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Updated November 2019
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Protein Info
Short Name:
GCN1L1
Full Name:
Translational activator GCN1
Alias:
GCN1; GCN1L; GCN1-like protein 1; HsGCN1
Type:
Uncharacterized protein, may regulate E2AK4 kinase
Mass (Da):
292744
Number AA:
2671
UniProt ID:
Q92616
International Prot ID:
IPI00001159
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005840
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006417
GO:0009889
GO:0010468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
A
A
D
T
Q
V
S
E
T
L
K
Site 2
S8
M
A
A
D
T
Q
V
S
E
T
L
K
R
F
A
Site 3
T10
A
D
T
Q
V
S
E
T
L
K
R
F
A
G
K
Site 4
S22
A
G
K
V
T
T
A
S
V
K
E
R
R
E
I
Site 5
S31
K
E
R
R
E
I
L
S
E
L
G
K
C
V
A
Site 6
T57
L
C
K
L
F
C
L
T
L
H
R
Y
R
D
A
Site 7
Y61
F
C
L
T
L
H
R
Y
R
D
A
A
S
R
R
Site 8
S66
H
R
Y
R
D
A
A
S
R
R
A
L
Q
A
A
Site 9
S92
T
A
K
N
L
L
H
S
L
Q
S
S
G
I
G
Site 10
S95
N
L
L
H
S
L
Q
S
S
G
I
G
S
K
A
Site 11
S96
L
L
H
S
L
Q
S
S
G
I
G
S
K
A
G
Site 12
S100
L
Q
S
S
G
I
G
S
K
A
G
V
P
S
K
Site 13
S106
G
S
K
A
G
V
P
S
K
S
S
G
S
A
A
Site 14
S130
L
V
R
I
V
F
P
S
R
A
K
R
Q
G
D
Site 15
S157
L
L
E
V
L
G
G
S
H
K
H
A
V
D
G
Site 16
S189
Q
Y
L
S
A
I
L
S
L
E
P
N
Q
N
Y
Site 17
Y196
S
L
E
P
N
Q
N
Y
A
G
M
L
G
L
L
Site 18
S217
H
K
E
M
D
V
V
S
Q
H
K
S
A
L
L
Site 19
S221
D
V
V
S
Q
H
K
S
A
L
L
D
F
Y
M
Site 20
Y241
S
K
V
K
P
P
K
Y
L
L
D
S
C
A
P
Site 21
S245
P
P
K
Y
L
L
D
S
C
A
P
L
L
R
Y
Site 22
Y252
S
C
A
P
L
L
R
Y
L
S
H
S
E
F
K
Site 23
S254
A
P
L
L
R
Y
L
S
H
S
E
F
K
D
L
Site 24
S269
I
L
P
T
I
Q
K
S
L
L
R
S
P
E
N
Site 25
S273
I
Q
K
S
L
L
R
S
P
E
N
V
I
E
T
Site 26
S309
G
L
A
G
H
L
K
S
N
S
P
R
L
M
D
Site 27
S311
A
G
H
L
K
S
N
S
P
R
L
M
D
E
A
Site 28
S330
R
N
L
A
R
Q
C
S
D
S
S
A
M
E
S
Site 29
S332
L
A
R
Q
C
S
D
S
S
A
M
E
S
L
T
Site 30
S333
A
R
Q
C
S
D
S
S
A
M
E
S
L
T
K
Site 31
S337
S
D
S
S
A
M
E
S
L
T
K
H
L
F
A
Site 32
S349
L
F
A
I
L
G
G
S
E
G
K
L
T
V
V
Site 33
T354
G
G
S
E
G
K
L
T
V
V
A
Q
K
M
S
Site 34
T418
A
L
W
C
N
R
F
T
M
E
V
P
K
K
L
Site 35
S434
E
W
F
K
K
A
F
S
L
K
T
S
T
S
A
Site 36
T437
K
K
A
F
S
L
K
T
S
T
S
A
V
R
H
Site 37
S438
K
A
F
S
L
K
T
S
T
S
A
V
R
H
A
Site 38
S440
F
S
L
K
T
S
T
S
A
V
R
H
A
Y
L
Site 39
S478
Q
T
V
E
K
A
A
S
Q
S
T
Q
V
P
T
Site 40
S504
L
K
L
S
V
A
D
S
Q
A
E
A
K
L
S
Site 41
T541
A
S
E
D
A
L
C
T
V
L
H
L
T
E
R
Site 42
T546
L
C
T
V
L
H
L
T
E
R
L
F
L
D
H
Site 43
T558
L
D
H
P
H
R
L
T
G
N
K
V
Q
Q
Y
Site 44
Y565
T
G
N
K
V
Q
Q
Y
H
R
A
L
V
A
V
Site 45
T577
V
A
V
L
L
S
R
T
W
H
V
R
R
Q
A
Site 46
T587
V
R
R
Q
A
Q
Q
T
V
R
K
L
L
S
S
Site 47
S593
Q
T
V
R
K
L
L
S
S
L
G
G
F
K
L
Site 48
S594
T
V
R
K
L
L
S
S
L
G
G
F
K
L
A
Site 49
S613
E
E
L
K
T
V
L
S
S
H
K
V
L
P
L
Site 50
T631
V
T
D
A
G
E
V
T
E
A
G
K
A
Y
V
Site 51
Y637
V
T
E
A
G
K
A
Y
V
P
P
R
V
L
Q
Site 52
S651
Q
E
A
L
C
V
I
S
G
V
P
G
L
K
G
Site 53
T661
P
G
L
K
G
D
V
T
D
T
E
Q
L
A
Q
Site 54
T714
D
Q
I
I
P
R
M
T
T
Q
S
P
L
N
Q
Site 55
T715
Q
I
I
P
R
M
T
T
Q
S
P
L
N
Q
S
Site 56
S717
I
P
R
M
T
T
Q
S
P
L
N
Q
S
S
M
Site 57
S723
Q
S
P
L
N
Q
S
S
M
N
A
M
G
S
L
Site 58
S729
S
S
M
N
A
M
G
S
L
S
V
L
S
P
D
Site 59
T768
E
E
F
A
I
M
Q
T
P
A
G
E
L
Y
D
Site 60
Y774
Q
T
P
A
G
E
L
Y
D
K
S
I
I
Q
S
Site 61
S777
A
G
E
L
Y
D
K
S
I
I
Q
S
A
Q
Q
Site 62
S781
Y
D
K
S
I
I
Q
S
A
Q
Q
D
S
I
K
Site 63
S786
I
Q
S
A
Q
Q
D
S
I
K
K
A
N
M
K
Site 64
Y799
M
K
R
E
N
K
A
Y
S
F
K
E
Q
I
I
Site 65
S800
K
R
E
N
K
A
Y
S
F
K
E
Q
I
I
E
Site 66
T827
I
K
E
E
V
Q
L
T
S
K
Q
K
E
M
L
Site 67
T918
S
R
L
K
A
L
G
T
L
V
S
H
V
T
L
Site 68
S937
P
E
C
V
L
D
K
S
W
C
Q
E
E
L
S
Site 69
S944
S
W
C
Q
E
E
L
S
V
A
V
K
R
A
V
Site 70
T956
R
A
V
M
L
L
H
T
H
T
I
T
S
R
V
Site 71
T958
R
A
V
M
L
L
H
T
H
T
I
T
S
R
V
Site 72
T960
L
L
H
T
H
T
I
T
S
R
V
G
K
G
E
Site 73
S961
L
H
T
H
T
I
T
S
R
V
G
K
G
E
P
Site 74
T990
P
F
L
K
M
V
L
T
E
M
P
H
H
S
E
Site 75
S996
L
T
E
M
P
H
H
S
E
E
E
E
E
W
M
Site 76
S1019
V
Q
A
Q
L
R
A
S
P
N
T
P
P
G
R
Site 77
T1022
Q
L
R
A
S
P
N
T
P
P
G
R
V
D
E
Site 78
T1118
M
V
L
P
A
P
D
T
D
E
K
N
G
L
N
Site 79
S1150
K
L
A
E
R
L
W
S
M
M
G
L
D
L
Q
Site 80
S1184
Q
A
G
A
E
A
L
S
Q
A
V
A
R
Y
Q
Site 81
Y1205
M
G
R
L
M
E
I
Y
Q
E
K
L
Y
R
P
Site 82
Y1210
E
I
Y
Q
E
K
L
Y
R
P
P
P
V
L
D
Site 83
S1224
D
A
L
G
R
V
I
S
E
S
P
P
D
Q
W
Site 84
S1226
L
G
R
V
I
S
E
S
P
P
D
Q
W
E
A
Site 85
S1245
A
L
A
L
N
K
L
S
Q
Y
L
D
S
S
Q
Site 86
Y1247
A
L
N
K
L
S
Q
Y
L
D
S
S
Q
V
K
Site 87
S1250
K
L
S
Q
Y
L
D
S
S
Q
V
K
P
L
F
Site 88
S1251
L
S
Q
Y
L
D
S
S
Q
V
K
P
L
F
Q
Site 89
S1294
H
G
K
E
N
V
N
S
L
L
P
V
F
E
E
Site 90
Y1312
N
A
P
N
D
A
S
Y
D
A
V
R
Q
S
V
Site 91
S1318
S
Y
D
A
V
R
Q
S
V
V
V
L
M
G
S
Site 92
S1325
S
V
V
V
L
M
G
S
L
A
K
H
L
D
K
Site 93
S1333
L
A
K
H
L
D
K
S
D
P
K
V
K
P
I
Site 94
T1350
K
L
I
A
A
L
S
T
P
S
Q
Q
V
Q
E
Site 95
S1358
P
S
Q
Q
V
Q
E
S
V
A
S
C
L
P
P
Site 96
Y1391
Q
L
L
E
S
D
K
Y
A
E
R
K
G
A
A
Site 97
Y1474
C
F
G
D
G
N
Q
Y
V
R
E
A
A
D
D
Site 98
S1510
L
A
A
L
E
E
E
S
W
R
T
K
A
G
S
Site 99
T1513
L
E
E
E
S
W
R
T
K
A
G
S
V
E
L
Site 100
S1517
S
W
R
T
K
A
G
S
V
E
L
L
G
A
M
Site 101
T1544
P
N
I
V
P
K
L
T
E
V
L
T
D
S
H
Site 102
T1548
P
K
L
T
E
V
L
T
D
S
H
V
K
V
Q
Site 103
S1567
Q
A
L
R
Q
I
G
S
V
I
R
N
P
E
I
Site 104
T1586
P
V
L
L
D
A
L
T
D
P
S
R
K
T
Q
Site 105
T1592
L
T
D
P
S
R
K
T
Q
K
C
L
Q
T
L
Site 106
T1629
R
A
F
Q
D
R
S
T
D
T
R
K
M
A
A
Site 107
S1644
Q
I
I
G
N
M
Y
S
L
T
D
Q
K
D
L
Site 108
T1646
I
G
N
M
Y
S
L
T
D
Q
K
D
L
A
P
Site 109
Y1654
D
Q
K
D
L
A
P
Y
L
P
S
V
T
P
G
Site 110
S1665
V
T
P
G
L
K
A
S
L
L
D
P
V
P
E
Site 111
S1677
V
P
E
V
R
T
V
S
A
K
A
L
G
A
M
Site 112
T1703
L
L
P
W
L
M
E
T
L
T
Y
E
Q
S
S
Site 113
T1705
P
W
L
M
E
T
L
T
Y
E
Q
S
S
V
D
Site 114
Y1706
W
L
M
E
T
L
T
Y
E
Q
S
S
V
D
R
Site 115
S1709
E
T
L
T
Y
E
Q
S
S
V
D
R
S
G
A
Site 116
S1710
T
L
T
Y
E
Q
S
S
V
D
R
S
G
A
A
Site 117
S1714
E
Q
S
S
V
D
R
S
G
A
A
Q
G
L
A
Site 118
T1796
E
N
E
F
V
R
D
T
A
L
R
A
G
Q
R
Site 119
S1806
R
A
G
Q
R
V
I
S
M
Y
A
E
T
A
I
Site 120
S1834
D
L
W
R
I
R
F
S
S
V
Q
L
L
G
D
Site 121
T1854
S
G
V
T
G
K
M
T
T
E
T
A
S
E
D
Site 122
T1875
Q
S
N
K
A
I
I
T
A
L
G
V
E
R
R
Site 123
Y1890
N
R
V
L
A
G
L
Y
M
G
R
S
D
T
Q
Site 124
S1894
A
G
L
Y
M
G
R
S
D
T
Q
L
V
V
R
Site 125
T1896
L
Y
M
G
R
S
D
T
Q
L
V
V
R
Q
A
Site 126
T1915
W
K
I
V
V
S
N
T
P
R
T
L
R
E
I
Site 127
T1918
V
V
S
N
T
P
R
T
L
R
E
I
L
P
T
Site 128
T1943
S
T
C
A
D
K
R
T
I
A
A
R
T
L
G
Site 129
S1974
I
L
E
E
G
L
R
S
Q
K
S
D
E
R
Q
Site 130
S1977
E
G
L
R
S
Q
K
S
D
E
R
Q
G
V
C
Site 131
S1993
G
L
S
E
I
M
K
S
T
S
R
D
A
V
L
Site 132
T2009
F
S
E
S
L
V
P
T
A
R
K
A
L
C
D
Site 133
T2028
V
R
E
A
A
A
K
T
F
E
Q
L
H
S
T
Site 134
S2034
K
T
F
E
Q
L
H
S
T
I
G
H
Q
A
L
Site 135
T2085
P
Y
L
V
P
K
L
T
T
P
P
V
N
T
R
Site 136
T2086
Y
L
V
P
K
L
T
T
P
P
V
N
T
R
V
Site 137
T2126
A
L
K
E
K
L
G
T
P
D
E
Q
L
E
M
Site 138
S2142
N
C
Q
A
V
I
L
S
V
E
D
D
T
G
H
Site 139
S2162
D
L
L
E
A
T
R
S
P
E
V
G
M
R
Q
Site 140
S2182
L
N
I
Y
C
S
R
S
K
A
D
Y
T
S
H
Site 141
Y2186
C
S
R
S
K
A
D
Y
T
S
H
L
R
S
L
Site 142
T2187
S
R
S
K
A
D
Y
T
S
H
L
R
S
L
V
Site 143
S2188
R
S
K
A
D
Y
T
S
H
L
R
S
L
V
S
Site 144
S2192
D
Y
T
S
H
L
R
S
L
V
S
G
L
I
R
Site 145
S2205
I
R
L
F
N
D
S
S
P
V
V
L
E
E
S
Site 146
T2220
W
D
A
L
N
A
I
T
K
K
L
D
A
G
N
Site 147
T2262
C
L
P
K
K
G
V
T
S
I
L
P
V
L
R
Site 148
S2263
L
P
K
K
G
V
T
S
I
L
P
V
L
R
E
Site 149
T2274
V
L
R
E
G
V
L
T
G
S
P
E
Q
K
E
Site 150
S2276
R
E
G
V
L
T
G
S
P
E
Q
K
E
E
A
Site 151
S2319
R
I
L
G
D
R
F
S
W
N
V
K
A
A
L
Site 152
T2351
F
L
P
Q
L
Q
T
T
F
T
K
A
L
Q
D
Site 153
S2359
F
T
K
A
L
Q
D
S
N
R
G
V
R
L
K
Site 154
T2403
E
D
P
G
V
R
D
T
M
L
Q
A
L
R
F
Site 155
T2442
L
G
H
D
E
D
N
T
R
I
S
S
A
G
C
Site 156
S2445
D
E
D
N
T
R
I
S
S
A
G
C
L
G
E
Site 157
S2446
E
D
N
T
R
I
S
S
A
G
C
L
G
E
L
Site 158
Y2505
G
R
L
C
A
G
R
Y
S
S
D
V
Q
E
M
Site 159
S2506
R
L
C
A
G
R
Y
S
S
D
V
Q
E
M
I
Site 160
S2515
D
V
Q
E
M
I
L
S
S
A
T
A
D
R
I
Site 161
T2542
L
M
R
H
H
I
E
T
G
G
G
Q
L
P
A
Site 162
S2564
K
C
L
Q
N
P
S
S
D
I
R
L
V
A
E
Site 163
T2606
D
N
T
K
D
K
N
T
V
V
R
A
Y
S
D
Site 164
Y2611
K
N
T
V
V
R
A
Y
S
D
Q
A
I
V
N
Site 165
S2631
Q
G
E
E
V
F
Q
S
L
S
K
I
L
D
V
Site 166
S2651
L
N
E
V
N
R
R
S
L
K
K
L
A
S
Q
Site 167
S2657
R
S
L
K
K
L
A
S
Q
A
D
S
T
E
Q
Site 168
S2661
K
L
A
S
Q
A
D
S
T
E
Q
V
D
D
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation