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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HPS1
Full Name:
Hermansky-Pudlak syndrome 1 protein
Alias:
Hermansky-Pudlak syndrome 1; HPS
Type:
Unknown function
Mass (Da):
79290
Number AA:
UniProt ID:
Q92902
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
GO:0005887
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0046983
PhosphoSite+
KinaseNET
Biological Process:
GO:0007040
GO:0050896
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
E
G
A
E
V
L
F
Y
W
T
D
Q
E
F
E
Site 2
S25
T
D
Q
E
F
E
E
S
L
R
L
K
F
G
Q
Site 3
S33
L
R
L
K
F
G
Q
S
E
N
E
E
E
E
L
Site 4
T68
M
L
E
K
L
S
D
T
Y
T
C
F
S
T
E
Site 5
Y69
L
E
K
L
S
D
T
Y
T
C
F
S
T
E
N
Site 6
T70
E
K
L
S
D
T
Y
T
C
F
S
T
E
N
G
Site 7
T99
I
A
I
N
G
D
H
T
E
S
E
G
D
L
R
Site 8
Y110
G
D
L
R
R
K
L
Y
V
L
K
Y
L
F
E
Site 9
T155
H
F
Q
S
L
L
W
T
Y
S
R
L
R
E
Q
Site 10
S157
Q
S
L
L
W
T
Y
S
R
L
R
E
Q
E
Q
Site 11
S198
V
I
Q
A
V
N
T
S
P
E
R
G
G
E
E
Site 12
Y221
H
S
K
L
L
A
F
Y
S
S
H
S
A
S
S
Site 13
S222
S
K
L
L
A
F
Y
S
S
H
S
A
S
S
L
Site 14
S223
K
L
L
A
F
Y
S
S
H
S
A
S
S
L
R
Site 15
S225
L
A
F
Y
S
S
H
S
A
S
S
L
R
P
A
Site 16
S227
F
Y
S
S
H
S
A
S
S
L
R
P
A
D
L
Site 17
S228
Y
S
S
H
S
A
S
S
L
R
P
A
D
L
L
Site 18
S249
Q
D
L
Y
P
S
E
S
T
A
E
D
D
I
Q
Site 19
S258
A
E
D
D
I
Q
P
S
P
R
R
A
R
S
S
Site 20
S264
P
S
P
R
R
A
R
S
S
Q
N
I
P
V
Q
Site 21
S265
S
P
R
R
A
R
S
S
Q
N
I
P
V
Q
Q
Site 22
S275
I
P
V
Q
Q
A
W
S
P
H
S
T
G
P
T
Site 23
S278
Q
Q
A
W
S
P
H
S
T
G
P
T
G
G
S
Site 24
T279
Q
A
W
S
P
H
S
T
G
P
T
G
G
S
S
Site 25
T282
S
P
H
S
T
G
P
T
G
G
S
S
A
E
T
Site 26
T289
T
G
G
S
S
A
E
T
E
T
D
S
F
S
L
Site 27
T291
G
S
S
A
E
T
E
T
D
S
F
S
L
P
E
Site 28
S293
S
A
E
T
E
T
D
S
F
S
L
P
E
E
Y
Site 29
S295
E
T
E
T
D
S
F
S
L
P
E
E
Y
F
T
Site 30
Y300
S
F
S
L
P
E
E
Y
F
T
P
A
P
S
P
Site 31
T302
S
L
P
E
E
Y
F
T
P
A
P
S
P
G
D
Site 32
S306
E
Y
F
T
P
A
P
S
P
G
D
Q
S
S
G
Site 33
S311
A
P
S
P
G
D
Q
S
S
G
S
T
I
W
L
Site 34
S312
P
S
P
G
D
Q
S
S
G
S
T
I
W
L
E
Site 35
S314
P
G
D
Q
S
S
G
S
T
I
W
L
E
G
G
Site 36
T315
G
D
Q
S
S
G
S
T
I
W
L
E
G
G
T
Site 37
T322
T
I
W
L
E
G
G
T
P
P
M
D
A
L
Q
Site 38
Y361
D
A
N
V
K
E
S
Y
C
P
L
V
P
H
T
Site 39
S403
S
Q
L
M
D
G
F
S
M
L
E
K
K
L
K
Site 40
S418
E
G
P
E
P
G
A
S
L
R
S
Q
P
L
V
Site 41
S421
E
P
G
A
S
L
R
S
Q
P
L
V
G
D
L
Site 42
T447
G
A
Q
E
I
Q
S
T
W
L
E
F
K
A
K
Site 43
S457
E
F
K
A
K
A
F
S
K
S
E
P
G
S
S
Site 44
S459
K
A
K
A
F
S
K
S
E
P
G
S
S
W
E
Site 45
S463
F
S
K
S
E
P
G
S
S
W
E
L
L
Q
A
Site 46
S464
S
K
S
E
P
G
S
S
W
E
L
L
Q
A
C
Site 47
T488
I
Y
R
L
N
F
L
T
T
A
P
S
R
G
G
Site 48
T489
Y
R
L
N
F
L
T
T
A
P
S
R
G
G
P
Site 49
S492
N
F
L
T
T
A
P
S
R
G
G
P
H
L
P
Site 50
T515
R
L
M
R
E
K
L
T
D
W
K
D
F
L
L
Site 51
S525
K
D
F
L
L
V
K
S
R
R
N
I
T
M
V
Site 52
T530
V
K
S
R
R
N
I
T
M
V
S
Y
L
E
D
Site 53
Y534
R
N
I
T
M
V
S
Y
L
E
D
F
P
G
L
Site 54
Y546
P
G
L
V
H
F
I
Y
V
D
R
T
T
G
Q
Site 55
S558
T
G
Q
M
V
A
P
S
L
N
C
S
Q
K
T
Site 56
S562
V
A
P
S
L
N
C
S
Q
K
T
S
S
E
L
Site 57
S566
L
N
C
S
Q
K
T
S
S
E
L
G
K
G
P
Site 58
S567
N
C
S
Q
K
T
S
S
E
L
G
K
G
P
L
Site 59
Y592
L
I
Q
L
A
R
R
Y
L
Q
K
G
Y
T
T
Site 60
Y611
E
G
D
F
Y
C
S
Y
F
L
W
F
E
N
D
Site 61
Y621
W
F
E
N
D
M
G
Y
K
L
Q
M
I
E
V
Site 62
Y645
I
G
M
L
G
G
D
Y
Y
R
K
L
L
R
Y
Site 63
Y646
G
M
L
G
G
D
Y
Y
R
K
L
L
R
Y
Y
Site 64
Y652
Y
Y
R
K
L
L
R
Y
Y
S
K
N
R
P
T
Site 65
Y653
Y
R
K
L
L
R
Y
Y
S
K
N
R
P
T
E
Site 66
S654
R
K
L
L
R
Y
Y
S
K
N
R
P
T
E
A
Site 67
T659
Y
Y
S
K
N
R
P
T
E
A
V
R
C
Y
E
Site 68
S695
A
R
R
L
W
E
A
S
R
I
P
L
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation