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Updated November 2019
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Protein Info
Short Name:
PRG4
Full Name:
Proteoglycan 4
Alias:
Articular superficial zone protein; BG174L6.2; CACP; Camptodactyly, arthropathy, coxa vara, pericarditis syndrome; FLJ32635; HAPO; Jacobs camptodactyly-arthropathy-pericarditis syndrome; JCAP; Lubricin; Megakaryocyte stimulating factor; MSF; Proteoglycan 4; Proteoglycan-4; Superficial zone proteoglycan; SZP
Type:
Secreted protein
Mass (Da):
151077
Number AA:
1404
UniProt ID:
Q92954
International Prot ID:
IPI00024825
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0030247
GO:0005515
GO:0005044
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0006955
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
F
V
I
Q
Q
V
S
S
Q
D
L
S
S
C
A
Site 2
S28
Q
V
S
S
Q
D
L
S
S
C
A
G
R
C
G
Site 3
S29
V
S
S
Q
D
L
S
S
C
A
G
R
C
G
E
Site 4
Y38
A
G
R
C
G
E
G
Y
S
R
D
A
T
C
N
Site 5
T65
P
D
F
K
R
V
C
T
A
E
L
S
C
K
G
Site 6
Y100
Y
D
K
C
C
P
D
Y
E
S
F
C
A
E
V
Site 7
S102
K
C
C
P
D
Y
E
S
F
C
A
E
V
H
N
Site 8
T111
C
A
E
V
H
N
P
T
S
P
P
S
S
K
K
Site 9
S112
A
E
V
H
N
P
T
S
P
P
S
S
K
K
A
Site 10
S115
H
N
P
T
S
P
P
S
S
K
K
A
P
P
P
Site 11
S116
N
P
T
S
P
P
S
S
K
K
A
P
P
P
S
Site 12
S123
S
K
K
A
P
P
P
S
G
A
S
Q
T
I
K
Site 13
S126
A
P
P
P
S
G
A
S
Q
T
I
K
S
T
T
Site 14
S131
G
A
S
Q
T
I
K
S
T
T
K
R
S
P
K
Site 15
T132
A
S
Q
T
I
K
S
T
T
K
R
S
P
K
P
Site 16
S136
I
K
S
T
T
K
R
S
P
K
P
P
N
K
K
Site 17
S151
K
T
K
K
V
I
E
S
E
E
I
T
E
E
H
Site 18
T155
V
I
E
S
E
E
I
T
E
E
H
S
V
S
E
Site 19
S159
E
E
I
T
E
E
H
S
V
S
E
N
Q
E
S
Site 20
S161
I
T
E
E
H
S
V
S
E
N
Q
E
S
S
S
Site 21
S166
S
V
S
E
N
Q
E
S
S
S
S
S
S
S
S
Site 22
S167
V
S
E
N
Q
E
S
S
S
S
S
S
S
S
S
Site 23
S168
S
E
N
Q
E
S
S
S
S
S
S
S
S
S
S
Site 24
S169
E
N
Q
E
S
S
S
S
S
S
S
S
S
S
S
Site 25
S170
N
Q
E
S
S
S
S
S
S
S
S
S
S
S
S
Site 26
S171
Q
E
S
S
S
S
S
S
S
S
S
S
S
S
T
Site 27
S172
E
S
S
S
S
S
S
S
S
S
S
S
S
T
I
Site 28
S173
S
S
S
S
S
S
S
S
S
S
S
S
T
I
R
Site 29
S174
S
S
S
S
S
S
S
S
S
S
S
T
I
R
K
Site 30
S175
S
S
S
S
S
S
S
S
S
S
T
I
R
K
I
Site 31
S176
S
S
S
S
S
S
S
S
S
T
I
R
K
I
K
Site 32
S177
S
S
S
S
S
S
S
S
T
I
R
K
I
K
S
Site 33
T178
S
S
S
S
S
S
S
T
I
R
K
I
K
S
S
Site 34
S184
S
T
I
R
K
I
K
S
S
K
N
S
A
A
N
Site 35
S185
T
I
R
K
I
K
S
S
K
N
S
A
A
N
R
Site 36
S188
K
I
K
S
S
K
N
S
A
A
N
R
E
L
Q
Site 37
T213
N
R
T
K
K
K
P
T
P
K
P
P
V
V
D
Site 38
T235
N
G
D
F
K
V
T
T
P
D
T
S
T
T
Q
Site 39
S249
Q
H
N
K
V
S
T
S
P
K
I
T
T
A
K
Site 40
T253
V
S
T
S
P
K
I
T
T
A
K
P
I
N
P
Site 41
S263
K
P
I
N
P
R
P
S
L
P
P
N
S
D
T
Site 42
S268
R
P
S
L
P
P
N
S
D
T
S
K
E
T
S
Site 43
T270
S
L
P
P
N
S
D
T
S
K
E
T
S
L
T
Site 44
S271
L
P
P
N
S
D
T
S
K
E
T
S
L
T
V
Site 45
S275
S
D
T
S
K
E
T
S
L
T
V
N
K
E
T
Site 46
T277
T
S
K
E
T
S
L
T
V
N
K
E
T
T
V
Site 47
T292
E
T
K
E
T
T
T
T
N
K
Q
T
S
T
D
Site 48
T304
S
T
D
G
K
E
K
T
T
S
A
K
E
T
Q
Site 49
S306
D
G
K
E
K
T
T
S
A
K
E
T
Q
S
I
Site 50
T310
K
T
T
S
A
K
E
T
Q
S
I
E
K
T
S
Site 51
S312
T
S
A
K
E
T
Q
S
I
E
K
T
S
A
K
Site 52
T316
E
T
Q
S
I
E
K
T
S
A
K
D
L
A
P
Site 53
S325
A
K
D
L
A
P
T
S
K
V
L
A
K
P
T
Site 54
T332
S
K
V
L
A
K
P
T
P
K
A
E
T
T
T
Site 55
T345
T
T
K
G
P
A
L
T
T
P
K
E
P
T
P
Site 56
T346
T
K
G
P
A
L
T
T
P
K
E
P
T
P
T
Site 57
T351
L
T
T
P
K
E
P
T
P
T
T
P
K
E
P
Site 58
T353
T
P
K
E
P
T
P
T
T
P
K
E
P
A
S
Site 59
T354
P
K
E
P
T
P
T
T
P
K
E
P
A
S
T
Site 60
S360
T
T
P
K
E
P
A
S
T
T
P
K
E
P
T
Site 61
T361
T
P
K
E
P
A
S
T
T
P
K
E
P
T
P
Site 62
T362
P
K
E
P
A
S
T
T
P
K
E
P
T
P
T
Site 63
T367
S
T
T
P
K
E
P
T
P
T
T
I
K
S
A
Site 64
T369
T
P
K
E
P
T
P
T
T
I
K
S
A
P
T
Site 65
T370
P
K
E
P
T
P
T
T
I
K
S
A
P
T
T
Site 66
S373
P
T
P
T
T
I
K
S
A
P
T
T
P
K
E
Site 67
T377
T
I
K
S
A
P
T
T
P
K
E
P
A
P
T
Site 68
T384
T
P
K
E
P
A
P
T
T
T
K
S
A
P
T
Site 69
T385
P
K
E
P
A
P
T
T
T
K
S
A
P
T
T
Site 70
T386
K
E
P
A
P
T
T
T
K
S
A
P
T
T
P
Site 71
S388
P
A
P
T
T
T
K
S
A
P
T
T
P
K
E
Site 72
T392
T
T
K
S
A
P
T
T
P
K
E
P
A
P
T
Site 73
T399
T
P
K
E
P
A
P
T
T
T
K
E
P
A
P
Site 74
T401
K
E
P
A
P
T
T
T
K
E
P
A
P
T
T
Site 75
T407
T
T
K
E
P
A
P
T
T
P
K
E
P
A
P
Site 76
T408
T
K
E
P
A
P
T
T
P
K
E
P
A
P
T
Site 77
T423
T
T
K
E
P
A
P
T
T
T
K
S
A
P
T
Site 78
T438
T
P
K
E
P
A
P
T
T
P
K
K
P
A
P
Site 79
T439
P
K
E
P
A
P
T
T
P
K
K
P
A
P
T
Site 80
T447
P
K
K
P
A
P
T
T
P
K
E
P
A
P
T
Site 81
T454
T
P
K
E
P
A
P
T
T
P
K
E
P
T
P
Site 82
T455
P
K
E
P
A
P
T
T
P
K
E
P
T
P
T
Site 83
T460
P
T
T
P
K
E
P
T
P
T
T
P
K
E
P
Site 84
T462
T
P
K
E
P
T
P
T
T
P
K
E
P
A
P
Site 85
T463
P
K
E
P
T
P
T
T
P
K
E
P
A
P
T
Site 86
T471
P
K
E
P
A
P
T
T
K
E
P
A
P
T
T
Site 87
T485
T
P
K
E
P
A
P
T
A
P
K
K
P
A
P
Site 88
T493
A
P
K
K
P
A
P
T
T
P
K
E
P
A
P
Site 89
T501
T
P
K
E
P
A
P
T
T
P
K
E
P
A
P
Site 90
T502
P
K
E
P
A
P
T
T
P
K
E
P
A
P
T
Site 91
T509
T
P
K
E
P
A
P
T
T
T
K
E
P
S
P
Site 92
T511
K
E
P
A
P
T
T
T
K
E
P
S
P
T
T
Site 93
S515
P
T
T
T
K
E
P
S
P
T
T
P
K
E
P
Site 94
T517
T
T
K
E
P
S
P
T
T
P
K
E
P
A
P
Site 95
T518
T
K
E
P
S
P
T
T
P
K
E
P
A
P
T
Site 96
S529
P
A
P
T
T
T
K
S
A
P
T
T
T
K
E
Site 97
T533
T
T
K
S
A
P
T
T
T
K
E
P
A
P
T
Site 98
T548
T
T
K
S
A
P
T
T
P
K
E
P
S
P
T
Site 99
S553
P
T
T
P
K
E
P
S
P
T
T
T
K
E
P
Site 100
T555
T
P
K
E
P
S
P
T
T
T
K
E
P
A
P
Site 101
T557
K
E
P
S
P
T
T
T
K
E
P
A
P
T
T
Site 102
T595
T
P
K
E
P
A
P
T
T
T
K
K
P
A
P
Site 103
T597
K
E
P
A
P
T
T
T
K
K
P
A
P
T
T
Site 104
T604
T
K
K
P
A
P
T
T
P
K
E
P
A
P
T
Site 105
T611
T
P
K
E
P
A
P
T
T
P
K
E
T
A
P
Site 106
T612
P
K
E
P
A
P
T
T
P
K
E
T
A
P
T
Site 107
T619
T
P
K
E
T
A
P
T
T
P
K
K
L
T
P
Site 108
T620
P
K
E
T
A
P
T
T
P
K
K
L
T
P
T
Site 109
T625
P
T
T
P
K
K
L
T
P
T
T
P
E
K
L
Site 110
T628
P
K
K
L
T
P
T
T
P
E
K
L
A
P
T
Site 111
T636
P
E
K
L
A
P
T
T
P
E
K
P
A
P
T
Site 112
T644
P
E
K
P
A
P
T
T
P
E
E
L
A
P
T
Site 113
T651
T
P
E
E
L
A
P
T
T
P
E
E
P
T
P
Site 114
T652
P
E
E
L
A
P
T
T
P
E
E
P
T
P
T
Site 115
T657
P
T
T
P
E
E
P
T
P
T
T
P
E
E
P
Site 116
T659
T
P
E
E
P
T
P
T
T
P
E
E
P
A
P
Site 117
T660
P
E
E
P
T
P
T
T
P
E
E
P
A
P
T
Site 118
T667
T
P
E
E
P
A
P
T
T
P
K
A
A
A
P
Site 119
T668
P
E
E
P
A
P
T
T
P
K
A
A
A
P
N
Site 120
T676
P
K
A
A
A
P
N
T
P
K
E
P
A
P
T
Site 121
T707
T
P
K
E
T
A
P
T
T
P
K
G
T
A
P
Site 122
T708
P
K
E
T
A
P
T
T
P
K
G
T
A
P
T
Site 123
T723
T
L
K
E
P
A
P
T
T
P
K
K
P
A
P
Site 124
T724
L
K
E
P
A
P
T
T
P
K
K
P
A
P
K
Site 125
T736
A
P
K
E
L
A
P
T
T
T
K
E
P
T
S
Site 126
T738
K
E
L
A
P
T
T
T
K
E
P
T
S
T
T
Site 127
S743
T
T
T
K
E
P
T
S
T
T
C
D
K
P
A
Site 128
T744
T
T
K
E
P
T
S
T
T
C
D
K
P
A
P
Site 129
T752
T
C
D
K
P
A
P
T
T
P
K
G
T
A
P
Site 130
T753
C
D
K
P
A
P
T
T
P
K
G
T
A
P
T
Site 131
T757
A
P
T
T
P
K
G
T
A
P
T
T
P
K
E
Site 132
T760
T
P
K
G
T
A
P
T
T
P
K
E
P
A
P
Site 133
T761
P
K
G
T
A
P
T
T
P
K
E
P
A
P
T
Site 134
T776
T
P
K
E
P
A
P
T
T
P
K
G
T
A
P
Site 135
T777
P
K
E
P
A
P
T
T
P
K
G
T
A
P
T
Site 136
T805
A
P
K
E
L
A
P
T
T
T
K
G
P
T
S
Site 137
T806
P
K
E
L
A
P
T
T
T
K
G
P
T
S
T
Site 138
T807
K
E
L
A
P
T
T
T
K
G
P
T
S
T
T
Site 139
S812
T
T
T
K
G
P
T
S
T
T
S
D
K
P
A
Site 140
T814
T
K
G
P
T
S
T
T
S
D
K
P
A
P
T
Site 141
S815
K
G
P
T
S
T
T
S
D
K
P
A
P
T
T
Site 142
T822
S
D
K
P
A
P
T
T
P
K
E
T
A
P
T
Site 143
T829
T
P
K
E
T
A
P
T
T
P
K
E
P
A
P
Site 144
T830
P
K
E
T
A
P
T
T
P
K
E
P
A
P
T
Site 145
T846
P
K
K
P
A
P
T
T
P
E
T
P
P
P
T
Site 146
T849
P
A
P
T
T
P
E
T
P
P
P
T
T
S
E
Site 147
T853
T
P
E
T
P
P
P
T
T
S
E
V
S
T
P
Site 148
T854
P
E
T
P
P
P
T
T
S
E
V
S
T
P
T
Site 149
S855
E
T
P
P
P
T
T
S
E
V
S
T
P
T
T
Site 150
T859
P
T
T
S
E
V
S
T
P
T
T
T
K
E
P
Site 151
T862
S
E
V
S
T
P
T
T
T
K
E
P
T
T
I
Site 152
T863
E
V
S
T
P
T
T
T
K
E
P
T
T
I
H
Site 153
T867
P
T
T
T
K
E
P
T
T
I
H
K
S
P
D
Site 154
T868
T
T
T
K
E
P
T
T
I
H
K
S
P
D
E
Site 155
S872
E
P
T
T
I
H
K
S
P
D
E
S
T
P
E
Site 156
S876
I
H
K
S
P
D
E
S
T
P
E
L
S
A
E
Site 157
T877
H
K
S
P
D
E
S
T
P
E
L
S
A
E
P
Site 158
S881
D
E
S
T
P
E
L
S
A
E
P
T
P
K
A
Site 159
T885
P
E
L
S
A
E
P
T
P
K
A
L
E
N
S
Site 160
S892
T
P
K
A
L
E
N
S
P
K
E
P
G
V
P
Site 161
T901
K
E
P
G
V
P
T
T
K
T
P
A
A
T
K
Site 162
T903
P
G
V
P
T
T
K
T
P
A
A
T
K
P
E
Site 163
T914
T
K
P
E
M
T
T
T
A
K
D
K
T
T
E
Site 164
T919
T
T
T
A
K
D
K
T
T
E
R
D
L
R
T
Site 165
T920
T
T
A
K
D
K
T
T
E
R
D
L
R
T
T
Site 166
T927
T
E
R
D
L
R
T
T
P
E
T
T
T
A
A
Site 167
T930
D
L
R
T
T
P
E
T
T
T
A
A
P
K
M
Site 168
T932
R
T
T
P
E
T
T
T
A
A
P
K
M
T
K
Site 169
T938
T
T
A
A
P
K
M
T
K
E
T
A
T
T
T
Site 170
T944
M
T
K
E
T
A
T
T
T
E
K
T
T
E
S
Site 171
T954
K
T
T
E
S
K
I
T
A
T
T
T
Q
V
T
Site 172
T958
S
K
I
T
A
T
T
T
Q
V
T
S
T
T
T
Site 173
S962
A
T
T
T
Q
V
T
S
T
T
T
Q
D
T
T
Site 174
T969
S
T
T
T
Q
D
T
T
P
F
K
I
T
T
L
Site 175
T978
F
K
I
T
T
L
K
T
T
T
L
A
P
K
V
Site 176
T1012
A
K
P
K
D
R
A
T
N
S
K
A
T
T
P
Site 177
S1014
P
K
D
R
A
T
N
S
K
A
T
T
P
K
P
Site 178
T1018
A
T
N
S
K
A
T
T
P
K
P
Q
K
P
T
Site 179
S1033
K
A
P
K
K
P
T
S
T
K
K
P
K
T
M
Site 180
T1039
T
S
T
K
K
P
K
T
M
P
R
V
R
K
P
Site 181
T1048
P
R
V
R
K
P
K
T
T
P
T
P
R
K
M
Site 182
T1049
R
V
R
K
P
K
T
T
P
T
P
R
K
M
T
Site 183
T1051
R
K
P
K
T
T
P
T
P
R
K
M
T
S
T
Site 184
T1056
T
P
T
P
R
K
M
T
S
T
M
P
E
L
N
Site 185
S1057
P
T
P
R
K
M
T
S
T
M
P
E
L
N
P
Site 186
T1058
T
P
R
K
M
T
S
T
M
P
E
L
N
P
T
Site 187
T1065
T
M
P
E
L
N
P
T
S
R
I
A
E
A
M
Site 188
T1082
T
T
T
R
P
N
Q
T
P
N
S
K
L
V
E
Site 189
S1085
R
P
N
Q
T
P
N
S
K
L
V
E
V
N
P
Site 190
S1094
L
V
E
V
N
P
K
S
E
D
A
G
G
A
E
Site 191
T1104
A
G
G
A
E
G
E
T
P
H
M
L
L
R
P
Site 192
T1119
H
V
F
M
P
E
V
T
P
D
M
D
Y
L
P
Site 193
Y1124
E
V
T
P
D
M
D
Y
L
P
R
V
P
N
Q
Site 194
T1155
G
K
P
V
D
G
L
T
T
L
R
N
G
T
L
Site 195
T1156
K
P
V
D
G
L
T
T
L
R
N
G
T
L
V
Site 196
S1174
G
H
Y
F
W
M
L
S
P
F
S
P
P
S
P
Site 197
S1177
F
W
M
L
S
P
F
S
P
P
S
P
A
R
R
Site 198
S1180
L
S
P
F
S
P
P
S
P
A
R
R
I
T
E
Site 199
T1186
P
S
P
A
R
R
I
T
E
V
W
G
I
P
S
Site 200
Y1228
N
D
I
K
D
A
G
Y
P
K
P
I
F
K
G
Site 201
S1248
G
Q
I
V
A
A
L
S
T
A
K
Y
K
N
W
Site 202
Y1252
A
A
L
S
T
A
K
Y
K
N
W
P
E
S
V
Site 203
Y1260
K
N
W
P
E
S
V
Y
F
F
K
R
G
G
S
Site 204
Y1271
R
G
G
S
I
Q
Q
Y
I
Y
K
Q
E
P
V
Site 205
Y1290
G
R
R
P
A
L
N
Y
P
V
Y
G
E
T
T
Site 206
Y1293
P
A
L
N
Y
P
V
Y
G
E
T
T
Q
V
R
Site 207
S1311
F
E
R
A
I
G
P
S
Q
T
H
T
I
R
I
Site 208
T1315
I
G
P
S
Q
T
H
T
I
R
I
Q
Y
S
P
Site 209
Y1320
T
H
T
I
R
I
Q
Y
S
P
A
R
L
A
Y
Site 210
S1321
H
T
I
R
I
Q
Y
S
P
A
R
L
A
Y
Q
Site 211
Y1327
Y
S
P
A
R
L
A
Y
Q
D
K
G
V
L
H
Site 212
S1355
N
V
V
T
S
A
I
S
L
P
N
I
R
K
P
Site 213
Y1365
N
I
R
K
P
D
G
Y
D
Y
Y
A
F
S
K
Site 214
Y1367
R
K
P
D
G
Y
D
Y
Y
A
F
S
K
D
Q
Site 215
Y1368
K
P
D
G
Y
D
Y
Y
A
F
S
K
D
Q
Y
Site 216
Y1375
Y
A
F
S
K
D
Q
Y
Y
N
I
D
V
P
S
Site 217
Y1376
A
F
S
K
D
Q
Y
Y
N
I
D
V
P
S
R
Site 218
T1384
N
I
D
V
P
S
R
T
A
R
A
I
T
T
R
Site 219
T1389
S
R
T
A
R
A
I
T
T
R
S
G
Q
T
L
Site 220
S1392
A
R
A
I
T
T
R
S
G
Q
T
L
S
K
V
Site 221
S1397
T
R
S
G
Q
T
L
S
K
V
W
Y
N
C
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation