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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TANK
Full Name:
TRAF family member-associated NF-kappa-B activator
Alias:
ITRAF; I-TRAF; TRAF family member-associated NFKB activator; TRAF2; TRAF-interacting protein
Type:
Adaptor/scaffold
Mass (Da):
47816
Number AA:
425
UniProt ID:
Q92844
International Prot ID:
IPI00299166
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
Q
A
C
M
D
R
D
S
A
V
K
E
L
Q
Q
Site 2
S49
R
E
Q
Q
E
Q
L
S
L
Q
Q
T
I
I
D
Site 3
T53
E
Q
L
S
L
Q
Q
T
I
I
D
K
L
K
S
Site 4
S67
S
Q
L
L
L
V
N
S
T
Q
D
N
N
Y
G
Site 5
Y73
N
S
T
Q
D
N
N
Y
G
C
V
P
L
L
E
Site 6
S82
C
V
P
L
L
E
D
S
E
T
R
K
N
N
L
Site 7
T84
P
L
L
E
D
S
E
T
R
K
N
N
L
T
L
Site 8
T90
E
T
R
K
N
N
L
T
L
D
Q
P
Q
D
K
Site 9
S116
K
V
R
R
Q
E
V
S
S
P
R
K
E
T
S
Site 10
S117
V
R
R
Q
E
V
S
S
P
R
K
E
T
S
A
Site 11
T122
V
S
S
P
R
K
E
T
S
A
R
S
L
G
S
Site 12
S123
S
S
P
R
K
E
T
S
A
R
S
L
G
S
P
Site 13
S126
R
K
E
T
S
A
R
S
L
G
S
P
L
L
H
Site 14
S129
T
S
A
R
S
L
G
S
P
L
L
H
E
R
G
Site 15
T141
E
R
G
N
I
E
K
T
F
W
D
L
K
E
E
Site 16
S164
K
A
Q
K
D
H
L
S
K
L
N
I
P
D
T
Site 17
T171
S
K
L
N
I
P
D
T
A
T
E
T
Q
C
S
Site 18
T173
L
N
I
P
D
T
A
T
E
T
Q
C
S
V
P
Site 19
T175
I
P
D
T
A
T
E
T
Q
C
S
V
P
I
Q
Site 20
T187
P
I
Q
C
T
D
K
T
D
K
Q
E
A
L
F
Site 21
S208
D
I
N
R
G
A
P
S
I
T
S
V
T
P
R
Site 22
S211
R
G
A
P
S
I
T
S
V
T
P
R
G
L
C
Site 23
T213
A
P
S
I
T
S
V
T
P
R
G
L
C
R
D
Site 24
T224
L
C
R
D
E
E
D
T
S
F
E
S
L
S
K
Site 25
S225
C
R
D
E
E
D
T
S
F
E
S
L
S
K
F
Site 26
S228
E
E
D
T
S
F
E
S
L
S
K
F
N
V
K
Site 27
S230
D
T
S
F
E
S
L
S
K
F
N
V
K
F
P
Site 28
S243
F
P
P
M
D
N
D
S
T
F
L
H
S
T
P
Site 29
T244
P
P
M
D
N
D
S
T
F
L
H
S
T
P
E
Site 30
S248
N
D
S
T
F
L
H
S
T
P
E
R
P
G
I
Site 31
T249
D
S
T
F
L
H
S
T
P
E
R
P
G
I
L
Site 32
S257
P
E
R
P
G
I
L
S
P
A
T
S
E
A
V
Site 33
S261
G
I
L
S
P
A
T
S
E
A
V
C
Q
E
K
Site 34
T305
S
A
I
Q
N
L
K
T
T
D
K
T
K
P
S
Site 35
T309
N
L
K
T
T
D
K
T
K
P
S
N
L
V
N
Site 36
T317
K
P
S
N
L
V
N
T
C
I
R
T
T
L
D
Site 37
Y338
P
G
D
H
N
A
L
Y
V
N
S
F
P
L
L
Site 38
S341
H
N
A
L
Y
V
N
S
F
P
L
L
D
P
S
Site 39
S354
P
S
D
A
P
F
P
S
L
D
S
P
G
K
A
Site 40
S357
A
P
F
P
S
L
D
S
P
G
K
A
I
R
G
Site 41
S378
K
P
F
P
N
Q
D
S
D
S
V
V
L
S
G
Site 42
S380
F
P
N
Q
D
S
D
S
V
V
L
S
G
T
D
Site 43
S384
D
S
D
S
V
V
L
S
G
T
D
S
E
L
H
Site 44
S406
C
Q
A
V
F
P
P
S
I
T
S
R
G
D
F
Site 45
S409
V
F
P
P
S
I
T
S
R
G
D
F
L
R
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation