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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv2.2
Full Name:
Potassium voltage-gated channel subfamily B member 2
Alias:
Delayed rectifier potassium channel protein; KCNB2; Potassium voltage-gated channel B, 2; Potassium voltage-gated channel, Shab-related subfamily, member 2; Potassium voltage-gated channel, Shab-related, 2; Voltage-gated potassium channel Kv2.2
Type:
Membrane, Voltage-gated potassium channel complex, Integral membrane protein
Mass (Da):
102563
Number AA:
911
UniProt ID:
Q92953
International Prot ID:
IPI00024330
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005251
GO:0030955
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0006940
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
P
P
G
L
N
R
K
T
S
R
S
T
L
S
L
Site 2
S14
P
G
L
N
R
K
T
S
R
S
T
L
S
L
P
Site 3
S16
L
N
R
K
T
S
R
S
T
L
S
L
P
P
E
Site 4
T17
N
R
K
T
S
R
S
T
L
S
L
P
P
E
P
Site 5
S19
K
T
S
R
S
T
L
S
L
P
P
E
P
V
D
Site 6
S30
E
P
V
D
I
I
R
S
K
T
C
S
R
R
V
Site 7
T32
V
D
I
I
R
S
K
T
C
S
R
R
V
K
I
Site 8
S34
I
I
R
S
K
T
C
S
R
R
V
K
I
N
V
Site 9
T52
N
H
E
V
L
W
R
T
L
D
R
L
P
R
T
Site 10
T59
T
L
D
R
L
P
R
T
R
L
G
K
L
R
D
Site 11
T69
G
K
L
R
D
C
N
T
H
E
S
L
L
E
V
Site 12
Y80
L
L
E
V
C
D
D
Y
N
L
N
E
N
E
Y
Site 13
Y87
Y
N
L
N
E
N
E
Y
F
F
D
R
H
P
G
Site 14
T97
D
R
H
P
G
A
F
T
S
I
L
N
F
Y
R
Site 15
S98
R
H
P
G
A
F
T
S
I
L
N
F
Y
R
T
Site 16
Y103
F
T
S
I
L
N
F
Y
R
T
G
K
L
H
M
Site 17
Y125
S
F
G
Q
E
L
D
Y
W
G
I
D
E
I
Y
Site 18
Y132
Y
W
G
I
D
E
I
Y
L
E
S
C
C
Q
A
Site 19
Y141
E
S
C
C
Q
A
R
Y
H
Q
K
K
E
Q
M
Site 20
T158
E
L
R
R
E
A
E
T
M
R
E
R
E
G
E
Site 21
T170
E
G
E
E
F
D
N
T
C
C
P
D
K
R
K
Site 22
T221
T
L
P
E
L
Q
E
T
D
E
F
G
Q
L
N
Site 23
S254
E
Y
L
L
R
F
L
S
S
P
N
K
W
K
F
Site 24
S255
Y
L
L
R
F
L
S
S
P
N
K
W
K
F
F
Site 25
S289
F
L
T
E
S
N
K
S
V
L
Q
F
Q
N
V
Site 26
T319
L
K
L
A
R
H
S
T
G
L
Q
S
L
G
F
Site 27
S323
R
H
S
T
G
L
Q
S
L
G
F
T
L
R
R
Site 28
T327
G
L
Q
S
L
G
F
T
L
R
R
S
Y
N
E
Site 29
T363
A
E
K
D
E
D
A
T
K
F
T
S
I
P
A
Site 30
Y388
T
V
G
Y
G
D
I
Y
P
K
T
L
L
G
K
Site 31
S448
E
R
A
K
R
N
G
S
I
V
S
M
N
L
K
Site 32
S451
K
R
N
G
S
I
V
S
M
N
L
K
D
A
F
Site 33
S481
E
S
A
N
T
K
D
S
A
D
D
N
H
L
S
Site 34
S488
S
A
D
D
N
H
L
S
P
S
R
W
K
W
A
Site 35
S500
K
W
A
R
K
A
L
S
E
T
S
S
N
K
S
Site 36
S504
K
A
L
S
E
T
S
S
N
K
S
F
E
N
K
Site 37
S507
S
E
T
S
S
N
K
S
F
E
N
K
Y
Q
E
Site 38
Y512
N
K
S
F
E
N
K
Y
Q
E
V
S
Q
K
D
Site 39
S516
E
N
K
Y
Q
E
V
S
Q
K
D
S
H
E
Q
Site 40
S520
Q
E
V
S
Q
K
D
S
H
E
Q
L
N
N
T
Site 41
T527
S
H
E
Q
L
N
N
T
S
S
S
S
P
Q
H
Site 42
S528
H
E
Q
L
N
N
T
S
S
S
S
P
Q
H
L
Site 43
S529
E
Q
L
N
N
T
S
S
S
S
P
Q
H
L
S
Site 44
S530
Q
L
N
N
T
S
S
S
S
P
Q
H
L
S
A
Site 45
S531
L
N
N
T
S
S
S
S
P
Q
H
L
S
A
Q
Site 46
S536
S
S
S
P
Q
H
L
S
A
Q
K
L
E
M
L
Site 47
Y544
A
Q
K
L
E
M
L
Y
N
E
I
T
K
T
Q
Site 48
T550
L
Y
N
E
I
T
K
T
Q
P
H
S
H
P
N
Site 49
S568
Q
E
K
P
E
R
P
S
A
Y
E
E
E
I
E
Site 50
S601
I
V
D
M
K
S
T
S
S
I
D
S
F
T
S
Site 51
S602
V
D
M
K
S
T
S
S
I
D
S
F
T
S
C
Site 52
S605
K
S
T
S
S
I
D
S
F
T
S
C
A
T
D
Site 53
T607
T
S
S
I
D
S
F
T
S
C
A
T
D
F
T
Site 54
S608
S
S
I
D
S
F
T
S
C
A
T
D
F
T
E
Site 55
S619
D
F
T
E
T
E
R
S
P
L
P
P
P
S
A
Site 56
S625
R
S
P
L
P
P
P
S
A
S
H
L
Q
M
K
Site 57
S627
P
L
P
P
P
S
A
S
H
L
Q
M
K
F
P
Site 58
T653
A
R
G
P
P
F
L
T
L
S
R
E
K
G
P
Site 59
S655
G
P
P
F
L
T
L
S
R
E
K
G
P
A
A
Site 60
T666
G
P
A
A
R
D
G
T
L
E
Y
A
P
V
D
Site 61
S683
V
N
L
D
A
S
G
S
Q
C
G
L
H
S
P
Site 62
S689
G
S
Q
C
G
L
H
S
P
L
Q
S
D
N
A
Site 63
S693
G
L
H
S
P
L
Q
S
D
N
A
T
D
S
P
Site 64
T697
P
L
Q
S
D
N
A
T
D
S
P
K
S
S
L
Site 65
S699
Q
S
D
N
A
T
D
S
P
K
S
S
L
K
G
Site 66
S702
N
A
T
D
S
P
K
S
S
L
K
G
S
N
P
Site 67
S703
A
T
D
S
P
K
S
S
L
K
G
S
N
P
L
Site 68
S707
P
K
S
S
L
K
G
S
N
P
L
K
S
R
S
Site 69
S712
K
G
S
N
P
L
K
S
R
S
L
K
V
N
F
Site 70
S714
S
N
P
L
K
S
R
S
L
K
V
N
F
K
E
Site 71
S725
N
F
K
E
N
R
G
S
A
P
Q
T
P
P
S
Site 72
T729
N
R
G
S
A
P
Q
T
P
P
S
T
A
R
P
Site 73
S732
S
A
P
Q
T
P
P
S
T
A
R
P
L
P
V
Site 74
T733
A
P
Q
T
P
P
S
T
A
R
P
L
P
V
T
Site 75
S745
P
V
T
T
A
D
F
S
L
T
T
P
Q
H
I
Site 76
T748
T
A
D
F
S
L
T
T
P
Q
H
I
S
T
I
Site 77
T760
S
T
I
L
L
E
E
T
P
S
Q
G
D
R
P
Site 78
S762
I
L
L
E
E
T
P
S
Q
G
D
R
P
L
L
Site 79
T771
G
D
R
P
L
L
G
T
E
V
S
A
P
C
Q
Site 80
S774
P
L
L
G
T
E
V
S
A
P
C
Q
G
P
S
Site 81
S781
S
A
P
C
Q
G
P
S
K
G
L
S
P
R
F
Site 82
S785
Q
G
P
S
K
G
L
S
P
R
F
P
K
Q
K
Site 83
S797
K
Q
K
L
F
P
F
S
S
R
E
R
R
S
F
Site 84
S798
Q
K
L
F
P
F
S
S
R
E
R
R
S
F
T
Site 85
S803
F
S
S
R
E
R
R
S
F
T
E
I
D
T
G
Site 86
T805
S
R
E
R
R
S
F
T
E
I
D
T
G
D
D
Site 87
T809
R
S
F
T
E
I
D
T
G
D
D
E
D
F
L
Site 88
S830
E
E
K
Q
V
D
S
S
P
N
C
F
A
D
K
Site 89
S839
N
C
F
A
D
K
P
S
D
G
R
D
P
L
R
Site 90
S850
D
P
L
R
E
E
G
S
V
G
S
S
S
P
Q
Site 91
S853
R
E
E
G
S
V
G
S
S
S
P
Q
D
T
G
Site 92
S854
E
E
G
S
V
G
S
S
S
P
Q
D
T
G
H
Site 93
S855
E
G
S
V
G
S
S
S
P
Q
D
T
G
H
N
Site 94
T859
G
S
S
S
P
Q
D
T
G
H
N
C
R
Q
D
Site 95
Y868
H
N
C
R
Q
D
I
Y
H
A
V
S
E
V
K
Site 96
S879
S
E
V
K
K
D
S
S
Q
E
G
C
K
M
E
Site 97
S896
L
F
A
P
E
I
H
S
N
P
G
D
T
G
Y
Site 98
Y903
S
N
P
G
D
T
G
Y
C
P
T
R
E
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation