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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF1
Full Name:
Rho guanine nucleotide exchange factor 1
Alias:
115 kDa guanine nucleotide exchange factor; ARHG1; GEF1; LBCL2; P115RhoGEF; P115-RhoGEF
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
102435
Number AA:
912
UniProt ID:
Q92888
International Prot ID:
IPI00339379
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005089
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007266
GO:0008283
GO:0050771
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
D
F
A
R
G
A
A
S
P
G
P
S
R
P
G
Site 2
S14
G
A
A
S
P
G
P
S
R
P
G
L
V
P
V
Site 3
S39
E
N
E
L
E
T
N
S
E
E
Q
N
S
Q
F
Site 4
S44
T
N
S
E
E
Q
N
S
Q
F
Q
S
L
E
Q
Site 5
S48
E
Q
N
S
Q
F
Q
S
L
E
Q
V
K
R
R
Site 6
S86
L
H
A
D
M
L
G
S
L
G
P
K
E
A
K
Site 7
Y100
K
K
A
F
L
D
F
Y
H
S
F
L
E
K
T
Site 8
T125
V
A
F
E
L
D
R
T
R
A
D
L
I
S
E
Site 9
S131
R
T
R
A
D
L
I
S
E
D
V
Q
R
R
F
Site 10
S159
R
Q
L
E
D
F
R
S
K
R
L
M
G
M
T
Site 11
T166
S
K
R
L
M
G
M
T
P
W
E
Q
E
L
A
Site 12
S185
W
V
G
R
D
R
A
S
Y
E
A
R
E
R
H
Site 13
Y186
V
G
R
D
R
A
S
Y
E
A
R
E
R
H
V
Site 14
T207
H
L
E
E
M
Q
H
T
I
S
T
D
E
E
K
Site 15
S209
E
E
M
Q
H
T
I
S
T
D
E
E
K
S
A
Site 16
S235
H
L
G
V
R
T
K
S
G
D
K
K
S
G
R
Site 17
S240
T
K
S
G
D
K
K
S
G
R
N
F
F
R
K
Site 18
S255
K
V
M
G
N
R
R
S
D
E
P
A
K
T
K
Site 19
T261
R
S
D
E
P
A
K
T
K
K
G
L
S
S
I
Site 20
T299
D
A
E
K
P
G
A
T
D
R
K
G
G
V
G
Site 21
S309
K
G
G
V
G
M
P
S
R
D
R
N
I
G
A
Site 22
T321
I
G
A
P
G
Q
D
T
P
G
V
S
L
H
P
Site 23
S325
G
Q
D
T
P
G
V
S
L
H
P
L
S
L
D
Site 24
S330
G
V
S
L
H
P
L
S
L
D
S
P
D
R
E
Site 25
S333
L
H
P
L
S
L
D
S
P
D
R
E
P
G
A
Site 26
S349
A
P
L
E
L
G
D
S
S
P
Q
G
P
M
S
Site 27
S350
P
L
E
L
G
D
S
S
P
Q
G
P
M
S
L
Site 28
S356
S
S
P
Q
G
P
M
S
L
E
S
L
A
P
P
Site 29
S359
Q
G
P
M
S
L
E
S
L
A
P
P
E
S
T
Site 30
S365
E
S
L
A
P
P
E
S
T
D
E
G
A
E
T
Site 31
T372
S
T
D
E
G
A
E
T
E
S
P
E
P
G
D
Site 32
S374
D
E
G
A
E
T
E
S
P
E
P
G
D
E
G
Site 33
S386
D
E
G
E
P
G
R
S
G
L
E
L
E
P
E
Site 34
T406
R
E
L
V
P
P
D
T
L
H
S
L
P
K
S
Site 35
S409
V
P
P
D
T
L
H
S
L
P
K
S
Q
V
K
Site 36
S413
T
L
H
S
L
P
K
S
Q
V
K
R
Q
E
V
Site 37
S485
L
M
K
R
R
Q
E
S
G
Y
L
I
E
E
I
Site 38
Y487
K
R
R
Q
E
S
G
Y
L
I
E
E
I
G
D
Site 39
S506
R
F
D
G
A
E
G
S
W
F
Q
K
I
S
S
Site 40
S513
S
W
F
Q
K
I
S
S
R
F
C
S
R
Q
S
Site 41
S517
K
I
S
S
R
F
C
S
R
Q
S
F
A
L
E
Site 42
S520
S
R
F
C
S
R
Q
S
F
A
L
E
Q
L
K
Site 43
T566
P
T
E
M
Q
R
L
T
K
Y
P
L
L
L
Q
Site 44
Y568
E
M
Q
R
L
T
K
Y
P
L
L
L
Q
S
I
Site 45
Y618
D
L
L
R
L
K
D
Y
Q
R
R
L
D
L
S
Site 46
S625
Y
Q
R
R
L
D
L
S
H
L
R
Q
S
S
D
Site 47
S630
D
L
S
H
L
R
Q
S
S
D
P
M
L
S
E
Site 48
S631
L
S
H
L
R
Q
S
S
D
P
M
L
S
E
F
Site 49
S636
Q
S
S
D
P
M
L
S
E
F
K
N
L
D
I
Site 50
T644
E
F
K
N
L
D
I
T
K
K
K
L
V
H
E
Site 51
T655
L
V
H
E
G
P
L
T
W
R
V
T
K
D
K
Site 52
T659
G
P
L
T
W
R
V
T
K
D
K
A
V
E
V
Site 53
S689
D
E
R
L
L
L
K
S
H
S
R
T
L
T
P
Site 54
S691
R
L
L
L
K
S
H
S
R
T
L
T
P
T
P
Site 55
T693
L
L
K
S
H
S
R
T
L
T
P
T
P
D
G
Site 56
T695
K
S
H
S
R
T
L
T
P
T
P
D
G
K
T
Site 57
T697
H
S
R
T
L
T
P
T
P
D
G
K
T
M
L
Site 58
T702
T
P
T
P
D
G
K
T
M
L
R
P
V
L
R
Site 59
S712
R
P
V
L
R
L
T
S
A
M
T
R
E
V
A
Site 60
Y726
A
T
D
H
K
A
F
Y
V
L
F
T
W
D
Q
Site 61
Y738
W
D
Q
E
A
Q
I
Y
E
L
V
A
Q
T
V
Site 62
T744
I
Y
E
L
V
A
Q
T
V
S
E
R
K
N
W
Site 63
S746
E
L
V
A
Q
T
V
S
E
R
K
N
W
C
A
Site 64
S769
L
K
V
P
A
P
A
S
R
P
K
P
R
P
S
Site 65
S776
S
R
P
K
P
R
P
S
P
S
S
T
R
E
P
Site 66
S778
P
K
P
R
P
S
P
S
S
T
R
E
P
L
L
Site 67
S779
K
P
R
P
S
P
S
S
T
R
E
P
L
L
S
Site 68
T780
P
R
P
S
P
S
S
T
R
E
P
L
L
S
S
Site 69
S786
S
T
R
E
P
L
L
S
S
S
E
N
G
N
G
Site 70
S787
T
R
E
P
L
L
S
S
S
E
N
G
N
G
G
Site 71
S788
R
E
P
L
L
S
S
S
E
N
G
N
G
G
R
Site 72
T797
N
G
N
G
G
R
E
T
S
P
A
D
A
R
T
Site 73
S798
G
N
G
G
R
E
T
S
P
A
D
A
R
T
E
Site 74
T804
T
S
P
A
D
A
R
T
E
R
I
L
S
D
L
Site 75
S809
A
R
T
E
R
I
L
S
D
L
L
P
F
C
R
Site 76
S863
V
P
G
G
G
P
L
S
P
A
R
T
Q
E
I
Site 77
T867
G
P
L
S
P
A
R
T
Q
E
I
Q
E
N
L
Site 78
S876
E
I
Q
E
N
L
L
S
L
E
E
T
M
K
Q
Site 79
T880
N
L
L
S
L
E
E
T
M
K
Q
L
E
E
L
Site 80
S899
C
R
L
R
P
L
L
S
Q
L
G
G
N
S
V
Site 81
S905
L
S
Q
L
G
G
N
S
V
P
Q
P
G
C
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation