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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HAS2
Full Name:
Hyaluronan synthase 2
Alias:
EC 2.4.1.212; HA synthase 2; Hyaluronic acid synthase 2
Type:
Membrane, Integral plasma membrane protein
Mass (Da):
63566
Number AA:
552
UniProt ID:
Q92819
International Prot ID:
IPI00023713
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0050501
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y42
Q
F
I
Q
T
D
N
Y
Y
F
S
F
G
L
Y
Site 2
Y43
F
I
Q
T
D
N
Y
Y
F
S
F
G
L
Y
G
Site 3
S74
E
H
R
K
M
K
K
S
L
E
T
P
I
K
L
Site 4
T77
K
M
K
K
S
L
E
T
P
I
K
L
N
K
T
Site 5
Y98
A
Y
Q
E
D
P
D
Y
L
R
K
C
L
Q
S
Site 6
S105
Y
L
R
K
C
L
Q
S
V
K
R
L
T
Y
P
Site 7
T110
L
Q
S
V
K
R
L
T
Y
P
G
I
K
V
V
Site 8
Y129
G
N
S
E
D
D
L
Y
M
M
D
I
F
S
E
Site 9
S163
G
P
G
E
T
D
E
S
H
K
E
S
S
Q
H
Site 10
S167
T
D
E
S
H
K
E
S
S
Q
H
V
T
Q
L
Site 11
S168
D
E
S
H
K
E
S
S
Q
H
V
T
Q
L
V
Site 12
T172
K
E
S
S
Q
H
V
T
Q
L
V
L
S
N
K
Site 13
Y195
G
G
K
R
E
V
M
Y
T
A
F
R
A
L
G
Site 14
T196
G
K
R
E
V
M
Y
T
A
F
R
A
L
G
R
Site 15
Y207
A
L
G
R
S
V
D
Y
V
Q
V
C
D
S
D
Site 16
S213
D
Y
V
Q
V
C
D
S
D
T
M
L
D
P
A
Site 17
T215
V
Q
V
C
D
S
D
T
M
L
D
P
A
S
S
Site 18
Y248
D
V
Q
I
L
N
K
Y
D
S
W
I
S
F
L
Site 19
S250
Q
I
L
N
K
Y
D
S
W
I
S
F
L
S
S
Site 20
S253
N
K
Y
D
S
W
I
S
F
L
S
S
V
R
Y
Site 21
Y287
I
S
G
P
L
G
M
Y
R
N
S
L
L
H
E
Site 22
S290
P
L
G
M
Y
R
N
S
L
L
H
E
F
V
E
Site 23
T318
F
G
D
D
R
H
L
T
N
R
V
L
S
L
G
Site 24
S323
H
L
T
N
R
V
L
S
L
G
Y
A
T
K
Y
Site 25
Y330
S
L
G
Y
A
T
K
Y
T
A
R
S
K
C
L
Site 26
T331
L
G
Y
A
T
K
Y
T
A
R
S
K
C
L
T
Site 27
S334
A
T
K
Y
T
A
R
S
K
C
L
T
E
T
P
Site 28
T338
T
A
R
S
K
C
L
T
E
T
P
I
E
Y
L
Site 29
T340
R
S
K
C
L
T
E
T
P
I
E
Y
L
R
W
Site 30
Y344
L
T
E
T
P
I
E
Y
L
R
W
L
N
Q
Q
Site 31
Y358
Q
T
R
W
S
K
S
Y
F
R
E
W
L
Y
N
Site 32
T412
N
I
L
L
F
L
L
T
V
Q
L
V
G
L
I
Site 33
S466
N
K
A
G
W
G
T
S
G
R
K
T
I
V
V
Site 34
Y497
G
G
V
I
F
T
I
Y
K
E
S
K
R
P
F
Site 35
S500
I
F
T
I
Y
K
E
S
K
R
P
F
S
E
S
Site 36
S505
K
E
S
K
R
P
F
S
E
S
K
Q
T
V
L
Site 37
S507
S
K
R
P
F
S
E
S
K
Q
T
V
L
I
V
Site 38
Y519
L
I
V
G
T
L
L
Y
A
C
Y
W
V
M
L
Site 39
Y522
G
T
L
L
Y
A
C
Y
W
V
M
L
L
T
L
Site 40
Y546
R
R
K
K
G
Q
Q
Y
D
M
V
L
D
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation