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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRN2
Full Name:
Receptor-type tyrosine-protein phosphatase N2
Alias:
EC 3.1.3.48; IA-2beta; IAR; IAR PTPRP; ICAAR; Islet cell autoantigen related protein; KIAA0387; Phogrin; Protein tyrosine phosphatase, receptor type, N polypeptide 2; PTPR2; R-PTP-N2
Type:
Receptor protein phosphatase, tyrosine; EC 3.1.3.48
Mass (Da):
111271
Number AA:
1015
UniProt ID:
Q92932
International Prot ID:
IPI00334666
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005001
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
R
V
L
P
A
A
P
S
S
V
P
R
G
R
Q
Site 2
S26
V
L
P
A
A
P
S
S
V
P
R
G
R
Q
L
Site 3
S124
L
R
R
P
E
A
S
S
P
A
R
P
S
K
H
Site 4
S129
A
S
S
P
A
R
P
S
K
H
S
V
G
S
E
Site 5
Y139
S
V
G
S
E
R
R
Y
S
R
E
G
G
A
A
Site 6
S247
H
H
L
M
A
A
L
S
A
Y
A
A
Q
R
P
Site 7
Y249
L
M
A
A
L
S
A
Y
A
A
Q
R
P
P
A
Site 8
S360
G
R
A
A
L
G
E
S
G
E
Q
A
D
G
P
Site 9
T619
S
T
K
F
I
A
L
T
L
V
S
L
A
C
I
Site 10
S622
F
I
A
L
T
L
V
S
L
A
C
I
L
G
V
Site 11
S642
L
I
Y
C
L
R
H
S
S
Q
H
R
L
K
E
Site 12
S643
I
Y
C
L
R
H
S
S
Q
H
R
L
K
E
K
Site 13
S652
H
R
L
K
E
K
L
S
G
L
G
G
D
P
G
Site 14
T663
G
D
P
G
A
D
A
T
A
A
Y
Q
E
L
C
Site 15
Y666
G
A
D
A
T
A
A
Y
Q
E
L
C
R
Q
R
Site 16
T676
L
C
R
Q
R
M
A
T
R
P
P
D
R
P
E
Site 17
T687
D
R
P
E
G
P
H
T
S
R
I
S
S
V
S
Site 18
S688
R
P
E
G
P
H
T
S
R
I
S
S
V
S
S
Site 19
S691
G
P
H
T
S
R
I
S
S
V
S
S
Q
F
S
Site 20
S692
P
H
T
S
R
I
S
S
V
S
S
Q
F
S
D
Site 21
S694
T
S
R
I
S
S
V
S
S
Q
F
S
D
G
P
Site 22
S695
S
R
I
S
S
V
S
S
Q
F
S
D
G
P
I
Site 23
S698
S
S
V
S
S
Q
F
S
D
G
P
I
P
S
P
Site 24
S704
F
S
D
G
P
I
P
S
P
S
A
R
S
S
A
Site 25
S706
D
G
P
I
P
S
P
S
A
R
S
S
A
S
S
Site 26
S709
I
P
S
P
S
A
R
S
S
A
S
S
W
S
E
Site 27
S710
P
S
P
S
A
R
S
S
A
S
S
W
S
E
E
Site 28
S712
P
S
A
R
S
S
A
S
S
W
S
E
E
P
V
Site 29
S713
S
A
R
S
S
A
S
S
W
S
E
E
P
V
Q
Site 30
S715
R
S
S
A
S
S
W
S
E
E
P
V
Q
S
N
Site 31
S721
W
S
E
E
P
V
Q
S
N
M
D
I
S
T
G
Site 32
T727
Q
S
N
M
D
I
S
T
G
H
M
I
L
S
Y
Site 33
S733
S
T
G
H
M
I
L
S
Y
M
E
D
H
L
K
Site 34
Y734
T
G
H
M
I
L
S
Y
M
E
D
H
L
K
N
Site 35
Y755
E
W
E
A
L
C
A
Y
Q
A
E
P
N
S
S
Site 36
S762
Y
Q
A
E
P
N
S
S
F
V
A
Q
R
E
E
Site 37
S776
E
N
V
P
K
N
R
S
L
A
V
L
T
Y
D
Site 38
T781
N
R
S
L
A
V
L
T
Y
D
H
S
R
V
L
Site 39
Y782
R
S
L
A
V
L
T
Y
D
H
S
R
V
L
L
Site 40
S794
V
L
L
K
A
E
N
S
H
S
H
S
D
Y
I
Site 41
S796
L
K
A
E
N
S
H
S
H
S
D
Y
I
N
A
Site 42
S798
A
E
N
S
H
S
H
S
D
Y
I
N
A
S
P
Site 43
Y800
N
S
H
S
H
S
D
Y
I
N
A
S
P
I
M
Site 44
S804
H
S
D
Y
I
N
A
S
P
I
M
D
H
D
P
Site 45
Y816
H
D
P
R
N
P
A
Y
I
A
T
Q
G
P
L
Site 46
T819
R
N
P
A
Y
I
A
T
Q
G
P
L
P
A
T
Site 47
T826
T
Q
G
P
L
P
A
T
V
A
D
F
W
Q
M
Site 48
Y868
P
D
E
G
S
N
L
Y
H
I
Y
E
V
N
L
Site 49
Y871
G
S
N
L
Y
H
I
Y
E
V
N
L
V
S
E
Site 50
Y891
D
F
L
V
R
S
F
Y
L
K
N
L
Q
T
N
Site 51
T902
L
Q
T
N
E
T
R
T
V
T
Q
F
H
F
L
Site 52
T904
T
N
E
T
R
T
V
T
Q
F
H
F
L
S
W
Site 53
Y912
Q
F
H
F
L
S
W
Y
D
R
G
V
P
S
S
Site 54
S918
W
Y
D
R
G
V
P
S
S
S
R
S
L
L
D
Site 55
S919
Y
D
R
G
V
P
S
S
S
R
S
L
L
D
F
Site 56
S920
D
R
G
V
P
S
S
S
R
S
L
L
D
F
R
Site 57
S922
G
V
P
S
S
S
R
S
L
L
D
F
R
R
K
Site 58
Y934
R
R
K
V
N
K
C
Y
R
G
R
S
C
P
I
Site 59
S952
C
S
D
G
A
G
R
S
G
T
Y
V
L
I
D
Site 60
Y955
G
A
G
R
S
G
T
Y
V
L
I
D
M
V
L
Site 61
T977
K
E
I
D
I
A
A
T
L
E
H
L
R
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation