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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC5A5
Full Name:
Sodium/iodide cotransporter
Alias:
Na(+)/I(-) cotransporter; Na(+)/I(-)-symporter; NIS; SC5A5; Sodium-iodide symporter; Solute carrier family 5 (sodium iodide symporter) member 5; Solute carrier family 5 member 5
Type:
Transporter
Mass (Da):
68666
Number AA:
643
UniProt ID:
Q92911
International Prot ID:
IPI00024248
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0015111
GO:0031402
PhosphoSite+
KinaseNET
Biological Process:
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Sodium/iodide cotransporter pan-specific antibody AB-NN325-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN325-1#Sodium/iodide cotransporter pan-specific antibody AB-NN325-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN325-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
A
V
E
T
G
E
R
P
T
F
G
Site 2
T11
V
E
T
G
E
R
P
T
F
G
A
W
D
Y
G
Site 3
S43
L
A
R
G
G
Q
R
S
A
E
D
F
F
T
G
Site 4
T49
R
S
A
E
D
F
F
T
G
G
R
R
L
A
A
Site 5
S66
V
G
L
S
L
S
A
S
F
M
S
A
V
Q
V
Site 6
Y83
V
P
S
E
A
Y
R
Y
G
L
K
F
L
W
M
Site 7
S116
F
Y
R
L
G
L
T
S
T
Y
E
Y
L
E
M
Site 8
T117
Y
R
L
G
L
T
S
T
Y
E
Y
L
E
M
R
Site 9
Y118
R
L
G
L
T
S
T
Y
E
Y
L
E
M
R
F
Site 10
Y120
G
L
T
S
T
Y
E
Y
L
E
M
R
F
S
R
Site 11
S126
E
Y
L
E
M
R
F
S
R
A
V
R
L
C
G
Site 12
T221
G
G
P
R
Q
V
L
T
L
A
Q
N
H
S
R
Site 13
S227
L
T
L
A
Q
N
H
S
R
I
N
L
M
D
F
Site 14
Y242
N
P
D
P
R
S
R
Y
T
F
W
T
F
V
V
Site 15
Y269
N
Q
A
Q
V
Q
R
Y
V
A
C
R
T
E
K
Site 16
S319
P
L
L
L
G
R
I
S
A
P
D
Q
Y
M
P
Site 17
T354
A
Y
S
G
T
L
S
T
A
S
T
S
I
N
A
Site 18
S377
L
I
K
P
R
L
R
S
L
A
P
R
K
L
V
Site 19
S469
G
A
T
L
Y
P
P
S
E
Q
T
M
R
V
L
Site 20
T472
L
Y
P
P
S
E
Q
T
M
R
V
L
P
S
S
Site 21
S504
A
L
L
P
A
N
D
S
S
R
A
P
S
S
G
Site 22
S505
L
L
P
A
N
D
S
S
R
A
P
S
S
G
M
Site 23
S509
N
D
S
S
R
A
P
S
S
G
M
D
A
S
R
Site 24
S510
D
S
S
R
A
P
S
S
G
M
D
A
S
R
P
Site 25
S515
P
S
S
G
M
D
A
S
R
P
A
L
A
D
S
Site 26
T550
G
A
L
I
S
C
L
T
G
P
T
K
R
S
T
Site 27
T553
I
S
C
L
T
G
P
T
K
R
S
T
L
A
P
Site 28
T557
T
G
P
T
K
R
S
T
L
A
P
G
L
L
W
Site 29
T571
W
W
D
L
A
R
Q
T
A
S
V
A
P
K
E
Site 30
S573
D
L
A
R
Q
T
A
S
V
A
P
K
E
E
V
Site 31
T596
K
G
P
E
E
L
P
T
G
N
K
K
P
P
G
Site 32
T607
K
P
P
G
F
L
P
T
N
E
D
R
L
F
F
Site 33
S625
K
E
L
E
G
A
G
S
W
T
P
C
V
G
H
Site 34
T627
L
E
G
A
G
S
W
T
P
C
V
G
H
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation