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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EVPL
Full Name:
Envoplakin
Alias:
210 kDa cornified envelope precursor; 210 kDa paraneoplastic pemphigus antigen; EVPK; P210
Type:
Adaptor/scaffold
Mass (Da):
231618
Number AA:
2033
UniProt ID:
Q92817
International Prot ID:
IPI00023711
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001533
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005198
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0008152
GO:0008544
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
F
K
G
L
S
K
G
S
Q
G
K
G
Site 2
S9
F
K
G
L
S
K
G
S
Q
G
K
G
S
P
K
Site 3
S14
K
G
S
Q
G
K
G
S
P
K
G
S
P
A
K
Site 4
S18
G
K
G
S
P
K
G
S
P
A
K
G
S
P
K
Site 5
S23
K
G
S
P
A
K
G
S
P
K
G
S
P
S
R
Site 6
S27
A
K
G
S
P
K
G
S
P
S
R
H
S
R
A
Site 7
S29
G
S
P
K
G
S
P
S
R
H
S
R
A
A
T
Site 8
S32
K
G
S
P
S
R
H
S
R
A
A
T
Q
E
L
Site 9
T36
S
R
H
S
R
A
A
T
Q
E
L
A
L
L
I
Site 10
S44
Q
E
L
A
L
L
I
S
R
M
Q
A
N
A
D
Site 11
T60
V
E
R
D
I
L
E
T
Q
K
R
L
Q
Q
D
Site 12
S71
L
Q
Q
D
R
L
N
S
E
Q
S
Q
A
L
Q
Site 13
S74
D
R
L
N
S
E
Q
S
Q
A
L
Q
H
Q
Q
Site 14
S86
H
Q
Q
E
T
G
R
S
L
K
E
A
E
V
L
Site 15
T127
K
Q
L
H
E
R
V
T
Q
E
C
A
E
Y
R
Site 16
Y133
V
T
Q
E
C
A
E
Y
R
A
L
Y
E
K
M
Site 17
Y137
C
A
E
Y
R
A
L
Y
E
K
M
V
L
P
P
Site 18
Y192
L
Q
K
E
I
D
A
Y
G
Q
Q
L
R
S
L
Site 19
S198
A
Y
G
Q
Q
L
R
S
L
V
G
P
D
A
A
Site 20
T206
L
V
G
P
D
A
A
T
I
R
S
Q
Y
R
D
Site 21
S209
P
D
A
A
T
I
R
S
Q
Y
R
D
L
L
K
Site 22
Y211
A
A
T
I
R
S
Q
Y
R
D
L
L
K
A
A
Site 23
S219
R
D
L
L
K
A
A
S
W
R
G
Q
S
L
G
Site 24
S224
A
A
S
W
R
G
Q
S
L
G
S
L
Y
T
H
Site 25
S227
W
R
G
Q
S
L
G
S
L
Y
T
H
L
Q
G
Site 26
Y229
G
Q
S
L
G
S
L
Y
T
H
L
Q
G
C
T
Site 27
T230
Q
S
L
G
S
L
Y
T
H
L
Q
G
C
T
R
Site 28
S240
Q
G
C
T
R
Q
L
S
A
L
A
E
Q
Q
R
Site 29
S255
R
I
L
Q
Q
D
W
S
D
L
M
A
D
P
A
Site 30
Y268
P
A
G
V
R
R
E
Y
E
H
F
K
Q
H
E
Site 31
S278
F
K
Q
H
E
L
L
S
Q
E
Q
S
V
N
Q
Site 32
S282
E
L
L
S
Q
E
Q
S
V
N
Q
L
E
D
D
Site 33
Y335
Q
L
Q
H
V
E
D
Y
R
R
F
Q
E
E
A
Site 34
S344
R
F
Q
E
E
A
D
S
V
S
Q
T
L
A
K
Site 35
S346
Q
E
E
A
D
S
V
S
Q
T
L
A
K
L
N
Site 36
T348
E
A
D
S
V
S
Q
T
L
A
K
L
N
S
N
Site 37
S354
Q
T
L
A
K
L
N
S
N
L
D
A
K
Y
S
Site 38
Y360
N
S
N
L
D
A
K
Y
S
P
A
P
G
G
P
Site 39
S361
S
N
L
D
A
K
Y
S
P
A
P
G
G
P
P
Site 40
T392
L
A
V
T
E
R
A
T
G
D
L
Q
R
R
S
Site 41
S399
T
G
D
L
Q
R
R
S
R
D
V
A
P
L
P
Site 42
S426
D
S
I
C
D
W
D
S
G
E
V
Q
L
L
Q
Site 43
S479
P
D
A
V
A
R
A
S
R
L
A
S
E
L
Q
Site 44
S483
A
R
A
S
R
L
A
S
E
L
Q
A
L
K
Q
Site 45
T494
A
L
K
Q
K
L
A
T
V
Q
S
R
L
K
A
Site 46
S497
Q
K
L
A
T
V
Q
S
R
L
K
A
S
A
V
Site 47
S502
V
Q
S
R
L
K
A
S
A
V
E
S
L
R
P
Site 48
S506
L
K
A
S
A
V
E
S
L
R
P
S
Q
Q
A
Site 49
S510
A
V
E
S
L
R
P
S
Q
Q
A
P
S
G
S
Site 50
S515
R
P
S
Q
Q
A
P
S
G
S
D
L
A
N
P
Site 51
T529
P
Q
A
Q
K
L
L
T
Q
M
T
R
L
D
G
Site 52
S554
A
W
A
R
A
P
L
S
R
P
T
P
L
E
D
Site 53
T557
R
A
P
L
S
R
P
T
P
L
E
D
L
E
G
Site 54
S568
D
L
E
G
R
I
H
S
H
E
G
T
A
Q
R
Site 55
T572
R
I
H
S
H
E
G
T
A
Q
R
L
Q
S
L
Site 56
S578
G
T
A
Q
R
L
Q
S
L
G
T
E
K
E
T
Site 57
S595
K
E
C
E
A
F
L
S
T
R
P
V
G
P
A
Site 58
S612
Q
L
P
V
A
L
N
S
V
K
N
K
F
S
D
Site 59
S625
S
D
V
Q
V
L
C
S
L
Y
G
E
K
A
K
Site 60
S673
G
A
L
Q
E
R
V
S
E
L
Q
R
Q
R
R
Site 61
T687
R
E
L
L
E
Q
Q
T
C
V
L
R
L
H
R
Site 62
T728
Q
R
Q
V
R
A
L
T
D
R
Y
H
A
V
G
Site 63
Y731
V
R
A
L
T
D
R
Y
H
A
V
G
D
Q
L
Site 64
T751
V
V
Q
D
A
A
L
T
Y
Q
Q
F
K
N
C
Site 65
Y752
V
Q
D
A
A
L
T
Y
Q
Q
F
K
N
C
K
Site 66
S772
W
L
E
H
L
P
R
S
Q
V
R
P
S
D
G
Site 67
S777
P
R
S
Q
V
R
P
S
D
G
P
S
Q
I
A
Site 68
S781
V
R
P
S
D
G
P
S
Q
I
A
Y
K
L
Q
Site 69
Y785
D
G
P
S
Q
I
A
Y
K
L
Q
A
Q
K
R
Site 70
T794
L
Q
A
Q
K
R
L
T
Q
E
I
Q
S
R
E
Site 71
T806
S
R
E
R
D
R
A
T
A
S
H
L
S
Q
A
Site 72
Y821
L
Q
A
A
L
Q
D
Y
E
L
Q
A
D
T
Y
Site 73
T827
D
Y
E
L
Q
A
D
T
Y
R
C
S
L
E
P
Site 74
Y828
Y
E
L
Q
A
D
T
Y
R
C
S
L
E
P
T
Site 75
S831
Q
A
D
T
Y
R
C
S
L
E
P
T
L
A
V
Site 76
T835
Y
R
C
S
L
E
P
T
L
A
V
S
A
P
K
Site 77
S839
L
E
P
T
L
A
V
S
A
P
K
R
P
R
V
Site 78
T897
L
S
E
D
I
R
R
T
H
D
A
K
Q
G
S
Site 79
S904
T
H
D
A
K
Q
G
S
E
S
P
A
Q
A
G
Site 80
S906
D
A
K
Q
G
S
E
S
P
A
Q
A
G
R
E
Site 81
S914
P
A
Q
A
G
R
E
S
E
A
L
K
A
Q
L
Site 82
S940
H
E
L
E
A
Q
R
S
Q
L
L
Q
L
R
T
Site 83
T947
S
Q
L
L
Q
L
R
T
Q
R
P
L
E
R
L
Site 84
Y963
E
K
E
V
V
E
F
Y
R
D
P
Q
L
E
G
Site 85
S971
R
D
P
Q
L
E
G
S
L
S
R
V
K
A
Q
Site 86
S973
P
Q
L
E
G
S
L
S
R
V
K
A
Q
V
E
Site 87
S1005
Q
K
V
V
Q
L
E
S
K
R
K
T
M
Q
P
Site 88
T1009
Q
L
E
S
K
R
K
T
M
Q
P
H
L
L
T
Site 89
S1030
E
R
D
P
G
L
D
S
Q
A
A
Q
L
R
I
Site 90
S1050
R
G
E
D
A
V
I
S
A
R
L
E
G
L
K
Site 91
S1128
E
D
L
E
R
A
I
S
S
V
E
P
K
V
I
Site 92
S1152
D
P
G
L
L
Q
E
S
S
R
L
R
S
L
L
Site 93
S1153
P
G
L
L
Q
E
S
S
R
L
R
S
L
L
E
Site 94
S1157
Q
E
S
S
R
L
R
S
L
L
E
E
E
R
T
Site 95
T1164
S
L
L
E
E
E
R
T
K
N
A
T
L
A
R
Site 96
T1168
E
E
R
T
K
N
A
T
L
A
R
E
L
S
D
Site 97
S1174
A
T
L
A
R
E
L
S
D
L
H
S
K
Y
S
Site 98
S1178
R
E
L
S
D
L
H
S
K
Y
S
V
V
E
K
Site 99
Y1180
L
S
D
L
H
S
K
Y
S
V
V
E
K
Q
R
Site 100
S1181
S
D
L
H
S
K
Y
S
V
V
E
K
Q
R
P
Site 101
T1206
I
F
Q
V
D
P
E
T
E
Q
E
I
T
R
L
Site 102
S1225
Q
E
M
A
G
K
R
S
G
V
E
K
E
V
E
Site 103
T1247
V
L
R
A
Q
K
P
T
V
E
Y
K
E
V
T
Site 104
T1254
T
V
E
Y
K
E
V
T
Q
E
V
V
R
H
E
Site 105
S1263
E
V
V
R
H
E
R
S
P
E
V
L
R
E
I
Site 106
S1283
Q
L
N
E
L
V
N
S
H
G
R
S
Q
E
Q
Site 107
S1287
L
V
N
S
H
G
R
S
Q
E
Q
L
I
R
L
Site 108
T1310
R
E
R
A
K
V
E
T
K
T
V
S
K
E
V
Site 109
T1312
R
A
K
V
E
T
K
T
V
S
K
E
V
V
R
Site 110
Y1352
R
A
A
E
D
A
V
Y
E
L
Q
S
K
R
L
Site 111
S1356
D
A
V
Y
E
L
Q
S
K
R
L
L
L
E
R
Site 112
T1378
V
V
Q
E
V
V
V
T
Q
K
D
P
K
L
R
Site 113
S1389
P
K
L
R
E
E
H
S
R
L
S
G
S
L
D
Site 114
S1392
R
E
E
H
S
R
L
S
G
S
L
D
E
E
V
Site 115
S1394
E
H
S
R
L
S
G
S
L
D
E
E
V
G
R
Site 116
S1424
E
E
Q
E
G
L
L
S
F
Q
E
D
R
S
K
Site 117
S1430
L
S
F
Q
E
D
R
S
K
K
L
A
V
E
R
Site 118
T1443
E
R
E
L
R
Q
L
T
L
R
I
Q
E
L
E
Site 119
T1455
E
L
E
K
R
P
P
T
V
Q
E
K
I
I
M
Site 120
S1477
K
D
P
D
L
E
K
S
T
E
A
L
R
W
D
Site 121
T1490
W
D
L
D
Q
E
K
T
Q
V
T
E
L
N
R
Site 122
S1514
D
V
L
Q
K
A
K
S
Q
E
K
T
I
Y
K
Site 123
T1518
K
A
K
S
Q
E
K
T
I
Y
K
E
V
I
R
Site 124
Y1520
K
S
Q
E
K
T
I
Y
K
E
V
I
R
V
Q
Site 125
T1548
E
M
L
N
R
E
R
T
A
R
Q
A
R
E
E
Site 126
T1569
E
R
I
D
R
A
E
T
L
G
R
T
W
S
R
Site 127
S1575
E
T
L
G
R
T
W
S
R
E
E
S
E
L
Q
Site 128
S1579
R
T
W
S
R
E
E
S
E
L
Q
R
A
R
D
Site 129
S1617
T
L
Q
L
Q
E
E
S
K
L
L
S
Q
K
T
Site 130
S1621
Q
E
E
S
K
L
L
S
Q
K
T
E
S
E
R
Site 131
T1624
S
K
L
L
S
Q
K
T
E
S
E
R
Q
K
A
Site 132
S1626
L
L
S
Q
K
T
E
S
E
R
Q
K
A
A
Q
Site 133
S1639
A
Q
R
G
Q
E
L
S
R
L
E
A
A
I
L
Site 134
Y1653
L
R
E
K
D
Q
I
Y
E
K
E
R
T
L
R
Site 135
T1658
Q
I
Y
E
K
E
R
T
L
R
D
L
H
A
K
Site 136
S1667
R
D
L
H
A
K
V
S
R
E
E
L
S
Q
E
Site 137
S1672
K
V
S
R
E
E
L
S
Q
E
T
Q
T
R
E
Site 138
T1680
Q
E
T
Q
T
R
E
T
N
L
S
T
K
I
S
Site 139
S1683
Q
T
R
E
T
N
L
S
T
K
I
S
I
L
E
Site 140
S1687
T
N
L
S
T
K
I
S
I
L
E
P
E
T
G
Site 141
S1698
P
E
T
G
K
D
M
S
P
Y
E
A
Y
K
R
Site 142
Y1700
T
G
K
D
M
S
P
Y
E
A
Y
K
R
G
I
Site 143
Y1703
D
M
S
P
Y
E
A
Y
K
R
G
I
I
D
R
Site 144
Y1713
G
I
I
D
R
G
Q
Y
L
Q
L
Q
E
L
E
Site 145
T1728
C
D
W
E
E
V
T
T
S
G
P
C
G
E
E
Site 146
S1729
D
W
E
E
V
T
T
S
G
P
C
G
E
E
S
Site 147
S1736
S
G
P
C
G
E
E
S
V
L
L
D
R
K
S
Site 148
S1743
S
V
L
L
D
R
K
S
G
K
Q
Y
S
I
E
Site 149
S1748
R
K
S
G
K
Q
Y
S
I
E
A
A
L
R
C
Site 150
S1759
A
L
R
C
R
R
I
S
K
E
E
Y
H
L
Y
Site 151
Y1763
R
R
I
S
K
E
E
Y
H
L
Y
K
D
G
H
Site 152
Y1766
S
K
E
E
Y
H
L
Y
K
D
G
H
L
P
I
Site 153
S1787
V
A
G
E
T
K
P
S
S
S
L
S
I
G
S
Site 154
S1788
A
G
E
T
K
P
S
S
S
L
S
I
G
S
I
Site 155
S1789
G
E
T
K
P
S
S
S
L
S
I
G
S
I
I
Site 156
S1791
T
K
P
S
S
S
L
S
I
G
S
I
I
S
K
Site 157
S1799
I
G
S
I
I
S
K
S
P
L
A
S
P
A
P
Site 158
S1803
I
S
K
S
P
L
A
S
P
A
P
Q
S
T
S
Site 159
S1808
L
A
S
P
A
P
Q
S
T
S
F
F
S
P
S
Site 160
T1809
A
S
P
A
P
Q
S
T
S
F
F
S
P
S
F
Site 161
S1810
S
P
A
P
Q
S
T
S
F
F
S
P
S
F
S
Site 162
S1813
P
Q
S
T
S
F
F
S
P
S
F
S
L
G
L
Site 163
S1817
S
F
F
S
P
S
F
S
L
G
L
G
D
D
S
Site 164
Y1831
S
F
P
I
A
G
I
Y
D
T
T
T
D
N
K
Site 165
T1833
P
I
A
G
I
Y
D
T
T
T
D
N
K
C
S
Site 166
T1835
A
G
I
Y
D
T
T
T
D
N
K
C
S
I
K
Site 167
T1854
K
N
M
L
D
P
I
T
G
Q
K
L
L
E
A
Site 168
S1873
G
G
I
V
D
L
L
S
R
E
R
Y
S
V
H
Site 169
Y1877
D
L
L
S
R
E
R
Y
S
V
H
K
A
M
E
Site 170
S1878
L
L
S
R
E
R
Y
S
V
H
K
A
M
E
R
Site 171
S1892
R
G
L
I
E
N
T
S
T
Q
R
L
L
N
A
Site 172
T1893
G
L
I
E
N
T
S
T
Q
R
L
L
N
A
Q
Site 173
T1911
T
G
I
E
D
P
V
T
K
K
R
L
S
V
G
Site 174
S1916
P
V
T
K
K
R
L
S
V
G
E
A
V
Q
K
Site 175
S1930
K
G
W
M
P
R
E
S
V
L
P
H
L
Q
V
Site 176
S1976
A
Q
L
L
Q
D
E
S
S
Y
E
K
D
L
T
Site 177
S1977
Q
L
L
Q
D
E
S
S
Y
E
K
D
L
T
D
Site 178
T1983
S
S
Y
E
K
D
L
T
D
P
I
S
K
E
R
Site 179
S1987
K
D
L
T
D
P
I
S
K
E
R
L
S
Y
K
Site 180
S1992
P
I
S
K
E
R
L
S
Y
K
E
A
M
G
R
Site 181
Y1993
I
S
K
E
R
L
S
Y
K
E
A
M
G
R
C
Site 182
S2006
R
C
R
K
D
P
L
S
G
L
L
L
L
P
A
Site 183
Y2018
L
P
A
A
L
E
G
Y
R
C
Y
R
S
A
S
Site 184
Y2021
A
L
E
G
Y
R
C
Y
R
S
A
S
P
T
V
Site 185
S2023
E
G
Y
R
C
Y
R
S
A
S
P
T
V
P
R
Site 186
S2025
Y
R
C
Y
R
S
A
S
P
T
V
P
R
S
L
Site 187
T2027
C
Y
R
S
A
S
P
T
V
P
R
S
L
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation