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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX12
Full Name:
Probable ATP-dependent RNA helicase DDX12
Alias:
Chlr2; Ddx12; Dead/h (asp-glu-ala-asp/his) box polypeptide 12; Dead/h (asp-glu-ala-asp/his) box polypeptide 12 (chl1-like helicase homologue, s. cerevisiae); EC 3.6.1.-
Type:
Nucleus protein
Mass (Da):
106006
Number AA:
950
UniProt ID:
Q92771
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
R
S
G
G
G
C
S
G
S
L
S
L
R
G
Site 2
S10
S
G
G
G
C
S
G
S
L
S
L
R
G
P
A
Site 3
S22
G
P
A
S
F
K
F
S
G
V
C
P
D
S
R
Site 4
Y50
E
D
F
M
A
E
L
Y
R
V
L
E
A
G
K
Site 5
S63
G
K
I
G
I
F
E
S
P
T
G
T
G
K
S
Site 6
S110
L
H
D
E
K
D
E
S
L
C
L
S
S
S
C
Site 7
S114
K
D
E
S
L
C
L
S
S
S
C
E
G
A
A
Site 8
T123
S
C
E
G
A
A
G
T
P
R
P
A
G
E
P
Site 9
Y174
Q
H
R
V
Q
L
K
Y
A
A
K
R
L
R
Q
Site 10
S193
R
E
N
L
L
R
L
S
R
E
M
L
E
T
G
Site 11
T199
L
S
R
E
M
L
E
T
G
P
E
A
E
R
P
Site 12
S211
E
R
P
E
Q
L
E
S
G
E
E
E
L
V
L
Site 13
Y221
E
E
L
V
L
A
E
Y
E
S
D
E
E
K
K
Site 14
S223
L
V
L
A
E
Y
E
S
D
E
E
K
K
V
A
Site 15
Y249
E
E
H
I
T
K
I
Y
H
C
S
R
T
H
S
Site 16
S268
F
V
H
E
V
K
K
S
P
F
G
K
D
V
R
Site 17
S278
G
K
D
V
R
L
V
S
L
G
S
R
Q
N
L
Site 18
Y337
K
Q
A
A
C
P
F
Y
N
H
E
Q
M
G
L
Site 19
Y372
E
A
R
A
C
P
Y
Y
G
S
R
L
A
I
P
Site 20
T420
E
A
H
N
L
I
D
T
T
T
S
M
H
S
V
Site 21
T421
A
H
N
L
I
D
T
T
T
S
M
H
S
V
E
Site 22
T422
H
N
L
I
D
T
T
T
S
M
H
S
V
E
V
Site 23
S426
D
T
T
T
S
M
H
S
V
E
V
S
G
S
Q
Site 24
S430
S
M
H
S
V
E
V
S
G
S
Q
L
C
Q
A
Site 25
S432
H
S
V
E
V
S
G
S
Q
L
C
Q
A
H
S
Site 26
S439
S
Q
L
C
Q
A
H
S
Q
L
L
Q
Y
M
E
Site 27
Y444
A
H
S
Q
L
L
Q
Y
M
E
R
Y
G
K
R
Site 28
T484
N
I
K
Q
N
P
N
T
Q
S
L
S
Q
T
G
Site 29
S486
K
Q
N
P
N
T
Q
S
L
S
Q
T
G
M
E
Site 30
S488
N
P
N
T
Q
S
L
S
Q
T
G
M
E
L
K
Site 31
T490
N
T
Q
S
L
S
Q
T
G
M
E
L
K
T
I
Site 32
T496
Q
T
G
M
E
L
K
T
I
N
D
F
L
F
Q
Site 33
Y517
N
L
F
K
V
Q
R
Y
C
E
K
S
M
I
S
Site 34
Y534
L
F
G
F
T
E
R
Y
G
A
V
F
S
S
R
Site 35
S539
E
R
Y
G
A
V
F
S
S
R
E
Q
P
K
L
Site 36
S555
G
F
Q
Q
F
L
Q
S
L
Q
P
R
T
T
E
Site 37
T561
Q
S
L
Q
P
R
T
T
E
A
L
A
A
P
A
Site 38
S571
L
A
A
P
A
D
E
S
Q
A
S
V
P
Q
P
Site 39
S574
P
A
D
E
S
Q
A
S
V
P
Q
P
A
S
P
Site 40
S580
A
S
V
P
Q
P
A
S
P
L
M
H
I
E
G
Site 41
T593
E
G
F
L
A
A
L
T
T
A
N
Q
D
G
R
Site 42
S604
Q
D
G
R
V
I
L
S
R
Q
G
S
L
S
Q
Site 43
S608
V
I
L
S
R
Q
G
S
L
S
Q
S
T
L
K
Site 44
S610
L
S
R
Q
G
S
L
S
Q
S
T
L
K
F
L
Site 45
S612
R
Q
G
S
L
S
Q
S
T
L
K
F
L
L
L
Site 46
S646
G
G
T
M
Q
P
V
S
N
F
R
Q
Q
L
L
Site 47
T694
S
N
Q
P
L
E
F
T
F
Q
K
R
D
L
P
Site 48
Y731
C
F
F
P
S
Y
E
Y
L
R
Q
V
H
A
H
Site 49
S760
K
I
F
Q
E
P
K
S
A
H
Q
V
E
Q
V
Site 50
Y771
V
E
Q
V
L
L
A
Y
S
R
C
L
Q
A
C
Site 51
S772
E
Q
V
L
L
A
Y
S
R
C
L
Q
A
C
G
Site 52
S799
S
V
V
G
G
K
M
S
E
G
I
N
F
S
D
Site 53
S805
M
S
E
G
I
N
F
S
D
N
L
G
R
C
V
Site 54
Y833
E
L
Q
E
K
M
A
Y
L
D
Q
T
L
P
R
Site 55
T837
K
M
A
Y
L
D
Q
T
L
P
R
A
P
G
Q
Site 56
S876
R
H
Q
K
D
F
A
S
I
V
L
L
D
Q
R
Site 57
S927
T
F
F
F
L
R
A
S
Q
P
R
D
H
I
S
Site 58
S934
S
Q
P
R
D
H
I
S
H
C
L
L
S
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation