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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RAD50
Full Name:
DNA repair protein RAD50
Alias:
HRad50; HRAD50; RAD50-2; RAD50-2 protein
Type:
DNA repair; Adaptor/scaffold; EC 3.6.-.-; Hydrolase
Mass (Da):
153892
Number AA:
1312
UniProt ID:
Q92878
International Prot ID:
IPI00549205
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000781
GO:0005634
GO:0005694
Uniprot
OncoNet
Molecular Function:
GO:0000014
GO:0000166
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0000018
GO:0000019
GO:0000723
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
M
S
I
L
G
V
R
S
F
G
I
E
D
K
D
Site 2
T26
D
K
D
K
Q
I
I
T
F
F
S
P
L
T
I
Site 3
T61
T
G
D
F
P
P
G
T
K
G
N
T
F
V
H
Site 4
T65
P
P
G
T
K
G
N
T
F
V
H
D
P
K
V
Site 5
T103
V
Q
R
S
M
V
C
T
Q
K
S
K
K
T
E
Site 6
S106
S
M
V
C
T
Q
K
S
K
K
T
E
F
K
T
Site 7
T113
S
K
K
T
E
F
K
T
L
E
G
V
I
T
R
Site 8
T119
K
T
L
E
G
V
I
T
R
T
K
H
G
E
K
Site 9
S128
T
K
H
G
E
K
V
S
L
S
S
K
C
A
E
Site 10
S130
H
G
E
K
V
S
L
S
S
K
C
A
E
I
D
Site 11
S167
E
D
S
N
W
P
L
S
E
G
K
A
L
K
Q
Site 12
S181
Q
K
F
D
E
I
F
S
A
T
R
Y
I
K
A
Site 13
T198
T
L
R
Q
V
R
Q
T
Q
G
Q
K
V
K
E
Site 14
Y206
Q
G
Q
K
V
K
E
Y
Q
M
E
L
K
Y
L
Site 15
Y212
E
Y
Q
M
E
L
K
Y
L
K
Q
Y
K
E
K
Site 16
S229
E
I
R
D
Q
I
T
S
K
E
A
Q
L
T
S
Site 17
T235
T
S
K
E
A
Q
L
T
S
S
K
E
I
V
K
Site 18
S237
K
E
A
Q
L
T
S
S
K
E
I
V
K
S
Y
Site 19
S243
S
S
K
E
I
V
K
S
Y
E
N
E
L
D
P
Site 20
S263
K
E
I
E
H
N
L
S
K
I
M
K
L
D
N
Site 21
S277
N
E
I
K
A
L
D
S
R
K
K
Q
M
E
K
Site 22
S287
K
Q
M
E
K
D
N
S
E
L
E
E
K
M
E
Site 23
Y308
D
E
Q
L
N
D
L
Y
H
N
H
Q
R
T
V
Site 24
T314
L
Y
H
N
H
Q
R
T
V
R
E
K
E
R
K
Site 25
S344
R
L
L
N
Q
E
K
S
E
L
L
V
E
Q
G
Site 26
S369
E
H
I
R
A
R
D
S
L
I
Q
S
L
A
T
Site 27
S389
G
F
E
R
G
P
F
S
E
R
Q
I
K
N
F
Site 28
T437
D
E
I
R
D
K
K
T
G
L
G
R
I
I
E
Site 29
S447
G
R
I
I
E
L
K
S
E
I
L
S
K
K
Q
Site 30
S451
E
L
K
S
E
I
L
S
K
K
Q
N
E
L
K
Site 31
Y462
N
E
L
K
N
V
K
Y
E
L
Q
Q
L
E
G
Site 32
S471
L
Q
Q
L
E
G
S
S
D
R
I
L
E
L
D
Site 33
S489
I
K
A
E
R
E
L
S
K
A
E
K
N
S
N
Site 34
T499
E
K
N
S
N
V
E
T
L
K
M
E
V
I
S
Site 35
T517
E
K
A
D
L
D
R
T
L
R
K
L
D
Q
E
Site 36
S557
E
Q
I
R
K
I
K
S
R
H
S
D
E
L
T
Site 37
S560
R
K
I
K
S
R
H
S
D
E
L
T
S
L
L
Site 38
T564
S
R
H
S
D
E
L
T
S
L
L
G
Y
F
P
Site 39
S565
R
H
S
D
E
L
T
S
L
L
G
Y
F
P
N
Site 40
Y569
E
L
T
S
L
L
G
Y
F
P
N
K
K
Q
L
Site 41
S584
E
D
W
L
H
S
K
S
K
E
I
N
Q
T
R
Site 42
T590
K
S
K
E
I
N
Q
T
R
D
R
L
A
K
L
Site 43
S603
K
L
N
K
E
L
A
S
S
E
Q
N
K
N
H
Site 44
S604
L
N
K
E
L
A
S
S
E
Q
N
K
N
H
I
Site 45
S623
K
R
K
E
E
Q
L
S
S
Y
E
D
K
L
F
Site 46
S624
R
K
E
E
Q
L
S
S
Y
E
D
K
L
F
D
Site 47
S635
K
L
F
D
V
C
G
S
Q
D
F
E
S
D
L
Site 48
S640
C
G
S
Q
D
F
E
S
D
L
D
R
L
K
E
Site 49
S652
L
K
E
E
I
E
K
S
S
K
Q
R
A
M
L
Site 50
T671
A
V
Y
S
Q
F
I
T
Q
L
T
D
E
N
Q
Site 51
T674
S
Q
F
I
T
Q
L
T
D
E
N
Q
S
C
C
Site 52
T690
V
C
Q
R
V
F
Q
T
E
A
E
L
Q
E
V
Site 53
S699
A
E
L
Q
E
V
I
S
D
L
Q
S
K
L
R
Site 54
S703
E
V
I
S
D
L
Q
S
K
L
R
L
A
P
D
Site 55
S714
L
A
P
D
K
L
K
S
T
E
S
E
L
K
K
Site 56
S717
D
K
L
K
S
T
E
S
E
L
K
K
K
E
K
Site 57
S738
G
L
V
P
M
R
Q
S
I
I
D
L
K
E
K
Site 58
T773
N
D
I
E
E
Q
E
T
L
L
G
T
I
M
P
Site 59
T777
E
Q
E
T
L
L
G
T
I
M
P
E
E
E
S
Site 60
T824
Q
G
I
D
L
D
R
T
V
Q
Q
V
N
Q
E
Site 61
T841
E
K
Q
H
K
L
D
T
V
S
S
K
I
E
L
Site 62
S843
Q
H
K
L
D
T
V
S
S
K
I
E
L
N
R
Site 63
S865
E
Q
I
Q
H
L
K
S
T
T
N
E
L
K
S
Site 64
S872
S
T
T
N
E
L
K
S
E
K
L
Q
I
S
T
Site 65
S895
E
E
Q
T
V
E
L
S
T
E
V
Q
S
L
Y
Site 66
T896
E
Q
T
V
E
L
S
T
E
V
Q
S
L
Y
R
Site 67
S900
E
L
S
T
E
V
Q
S
L
Y
R
E
I
K
D
Site 68
Y902
S
T
E
V
Q
S
L
Y
R
E
I
K
D
A
K
Site 69
S913
K
D
A
K
E
Q
V
S
P
L
E
T
T
L
E
Site 70
T917
E
Q
V
S
P
L
E
T
T
L
E
K
F
Q
Q
Site 71
Y957
K
V
K
N
I
H
G
Y
M
K
D
I
E
N
Y
Site 72
Y972
I
Q
D
G
K
D
D
Y
K
K
Q
K
E
T
E
Site 73
S988
N
K
V
I
A
Q
L
S
E
C
E
K
H
K
E
Site 74
T1010
L
M
R
Q
D
I
D
T
Q
K
I
Q
E
R
W
Site 75
T1023
R
W
L
Q
D
N
L
T
L
R
K
R
N
E
E
Site 76
S1055
M
Q
V
L
Q
M
K
S
E
H
Q
K
L
E
E
Site 77
Y1081
A
L
G
R
Q
K
G
Y
E
E
E
I
I
H
F
Site 78
Y1104
F
R
D
A
E
E
K
Y
R
E
M
M
I
V
M
Site 79
T1113
E
M
M
I
V
M
R
T
T
E
L
V
N
K
D
Site 80
T1114
M
M
I
V
M
R
T
T
E
L
V
N
K
D
L
Site 81
Y1124
V
N
K
D
L
D
I
Y
Y
K
T
L
D
Q
A
Site 82
Y1125
N
K
D
L
D
I
Y
Y
K
T
L
D
Q
A
I
Site 83
T1127
D
L
D
I
Y
Y
K
T
L
D
Q
A
I
M
K
Site 84
T1154
I
R
D
L
W
R
S
T
Y
R
G
Q
D
I
E
Site 85
Y1155
R
D
L
W
R
S
T
Y
R
G
Q
D
I
E
Y
Site 86
Y1162
Y
R
G
Q
D
I
E
Y
I
E
I
R
S
D
A
Site 87
S1176
A
D
E
N
V
S
A
S
D
K
R
R
N
Y
N
Site 88
Y1182
A
S
D
K
R
R
N
Y
N
Y
R
V
V
M
L
Site 89
Y1184
D
K
R
R
N
Y
N
Y
R
V
V
M
L
K
G
Site 90
S1202
L
D
M
R
G
R
C
S
A
G
Q
K
V
L
A
Site 91
S1244
L
D
R
E
N
I
E
S
L
A
H
A
L
V
E
Site 92
S1255
A
L
V
E
I
I
K
S
R
S
Q
Q
R
N
F
Site 93
S1257
V
E
I
I
K
S
R
S
Q
Q
R
N
F
Q
L
Site 94
Y1282
E
L
L
G
R
S
E
Y
V
E
K
F
Y
R
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation