KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EXT2
Full Name:
Exostosin-2
Alias:
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase;Multiple exostoses protein 2;Putative tumor suppressor protein EXT2
Type:
Mass (Da):
82255
Number AA:
718
UniProt ID:
Q93063
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
A
L
I
P
R
M
K
T
K
H
R
I
Y
Y
I
Site 2
S62
D
W
N
V
E
K
R
S
I
R
D
V
P
V
V
Site 3
S75
V
V
R
L
P
A
D
S
P
I
P
E
R
G
D
Site 4
T89
D
L
S
C
R
M
H
T
C
F
D
V
Y
R
C
Site 5
Y107
P
K
N
K
I
K
V
Y
I
Y
A
L
K
K
Y
Site 6
S121
Y
V
D
D
F
G
V
S
V
S
N
T
I
S
R
Site 7
S123
D
D
F
G
V
S
V
S
N
T
I
S
R
E
Y
Site 8
T125
F
G
V
S
V
S
N
T
I
S
R
E
Y
N
E
Site 9
S127
V
S
V
S
N
T
I
S
R
E
Y
N
E
L
L
Site 10
Y130
S
N
T
I
S
R
E
Y
N
E
L
L
M
A
I
Site 11
S138
N
E
L
L
M
A
I
S
D
S
D
Y
Y
T
D
Site 12
S140
L
L
M
A
I
S
D
S
D
Y
Y
T
D
D
I
Site 13
Y142
M
A
I
S
D
S
D
Y
Y
T
D
D
I
N
R
Site 14
Y143
A
I
S
D
S
D
Y
Y
T
D
D
I
N
R
A
Site 15
T144
I
S
D
S
D
Y
Y
T
D
D
I
N
R
A
C
Site 16
Y199
L
P
G
G
P
P
D
Y
N
T
A
L
D
V
P
Site 17
T201
G
G
P
P
D
Y
N
T
A
L
D
V
P
R
D
Site 18
T221
G
G
G
F
S
T
W
T
Y
R
Q
G
Y
D
V
Site 19
Y222
G
G
F
S
T
W
T
Y
R
Q
G
Y
D
V
S
Site 20
Y226
T
W
T
Y
R
Q
G
Y
D
V
S
I
P
V
Y
Site 21
S229
Y
R
Q
G
Y
D
V
S
I
P
V
Y
S
P
L
Site 22
Y252
K
G
P
G
P
R
Q
Y
F
L
L
S
S
Q
V
Site 23
S256
P
R
Q
Y
F
L
L
S
S
Q
V
G
L
H
P
Site 24
S257
R
Q
Y
F
L
L
S
S
Q
V
G
L
H
P
E
Site 25
Y265
Q
V
G
L
H
P
E
Y
R
E
D
L
E
A
L
Site 26
S290
L
D
K
C
T
N
L
S
E
G
V
L
S
V
R
Site 27
S295
N
L
S
E
G
V
L
S
V
R
K
R
C
H
K
Site 28
Y308
H
K
H
Q
V
F
D
Y
P
Q
V
L
Q
E
A
Site 29
S353
D
S
Y
I
L
P
F
S
E
V
L
D
W
K
R
Site 30
S362
V
L
D
W
K
R
A
S
V
V
V
P
E
E
K
Site 31
S371
V
V
P
E
E
K
M
S
D
V
Y
S
I
L
Q
Site 32
Y374
E
E
K
M
S
D
V
Y
S
I
L
Q
S
I
P
Site 33
S375
E
K
M
S
D
V
Y
S
I
L
Q
S
I
P
Q
Site 34
S379
D
V
Y
S
I
L
Q
S
I
P
Q
R
Q
I
E
Site 35
Y419
Q
I
I
N
D
R
I
Y
P
Y
A
A
I
S
Y
Site 36
Y421
I
N
D
R
I
Y
P
Y
A
A
I
S
Y
E
E
Site 37
T457
P
P
Q
S
Q
G
F
T
A
I
V
L
T
Y
D
Site 38
S468
L
T
Y
D
R
V
E
S
L
F
R
V
I
T
E
Site 39
S500
N
K
N
P
P
E
D
S
L
W
P
K
I
R
V
Site 40
T514
V
P
L
K
V
V
R
T
A
E
N
K
L
S
N
Site 41
S520
R
T
A
E
N
K
L
S
N
R
F
F
P
Y
D
Site 42
Y526
L
S
N
R
F
F
P
Y
D
E
I
E
T
E
A
Site 43
S546
D
D
I
I
M
L
T
S
D
E
L
Q
F
G
Y
Site 44
Y553
S
D
E
L
Q
F
G
Y
E
V
W
R
E
F
P
Site 45
Y566
F
P
D
R
L
V
G
Y
P
G
R
L
H
L
W
Site 46
Y603
G
A
A
F
Y
H
K
Y
F
N
Y
L
Y
T
Y
Site 47
Y608
H
K
Y
F
N
Y
L
Y
T
Y
K
M
P
G
D
Site 48
Y610
Y
F
N
Y
L
Y
T
Y
K
M
P
G
D
I
K
Site 49
T647
G
K
A
V
I
K
V
T
P
R
K
K
F
K
C
Site 50
T668
D
G
L
S
L
D
Q
T
H
M
V
E
R
S
E
Site 51
Y701
H
R
A
D
P
V
L
Y
K
D
D
F
P
E
K
Site 52
S711
D
F
P
E
K
L
K
S
F
P
N
I
G
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation