KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PTPRU
Full Name:
Receptor-type tyrosine-protein phosphatase U
Alias:
EC 3.1.3.48; Fmi; Glepp1; Hptp-j; Pancreatic carcinoma phosphatase 2; PCP2; Protein-tyrosine phosphatase J; PTP-J; R-PTP-U
Type:
Protein-tyrosine phosphatase (receptor)
Mass (Da):
160228
Number AA:
1430
UniProt ID:
Q92729
International Prot ID:
IPI00023197
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005911
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0008013
GO:0005001
PhosphoSite+
KinaseNET
Biological Process:
GO:0060070
GO:0030154
GO:0030336
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S207
V
N
A
G
Q
N
A
S
F
Q
C
M
A
A
G
Site 2
Y524
I
T
Q
Y
E
I
S
Y
Q
S
I
E
S
S
D
Site 3
Y551
S
K
L
R
N
E
T
Y
H
V
F
S
N
L
H
Site 4
Y625
R
G
A
P
I
S
V
Y
Q
V
I
V
E
E
E
Site 5
Y777
I
R
K
G
R
D
H
Y
A
Y
S
Y
Y
P
K
Site 6
Y779
K
G
R
D
H
Y
A
Y
S
Y
Y
P
K
P
V
Site 7
Y781
R
D
H
Y
A
Y
S
Y
Y
P
K
P
V
N
M
Site 8
Y782
D
H
Y
A
Y
S
Y
Y
P
K
P
V
N
M
T
Site 9
T792
P
V
N
M
T
K
A
T
V
N
Y
R
Q
E
K
Site 10
S809
M
M
S
A
V
D
R
S
F
T
D
Q
S
T
L
Site 11
T811
S
A
V
D
R
S
F
T
D
Q
S
T
L
Q
E
Site 12
S814
D
R
S
F
T
D
Q
S
T
L
Q
E
D
E
R
Site 13
T815
R
S
F
T
D
Q
S
T
L
Q
E
D
E
R
L
Site 14
S825
E
D
E
R
L
G
L
S
F
M
D
T
H
G
Y
Site 15
T829
L
G
L
S
F
M
D
T
H
G
Y
S
T
R
G
Site 16
Y832
S
F
M
D
T
H
G
Y
S
T
R
G
D
Q
R
Site 17
S833
F
M
D
T
H
G
Y
S
T
R
G
D
Q
R
S
Site 18
S840
S
T
R
G
D
Q
R
S
G
G
V
T
E
A
S
Site 19
T844
D
Q
R
S
G
G
V
T
E
A
S
S
L
L
G
Site 20
S847
S
G
G
V
T
E
A
S
S
L
L
G
G
S
P
Site 21
S848
G
G
V
T
E
A
S
S
L
L
G
G
S
P
R
Site 22
S853
A
S
S
L
L
G
G
S
P
R
R
P
C
G
R
Site 23
S863
R
P
C
G
R
K
G
S
P
Y
H
T
G
Q
L
Site 24
Y865
C
G
R
K
G
S
P
Y
H
T
G
Q
L
H
P
Site 25
T867
R
K
G
S
P
Y
H
T
G
Q
L
H
P
A
V
Site 26
Y898
G
Y
G
F
K
Q
E
Y
E
S
F
F
E
G
W
Site 27
Y925
R
Q
E
P
M
P
A
Y
D
R
H
R
V
K
L
Site 28
Y943
L
G
D
P
N
A
D
Y
I
N
A
N
Y
I
D
Site 29
Y952
N
A
N
Y
I
D
G
Y
H
R
S
N
H
F
I
Site 30
T961
R
S
N
H
F
I
A
T
Q
G
P
K
P
E
M
Site 31
S1006
S
R
Y
W
P
E
D
S
D
T
Y
G
D
I
K
Site 32
Y1009
W
P
E
D
S
D
T
Y
G
D
I
K
I
M
L
Site 33
Y1037
F
A
L
E
R
R
G
Y
S
A
R
H
E
V
R
Site 34
S1038
A
L
E
R
R
G
Y
S
A
R
H
E
V
R
Q
Site 35
Y1058
W
P
E
H
G
V
P
Y
H
A
T
G
L
L
A
Site 36
S1073
F
I
R
R
V
K
A
S
T
P
P
D
A
G
P
Site 37
T1074
I
R
R
V
K
A
S
T
P
P
D
A
G
P
I
Site 38
S1155
G
E
T
T
I
P
V
S
E
F
K
A
T
Y
K
Site 39
S1171
M
I
R
I
D
P
Q
S
N
S
S
Q
L
R
E
Site 40
S1174
I
D
P
Q
S
N
S
S
Q
L
R
E
E
F
Q
Site 41
T1182
Q
L
R
E
E
F
Q
T
L
N
S
V
T
P
P
Site 42
S1185
E
E
F
Q
T
L
N
S
V
T
P
P
L
D
V
Site 43
T1187
F
Q
T
L
N
S
V
T
P
P
L
D
V
E
E
Site 44
S1209
R
N
R
D
K
N
R
S
M
D
V
L
P
P
D
Site 45
S1224
R
C
L
P
F
L
I
S
T
D
G
D
S
N
N
Site 46
T1225
C
L
P
F
L
I
S
T
D
G
D
S
N
N
Y
Site 47
S1229
L
I
S
T
D
G
D
S
N
N
Y
I
N
A
A
Site 48
T1238
N
Y
I
N
A
A
L
T
D
S
Y
T
R
S
A
Site 49
S1256
V
T
L
H
P
L
Q
S
T
T
P
D
F
W
R
Site 50
T1258
L
H
P
L
Q
S
T
T
P
D
F
W
R
L
V
Site 51
Y1266
P
D
F
W
R
L
V
Y
D
Y
G
C
T
S
I
Site 52
Y1300
P
E
P
G
R
Q
Q
Y
G
L
M
E
V
E
F
Site 53
S1327
V
F
R
V
Q
N
I
S
R
L
Q
E
G
H
L
Site 54
T1350
R
W
S
A
Y
R
D
T
P
D
S
K
K
A
F
Site 55
S1353
A
Y
R
D
T
P
D
S
K
K
A
F
L
H
L
Site 56
T1376
A
E
S
G
D
G
R
T
I
V
H
C
L
N
G
Site 57
T1414
D
V
F
F
A
A
K
T
L
R
N
Y
K
P
N
Site 58
Y1418
A
A
K
T
L
R
N
Y
K
P
N
M
V
E
T
Site 59
Y1433
M
D
Q
Y
H
F
C
Y
D
V
A
L
E
Y
L
Site 60
Y1439
C
Y
D
V
A
L
E
Y
L
E
G
L
E
S
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation