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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHX38
Full Name:
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
Alias:
ATP-dependent RNA helicase DHX38; DDX38; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38; DEAH (Asp-Glu-Ala-His) box polypeptide 38; DEAH box protein 38; EC 3.6.1.-; PRP16
Type:
Spliceosome, Nucleus protein
Mass (Da):
140503
Number AA:
1227
UniProt ID:
Q92620
International Prot ID:
IPI00294211
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004004
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
D
T
S
E
D
A
S
I
H
R
L
E
G
T
Site 2
S29
V
G
G
L
I
C
K
S
K
S
A
A
S
E
Q
Site 3
S31
G
L
I
C
K
S
K
S
A
A
S
E
Q
H
V
Site 4
S47
K
A
P
A
P
R
P
S
L
L
G
L
D
L
L
Site 5
S56
L
G
L
D
L
L
A
S
L
K
R
R
E
R
E
Site 6
S74
D
G
E
D
K
K
K
S
K
V
S
S
Y
K
D
Site 7
S78
K
K
K
S
K
V
S
S
Y
K
D
W
E
E
S
Site 8
Y110
N
I
R
K
D
R
H
Y
R
S
A
R
V
E
T
Site 9
S112
R
K
D
R
H
Y
R
S
A
R
V
E
T
P
S
Site 10
T117
Y
R
S
A
R
V
E
T
P
S
H
P
G
G
V
Site 11
S119
S
A
R
V
E
T
P
S
H
P
G
G
V
S
E
Site 12
S125
P
S
H
P
G
G
V
S
E
E
F
W
E
R
S
Site 13
S132
S
E
E
F
W
E
R
S
R
Q
R
E
R
E
R
Site 14
Y145
E
R
R
E
H
G
V
Y
A
S
S
K
E
E
K
Site 15
S148
E
H
G
V
Y
A
S
S
K
E
E
K
D
W
K
Site 16
S159
K
D
W
K
K
E
K
S
R
D
R
D
Y
D
R
Site 17
Y164
E
K
S
R
D
R
D
Y
D
R
K
R
D
R
D
Site 18
S176
D
R
D
E
R
D
R
S
R
H
S
S
R
S
E
Site 19
S179
E
R
D
R
S
R
H
S
S
R
S
E
R
D
G
Site 20
S180
R
D
R
S
R
H
S
S
R
S
E
R
D
G
G
Site 21
S182
R
S
R
H
S
S
R
S
E
R
D
G
G
S
E
Site 22
S188
R
S
E
R
D
G
G
S
E
R
S
S
R
R
N
Site 23
S191
R
D
G
G
S
E
R
S
S
R
R
N
E
P
E
Site 24
S192
D
G
G
S
E
R
S
S
R
R
N
E
P
E
S
Site 25
S199
S
R
R
N
E
P
E
S
P
R
H
R
P
K
D
Site 26
T209
H
R
P
K
D
A
A
T
P
S
R
S
T
W
E
Site 27
T214
A
A
T
P
S
R
S
T
W
E
E
E
D
S
G
Site 28
S220
S
T
W
E
E
E
D
S
G
Y
G
S
S
R
R
Site 29
Y222
W
E
E
E
D
S
G
Y
G
S
S
R
R
S
Q
Site 30
S224
E
E
D
S
G
Y
G
S
S
R
R
S
Q
W
E
Site 31
S225
E
D
S
G
Y
G
S
S
R
R
S
Q
W
E
S
Site 32
S228
G
Y
G
S
S
R
R
S
Q
W
E
S
P
S
P
Site 33
S232
S
R
R
S
Q
W
E
S
P
S
P
T
P
S
Y
Site 34
S234
R
S
Q
W
E
S
P
S
P
T
P
S
Y
R
D
Site 35
T236
Q
W
E
S
P
S
P
T
P
S
Y
R
D
S
E
Site 36
S238
E
S
P
S
P
T
P
S
Y
R
D
S
E
R
S
Site 37
Y239
S
P
S
P
T
P
S
Y
R
D
S
E
R
S
H
Site 38
S242
P
T
P
S
Y
R
D
S
E
R
S
H
R
L
S
Site 39
S245
S
Y
R
D
S
E
R
S
H
R
L
S
T
R
D
Site 40
S249
S
E
R
S
H
R
L
S
T
R
D
R
D
R
S
Site 41
T250
E
R
S
H
R
L
S
T
R
D
R
D
R
S
V
Site 42
S256
S
T
R
D
R
D
R
S
V
R
G
K
Y
S
D
Site 43
Y261
D
R
S
V
R
G
K
Y
S
D
D
T
P
L
P
Site 44
S262
R
S
V
R
G
K
Y
S
D
D
T
P
L
P
T
Site 45
T265
R
G
K
Y
S
D
D
T
P
L
P
T
P
S
Y
Site 46
T269
S
D
D
T
P
L
P
T
P
S
Y
K
Y
N
E
Site 47
S271
D
T
P
L
P
T
P
S
Y
K
Y
N
E
W
A
Site 48
Y272
T
P
L
P
T
P
S
Y
K
Y
N
E
W
A
D
Site 49
S286
D
D
R
R
H
L
G
S
T
P
R
L
S
R
G
Site 50
T287
D
R
R
H
L
G
S
T
P
R
L
S
R
G
R
Site 51
S291
L
G
S
T
P
R
L
S
R
G
R
G
R
R
E
Site 52
S305
E
E
G
E
E
G
I
S
F
D
T
E
E
E
R
Site 53
T308
E
E
G
I
S
F
D
T
E
E
E
R
Q
Q
W
Site 54
Y327
R
Q
A
D
R
D
W
Y
M
M
D
E
G
Y
D
Site 55
Y347
L
A
Y
S
S
E
D
Y
V
R
R
R
E
Q
H
Site 56
S364
K
Q
K
Q
K
R
I
S
A
Q
R
R
Q
I
N
Site 57
T379
E
D
N
E
R
W
E
T
N
R
M
L
T
S
G
Site 58
T384
W
E
T
N
R
M
L
T
S
G
V
V
H
R
L
Site 59
S448
A
I
I
A
R
K
G
S
Q
T
V
R
K
H
R
Site 60
T450
I
A
R
K
G
S
Q
T
V
R
K
H
R
E
Q
Site 61
T473
K
H
W
E
L
A
G
T
K
L
G
D
I
M
G
Site 62
Y499
T
E
D
G
K
V
D
Y
R
T
E
Q
K
F
A
Site 63
T501
D
G
K
V
D
Y
R
T
E
Q
K
F
A
D
H
Site 64
S513
A
D
H
M
K
R
K
S
E
A
S
S
E
F
A
Site 65
S516
M
K
R
K
S
E
A
S
S
E
F
A
K
K
K
Site 66
S517
K
R
K
S
E
A
S
S
E
F
A
K
K
K
S
Site 67
S524
S
E
F
A
K
K
K
S
I
L
E
Q
R
Q
Y
Site 68
T563
E
T
G
S
G
K
T
T
Q
L
T
Q
Y
L
H
Site 69
T566
S
G
K
T
T
Q
L
T
Q
Y
L
H
E
D
G
Site 70
Y568
K
T
T
Q
L
T
Q
Y
L
H
E
D
G
Y
T
Site 71
Y574
Q
Y
L
H
E
D
G
Y
T
D
Y
G
M
I
G
Site 72
T575
Y
L
H
E
D
G
Y
T
D
Y
G
M
I
G
C
Site 73
Y577
H
E
D
G
Y
T
D
Y
G
M
I
G
C
T
Q
Site 74
S592
P
R
R
V
A
A
M
S
V
A
K
R
V
S
E
Site 75
S598
M
S
V
A
K
R
V
S
E
E
M
G
G
N
L
Site 76
Y611
N
L
G
E
E
V
G
Y
A
I
R
F
E
D
C
Site 77
T619
A
I
R
F
E
D
C
T
S
E
N
T
L
I
K
Site 78
S637
D
G
I
L
L
R
E
S
L
R
E
A
D
L
D
Site 79
Y646
R
E
A
D
L
D
H
Y
S
A
I
I
M
D
E
Site 80
S647
E
A
D
L
D
H
Y
S
A
I
I
M
D
E
A
Site 81
S676
R
E
V
V
A
R
R
S
D
L
K
L
I
V
T
Site 82
T718
V
D
I
L
F
S
K
T
P
Q
E
D
Y
V
E
Site 83
Y723
S
K
T
P
Q
E
D
Y
V
E
A
A
V
K
Q
Site 84
S757
Q
E
D
I
E
V
T
S
D
Q
I
V
E
H
L
Site 85
S784
P
I
Y
S
Q
L
P
S
D
L
Q
A
K
I
F
Site 86
S846
A
L
Q
I
Y
P
I
S
Q
A
N
A
N
Q
R
Site 87
S854
Q
A
N
A
N
Q
R
S
G
R
A
G
R
T
G
Site 88
Y869
P
G
Q
C
F
R
L
Y
T
Q
S
A
Y
K
N
Site 89
T870
G
Q
C
F
R
L
Y
T
Q
S
A
Y
K
N
E
Site 90
T881
Y
K
N
E
L
L
T
T
T
V
P
E
I
Q
R
Site 91
T882
K
N
E
L
L
T
T
T
V
P
E
I
Q
R
T
Site 92
T940
L
D
N
T
G
G
L
T
S
T
G
R
L
M
V
Site 93
S941
D
N
T
G
G
L
T
S
T
G
R
L
M
V
E
Site 94
S994
P
K
G
R
E
E
E
S
D
Q
I
R
E
K
F
Site 95
S1006
E
K
F
A
V
P
E
S
D
H
L
T
Y
L
N
Site 96
T1010
V
P
E
S
D
H
L
T
Y
L
N
V
Y
L
Q
Site 97
Y1011
P
E
S
D
H
L
T
Y
L
N
V
Y
L
Q
W
Site 98
Y1015
H
L
T
Y
L
N
V
Y
L
Q
W
K
N
N
N
Site 99
S1058
I
M
V
Q
Q
R
M
S
L
A
S
C
G
T
D
Site 100
Y1090
K
L
K
G
I
G
E
Y
V
N
I
R
T
G
M
Site 101
T1125
V
Y
H
E
L
V
M
T
T
K
E
Y
M
Q
C
Site 102
Y1149
A
E
L
G
P
M
F
Y
S
V
K
Q
A
G
K
Site 103
S1150
E
L
G
P
M
F
Y
S
V
K
Q
A
G
K
S
Site 104
S1194
R
Q
E
Q
E
K
R
S
P
L
G
S
V
R
S
Site 105
S1198
E
K
R
S
P
L
G
S
V
R
S
T
K
I
Y
Site 106
S1201
S
P
L
G
S
V
R
S
T
K
I
Y
T
P
G
Site 107
T1202
P
L
G
S
V
R
S
T
K
I
Y
T
P
G
R
Site 108
Y1205
S
V
R
S
T
K
I
Y
T
P
G
R
K
E
Q
Site 109
T1206
V
R
S
T
K
I
Y
T
P
G
R
K
E
Q
G
Site 110
T1217
K
E
Q
G
E
P
M
T
P
R
R
T
P
A
R
Site 111
T1221
E
P
M
T
P
R
R
T
P
A
R
F
G
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation