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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCSK5
Full Name:
Proprotein convertase subtilisin/kexin type 5
Alias:
Proprotein convertase 5;Proprotein convertase 6;Subtilisin/kexin-like protease PC5
Type:
Mass (Da):
101649
Number AA:
913
UniProt ID:
Q92824
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y35
P
V
C
R
T
R
V
Y
T
N
H
W
A
V
K
Site 2
S55
P
E
A
N
R
I
A
S
K
Y
G
F
I
N
I
Site 3
Y57
A
N
R
I
A
S
K
Y
G
F
I
N
I
G
Q
Site 4
Y71
Q
I
G
A
L
K
D
Y
Y
H
F
Y
H
S
R
Site 5
Y72
I
G
A
L
K
D
Y
Y
H
F
Y
H
S
R
T
Site 6
Y75
L
K
D
Y
Y
H
F
Y
H
S
R
T
I
K
R
Site 7
T79
Y
H
F
Y
H
S
R
T
I
K
R
S
V
I
S
Site 8
S83
H
S
R
T
I
K
R
S
V
I
S
S
R
G
T
Site 9
S86
T
I
K
R
S
V
I
S
S
R
G
T
H
S
F
Site 10
S87
I
K
R
S
V
I
S
S
R
G
T
H
S
F
I
Site 11
T90
S
V
I
S
S
R
G
T
H
S
F
I
S
M
E
Site 12
S92
I
S
S
R
G
T
H
S
F
I
S
M
E
P
K
Site 13
S95
R
G
T
H
S
F
I
S
M
E
P
K
V
E
W
Site 14
Y116
K
K
R
T
K
R
D
Y
D
F
S
R
A
Q
S
Site 15
S119
T
K
R
D
Y
D
F
S
R
A
Q
S
T
Y
F
Site 16
S123
Y
D
F
S
R
A
Q
S
T
Y
F
N
D
P
K
Site 17
Y125
F
S
R
A
Q
S
T
Y
F
N
D
P
K
W
P
Site 18
Y160
E
G
A
W
K
R
G
Y
T
G
K
N
I
V
V
Site 19
T161
G
A
W
K
R
G
Y
T
G
K
N
I
V
V
T
Site 20
Y185
H
P
D
L
M
Q
N
Y
D
A
L
A
S
C
D
Site 21
Y204
D
L
D
P
M
P
R
Y
D
A
S
N
E
N
K
Site 22
S207
P
M
P
R
Y
D
A
S
N
E
N
K
H
G
T
Site 23
T250
R
M
L
D
G
D
V
T
D
M
V
E
A
K
S
Site 24
S257
T
D
M
V
E
A
K
S
V
S
F
N
P
Q
H
Site 25
S259
M
V
E
A
K
S
V
S
F
N
P
Q
H
V
H
Site 26
Y268
N
P
Q
H
V
H
I
Y
S
A
S
W
G
P
D
Site 27
T280
G
P
D
D
D
G
K
T
V
D
G
P
A
P
L
Site 28
T288
V
D
G
P
A
P
L
T
R
Q
A
F
E
N
G
Site 29
S311
G
S
V
F
V
W
A
S
G
N
G
G
R
S
K
Site 30
S322
G
R
S
K
D
H
C
S
C
D
G
Y
T
N
S
Site 31
Y326
D
H
C
S
C
D
G
Y
T
N
S
I
Y
T
I
Site 32
S329
S
C
D
G
Y
T
N
S
I
Y
T
I
S
I
S
Site 33
Y331
D
G
Y
T
N
S
I
Y
T
I
S
I
S
S
T
Site 34
T332
G
Y
T
N
S
I
Y
T
I
S
I
S
S
T
A
Site 35
S334
T
N
S
I
Y
T
I
S
I
S
S
T
A
E
S
Site 36
S336
S
I
Y
T
I
S
I
S
S
T
A
E
S
G
K
Site 37
S337
I
Y
T
I
S
I
S
S
T
A
E
S
G
K
K
Site 38
T338
Y
T
I
S
I
S
S
T
A
E
S
G
K
K
P
Site 39
S341
S
I
S
S
T
A
E
S
G
K
K
P
W
Y
L
Site 40
Y347
E
S
G
K
K
P
W
Y
L
E
E
C
S
S
T
Site 41
S353
W
Y
L
E
E
C
S
S
T
L
A
T
T
Y
S
Site 42
T354
Y
L
E
E
C
S
S
T
L
A
T
T
Y
S
S
Site 43
T357
E
C
S
S
T
L
A
T
T
Y
S
S
G
E
S
Site 44
T358
C
S
S
T
L
A
T
T
Y
S
S
G
E
S
Y
Site 45
Y359
S
S
T
L
A
T
T
Y
S
S
G
E
S
Y
D
Site 46
S360
S
T
L
A
T
T
Y
S
S
G
E
S
Y
D
K
Site 47
S364
T
T
Y
S
S
G
E
S
Y
D
K
K
I
I
T
Site 48
Y365
T
Y
S
S
G
E
S
Y
D
K
K
I
I
T
T
Site 49
T379
T
D
L
R
Q
R
C
T
D
N
H
T
G
T
S
Site 50
T383
Q
R
C
T
D
N
H
T
G
T
S
A
S
A
P
Site 51
T407
L
E
A
N
P
F
L
T
W
R
D
V
Q
H
V
Site 52
S419
Q
H
V
I
V
R
T
S
R
A
G
H
L
N
A
Site 53
T431
L
N
A
N
D
W
K
T
N
A
A
G
F
K
V
Site 54
T461
M
E
A
E
K
W
T
T
V
P
R
Q
H
V
C
Site 55
T478
S
T
D
R
Q
I
K
T
I
R
P
N
S
A
V
Site 56
S483
I
K
T
I
R
P
N
S
A
V
R
S
I
Y
K
Site 57
S487
R
P
N
S
A
V
R
S
I
Y
K
A
S
G
C
Site 58
Y489
N
S
A
V
R
S
I
Y
K
A
S
G
C
S
D
Site 59
Y504
N
P
N
R
H
V
N
Y
L
E
H
V
V
V
R
Site 60
T513
E
H
V
V
V
R
I
T
I
T
H
P
R
R
G
Site 61
Y525
R
R
G
D
L
A
I
Y
L
T
S
P
S
G
T
Site 62
T527
G
D
L
A
I
Y
L
T
S
P
S
G
T
R
S
Site 63
S528
D
L
A
I
Y
L
T
S
P
S
G
T
R
S
Q
Site 64
S530
A
I
Y
L
T
S
P
S
G
T
R
S
Q
L
L
Site 65
T532
Y
L
T
S
P
S
G
T
R
S
Q
L
L
A
N
Site 66
S534
T
S
P
S
G
T
R
S
Q
L
L
A
N
R
L
Site 67
Y573
G
D
W
V
L
E
V
Y
D
T
P
S
Q
L
R
Site 68
T575
W
V
L
E
V
Y
D
T
P
S
Q
L
R
N
F
Site 69
S577
L
E
V
Y
D
T
P
S
Q
L
R
N
F
K
T
Site 70
T584
S
Q
L
R
N
F
K
T
P
G
K
L
K
E
W
Site 71
S592
P
G
K
L
K
E
W
S
L
V
L
Y
G
T
S
Site 72
Y596
K
E
W
S
L
V
L
Y
G
T
S
V
Q
P
Y
Site 73
S599
S
L
V
L
Y
G
T
S
V
Q
P
Y
S
P
T
Site 74
Y603
Y
G
T
S
V
Q
P
Y
S
P
T
N
E
F
P
Site 75
S604
G
T
S
V
Q
P
Y
S
P
T
N
E
F
P
K
Site 76
Y617
P
K
V
E
R
F
R
Y
S
R
V
E
D
P
T
Site 77
S618
K
V
E
R
F
R
Y
S
R
V
E
D
P
T
D
Site 78
T624
Y
S
R
V
E
D
P
T
D
D
Y
G
T
E
D
Site 79
Y627
V
E
D
P
T
D
D
Y
G
T
E
D
Y
A
G
Site 80
T629
D
P
T
D
D
Y
G
T
E
D
Y
A
G
P
C
Site 81
Y632
D
D
Y
G
T
E
D
Y
A
G
P
C
D
P
E
Site 82
S641
G
P
C
D
P
E
C
S
E
V
G
C
D
G
P
Site 83
Y679
S
S
C
P
P
G
H
Y
H
A
D
K
K
R
C
Site 84
Y711
C
M
S
C
K
Y
G
Y
F
L
N
E
E
T
N
Site 85
T722
E
E
T
N
S
C
V
T
H
C
P
D
G
S
Y
Site 86
Y729
T
H
C
P
D
G
S
Y
Q
D
T
K
K
N
L
Site 87
T732
P
D
G
S
Y
Q
D
T
K
K
N
L
C
R
K
Site 88
S761
T
E
C
R
D
G
L
S
L
Q
G
S
R
C
S
Site 89
S765
D
G
L
S
L
Q
G
S
R
C
S
V
S
C
E
Site 90
S768
S
L
Q
G
S
R
C
S
V
S
C
E
D
G
R
Site 91
S770
Q
G
S
R
C
S
V
S
C
E
D
G
R
Y
F
Site 92
Y776
V
S
C
E
D
G
R
Y
F
N
G
Q
D
C
Q
Site 93
Y823
Q
S
C
S
I
S
Y
Y
F
D
H
S
S
E
N
Site 94
S827
I
S
Y
Y
F
D
H
S
S
E
N
G
Y
K
S
Site 95
Y832
D
H
S
S
E
N
G
Y
K
S
C
K
K
C
D
Site 96
S834
S
S
E
N
G
Y
K
S
C
K
K
C
D
I
S
Site 97
T854
G
P
G
F
K
N
C
T
S
C
P
S
G
Y
L
Site 98
S855
P
G
F
K
N
C
T
S
C
P
S
G
Y
L
L
Site 99
T877
G
A
I
C
K
D
A
T
E
E
S
W
A
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation