PhosphoNET

           
Protein Info 
   
Short Name:  FRZB
Full Name:  Secreted frizzled-related protein 3
Alias:  FIZ; FRE; Frezzled; Fritz; Frizzled-related protein; Frizzled-related protein 1; FRP; FRP-3; FRZB1; FrzB-1; FRZB-PEN; FZRB; Secreted frizzled-related protein 3; SFRP3; SRFP3
Type:  Secreted protein
Mass (Da):  36254
Number AA:  325
UniProt ID:  Q92765
International Prot ID:  IPI00294650
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005576  GO:0016020   Uniprot OncoNet
Molecular Function:  GO:0017147     PhosphoSite+ KinaseNET
Biological Process:  GO:0016055  GO:0030154  GO:0030178 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S110EPIKPCKSVCERARQ
Site 2Y126CEPILIKYRHSWPEN
Site 3S165GADFPMDSSNGNCRG
Site 4S174NGNCRGASSERCKCK
Site 5S175GNCRGASSERCKCKP
Site 6T186KCKPIRATQKTYFRN
Site 7Y190IRATQKTYFRNNYNY
Site 8Y195KTYFRNNYNYVIRAK
Site 9Y197YFRNNYNYVIRAKVK
Site 10T214KTKCHDVTAVVEVKE
Site 11S225EVKEILKSSLVNIPR
Site 12S226VKEILKSSLVNIPRD
Site 13T234LVNIPRDTVNLYTSS
Site 14Y238PRDTVNLYTSSGCLC
Site 15T239RDTVNLYTSSGCLCP
Site 16Y254PLNVNEEYIIMGYED
Site 17Y259EEYIIMGYEDEERSR
Site 18S273RLLLVEGSIAEKWKD
Site 19S299KLRHLGLSKSDSSNS
Site 20S301RHLGLSKSDSSNSDS
Site 21S303LGLSKSDSSNSDSTQ
Site 22S304GLSKSDSSNSDSTQS
Site 23S306SKSDSSNSDSTQSQK
Site 24S308SDSSNSDSTQSQKSG
Site 25T309DSSNSDSTQSQKSGR
Site 26S311SNSDSTQSQKSGRNS
Site 27S314DSTQSQKSGRNSNPR
Site 28S318SQKSGRNSNPRQARN
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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