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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Pxdn
Full Name:
Peroxidasin homolog
Alias:
D2S448; D2S448E; KIAA0230; melanoma-associated antigen MG50; MG50; peroxidasin; PRG2; PXN
Type:
Oxidoreductase; EC 1.11.1.7
Mass (Da):
167210
Number AA:
UniProt ID:
Q92626
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0020037
GO:0005152
PhosphoSite+
KinaseNET
Biological Process:
GO:0042744
GO:0006955
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S103
N
Q
I
K
R
I
P
S
G
A
F
E
D
L
E
Site 2
Y114
E
D
L
E
N
L
K
Y
L
Y
L
Y
K
N
E
Site 3
Y116
L
E
N
L
K
Y
L
Y
L
Y
K
N
E
I
Q
Site 4
Y118
N
L
K
Y
L
Y
L
Y
K
N
E
I
Q
S
I
Site 5
T148
L
H
F
N
Q
I
E
T
L
D
P
D
S
F
Q
Site 6
S153
I
E
T
L
D
P
D
S
F
Q
H
L
P
K
L
Site 7
S191
M
K
R
L
R
L
D
S
N
T
L
H
C
D
C
Site 8
T193
R
L
R
L
D
S
N
T
L
H
C
D
C
E
I
Site 9
T209
W
L
A
D
L
L
K
T
Y
A
E
S
G
N
A
Site 10
Y210
L
A
D
L
L
K
T
Y
A
E
S
G
N
A
Q
Site 11
Y224
Q
A
A
A
I
C
E
Y
P
R
R
I
Q
G
R
Site 12
S232
P
R
R
I
Q
G
R
S
V
A
T
I
T
P
E
Site 13
T237
G
R
S
V
A
T
I
T
P
E
E
L
N
C
E
Site 14
T249
N
C
E
R
P
R
I
T
S
E
P
Q
D
A
D
Site 15
S250
C
E
R
P
R
I
T
S
E
P
Q
D
A
D
V
Site 16
Y264
V
T
S
G
N
T
V
Y
F
T
C
R
A
E
G
Site 17
T266
S
G
N
T
V
Y
F
T
C
R
A
E
G
N
P
Site 18
S287
L
R
N
N
N
E
L
S
M
K
T
D
S
R
L
Site 19
T290
N
N
E
L
S
M
K
T
D
S
R
L
N
L
L
Site 20
S292
E
L
S
M
K
T
D
S
R
L
N
L
L
D
D
Site 21
T301
L
N
L
L
D
D
G
T
L
M
I
Q
N
T
Q
Site 22
T328
N
V
A
G
E
V
K
T
Q
E
V
T
L
R
Y
Site 23
T332
E
V
K
T
Q
E
V
T
L
R
Y
F
G
S
P
Site 24
Y335
T
Q
E
V
T
L
R
Y
F
G
S
P
A
R
P
Site 25
T343
F
G
S
P
A
R
P
T
F
V
I
Q
P
Q
N
Site 26
S364
E
S
V
T
L
E
C
S
A
T
G
H
P
P
P
Site 27
T366
V
T
L
E
C
S
A
T
G
H
P
P
P
R
I
Site 28
S374
G
H
P
P
P
R
I
S
W
T
R
G
D
R
T
Site 29
T381
S
W
T
R
G
D
R
T
P
L
P
V
D
P
R
Site 30
S413
D
S
G
E
Y
A
C
S
A
T
N
N
I
D
S
Site 31
T436
V
Q
A
L
P
Q
F
T
V
T
P
Q
D
R
V
Site 32
T467
P
P
P
V
I
A
W
T
K
G
G
S
Q
L
S
Site 33
S474
T
K
G
G
S
Q
L
S
V
D
R
R
H
L
V
Site 34
S483
D
R
R
H
L
V
L
S
S
G
T
L
R
I
S
Site 35
S490
S
S
G
T
L
R
I
S
G
V
A
L
H
D
Q
Site 36
T518
Q
K
V
V
A
H
L
T
V
Q
P
R
V
T
P
Site 37
S547
A
N
V
Q
L
P
C
S
S
Q
G
E
P
E
P
Site 38
T557
G
E
P
E
P
A
I
T
W
N
K
D
G
V
Q
Site 39
T566
N
K
D
G
V
Q
V
T
E
S
G
K
F
H
I
Site 40
S574
E
S
G
K
F
H
I
S
P
E
G
F
L
T
I
Site 41
Y592
G
P
A
D
A
G
R
Y
E
C
V
A
R
N
T
Site 42
T599
Y
E
C
V
A
R
N
T
I
G
S
A
S
V
S
Site 43
S617
S
V
N
V
P
D
V
S
R
N
G
D
P
F
V
Site 44
S641
T
V
D
R
A
I
N
S
T
R
T
H
L
F
D
Site 45
T642
V
D
R
A
I
N
S
T
R
T
H
L
F
D
S
Site 46
S649
T
R
T
H
L
F
D
S
R
P
R
S
P
N
D
Site 47
S653
L
F
D
S
R
P
R
S
P
N
D
L
L
A
L
Site 48
Y663
D
L
L
A
L
F
R
Y
P
R
D
P
Y
T
V
Site 49
Y668
F
R
Y
P
R
D
P
Y
T
V
E
Q
A
R
A
Site 50
T669
R
Y
P
R
D
P
Y
T
V
E
Q
A
R
A
G
Site 51
Y703
V
D
L
N
G
T
S
Y
H
Y
N
D
L
V
S
Site 52
S721
L
N
L
I
A
N
L
S
G
C
T
A
H
R
R
Site 53
S759
Q
H
P
M
W
G
A
S
L
T
A
F
E
R
L
Site 54
S769
A
F
E
R
L
L
K
S
V
Y
E
N
G
F
N
Site 55
Y771
E
R
L
L
K
S
V
Y
E
N
G
F
N
T
P
Site 56
T777
V
Y
E
N
G
F
N
T
P
R
G
I
N
P
H
Site 57
Y787
G
I
N
P
H
R
L
Y
N
G
H
A
L
P
M
Site 58
T807
T
T
L
I
G
T
E
T
V
T
P
D
E
Q
F
Site 59
T809
L
I
G
T
E
T
V
T
P
D
E
Q
F
T
H
Site 60
S837
D
S
T
V
V
A
L
S
Q
A
R
F
S
D
G
Site 61
S842
A
L
S
Q
A
R
F
S
D
G
Q
H
C
S
N
Site 62
S859
S
N
D
P
P
C
F
S
V
M
I
P
P
N
D
Site 63
S867
V
M
I
P
P
N
D
S
R
A
R
S
G
A
R
Site 64
S871
P
N
D
S
R
A
R
S
G
A
R
C
M
F
F
Site 65
S887
R
S
S
P
V
C
G
S
G
M
T
S
L
L
M
Site 66
T890
P
V
C
G
S
G
M
T
S
L
L
M
N
S
V
Site 67
S896
M
T
S
L
L
M
N
S
V
Y
P
R
E
Q
I
Site 68
Y898
S
L
L
M
N
S
V
Y
P
R
E
Q
I
N
Q
Site 69
Y909
Q
I
N
Q
L
T
S
Y
I
D
A
S
N
V
Y
Site 70
S913
L
T
S
Y
I
D
A
S
N
V
Y
G
S
T
E
Site 71
S925
S
T
E
H
E
A
R
S
I
R
D
L
A
S
H
Site 72
S931
R
S
I
R
D
L
A
S
H
R
G
L
L
R
Q
Site 73
S944
R
Q
G
I
V
Q
R
S
G
K
P
L
L
P
F
Site 74
T957
P
F
A
T
G
P
P
T
E
C
M
R
D
E
N
Site 75
S966
C
M
R
D
E
N
E
S
P
I
P
C
F
L
A
Site 76
T989
L
G
L
T
S
M
H
T
L
W
F
R
E
H
N
Site 77
T1000
R
E
H
N
R
I
A
T
E
L
L
K
L
N
P
Site 78
Y1015
H
W
D
G
D
T
I
Y
Y
E
T
R
K
I
V
Site 79
Y1016
W
D
G
D
T
I
Y
Y
E
T
R
K
I
V
G
Site 80
T1046
L
G
E
V
G
M
R
T
L
G
E
Y
H
G
Y
Site 81
Y1050
G
M
R
T
L
G
E
Y
H
G
Y
D
P
G
I
Site 82
Y1053
T
L
G
E
Y
H
G
Y
D
P
G
I
N
A
G
Site 83
S1104
P
L
H
K
A
F
F
S
P
F
R
I
V
N
E
Site 84
S1132
A
G
K
M
R
V
P
S
Q
L
L
N
T
E
L
Site 85
T1140
Q
L
L
N
T
E
L
T
E
R
L
F
S
M
A
Site 86
Y1170
R
D
H
G
I
P
P
Y
H
D
Y
R
V
Y
C
Site 87
Y1173
G
I
P
P
Y
H
D
Y
R
V
Y
C
N
L
S
Site 88
Y1176
P
Y
H
D
Y
R
V
Y
C
N
L
S
A
A
H
Site 89
S1180
Y
R
V
Y
C
N
L
S
A
A
H
T
F
E
D
Site 90
T1184
C
N
L
S
A
A
H
T
F
E
D
L
K
N
E
Site 91
Y1205
R
E
K
L
K
R
L
Y
G
S
T
L
N
I
D
Site 92
Y1251
R
D
G
D
R
L
W
Y
E
N
P
G
V
F
S
Site 93
S1258
Y
E
N
P
G
V
F
S
P
A
Q
L
T
Q
I
Site 94
T1263
V
F
S
P
A
Q
L
T
Q
I
K
Q
T
S
L
Site 95
S1286
D
N
I
T
R
V
Q
S
D
V
F
R
V
A
E
Site 96
S1300
E
F
P
H
G
Y
G
S
C
D
E
I
P
R
V
Site 97
Y1330
G
Q
F
N
A
F
S
Y
H
F
R
G
R
R
S
Site 98
S1337
Y
H
F
R
G
R
R
S
L
E
F
S
Y
Q
E
Site 99
S1341
G
R
R
S
L
E
F
S
Y
Q
E
D
K
P
T
Site 100
Y1342
R
R
S
L
E
F
S
Y
Q
E
D
K
P
T
K
Site 101
T1348
S
Y
Q
E
D
K
P
T
K
K
T
R
P
R
K
Site 102
T1351
E
D
K
P
T
K
K
T
R
P
R
K
I
P
S
Site 103
S1358
T
R
P
R
K
I
P
S
V
G
R
Q
G
E
H
Site 104
S1367
G
R
Q
G
E
H
L
S
N
S
T
S
A
F
S
Site 105
S1369
Q
G
E
H
L
S
N
S
T
S
A
F
S
T
R
Site 106
S1371
E
H
L
S
N
S
T
S
A
F
S
T
R
S
D
Site 107
S1374
S
N
S
T
S
A
F
S
T
R
S
D
A
S
G
Site 108
T1375
N
S
T
S
A
F
S
T
R
S
D
A
S
G
T
Site 109
S1377
T
S
A
F
S
T
R
S
D
A
S
G
T
N
D
Site 110
T1395
F
V
L
E
M
Q
K
T
I
T
D
L
R
T
Q
Site 111
T1401
K
T
I
T
D
L
R
T
Q
I
K
K
L
E
S
Site 112
S1411
K
K
L
E
S
R
L
S
T
T
E
C
V
D
A
Site 113
T1412
K
L
E
S
R
L
S
T
T
E
C
V
D
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation