
I
K
L
Site 37
T393
Q
E
Y
Q
D
L
L
T
P
V
L
H
H
T
T
Site 38
Y403
L
H
H
T
T
E
G
Y
P
V
V
P
K
Y
Y
Site 39
Y409
G
Y
P
V
V
P
K
Y
Y
Y
V
P
A
D
F
Site 40
Y419
V
P
A
D
F
V
E
Y
E
K
N
N
P
G
S
Site 41
S426
Y
E
K
N
N
P
G
S
Q
K
R
F
P
S
N
Site 42
S432
G
S
Q
K
R
F
P
S
N
C
G
R
D
G
K
Site 43
S460
L
L
A
D
E
L
I
S
P
K
D
I
D
P
V
Site 44
Y470
D
I
D
P
V
Q
R
Y
V
P
L
K
D
Q
R
Site 45
S480
L
K
D
Q
R
N
V
S
M
R
F
S
N
Q
G
Site 46
S484
R
N
V
S
M
R
F
S
N
Q
G
P
L
E
N
Site 47
T519
T
Y
G
I
Q
T
Q
T
P
Q
Q
V
E
P
I
Site 48
S550
I
N
E
K
L
G
L
S
G
R
P
D
R
P
I
Site 49
Y608
A
L
Q
F
I
K
Q
Y
W
K
M
H
G
R
P
Site 50
S629
R
E
D
N
I
R
G
S
R
F
N
P
I
L
D
Site 51
S674
Q
L
D
F
L
R
I
S
D
T
E
E
L
P
E
Site 52
T676
D
F
L
R
I
S
D
T
E
E
L
P
E
F
K
Site 53
S684
E
E
L
P
E
F
K
S
F
E
E
L
E
P
P
Site 54
S694
E
L
E
P
P
K
H
S
K
V
K
R
Q
S
S
Site 55
S700
H
S
K
V
K
R
Q
S
S
T
P
S
A
P
E
Site 56
S701
S
K
V
K
R
Q
S
S
T
P
S
A
P
E
L
Site 57
T702
K
V
K
R
Q
S
S
T
P
S
A
P
E
L
G
Site 58
S704
K
R
Q
S
S
T
P
S
A
P
E
L
G
Q
Q
Site 59
T724
S
E
W
K
D
K
P
T
H
E
I
L
Q
K
L
Site 60
T761
N
F
I
T
K
E
G
T
V
S
D
H
I
E
R
Site 61
S763
I
T
K
E
G
T
V
S
D
H
I
E
R
V
Y
Site 62
Y770
S
D
H
I
E
R
V
Y
R
R
A
G
S
Q
K
Site 63
S775
R
V
Y
R
R
A
G
S
Q
K
L
W
L
A
V
Site 64
T789
V
R
Y
G
A
A
F
T
Q
K
F
S
S
S
I
Site 65
S795
F
T
Q
K
F
S
S
S
I
A
P
H
I
T
T
Site 66
S823
G
H
E
E
E
V
I
S
N
P
L
S
P
R
V
Site 67
Y836
R
V
I
Q
N
I
I
Y
Y
K
C
N
T
H
D
Site 68
Y837
V
I
Q
N
I
I
Y
Y
K
C
N
T
H
D
E
Site 69
Y900
D
K
P
A
L
D
L
Y
Q
L
S
P
S
E
V
Site 70
S903
A
L
D
L
Y
Q
L
S
P
S
E
V
K
Q
L
Site 71
S905
D
L
Y
Q
L
S
P
S
E
V
K
Q
L
L
L
Site 72
S933
N
R
R
Q
I
D
G
S
L
N
R
T
P
T
G
Site 73
T937
I
D
G
S
L
N
R
T
P
T
G
F
Y
D
R
Site 74
T939
G
S
L
N
R
T
P
T
G
F
Y
D
R
V
W
Site 75
Y942
N
R
T
P
T
G
F
Y
D
R
V
W
Q
I
L
Site 76
T968
K
H
L
P
Q
Q
P
T
L
S
D
M
T
M
Y
Site 77
S970
L
P
Q
Q
P
T
L
S
D
M
T
M
Y
E
M
Site 78
Y995
G
N
I
D
Q
P
Q
Y
R
Q
I
V
V
E
L
Site 79
T1052
I
E
K
Q
D
D
M
T
S
F
Y
N
T
P
P
Site 80
S1053
E
K
Q
D
D
M
T
S
F
Y
N
T
P
P
L
Site 81
Y1055
Q
D
D
M
T
S
F
Y
N
T
P
P
L
G
K
Site 82
T1057
D
M
T
S
F
Y
N
T
P
P
L
G
K
R
G
Site 83
T1065
P
P
L
G
K
R
G
T
C
S
Y
L
T
K
A
Site 84
Y1068
G
K
R
G
T
C
S
Y
L
T
K
A
V
M
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation